Celiac Profile

The Celiac Profile is a comprehensive serologic profile that uses widely accepted immunologic biomarkers to aid in the diagnosis of Celiac disease and gluten sensitivity. 

What Is Included in the Celiac Profile by Genova Diagnostics?

The following markers are included in this profile: 

IgA and IgG Antibodies against Deamidated Gliadin Peptides: These antibodies against partially broken-down gliadin molecules that stimulate a T cell antibody response in susceptible

Anti-DGP IgA

Anti-DGP IgG

IgA and IgG Anti-Tissue Transglutaminase Antibodies: antibodies against the anti-tissue transglutaminase enzyme which is released in response to inflammation

Anti-tTG IgA

Anti-tTG IgG

Total IgA

Anti-EMA IgA (IgA Anti-Endomysial Antibodies)

Why is the Celiac Profile by Genova Diagnostics Clinically Relevant?

This panel includes serum antibodies against groups of antibodies that have been shown to have a high clinical correlation with the diagnosis of celiac disease.  [1., 2.]

Compared to the gold standard for diagnosis of celiac disease, an intestinal biopsy and pathology, this serum test is a much less invasive and still highly-specific and sensitive alternative to understanding whether a patient suffering with digestive and exta-intestinal manifestations may be living with celiac disease.  [1., 2.]

Who Can Benefit from the Celiac Profile by Genova Diagnostics?

A variety of individuals may benefit from the Celiac Profile by Genova Diagnostics: 

Individuals experiencing symptoms such as gastrointestinal discomfort including gas, bloating, loose stool

People with malabsorption issues and/or unexplained nutrient deficiencies

Individuals with a family history of celiac disease

People with autoimmune conditions

Patients with Hashimoto’s thyroiditis, especially those with an increased need for T4 due to malabsorption [3.]

People suspected of having celiac disease, who want to avoid a biopsy procedure

Collection and Shipping

For a complete list of collection instructions, click here.

Additional Resources for Clinicians

Article: How to Interpret Your Celiac Blood Test Results

References: 

[1.] Jafari SA, Alami A, Sedghi N, Kianifar H, Kiani MA, Khalesi M, Derafshi R. Diagnostic accuracy of anti-DGP (IgG) for celiac disease. J Family Med Prim Care. 2023 Jan;12(1):42-46. doi: 10.4103/jfmpc.jfmpc_326_22. Epub 2023 Feb 15. PMID: 37025242; PMCID: PMC10071923. 

[2.] Ortiz G, Messere G, Toca MDC, Fiorucci M, Bigliardi R, Vidal J, Reynoso R. IgA anti-tissue transglutaminase antibodies and IgG antibodies against deamidated gliadin peptides as predictors of celiac disease. Arch Argent Pediatr. 2019 Feb 1;117(1):52-55. English, Spanish. doi: 10.5546/aap.2019.eng.52. PMID: 30652447.

[3.] Sedhom R, Katz K. Celiac Disease and Treatment of Hypothyroidism: An Unappreciated Problem: 2049. Official journal of the American College of Gastroenterology | ACG. 2016;111:S978. Accessed February 20, 2024. https://journals.lww.com/ajg/fulltext/2016/10001/celiac_disease_and_treatment_of_hypothyroidism__an.2049.aspx#:~:text=There%20is%20evidence%20demonstrating%20a