Dermatology
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October 9, 2024

What Lab Tests Should You Get For Acne?

Medically Reviewed by
Updated On
October 25, 2024

Acne is a skin condition that arises when excess oil production, disordered skin cell shedding, bacterial overgrowth, and the immune system cause clogged pores and inflammation. 

While mild cases of acne may respond to topical treatments and diligent skincare routines, more severe or persistent cases often require a deeper, more integrative approach. Studies show that 12.2-80% of individuals experience relapse or treatment failure with conventional acne medications, depending on the treatment modality (36, 65). 

This highlights the need for more comprehensive strategies to address acne's underlying causes. Laboratory testing helps identify the root causes of acne beyond surface-level symptoms. 

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When Are Lab Tests Necessary for Acne?

In most cases, acne can be diagnosed with a thorough physical examination and medical history. However, the clinical utility of laboratory tests becomes evident in specific scenarios – such as severe cases, those unresponsive to first-line treatments, or when underlying triggers like hormonal imbalances or food allergies are suspected and require confirmation.

What triggers one person's acne may differ from another's. Lab tests are valuable for dermatologists because they help identify the specific factors responsible for an individual's acne. This enables providers to move beyond generic treatments and adopt a targeted strategy that enhances treatment outcomes and minimizes unnecessary interventions.

Signs and symptoms that indicate it's time to consider lab tests to personalize your acne treatment protocol include: 

Common Lab Tests for Acne: What to Expect

Although not all of these tests are necessary for every patient, they represent common options that individuals might consider discussing with their healthcare providers. 

Hormonal Testing

Androgens, often called male sex hormones (but also present in women in smaller amounts), increase the size and activity of sebaceous (oil) glands in the skin. Dehydroepiandrosterone (DHEA), testosterone, and dihydrotestosterone (DHT) are examples of androgens. 

Elevated androgen levels lead to overproduction of sebum, which can clog pores and create an environment conducive to the growth of acne-causing bacteria (59). Conditions characterized by androgen excess, such as polycystic ovary syndrome (PCOS), often present with acne as a symptom. 

In addition to having an excess of androgens, women with PCOS commonly have an LH:FSH ratio of greater than 1. To calculate this ratio, measure the serum levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Then, divide the LH level by the FSH level. 

Changes in estrogen and progesterone related to the menstrual cycle influence skin health, which is why many women experience acne breakouts as a physical symptom of premenstrual syndrome (PMS), pregnancy, and menopause. 

While estrogen and progesterone can be measured in blood, the natural fluctuations in their levels from day to day can make catching hormonal imbalances difficult. Instead, providers often use multi-day salivary or urinary tests to measure these hormones throughout a menstrual cycle. (30) 

Use the following labs to screen for hypothalamic-pituitary-gonadal (HPG) axis dysfunction and sex hormone imbalances as a cause of acne:

Insulin and Blood Sugar Tests

Insulin resistance occurs when the body's cells do not respond effectively to insulin, leading to impaired glucose uptake and elevated blood sugar levels. This is problematic for acne-prone skin because insulin stimulates the production of androgens and insulin-like growth factor 1 (IGF-1). Like androgens, IGF-1 promotes sebum production. (55)

High blood sugar and insulin resistance are also linked to systemic inflammation, which can worsen acne symptoms. Inflammatory processes in the skin can lead to increased redness, swelling, and discomfort associated with more severe acne types, like nodulocystic acne.

The Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) is a widely used method for estimating insulin resistance based on fasting blood glucose and insulin levels. A score below 1.0 indicates optimal insulin sensitivity, scores between 1.0 and 1.9 suggest early insulin resistance, and scores above 2.9 indicate significant insulin resistance (39). 

Studies have found that nearly 43% of patients with acne are insulin-resistant, with a positive correlation between HOMA-IR and acne severity, meaning that acne tends to worsen as insulin resistance increases.

Use the following labs to screen for dysglycemia (abnormal blood sugar) and insulin resistance as a cause of acne:

Cortisol and Stress Hormone Testing

Chronic stress impacts skin health through the activation of the hypothalamic-pituitary-adrenal (HPA) axis, which leads to increased corticotropin-releasing hormone (CRH) and cortisol secretion. Chronic elevations of CRH cortisol are linked to increased systemic inflammation and heightened oil production from sebaceous glands, which aggravates existing lesions and creates an environment that promotes new breakouts.

Cortisol testing can be performed using blood, saliva, or urine samples to assess the impact of stress on the body. Each method provides insights into cortisol levels at different times of the day or in response to specific stressors. 

Use the following labs to screen for chronic stress and cortisol dysregulation as a cause of acne:

Thyroid Function Tests

The thyroid is a butterfly-shaped gland that regulates metabolism by secreting thyroid hormones (T4 and T3), which influence various physiological processes, including skin cell proliferation, differentiation, and function. When thyroid hormone levels are imbalanced, as seen in conditions like hypothyroidism or hyperthyroidism, it can lead to dermatological changes, including: 

  • Dry skin
  • Oily skin
  • Excessive sweating

One study found that 72% of patients with severe acne had autoimmune thyroid disease (Hashimoto's thyroiditis or Graves' disease), and the presence of thyroid antibodies called anti-thyroglobulin (anti-TG) doubled the risk of severe acne.

Use the following labs to screen for thyroid dysfunction as a cause of acne:

Blood Tests for Nutrient Deficiencies

Vitamin D is essential for numerous bodily functions, including immune system regulation and inflammation control. Studies have shown that individuals with acne often have lower levels of vitamin D, and supplementation improves acne severity by reducing inflammation, decreasing sebum secretion, and inhibiting the growth of acne-causing bacteria (52). 

Zinc is an antioxidant mineral that is another critical nutrient for skin health through its involvement in immune function, DNA synthesis, cell division, and wound healing. Zinc possesses anti-inflammatory and antibacterial properties, making it particularly beneficial for acne management. Supplementation with zinc has been shown to improve acne symptoms in various studies. (48, 52)

Use the following labs to screen for nutrient deficiencies as a cause of acne:

Additional Tests for Specific Cases

In specific scenarios, your doctor may also recommend ordering additional tests. 

Polycystic Ovary Syndrome (PCOS) Panel

PCOS is a common hormonal disorder that affects 7% of women of reproductive age in the United States. 

Doctors should suspect PCOS in patients with the following:

  • Irregular periods
  • Hirsutism (excessive male-pattern hair growth)
  • Acne
  • Weight gain/difficult weight loss
  • Polycystic ovaries as seen on ultrasound (9) 

PCOS is diagnosed using the Rotterdam Criteria, but a more comprehensive laboratory evaluation is warranted for this condition, given its association with cardiometabolic disease. 

These labs help assess hormonal imbalances and screen for high cholesterol, insulin resistance, high blood sugar, and inflammation:

Comprehensive Metabolic Panel (CMP)

Isotretinoin is an oral prescription medication used to treat severe nodular acne unresponsive to conventional therapy. The FDA issued a black box warning for isotretinoin for its potential to cause severe, life-threatening congenital disabilities if taken during pregnancy. (51) 

Other side effects associated with its use include:

To monitor patients on isotretinoin therapy, healthcare providers should:

  • Order two pregnancy tests before therapy and one test at monthly intervals during treatment
  • Evaluate blood sugar frequently 
  • Measure lipid levels at weekly or biweekly intervals for one month
  • Perform hepatic function tests at weekly or biweekly intervals for one month (51)

Blood sugar and hepatic function tests are included in a comprehensive metabolic panel (CMP). 

How Test Results Influence Treatment Plans

Laboratory test results allow healthcare providers to personalize a root-cause approach to acne management. 

Hormonal Therapies

Identifying hormonal imbalances in androgens, estrogen, and/or progesterone should prompt healthcare providers to consider hormonal treatments for acne. 

Prescription medications that target hormonal imbalances include: 

  • Combined oral contraceptive pills
  • Antiandrogen drugs, such as spironolactone

Natural options for balancing hormones and supporting a healthy menstrual cycle include: 

Dietary and Lifestyle Modifications

Reversing insulin resistance requires a holistic approach that begins with lifestyle adjustments, including: 

In some cases, natural supplements and prescription medications may be recommended to control blood sugar levels, improve insulin sensitivity, and reduce acne symptoms more quickly. Examples include: 

  • Chromium improves insulin's binding to its receptors, increases insulin-mediated glucose uptake into cells, and enhances the activity of enzymes involved in carbohydrate metabolism.
  • Cinnamon supports lower blood sugar levels by facilitating glucose uptake into cells.
  • Magnesium acts as a cofactor for various enzymes involved in insulin signaling, 
  • Metformin decreases the amount of glucose the liver produces, reduces intestinal absorption of glucose, and increases glucose uptake in peripheral tissues.

Stress Management Interventions

Cortisol testing can reveal both hyper-responsiveness and hypo-responsiveness of the adrenal glands, depending on the duration of stress exposure.

​​Excessive cortisol production requires interventions aimed at reducing cortisol levels and managing symptoms of stress and anxiety. Treatment options include:

Insufficient cortisol production requires interventions that focus on nourishing the adrenal glands:

  • Nutrient support with B vitamins, vitamin C, magnesium, and zinc
  • Stimulating adaptogenic herbs, such as licorice, which prolongs the half-life of cortisol

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Key Takeaways

  • Laboratory tests help identify acne's underlying causes and triggers.
  • Utilizing lab test results, healthcare providers can develop targeted therapies that address specific triggers, ultimately leading to more effective management of even the most stubborn acne cases. 
  • If you suspect hormonal imbalances, nutritional deficiencies, or other medical conditions are affecting your skin, talk to your doctor about ordering investigative labs.
  • With the right diagnosis and implementation of a targeted treatment protocol, acne can be managed effectively, achieving clearer skin.
The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.

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Lab Tests in This Article

Female Hormone Panel by Boston Heart Diagnostics
Serum
The Female Hormone Panel provides a broad assessment of sex and adrenal hormones important to women's health. It cannot be ordered for females under seven years of age. Please be advised that Boston Heart Diagnostics policy states that practitioners cannot order labs on themselves or their immediate family members.
HOMA-IR by Boston Heart Diagnostics
Serum
This test uses the Homeostatic Model Assessment to approximate a patient's insulin resistance. Please be advised that Boston Heart Diagnostics policy states that practitioners cannot order labs on themselves or their immediate family members.
Metabolomic Profile by Doctor's Data
Serum
The Metabolomic Profile assesses an at-risk patient's likelihood of developing metabolic syndrome. Early detection of metabolic syndrome risk is important because associated symptoms may not be evident until it is well advanced.
CardioPro Advanced by Access Med Labs
Serum
The CardioPro Advanced builds upon the CardioPro Basic by adding two more essential components to provide a clearer picture of a patient’s cardiovascular state. It includes the PLAC test and Vitamin D, 25-OH, which is proven to be preventative for heart disease and strokes.
Micronutrient Test by SpectraCell Laboratories
Whole Blood
The SpectraCell Micronutrient Test analyzes over 30 vitamins, minerals, and other nutrients to determine nutritional deficiencies. It also analyzes the performance and functional deficiencies of these micronutrients. This test is not recommended for patients under 12 years of age.
Vitamin D, 25-Hydroxy by Empire City Laboratories Inc.
Serum
The Vitamin D, 25-Hydroxy test measures the level of 25-hydroxyvitamin D in the blood, which is the primary form of vitamin D circulating in the bloodstream. Vitamin D is essential for calcium absorption, bone health, and immune function. This test is used to evaluate vitamin D status and diagnose deficiencies or excesses.
Zinc RBC by Access Med Labs
Red Blood Cells
This is a single-marker test measuring zinc in red blood cells. It can be used to determine zinc deficiency or excess.
FSH & LH by Access Med Labs
Serum
This test measures the levels of FSH and LH in serum. FSH is used in the differential diagnosis of gonadal and pituitary insufficiency. LH is used to evaluate the normalcy of the hypothalamic-pituitary-gonadal axis and to diagnose and treat infertility in women.
DHEA-S by Access Labcorp Draw
Serum
This is a single-marker test measuring DHEA-S. DHEA-S is used to evaluate androgen imbalances.
TSH by Access Med Labs
Serum
This is a single-marker test measuring thyroid-stimulating hormone (TSH). It is used to evaluate thyroid function.
T3, Free by Access Labcorp Draw
Serum
This is a single-marker test measuring free triiodothyronine (free T3). It is used to evaluate thyroid function.
T4, Free by Access Med Labs
Serum
This is a single-marker test measuring free T4. It is used to evaluate thyroid function.
Comprehensive Thyroid Panel w/ Antibodies by Precision Point
Serum
Precision Point Diagnostics' Comprehensive Thyroid Panel w/ Antibodies goes above and beyond routine thyroid tests, which only measure thyroid stimulating hormone (TSH) and total T4. It gives a comprehensive view of thyroid function by measuring TSH, T3 (free and total), T4 (free and total), and anti-thyroglobulin and thyroid peroxidase antibodies.
DHT (Dihydrotestosterone) by Access Med Labs
Serum
This is a single-marker test measuring dihydrotestosterone (DHT). DHT is crucial to virilization and is necessary to mitigate estrogen’s effects in men.
DUTCH Cycle Mapping Plus by Precision Analytical (DUTCH)
Saliva
Urine
The DUTCH Cycle Mapping™ PLUS provides a comprehensive analysis of a woman's monthly cycle, including hormone metabolites and the Cortisol Awakening Response (CAR). This helps to identify issues with infertility, PCOS, and other month-long symptoms. This test includes the insomnia cortisol sample. This test cannot be ordered for patients under 12 years of age.
Testosterone, Free & Total w/ SHBG by Access Labcorp Draw
Serum
This test measures free testosterone, total testosterone, and SHBG. It is used to assess hirsutism and masculinization in women and testicular function in males.
Glucose, Fasting, Plasma by Access Med Labs
Plasma
This is a single-marker test measuring fasting glucose. Glucose levels are used for the diagnosis and treatment of carbohydrate metabolic disorders.
Insulin, Fasting by Access Med Labs
Serum
This is a single-marker test measuring fasting insulin. It is useful for monitoring insulin production in diabetes mellitus and hypoglycemia.

References

  1. Barilo, A. A., & Smirnova, S. V. (2022). [Food allergy as a risk factor for acne]. Voprosy Pitaniia, 91(6), 68–75. https://doi.org/10.33029/0042-8833-2022-91-6-68-75
  2. Bertagna, B. (2023a, November 28). Zinc For Acne: A Natural Approach to Combatting Breakouts. Rupa Health. https://www.rupahealth.com/post/zinc-for-acne-a-natural-approach-to-combatting-breakouts
  3. Bertagna, B. (2023, November 30). Cassia Cinnamon For Diabetes: Are You Eating The Right Kind of Cinnamon For Your Blood Sugar? Rupa Health. https://www.rupahealth.com/post/cassia-cinnamon-for-diabetes-are-you-eating-the-right-kind-of-cinnamon-for-your-blood-sugar
  4. Bertagna, B. (2023, December 15). Chromium For Diabetes: Functional Medicine Insight For Management. Rupa Health. https://www.rupahealth.com/post/chromium-for-diabetes-functional-medicine-insight-for-management
  5. Bertagna, B. (2024, January 8). Can B Vitamins Supercharge Your Energy Levels? Rupa Health. https://www.rupahealth.com/post/can-b-vitamins-supercharge-your-energy-levels
  6. Bertagna, B. (2024, January 9). The Prediabetes Diet: Building a Balanced Meal Plan for Optimal Blood Sugar Control. Rupa Health. https://www.rupahealth.com/post/the-prediabetes-diet-building-a-balanced-meal-plan-for-optimal-blood-sugar-control
  7. Christ, J. P., & Cedars, M. I. (2023). Current Guidelines for Diagnosing PCOS. Diagnostics, 13(6), 1113. https://doi.org/10.3390/diagnostics13061113
  8. Christie, J. (2022, April 22). A Functional Medicine Approach to PMS. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-pms
  9. Christie, J. (2024, April 1). A Root Cause Medicine Protocol for PCOS. Rupa Health. https://www.rupahealth.com/post/a-root-cause-medicine-protocol-for-pcos
  10. Cloyd, J. (2023, March 7). An integrative medicine approach to fatigue. Rupa Health. https://www.rupahealth.com/post/an-integrative-medicine-approach-to-fatigue
  11. Cloyd, J. (2023, March 27). An Integrative Approach to Dermatology. Rupa Health. https://www.rupahealth.com/post/an-integrative-approach-to-dermatology
  12. Cloyd, J. (2023, March 30). A Functional Medicine Approach to Cystic Acne. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-cystic-acne
  13. Cloyd, J. (2023, May 25). A Functional Medicine Hashimoto Treatment Protocol: Testing, Supplements, and Nutrition. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-hashimoto-treatment-protocol-testing-supplements-and-nutrition
  14. Cloyd, J. (2023, July 5). Integrative Approaches to Managing High Blood Sugar: Specialty Testing, Lifestyle Modifications, and Natural Remedies. Rupa Health. https://www.rupahealth.com/post/integrative-approaches-to-managing-high-blood-sugar-testing-lifestyle-modifications-and-natural-remedies
  15. Cloyd, J. (2023, July 20). A functional medicine PCOS protocol: Comprehensive testing, therapeutic diet, and supplements. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-pcos-protocol-comprehensive-testing-therapeutic-diet-and-supplements
  16. Cloyd, J. (2023, September 8). A Functional Medicine Approach to Addressing Hair Loss in Women. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-addressing-hair-loss-in-women
  17. Cloyd, J. (2023, October 6). The Top 4 Therapeutic Uses of Licorice. Rupa Health. https://www.rupahealth.com/post/the-top-4-therapeutic-uses-of-licorice
  18. Cloyd, J. (2023, October 17). How You Can Use Ashwagandha: The Top 5 Proven Healing Benefits of this Ancient Herb. Rupa Health. https://www.rupahealth.com/post/the-top-5-therapeutic-uses-of-ashwagandha
  19. Cloyd, J. (2023, October 30). How To Interpret Your Cortisol Urine Test Results. Rupa Health. https://www.rupahealth.com/post/how-to-interpret-your-cortisol-urine-test-results
  20. Cloyd, J. (2023, December 1). The Functional Medicine Protocol For Beating Burnout with Adrenal Support. Rupa Health. https://www.rupahealth.com/post/the-functional-medicine-protocol-for-beating-burnout-with-adrenal-support
  21. Cloyd, J. (2024, January 3). Saliva Testing: Cortisol and Hormone Test Result Interpretation Guide. Rupa Health. https://www.rupahealth.com/post/saliva-testing-cortisol-and-hormone-test-result-interpretation-guide
  22. Cloyd, J. (2024, January 15). Chasteberry (Vitex): A Herbal Approach to Hormonal Imbalance in Women's Health. Rupa Health. https://www.rupahealth.com/post/chasteberry-vitex-a-herbal-approach-to-hormonal-imbalance-in-womens-health
  23. Cloyd, J. (2024, January 22). Interpreting Liver Enzyme Tests: ALT, AST, and ALP in Liver Health Monitoring. Rupa Health. https://www.rupahealth.com/post/interpreting-liver-enzyme-tests-alt-ast-and-alp-in-liver-health-monitoring
  24. Cloyd, J. (2024, April 11). Guide to Androgens: Definition, Functions, and More. Rupa Health. https://www.rupahealth.com/post/androgen-hormones
  25. Cloyd, J. (2024, June 3). Cortisol Dysregulation: Causes, Symptoms & Management. Rupa Health. https://www.rupahealth.com/post/cortisol-dysregulation
  26. Cloyd, K. (2023, September 7). Unlocking Hormonal Health: A Comprehensive Guide to Understanding and Choosing the Right Hormonal Testing for Your Patients. Rupa Health. https://www.rupahealth.com/post/unlocking-hormonal-health-a-comprehensive-guide-to-understanding-and-choosing-the-right-hormonal-testing-for-your-patients
  27. Cloyd, K. (2023, December 19). How to interpret your lipid panel results. Rupa Health. https://www.rupahealth.com/post/how-to-interpret-your-lipid-panel-results
  28. Coleman, E. (2024, May 31). Metformin: Can It Help With Insulin Resistance? Rupa Health. https://www.rupahealth.com/post/metformin-can-it-help-with-insulin-resistance
  29. Cruz, K. J. C., de Oliveira, A. R. S., Pinto, D. P., et al. (2014). Influence of Magnesium on Insulin Resistance in Obese Women. Biological Trace Element Research, 160(3), 305–310. https://doi.org/10.1007/s12011-014-0044-2
  30. DeCesaris, L. (2023, August 16). How To Test For Female Hormones: A Comprehensive Guide. Rupa Health. https://www.rupahealth.com/post/how-to-test-for-female-hormones-a-comprehensive-guide
  31. DePorto, T. (2022, September 13). Understanding acne and how to treat it naturally. Rupa Health. https://www.rupahealth.com/post/understanding-acne-and-how-to-treat-it-naturally
  32. DePorto, T. (2023, January 6). Omega 3's: The Superfood Nutrient You Need To Know About. Rupa Health. https://www.rupahealth.com/post/omega-3s-the-superfood-nutrient-you-need-to-know-about
  33. Dihydrotestosterone. (2020). Rupa Health. https://www.rupahealth.com/biomarkers/dht
  34. Diorio, B. (2023, March 17). How to test for hypothalamic-pituitary-adrenal (HPA) axis dysfunction. Rupa Health. https://www.rupahealth.com/post/what-is-the-hypothalamic-pituitary-adrenal-hpa-axis
  35. Endres, L., Tit, D. M., Bungau, S., et al. (2021). Incidence and Clinical Implications of Autoimmune Thyroiditis in the Development of Acne in Young Patients. Diagnostics, 11(5), 794. https://doi.org/10.3390/diagnostics11050794
  36. Frénard, C., Mansouri, S., Corvec, S., et al. (2021). Prepubertal acne: A retrospective study. International Journal of Women’s Dermatology, 7(4). https://doi.org/10.1016/j.ijwd.2021.03.010
  37. Garrison, K. (2024, March 12). 8 Supplements that Balance Hormones to Look Out For. Rupa Health. https://www.rupahealth.com/post/supplements-to-balance-hormones
  38. Henry, E. (2022, January 4). How To Reverse Weight Gain And Slowed Metabolism. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-slow-metabolism-middle-age
  39. HOMA-IR. Healthmatters. https://healthmatters.io/understand-blood-test-results/homa-ir
  40. Isotretinoin Capsules. (2024). Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/19186-isotretinoin-capsules
  41. Khunger, N., & Mehrotra, K. (2019). Menopausal Acne – Challenges And Solutions. International Journal of Women’s Health, Volume 11, 555–567. https://doi.org/10.2147/ijwh.s174292
  42. Klein, C. E. (2003). The Hypothalamic-Pituitary-Gonadal Axis. Holland-Frei Cancer Medicine. 6th Edition, 6th Edition. https://www.ncbi.nlm.nih.gov/books/NBK13386/
  43. Ly, S., Kamal, K., Manjaly, P., et al. (2022). Treatment of Acne Vulgaris During Pregnancy and Lactation: A Narrative Review. Dermatology and Therapy, 13(1), 115–130. https://doi.org/10.1007/s13555-022-00854-3
  44. Maholy, N. (2023, April 14). How to reduce stress through mind-body therapies. Rupa Health. https://www.rupahealth.com/post/how-to-reduce-stress-through-mind-body-therapies
  45. Maholy, N. (2023, April 21). A Functional Medicine Protocol for Hyper Responsiveness Adrenal Dysregulation. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-protocol-for-hyper-responsiveness-adrenal-dysregulation
  46. Maholy, N. (2023, April 24). A Functional Medicine Protocol for Hypo-Responsiveness Adrenal Dysregulation. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-protocol-for-hypo-responsiveness-adrenal-dysregulation
  47. Makrantonaki, E., Ganceviciene, R., & Zouboulis, C. C. (2011). An update on the role of the sebaceous gland in the pathogenesis of acne. Dermato-Endocrinology, 3(1), 41–49. https://doi.org/10.4161/derm.3.1.13900
  48. Michaëlsson, G., Juhlin, L., & Vahlquist, A. (1977). Effects of oral zinc and vitamin A in acne. Archives of Dermatology, 113(1), 31–36. https://doi.org/10.1001/archderm.1977.01640010033003
  49. Morshed, S., Banu, H., Akhtar, N., et al. (2021). Luteinizing Hormone to Follicle-Stimulating Hormone Ratio Significantly Correlates With Androgen Level and Manifestations Are More Frequent With Hyperandrogenemia in Women With Polycystic Ovary Syndrome. Journal of Endocrinology and Metabolism, 11(1), 14–21. https://doi.org/10.14740/jem716
  50. Mustafa, A. I., Kadah, A. S., Fawzy, E. M., et al. (2022). Serum Fetuin-A: A Novel Potential Link Between Post-adolescent Acne and Insulin Resistance. The Journal of Clinical and Aesthetic Dermatology, 15(12), 33–37. https://jcadonline.com/post-adolescent-acne-insulin-resistance/
  51. Pile, H. D., & Sadiq, N. M. (2023). Isotretinoin. PubMed; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK525949/#article-23791.s6
  52. Podgórska, A., Puścion-Jakubik, A., Markiewicz-Żukowska, R., et al. (2021). Acne Vulgaris and Intake of Selected Dietary Nutrients—A Summary of Information. Healthcare, 9(6), 668. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226785/
  53. Rao, J. (2020). Acne Vulgaris Workup. Medscape. https://emedicine.medscape.com/article/1069804-workup#c6
  54. Rocha, M. A., & Bagatin, E. (2018). Adult-onset acne: prevalence, impact, and management challenges. Clinical, Cosmetic and Investigational Dermatology, Volume 11, 59–69. https://doi.org/10.2147/ccid.s137794
  55. Sadowska-Przytocka, A., Gruszczyńska, M., Ostałowska, A., et al. (2022). Insulin resistance in the course of acne – literature review. Advances in Dermatology and Allergology/Postȩpy Dermatologii I Alergologii, 39(2), 231–238. https://doi.org/10.5114/ada.2021.107101
  56. Srivastava, P. R., Khare, J., Saxena, A., et al. (2024). Correlation between acne and insulin resistance; experience from central India. Journal of Family Medicine and Primary Care, 13(2), 723–725. https://doi.org/10.4103/jfmpc.jfmpc_1232_23
  57. Stanford, J. (2024, March 21). Insulin Resistance and Inflammation: Understanding the Connection. Rupa Health. https://www.rupahealth.com/post/insulin-resistance-and-inflammation-understanding-the-connection
  58. Stanford, J. (2024, May 22). What is Insulin Resistance and What is the Effect on the Body? Rupa Health. https://www.rupahealth.com/post/what-is-insulin-resistance-effects
  59. Sutaria, A. H., Masood, S., Saleh, H. M., et al. (2019, October 25). Acne Vulgaris. National Library of Medicine; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK459173/
  60. Sweetnich, J. (2023, February 24). The Importance of Testing DHEA Levels. Rupa Health. https://www.rupahealth.com/post/evidence-based-health-benefits-of-dhea
  61. Sweetnich, J. (2023, February 28). How to Balance Cortisol Levels Naturally. Rupa Health. https://www.rupahealth.com/post/how-to-balance-cortisol-levels-naturally
  62. Sweetnich, J. (2023, February 28). Testosterone Testing 101. Rupa Health. https://www.rupahealth.com/post/testosterone-testing-101
  63. Sweetnich, J. (2023, April 13). How To Get Rid of Hormonal Acne Naturally. Rupa Health. https://www.rupahealth.com/post/how-to-get-rid-of-hormonal-acne-naturally
  64. Sweetnich, J. (2023, May 4). Vitamin D 101. Rupa Health. https://www.rupahealth.com/post/vitamin-d-101-testing-rdas-and-supplementing
  65. Trivedi, M. K., Shinkai, K., & Murase, J. E. (2017). A Review of hormone-based therapies to treat adult acne vulgaris in women. International Journal of Women’s Dermatology, 3(1), 44–52. https://doi.org/10.1016/j.ijwd.2017.02.018
  66. Weinberg, J. L. (2022, September 7). An Integrative Medicine Approach to Hypothyroidism. Rupa Health. https://www.rupahealth.com/post/understanding-hypothyroidism-and-how-to-treat-it-naturally
  67. Weinberg, J. L. (2023, January 24). Functional Medicine Treatment for Graves' Disease. Rupa Health. https://www.rupahealth.com/post/functional-medicine-treatment-for-graves-disease
  68. Weinberg, J. L. (2023, February 7). A Functional Medicine Protocol for Hyperthyroidism. Rupa Health. https://www.rupahealth.com/post/5-functional-medicine-labs-that-can-assist-a-root-cause-treatment-for-hyperthyroidism
  69. Weinberg, J. L. (2024, March 14). The Impact of Stress on Inflammation: Coping Strategies for a Healthier Life. Rupa Health. https://www.rupahealth.com/post/the-impact-of-stress-on-inflammation-coping-strategies-for-a-healthier-life
  70. Yoshimura, H. (2023, March 30). The Importance of Running Comprehensive Metabolic Panel (CMP) on Your Patients. Rupa Health. https://www.rupahealth.com/post/the-importance-of-running-comprehensive-metabolic-panel-cmp-on-your-patients
  71. Yoshimura, H. (2023, June 26). Unlocking radiant skin by reducing stress hormones: The power of specialty labs, integrative nutrition, and stress-busting supplement recommendations. Rupa Health. https://www.rupahealth.com/post/the-impact-of-stress-on-skin-health-and-how-to-manage-it-with-integrative-medicine
  72. Yoshimura, H. (2023, August 7). Top Labs To Run Bi-Annually On Your Irregular Menstrual Cycle Patients. Rupa Health. https://www.rupahealth.com/post/top-labs-to-run-bi-annually-on-your-irregular-menstrual-cycle-patients
  73. Yoshimura, H. (2023, November 7). The remarkable power of exercise on our health: A comprehensive overview. Rupa Health. https://www.rupahealth.com/post/the-remarkable-power-of-exercise-on-our-health-a-comprehensive-overview
  74. Yoshimura, H. (2024, February 29). Testing and Managing Mixed Hyperlipidemia: Challenges and Opportunities. Rupa Health. https://www.rupahealth.com/post/testing-and-managing-mixed-hyperlipidemia-challenges-and-opportunities
Jaime Cloyd
Author
Dr. Jaime Cloyd ND
Naturopathic Physician based in the greater Seattle area
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