ELISA / ACT Biotechnologies, established in 1984, focuses on immunological diagnostics with its Lymphocyte Response Assay (LRA) test, which is specialized in detecting delayed hypersensitivities.
With a commitment to advancing immune health, ELISA/ACT Biotechnologies prioritizes a proactive approach to healthcare. They advocate for the use of "predictive goal values" to enhance clinical outcomes over traditional lab ranges, offering extensive testing options for delayed hypersensitivity—the most in the industry.
Their comprehensive support for patients and practitioners is underpinned by extensive expertise in clinical medicine, biochemistry, immunology, integrative health, and nutrition, driving their mission to improve health through precise diagnostics and tailored treatment plans.
ELISA/ACT Biotechnologies, established in 1984, began with the development of the Lymphocyte Response Assay (LRA) to detect delayed hypersensitivities. This innovative test evaluates the immune system's response to environmental and microbial antigens such as foods, color agents, and chemicals. The LRA precisely measures reactions through three key hypersensitivity pathways: Reactive Antibody, Immune Complex, and T-Cell responses.
With over 30 years of expertise, ELISA/ACT Biotechnologies leverages patented technologies, patient-centric guidance, and value-added support to offer successful strategies for identifying and addressing the underlying causes of chronic diseases and immune dysfunctions.
Their clinically validated tests and personalized treatment plans have consistently proven effective in managing chronic autoimmune conditions and immune dysfunction syndromes, helping to restore patients' health and well-being.
The insights provided by these tests have proven instrumental in managing and treating conditions like asthma, migraines, irritable bowel syndrome (IBS), diabetes, and fibromyalgia, particularly those associated with chronic inflammation and autoimmunity.
In the United States approximately one in six people, or 40 million individuals, suffer from autoimmune and immune dysfunction diseases, leading to an annual expenditure of over $300 billion on treatments that often fail to alleviate suffering or improve health.
In response to this challenge, Dr. Russell M. Jaffe, MD, Ph.D., CCN, NACB, developed the LRA (LRA by ELISA/ACT™) tests and treatment plans in 1984. These tests allow physicians to precisely identify the underlying causes of many chronic conditions by directly analyzing lymphocytes. The LRA tests detect all three types of delayed food and chemical hypersensitivities, covering up to 512 items, thereby helping patients achieve sustained relief from their symptoms.
The Lymphocyte Response Assay (LRA) tests by ELISA/ACT are advanced diagnostic tools designed to uncover hidden causes of common health issues by directly analyzing lymphocytes—long-lived white blood cells that carry memory and indicate health status.
These tests are unique as they are the only ones that measure all three types of delayed sensitivity reactions: reactive antibody (IgA, IgM, IgG), immune complexes, and T cell direct activation, providing a comprehensive view of the immune system's response.
Conducted ex vivo, the LRA tests observe lymphocytes' reactions under controlled conditions, mirroring their behavior in the bloodstream. This method offers precise insights into delayed allergies by distinguishing between symptom-provoking reactions and mere antibody presence, which enhances the reliability and scope of the diagnosis.
Dr. Russell Jaffe, the founder of ELISA / ACT Biotechnologies, is an alumnus of Boston University School of Medicine who embarked on his career at the National Institutes of Health where he specialized in clinical chemistry.
Originally a skeptic of holistic health practices, his explorations into various traditional healing systems like Chinese Medicine and homeopathy transformed his perspective, leading him to found the Health Studies Collegium and PERQUE Integrative Health.
The clinical staff and client services team at ELISA / ACT Biotechnologies prioritize ease and support in working with healthcare professionals to restore patient health. They are present through the entire process from providing assistance with test administration to guiding both patients and office staff through the process of ordering and implementing their tests and treatment plans.
They process blood samples within 24 hours, ensuring that detailed reports are delivered promptly within 7-10 business days.
In addition to support through the ordering, sampling, and implementation process, ELISA / ACT Biotechnologies also provide expert nutritional counseling, implementation of dietary plans, and offer specialized support for complex cases, serving as a valuable clinical resource for practitioners.
Many of their test results are accompanied by nutritional, supplemental, and behavioral recommendations based on the patient’s answers to a health assessment questionnaire.
Additionally, they offer trainings and information regarding their testing process and the immune system.
ELISA / ACT Biotechnologies states that “the LRA by ELISA/ACT testing system is comprehensive and highly reproducible with a split sample daily variance of less than 3% of the items tested. This compares with 15-30% variance for other lymphocyte cell culture methods and 5-15% variance for older antibody procedures (like ELISA IgG / EIA).”
ELISA / ACT Biotechnologies is renowned for its comprehensive array of tests that help identify delayed hypersensitivities, which are crucial for diagnosing and managing various health conditions.
ELISA / ACT Biotechnologies offers a variety of Lymphocyte Response Assay (LRA) panels designed to detect immune reactions to a wide range of substances that might affect individual health.
These LRA Tests leverage advanced technology to monitor real-time immune reactions of lymphocytes, detecting all three types of delayed hypersensitivities: Type 2 (IgA, IgM, IgG), Type 3 Immune Complex, and Type 4 T cell-mediated.
Test results classify immune reactions as strong, moderate, or non-reactive and provide detailed descriptions of reactive items. For effective management, patients are advised to avoid substances causing strong reactions for six months and moderate reactions for three months, helping reduce immune burden and facilitate recovery.
The LRA Basic 144 Panel
The LRA Basic 144 Panel evaluates hypersensitivities to common allergens including foods, environmental chemicals, molds, additives, preservatives, and color additives. This panel is suited for patients exhibiting simple, recent-onset symptoms and provides a foundational insight into their immune responses.
It includes 66 commonly consumed foods, 15 environmental chemicals, 15 additives and preservatives, 28 molds, and 20 color additives.
This test is particularly useful for patients experiencing symptoms such as unexplained gastrointestinal issues, skin conditions, headaches, brain fog, joint pain, and autoimmune diseases.
LRA Enhanced Basic 212 Panel
The LRA Enhanced Basic Panel by ELISA/ACT Biotechnologies is a comprehensive sensitivity test designed to detect delayed hypersensitivities to 134 foods, 15 environmental chemicals, 15 additives and preservatives, 28 molds, and 20 color additives.
This panel is ideal for individuals experiencing initial symptoms of food and environmental allergies, such as digestive issues, skin conditions, joint pain, and autoimmune disorders.
LRA Comprehensive 317 Panel
The LRA Comprehensive 317 Panel is a detailed sensitivity test that identifies delayed hypersensitivities to 166 foods, 61 environmental chemicals, 28 additives and preservatives, 28 molds, 20 color additives, and 14 toxic minerals/metals.
This panel is particularly suited for patients with complex, chronic conditions or those experiencing symptoms related to food and environmental allergies, such as digestive issues, skin conditions, chronic pain, autoimmune diseases, and more.
LRA Professional’s Choice 389 Panel
The LRA Professional’s Choice 389 Panel is an extensive sensitivity test that identifies delayed hypersensitivities to 238 foods, 61 environmental chemicals, 28 additives and preservatives, 28 molds, 20 color additives, and 14 toxic minerals/metals.
Designed for patients with complex, chronic conditions or those showing symptoms related to food and environmental allergies, this panel is crucial for diagnosing issues like digestive disorders, autoimmune diseases, chronic fatigue, and skin conditions.
LRA Professional’s Choice Plus 406 Panel
The LRA Professional's Choice Plus 406 Panel is an extensive sensitivity test that identifies delayed hypersensitivities to 238 foods, 61 environmental chemicals, 45 additives and preservatives, 28 molds, 20 color additives, and 14 toxic minerals/metals.
This panel is ideal for patients with complex, long-standing conditions or those experiencing a wide range of symptoms such as gastrointestinal issues, autoimmune diseases, chronic fatigue, skin conditions, and respiratory problems like rhinitis and sinusitis.
In addition to broad panels, ELISA / ACT Biotechnologies offers specialized blocks that focus on specific types of hypersensitivities. Below is a list of their more popular test blocks, although they offer a wide variety of test blocks.
The LRA Silicone Hypersensitivity Block, for example, is tailored for individuals with breast implants who may be experiencing allergic symptoms. This test is specifically designed to detect delayed hypersensitivities to 19 common items associated with breast augmentation and other implants.
This test is particularly beneficial for individuals with concerns about implant component sensitivity or those considering implant procedures.
The LRA Orthopedic and LRA Dental tests are specialized for sensitivities related to materials used in orthopedic and dental treatments. These tests assess reactivity to a variety of chemicals found in these materials, providing critical information that can guide the choice of materials in patient treatments to avoid immune reactions.
ELISA/ACT Biotechnologies offers multiple Food Sensitivity Test Blocks, including:
They offer a variety of other specialty Test Blocks including:
Additionally, they offer Test Blocks that assess environmental sensitivities as well as combination panels:
Click here to view their complete test menu.
ELISA ACT specializes in their lymphocyte response assay for detecting delayed hypersensitivities.
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