Micronutrient Test

The SpectraCell Micronutrient Test is a comprehensive analysis tool that examines 31 essential vitamins, minerals, and other nutrients to pinpoint potential deficiencies and assess functional status. Micronutrients, including vitamins and minerals, are vital for maintaining normal metabolism, growth, and overall physical well-being. 

While vitamins are organic compounds essential for various bodily functions and obtained exclusively from the diet, minerals are inorganic nutrients crucial for optimal health, obtained from trace amounts in food. 

These micronutrients play pivotal roles in numerous physiological processes, such as energy production, immune system function, inflammation reduction, antioxidant defense, hormonal balance, cellular aging prevention, tissue health maintenance, and cancer prevention and management.

Micronutrient deficiencies can lead to a wide range of health issues and complications, including impaired immune function, increased susceptibility to infections, compromised cognitive function, poor wound healing, fatigue, anemia, bone disorders, low energy, poor skin health, hair loss, chronic diseases. [11., 16.] 

These deficiencies disrupt essential physiological processes and can significantly impact overall health and well-being.

Understanding and addressing micronutrient deficiencies through the SpectraCell Micronutrient Test can support overall health and prevent various health issues by optimizing nutrient status.

What is Assessed in the Micronutrient Test by Spectracell Laboratories?

The Micronutrient Test assesses an individual’s level of the following vitamins, minerals, and nutrients:

Vitamin B12: vitamin B12, or cobalamin,  is essential for nerve function, DNA synthesis, and red blood cell production. Deficiency can lead to anemia, neuropathy, cognitive impairment, and cardiovascular disease.  Cobalamin is attached to different groups in biochemical settings, and many of these are also available as supplements, which may provide different health benefits.  

[4.]

Vitamin C: vitamin C is a potent antioxidant involved in collagen synthesis, immune function, and wound healing. It also enhances iron absorption and protects against oxidative stress. [1.] 

Vitamin D3: vitamin D3 is also a hormone and it plays a crucial role in calcium metabolism, bone health, immune function, and modulation of inflammatory responses. Deficiency is associated with increased risk of osteoporosis, autoimmune diseases, and infections.  [8.]

Vitamin E: vitamin E is a fat-soluble antioxidant that protects cell membranes from oxidative damage. It plays a role in immune function, skin health, and cardiovascular protection. Deficiency may increase the risk of cardiovascular disease and neurodegenerative disorders.  [28.]

Vitamin K2: vitamin K2 is essential for blood coagulation, bone metabolism, and cardiovascular health. It activates proteins involved in calcium regulation, promoting bone mineralization and reducing arterial calcification. [19.]

Folate: folate is essential for DNA synthesis, cell division, and methylation reactions. It plays a critical role in fetal development, cardiovascular health, and prevention of neural tube defects. Deficiency is associated with anemia and increased risk of birth defects. [29.]

CoQ10: coenzyme Q10 is a mitochondrial antioxidant involved in energy production and cellular respiration. It supports cardiovascular health, reduces oxidative stress, and may improve symptoms of heart failure and neurodegenerative diseases.  [42.]

Vitamin B6: vitamin B6, also known as pyridoxine, is involved in amino acid metabolism, neurotransmitter synthesis, and hemoglobin production. It plays a crucial role in immune function, cognitive development, and maintaining healthy nervous and cardiovascular systems.  [2.] 

Vitamin B3 (Niacin): vitamin B3, in its active forms nicotinic acid and nicotinamide, is essential for energy metabolism, DNA repair, and cell signaling. It plays a crucial role in maintaining healthy skin, digestive function, and nervous system function. [12., 34.]

Vitamin B2 (Riboflavin): vitamin B2 is involved in energy metabolism, red blood cell production, and antioxidant defense. It plays a critical role in maintaining healthy skin, vision, and mucous membranes. [35.] 

Vitamin B1 (Thiamine): vitamin B1 is essential for carbohydrate metabolism, nerve function, and energy production. It plays a crucial role in maintaining normal cardiac function, brain health, and overall energy metabolism. [24.] 

Vitamin A: vitamin A is essential for vision, immune function, and cellular differentiation. It plays a critical role in maintaining healthy skin, mucous membranes, and reproductive health.  The active form of vitamin A is retinol.  Vitamin A deficiency and vitamin A toxicity both have important implications for human health.  [27.]

Pantothenic Acid: pantothenic acid is a B vitamin, also known as vitamin B5, that plays a vital role in energy metabolism, synthesizing fatty acids, cholesterol, steroid hormones, and neurotransmitters. It is an important cofactor in adrenal health.  Deficiency can lead to symptoms such as fatigue, irritability, numbness, and tingling.  [40.]

Biotin: biotin, also known as vitamin B7, is essential for energy metabolism, fatty acid synthesis, and glucose regulation. It plays a crucial role in maintaining healthy hair, skin, and nails. Measuring biotin levels helps assess nutritional status and diagnose biotin deficiency, which can present with dermatological, neurological, and metabolic symptoms.  [6.]

Selenium: selenium is an essential trace mineral with antioxidant properties, crucial for thyroid function, immune response, and DNA synthesis. Deficiency is linked to thyroid disorders, weakened immunity, mood disorders, and increased risk of certain cancers. [38.] 

Calcium: calcium is necessary for bone health, muscle function, nerve transmission, and blood clotting. Inadequate intake can lead to osteoporosis, muscle cramps, and impaired nerve function. [D13.] 

Chromium: chromium is involved in carbohydrate and lipid metabolism, enhancing insulin sensitivity and regulating blood sugar levels. Deficiency may contribute to glucose intolerance and insulin resistance. [5.] 

Copper: copper balance is essential; too much or too little has detrimental effects on human health.  Copper plays a role in energy production, iron metabolism, connective tissue formation, and antioxidant defense. Deficiency can lead to anemia, osteoporosis, and impaired immune function. [32.] 

Zinc: zinc is essential for immune function, wound healing, DNA synthesis, antioxidant function and protein metabolism. Deficiency can impair immune response, delay wound healing, and may be associated with mood disturbances.  [25.37.]

Magnesium: magnesium  is involved in over 300 enzymatic reactions, including energy production, muscle function, and nerve transmission. Deficiency can manifest as muscle cramps, fatigue, cardiovascular abnormalities, and through downstream effects on various physiological systems it may have various other manifestations. 

Manganese: manganese is essential for bone formation, collagen production, and antioxidant defense. Deficiency may impair growth, reproductive function, and glucose metabolism. [30.]

Glutathione: glutathione is a potent antioxidant that protects cells from oxidative damage, supports immune function, and detoxifies harmful substances. Low levels are associated with increased oxidative stress and various health conditions.  [36.]

Alpha-Lipoic Acid: alpha-lipoic acid is a potent antioxidant with anti-inflammatory properties. It plays a critical role in mitochondrial function, glucose metabolism, and nerve health. Measuring alpha-lipoic acid levels can help assess antioxidant status and guide supplementation in conditions such as diabetic neuropathy and neurodegenerative diseases. [33.] 

Oleic Acid: oleic acid is an omega-9 monounsaturated fatty acid found in various dietary sources such as olive oil and avocados. It plays a crucial role in cardiovascular health, inflammation regulation, and insulin sensitivity. Measuring oleic acid levels helps assess dietary intake and metabolic health.  [39.]

Carnitine: carnitine plays a role in fatty acid metabolism, facilitating the transport of fatty acids into mitochondria for energy production. Deficiency can lead to muscle weakness, fatigue, and impaired exercise performance. [3.] 

Inositol: inositol is involved in cell signaling, neurotransmitter function, and lipid metabolism. It may have benefits in conditions such as anxiety, depression, and polycystic ovary syndrome (PCOS) through its cell-signaling effects on insulin.  [23.]

Choline: choline is important for brain development, neurotransmitter synthesis, and liver function. Inadequate intake may impair memory, cognitive function, and liver health.  It is especially important in pregnancy and breastfeeding. 

Serine: serine is involved in the synthesis of proteins, nucleotides, and neurotransmitters. It plays a role in cell proliferation, immune function, and brain health. [18.] 

Glutamine: glutamine is the most abundant amino acid in the body and plays a crucial role in protein synthesis, immune function, and intestinal health.  Deficiency can impair immune response and gut integrity. [10.]

Asparagine: asparagine is involved in protein synthesis, neurotransmitter function, and regulation of cellular metabolism. It may play a role in maintaining cognitive function and mood stability.  It may also be an important regulator in cancer development and proliferation.  [22.] 

Cysteine: cysteine is a precursor to glutathione, a powerful antioxidant, and plays a role in detoxification, immune function, and protein synthesis. Deficiency may impair antioxidant defense and increase oxidative stress.  [9.]

Total Antioxidant Function: total antioxidant function measures the overall capacity of cells to resist damage caused by oxidative stress.  The protective effect is due to robust antioxidant level in the body that neutralize free radicals and prevent oxidative damage. It reflects the body's ability to maintain cellular integrity and reduce the risk of chronic diseases. [45.]  

Total Immune Function: the Immunidex assessment provides a score reflecting how well an individual’s immune system can resist outside threats.  It may provide important information regarding immune function in warding off disease, fighting cancer, and mitigating an autoimmune response.  [44.]

Glucose-Insulin Metabolism: monitoring glucose-insulin metabolism helps assess insulin sensitivity, glucose utilization, and risk of metabolic disorders such as diabetes mellitus. Dysregulation in glucose-insulin metabolism can lead to hyperglycemia, insulin resistance, and metabolic syndrome. [43.] 

Fructose Sensitivity: fructose sensitivity refers to the body's inability to properly metabolize fructose, leading to symptoms such as bloating, abdominal pain, and diarrhea. Measuring fructose sensitivity helps diagnose fructose malabsorption and guide dietary interventions to alleviate symptoms.  [14.]

Who Could Benefit from the Micronutrient Test by Spectracell Laboratories? 

The Micronutrient Test by Spectracell can benefit individuals who are experiencing symptoms of micronutrient deficiencies or seeking to optimize their nutritional status. It is particularly beneficial for individuals with chronic diseases, metabolic disorders, gastrointestinal issues, autoimmune conditions, and those following restrictive diets. 

Additionally, athletes, the elderly, and individuals with high stress levels may also benefit from this test to ensure adequate nutrient intake for optimal health and performance.

Individuals with chronic diseases: people living with conditions such as diabetes, cardiovascular diseases, and cancer, as micronutrient deficiencies can exacerbate symptoms and contribute to disease progression. [21.]

People with gastrointestinal disorders: Crohn's disease, ulcerative colitis, celiac disease, and irritable bowel syndrome, and other gastrointestinal conditions  as these conditions can impair nutrient absorption and increase the risk of deficiencies. [17.]

Individuals with metabolic disorders such as obesity and metabolic syndrome: imbalances in micronutrient levels may contribute to metabolic dysfunction. [46.]

Athletes and physically active individuals: these people  have increased nutrient requirements due to higher energy expenditure and oxidative stress during exercise.  [15.]

Elderly individuals: elderly populations are at greater risk of micronutrient deficiencies due to decreased absorption, altered metabolism, and dietary intake [20.]

People following restrictive diets: people following specific weight loss diets, traditional ketogenic, vegan or vegetarian diets may benefit from this test as these diets may lack certain micronutrients typically found in animal-based foods  [7.]

Individuals with autoimmune conditions: micronutrients play a role in modulating immune function and inflammation; the link between autoimmunity and impaired intestinal barrier function may cause or worsen micronutrient deficiencies.   [26.]

People with decreased caloric intake: disordered eating and bariatric surgery cause a chronically decreased intake of calories, and this may also lead to chronic deficiencies in one or many micronutrients.  [41.]

REFERENCES

[1.] Abdullah M, Jamil RT, Attia FN. Vitamin C (Ascorbic Acid) [Updated 2023 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK499877/

[2.] Abosamak NER, Gupta V. Vitamin B6 (Pyridoxine) [Updated 2023 Aug 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557436/ 

[3.] Adeva-Andany MM, Calvo-Castro I, Fernández-Fernández C, Donapetry-García C, Pedre-Piñeiro AM. Significance ofl-carnitine for human health. IUBMB Life. 2017;69(8):578-594. doi:https://doi.org/10.1002/iub.1646

[4] Al Amin ASM, Gupta V. Vitamin B12 (Cobalamin) [Updated 2023 Jul 16]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559132/

Allen MJ, Sharma S. Magnesium. [Updated 2023 Feb 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK519036/

[5.] Anderson RA. Nutritional role of chromium. Sci Total Environ. 1981 Jan;17(1):13-29. doi: 10.1016/0048-9697(81)90104-2. PMID: 7010598.

[6.] Bistas KG, Tadi P. Biotin. [Updated 2023 Jul 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554493/

[7.] Calton JB. Prevalence of micronutrient deficiency in popular diet plans. Journal of the International Society of Sports Nutrition. 2010;7(1). doi:https://doi.org/10.1186/1550-2783-7-24

[8.] Chauhan K, Shahrokhi M, Huecker MR. Vitamin D. [Updated 2023 Apr 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441912/ 

[9.] Clemente Plaza N, Reig García-Galbis M, Martínez-Espinosa RM. Effects of the Usage of l-Cysteine (l-Cys) on Human Health. Molecules. 2018 Mar 3;23(3):575. doi: 10.3390/molecules23030575. PMID: 29510494; PMCID: PMC6017824.

[10.] Cruzat V, Macedo Rogero M, Noel Keane K, Curi R, Newsholme P. Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation. Nutrients. 2018 Oct 23;10(11):1564. doi: 10.3390/nu10111564. PMID: 30360490; PMCID: PMC6266414.

[11.] DiBaise M, Tarleton SM. Hair, Nails, and Skin: Differentiating Cutaneous Manifestations of Micronutrient Deficiency. Nutr Clin Pract. 2019 Aug;34(4):490-503. doi: 10.1002/ncp.10321. Epub 2019 May 29. PMID: 31144371. 

[12.] Djadjo S, Bajaj T. Niacin. [Updated 2023 Mar 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK541036/

[13.] Drake TM, Gupta V. Calcium. [Updated 2024 Jan 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557683/

[14.] Fedewa A, Rao SS. Dietary fructose intolerance, fructan intolerance and FODMAPs. Curr Gastroenterol Rep. 2014 Jan;16(1):370. doi: 10.1007/s11894-013-0370-0. PMID: 24357350; PMCID: PMC3934501.

[15.] Ghazzawi HA, Hussain MA, Raziq KM, Alsendi KK, Alaamer RO, Jaradat M, Alobaidi S, Al Aqili R, Trabelsi K, Jahrami H. Exploring the Relationship between Micronutrients and Athletic Performance: A Comprehensive Scientific Systematic Review of the Literature in Sports Medicine. Sports (Basel). 2023 May 24;11(6):109. doi: 10.3390/sports11060109. PMID: 37368559; PMCID: PMC10302780.

[16.] Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients. 2020 Jan 16;12(1):236. doi: 10.3390/nu12010236. PMID: 31963293; PMCID: PMC7019735.

[17.] Hallert C, Grant C, Grehn S, Grännö C, Hultén S, Midhagen G, Ström M, Svensson H, Valdimarsson T. Evidence of poor vitamin status in coeliac patients on a gluten-free diet for 10 years. Aliment Pharmacol Ther. 2002 Jul;16(7):1333-9. doi: 10.1046/j.1365-2036.2002.01283.x. PMID: 12144584. 

[18.] Holeček M. Serine Metabolism in Health and Disease and as a Conditionally Essential Amino Acid. Nutrients. 2022 May 9;14(9):1987. doi: 10.3390/nu14091987. PMID: 35565953; PMCID: PMC9105362.

[19.] Imbrescia K, Moszczynski Z. Vitamin K. [Updated 2023 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK551578/

[20.] Kaur D, Rasane P, Singh J, Kaur S, Kumar V, Mahato DK, Dey A, Dhawan K, Kumar S. Nutritional Interventions for Elderly and Considerations for the Development of Geriatric Foods. Curr Aging Sci. 2019;12(1):15-27. doi: 10.2174/1874609812666190521110548. PMID: 31109282; PMCID: PMC6971894.

[21.] Kiani AK, Dhuli K, Donato K, Aquilanti B, Velluti V, Matera G, Iaconelli A, Connelly ST, Bellinato F, Gisondi P, Bertelli M. Main nutritional deficiencies. J Prev Med Hyg. 2022 Oct 17;63(2 Suppl 3):E93-E101. doi: 10.15167/2421-4248/jpmh2022.63.2S3.2752. PMID: 36479498; PMCID: PMC9710417.

[22.] Lomelino CL, Andring JT, McKenna R, Kilberg MS. Asparagine synthetase: Function, structure, and role in disease. J Biol Chem. 2017 Dec 8;292(49):19952-19958. doi: 10.1074/jbc.R117.819060. Epub 2017 Oct 30. PMID: 29084849; PMCID: PMC5723983.

[23.] López-Gambero AJ, Sanjuan C, Serrano-Castro PJ, Suárez J, Rodríguez de Fonseca F. The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases. Biomedicines. 2020 Aug 20;8(9):295. doi: 10.3390/biomedicines8090295. PMID: 32825356; PMCID: PMC7554709.

[24.] Martel JL, Kerndt CC, Doshi H, et al. Vitamin B1 (Thiamine) [Updated 2024 Jan 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482360/ 

[25.] Maxfield L, Shukla S, Crane JS. Zinc Deficiency. [Updated 2023 Jun 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK493231/ 

[26.] Mazzucca CB, Raineri D, Cappellano G, Chiocchetti A. How to Tackle the Relationship between Autoimmune Diseases and Diet: Well Begun Is Half-Done. Nutrients. 2021 Nov 5;13(11):3956. doi: 10.3390/nu13113956. PMID: 34836210; PMCID: PMC8620243. 

[27.] McEldrew EP, Lopez MJ, Milstein H. Vitamin A. [Updated 2023 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482362/

[28.] Medina J, Gupta V. Vitamin E. [Updated 2023 May 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557737/

[29.] Merrell BJ, McMurry JP. Folic Acid. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554487/ 

[30.] National Institutes of Health. Office of Dietary Supplements - Manganese. Nih.gov. Published 2017. https://ods.od.nih.gov/factsheets/Manganese-HealthProfessional/

[31] National Institutes of Health. Office of Dietary Supplements - Choline. Nih.gov. Published 2017. https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/

[32.] National Research Council (US) Committee on Copper in Drinking Water. Copper in Drinking Water. Washington (DC): National Academies Press (US); 2000. 2, Physiological Role of Copper. Available from: https://www.ncbi.nlm.nih.gov/books/NBK225407/

[33.] Nguyen H, Pellegrini MV, Gupta V. Alpha-Lipoic Acid. [Updated 2024 Jan 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK564301/ 

[34.] Peechakara BV, Gupta M. Vitamin B3. [Updated 2022 Jun 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK526107/

[35.] Peechakara BV, Sina RE, Gupta M. Vitamin B2 (Riboflavin) [Updated 2024 Feb 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK525977/

[36.] Pizzorno J. Glutathione! Integr Med (Encinitas). 2014 Feb;13(1):8-12. PMID: 26770075; PMCID: PMC4684116.

[37.] Rabinovich D, Smadi Y. Zinc. [Updated 2023 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK547698/

[38.] Rayman MP. The importance of selenium to human health. Lancet. 2000 Jul 15;356(9225):233-41. doi: 10.1016/S0140-6736(00)02490-9. PMID: 10963212.

[39.] Sales-Campos H, Souza PR, Peghini BC, da Silva JS, Cardoso CR. An overview of the modulatory effects of oleic acid in health and disease. Mini Rev Med Chem. 2013 Feb;13(2):201-10. PMID: 23278117.

[40.] Sanvictores T, Chauhan S. Vitamin B5 (Pantothenic Acid) [Updated 2023 Jun 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK563233/

[41.] Shankar P, Boylan M, Sriram K. Micronutrient deficiencies after bariatric surgery. Nutrition. 2010 Nov-Dec;26(11-12):1031-7. doi: 10.1016/j.nut.2009.12.003. Epub 2010 Apr 3. PMID: 20363593.

[42.] Sood B, Patel P, Keenaghan M. Coenzyme Q10. [Updated 2024 Jan 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK531491/ 

[43.] SpectraCell Laboratories | Online Library-MNT Glucose/Insulin Metabolism. www.spectracell.com. Accessed February 9, 2024. https://www.spectracell.com/online-library-mnt-glucoseinsulin-metabolism 

[44.] SpectraCell Introduces ImmunidexTM. www.spectracell.com. Accessed February 9, 2024. https://www.spectracell.com/blog/posts/bid-74986-spectracell-introduces-immunidex 

[45.] SpectraCell Laboratories | MNT. www.spectracell.com. Accessed February 9, 2024. https://www.spectracell.com/mnt/ 

[46.] Via M. The malnutrition of obesity: micronutrient deficiencies that promote diabetes. ISRN Endocrinol. 2012;2012:103472. doi: 10.5402/2012/103472. Epub 2012 Mar 15. PMID: 22462011; PMCID: PMC3313629.