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Reference Guide
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Anti-tTG IgA
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Anti-tTG IgA
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Anti-tTG IgA

What's 
Anti-tTG IgA
?
Anti-tTG IgA is a specific kind of defense substance that your body's protection system creates. It's important because it's closely connected to the health of your gut. The "tTG" part stands for tissue transglutaminase, an enzyme found in different parts of your body, but mostly in your intestines. The "IgA" refers to Immunoglobulin A, a group of defense substances that help protect the moist surfaces of your body. When your body's protection system senses something harmful, it produces Anti-tTG IgA to fight it off. This defense substance is often checked when looking into certain health issues related to the body's protection response and gut health.
If Your Levels Are High
Having higher than normal levels of Anti-tTG IgA might mean that your body's defense system is reacting to something it thinks is harmful in your gut. This could be caused by various things, such as your body not liking certain foods, coming into contact with bad bacteria, or an imbalance of the good and bad bacteria in your gut. Sometimes, taking certain medications or being stressed can also cause an increase in Anti-tTG IgA levels. In some cases, high levels of this defense substance might be linked to conditions like celiac disease, which is when your body has a negative reaction to gluten, a protein found in wheat, barley, and rye. However, it's important to remember that this is just one part of the bigger picture and there could be other factors involved as well.
Symptoms of High Levels
Symptoms of high levels of Anti-tTG IgA may include digestive issues such as bloating, diarrhea, or constipation, unexplained weight loss, fatigue, and skin rashes.
If Your Levels are Low
Low levels of Anti-tTG IgA might mean that your body's defense system isn't working as well as it should, especially in your gut. This could be due to a variety of reasons, such as a weak immune system, ongoing stress, or not getting the right nutrients from your diet. Some medications, like those that suppress the immune system, could also play a role in lowering these levels. It's important to note that some people naturally produce less IgA, which could result in lower Anti-tTG IgA levels. Additionally, conditions like selective IgA deficiency, a common immune system issue, could be a possible cause for these low levels.
Symptoms of Low Levels
Symptoms of low levels of Anti-tTG IgA may not be easily noticeable, as they can be quite subtle and varied. However, some individuals might experience frequent infections, particularly of the mucous membranes such as the gastrointestinal tract, leading to symptoms like persistent diarrhea or constipation, bloating, and abdominal discomfort.

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