ION Profile

The ION Profile by Genova Diagnostics is a comprehensive nutritional assessment that provides a deep dive into an individual's nutritional status, offering insights that can guide personalized therapeutic interventions. 

This profile encompasses a variety of tests that analyze blood and urine samples to evaluate over 100 key nutritional and metabolic biomarkers. The aim is to identify nutritional deficiencies, imbalances, and underlying health issues that might not be apparent through conventional testing.

What does the ION Profile test?

Organic Acids: Measures organic acid levels in urine to assess cellular energy production, detoxification processes, neurotransmitter breakdown, and intestinal microbial activity. Elevated or decreased levels of specific organic acids can indicate nutritional deficiencies, metabolic dysfunctions, protein maldigestion or overgrowth of yeast and bacteria in the intestines. [2., 10.]

Amino Acids: Analyzes serum levels of essential and non-essential amino acids to evaluate dietary protein intake, digestion, absorption, and metabolic disorders. Amino acid imbalances can affect mood, immunity, cognitive function, and physical health. [11.]

Fatty Acid Profile: Assesses the levels of mono- and polyunsaturated fatty acids including omega-3 and omega-6 fatty acids as well as saturated fatty acids and trans fats.  Healthy fats are essential for hormone, brain, and cellular health, as well as a balanced inflammation response; this profile provides insights into dietary intake, ratio of healthy vs. unhealthy fatty acids, and the need for supplementation. [1., 9.]

Nutrient and Toxic Element Profile: Measures essential nutrients including vitamins and minerals required for optimal health.  The ION Profile also uncovers the presence of toxic heavy metals and screens for the presence of biomarkers that may indicate exposure to environmental toxins including pesticides, herbicides, fungicides, petrochemicals, and others.  Essential elements are crucial for numerous metabolic processes, while environmental toxins and toxic metals can interfere with these processes and lead to health issues. [3., 7.]

Antioxidant Vitamins: Tests for levels of vitamins A, C, E, and beta-carotene to assess antioxidant status and the body's ability to combat oxidative stress, which is linked to chronic diseases and aging. [6.]

Coenzyme Q10 and Vitamin D: Evaluates levels of CoQ10, essential for energy production and antioxidant protection, and vitamin D, important for bone health, immune function, and inflammation modulation. [5.8]

The ION Profile is particularly useful for individuals experiencing unexplained symptoms such as fatigue, mood disorders, digestive issues, and chronic health conditions. By identifying specific nutritional imbalances and metabolic dysfunctions, healthcare providers can develop targeted treatment plans that may include dietary modifications, supplementation, and lifestyle changes.

For those considering the ION Profile, it's crucial to work with a healthcare provider knowledgeable in interpreting the results within the context of your overall health and lifestyle. This personalized approach ensures that the insights gained from the profile translate into effective, practical interventions for improving your health and wellbeing.

Who should get an ION Profile?

The ION Profile by Genova Diagnostics is a comprehensive test that can benefit a wide range of individuals, particularly those who are seeking a deeper understanding of their nutritional status and metabolic health. Here are some groups who might find the ION Profile especially useful:

Individuals with Chronic Health Conditions: People suffering from chronic conditions such as fibromyalgia, chronic fatigue syndrome, autoimmune diseases, or digestive disorders may benefit from the ION Profile. It can help identify underlying nutritional deficiencies or imbalances that may contribute to their symptoms. [2.]

Those Experiencing Unexplained Symptoms: For those with symptoms like fatigue, mood swings, brain fog, or unexplained weight changes that haven’t been resolved through standard medical testing, the ION Profile can provide insights into possible nutritional or metabolic factors. [10.]

People with a Family History of Health Issues: Individuals with a family history of cardiovascular disease, diabetes, or other metabolic conditions might use the ION Profile to identify preemptive nutritional and lifestyle interventions. [1., 2., 9.]

Athletes and Fitness Enthusiasts: Optimizing nutritional status is crucial for performance and recovery. The ION Profile can help athletes and those with active lifestyles identify specific needs for amino acids, antioxidants, and other nutrients essential for energy, endurance, and recovery. [7., 11.]

Individuals Focused on Preventative Health Care: For those proactive about their health and interested in longevity, the ION Profile offers a way to identify and correct nutritional imbalances before they lead to health issues. [1., 11.]

People Undergoing Major Lifestyle or Dietary Changes: Individuals who are transitioning to a vegetarian or vegan diet, undergoing weight loss surgery, or making other significant dietary changes may benefit from the ION Profile to ensure their nutritional needs are met. [1., 4.]

Healthcare Professionals Seeking Comprehensive Assessments for Patients: Practitioners in functional medicine, integrative health, and nutrition often recommend the ION Profile to get a detailed understanding of their patients' unique nutritional and metabolic status, enabling personalized treatment plans.

The ION Profile is a tool that should be used as part of a comprehensive health assessment, guided by a healthcare provider who can interpret the results in the context of your overall health history, lifestyle, and symptoms. Consulting with a healthcare provider who is knowledgeable about functional medicine and nutritional testing can help ensure that the information gained from the ION Profile is used effectively to support your health goals.

Sample collection

The ION Profile by Genova Diagnostics typically requires both blood and urine samples to evaluate the comprehensive array of nutritional and metabolic markers included in the test. The collection process involves specific steps for each type of sample to ensure accuracy and reliability of the test results. Here’s a breakdown of the sample collection instructions:

Blood Sample Collection:

Fasting Requirement: You are usually required to fast for 10-12 hours prior to the blood draw, consuming only water. This fasting state helps in obtaining accurate measurements of certain blood metabolites and nutrients that can be affected by food intake.

Preparation: It's recommended to drink plenty of water before the test to stay hydrated, making the blood draw easier. Avoiding strenuous exercise before the test is also advised.

Blood Draw: The blood sample is typically drawn by a healthcare professional at a clinic or a laboratory. They will collect the blood in specific tubes provided in the test kit. The amount of blood drawn depends on the exact panels being assessed but usually involves one or more vials.

Urine Sample Collection:

Timing: Urine is often collected at home using a test kit provided by Genova Diagnostics. Instructions may vary, but a common requirement is the first morning urine after your longest sleep period, which provides a concentrated sample.

Collection Process: You'll be given collection containers and sometimes preservatives to mix with the urine sample. It’s important to follow the specific instructions provided with your test kit, which may include collecting all urine over a 24-hour period or providing a single or first morning void.

Storage and Shipping: After collection, the urine sample might need to be stored in a refrigerator or freezer, as specified in the kit instructions, until it's shipped back to the lab for analysis. The kit usually includes shipping materials and preservatives to ensure the sample remains viable during transport.

General Instructions for Both Samples:

Documentation: Complete all necessary paperwork that accompanies the test kit, ensuring that your samples are correctly identified and processed.

Shipping: Carefully pack your samples according to the instructions provided, usually in a prepaid shipping container, and send them back to the laboratory for analysis.

It's crucial to follow the collection instructions precisely as provided with your test kit to ensure the validity of the results. If you have any questions or concerns about the collection process, it's best to contact Genova Diagnostics directly or consult with the healthcare provider who ordered the test for you. They can provide guidance and support to make sure the collection process is done correctly.

Additional information

Shipping Time: The samples should be shipped to the lab using FedEx, with an expected shipping duration of 5 to 10 days.

Turnaround Time: After the lab receives the samples, the turnaround time for the test results is approximately 21 days.

Test Preparation Starts: Participants are advised to begin their test preparation up to 4 days before the sample collection. This preparation might include dietary restrictions or fasting, depending on specific test requirements.

Number of Collection Days: The sample collection process is designed to be completed within 1 to 2 days, depending on whether blood, urine, or both types of samples are required.

Methods Used For Processing: The analysis of the samples utilizes a range of sophisticated laboratory techniques, including High-Performance Liquid Chromatography (HPLC), Enzymatic assays, Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS), Colorimetric Assays, Capillary Gas Chromatography/Mass Spectrometry (Capillary GC/MS), and Inductively Coupled Plasma Mass Spectrometry (ICP-MS).

These methods ensure accurate quantification and identification of the various nutritional and metabolic markers evaluated in the profile.

References

[1.]  Chang CY, Ke DS, Chen JY. Essential fatty acids and human brain. Acta Neurol Taiwan. 2009 Dec;18(4):231-41. PMID: 20329590.

[2.]  Clish CB. Metabolomics: an emerging but powerful tool for precision medicine. Cold Spring Harb Mol Case Stud. 2015 Oct;1(1):a000588. doi: 10.1101/mcs.a000588. PMID: 27148576; PMCID: PMC4850886.

[3.]  Fu Z, Xi S. The effects of heavy metals on human metabolism. Toxicol Mech Methods. 2020 Mar;30(3):167-176. doi: 10.1080/15376516.2019.1701594. Epub 2019 Dec 17. PMID: 31818169.

[4.]  Gasmi A, Bjørklund G, Mujawdiya PK, Semenova Y, Peana M, Dosa A, Piscopo S, Gasmi Benahmed A, Costea DO. Micronutrients deficiences in patients after bariatric surgery. Eur J Nutr. 2022 Feb;61(1):55-67. doi: 10.1007/s00394-021-02619-8. Epub 2021 Jul 23. PMID: 34302218.

[5.]  Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord. 2017 Jun;18(2):153-165. doi: 10.1007/s11154-017-9424-1. PMID: 28516265.

[6.]  Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018 Apr 26;13:757-772. doi: 10.2147/CIA.S158513. PMID: 29731617; PMCID: PMC5927356.

[7.]  Lukaski HC. Vitamin and mineral status: effects on physical performance. Nutrition. 2004 Jul-Aug;20(7-8):632-44. doi: 10.1016/j.nut.2004.04.001. PMID: 15212745.

[8.]  Mantle D, Turton N, Hargreaves IP. Depletion and Supplementation of Coenzyme Q10 in Secondary Deficiency Disorders. Front Biosci (Landmark Ed). 2022 Dec 19;27(12):322. doi: 10.31083/j.fbl2712322. PMID: 36624950.

[9.]  McCowen KC, Bistrian BR. Essential fatty acids and their derivatives. Curr Opin Gastroenterol. 2005 Mar;21(2):207-15. doi: 10.1097/01.mog.0000153361.90653.cb. PMID: 15711215.

[10.]  Tsoukalas D, Alegakis A, Fragkiadaki P, Papakonstantinou E, Nikitovic D, Karataraki A, Nosyrev AE, Papadakis EG, Spandidos DA, Drakoulis N, Tsatsakis AM. Application of metabolomics: Focus on the quantification of organic acids in healthy adults. Int J Mol Med. 2017 Jul;40(1):112-120. doi: 10.3892/ijmm.2017.2983. Epub 2017 May 10. PMID: 28498405; PMCID: PMC5466383.

[11.]  Wu G. Functional amino acids in nutrition and health. Amino Acids. 2013 Sep;45(3):407-11. doi: 10.1007/s00726-013-1500-6. Epub 2013 Apr 18. PMID: 23595206.