The Rickettsia Immunofluorescent Assay (IFA) is designed to detect Rickettsia–specific antibodies in human serum. These species include R. ricketsii and R. typhi, known to cause Rocky Mountain Spotted Fever and Murine Typhus, respectively. Titers rise during the first two–to–four weeks of illness and decline over the next six–to–12 months. This test is unavailable for patients over 65 when ordered through physician services.