Immunoserology of Lyme Panel B

This panel uses Immunosciences Lab's patented ELISA methodology, as well as the Western Blot technique, to measure 26 different antibodies against Lyme-specific antigens, Borrelia subspecies, and co-infections. It can detect active and chronic Lyme disease, including Lyme arthritis and neuroborreliosis that may be confused with multiple sclerosis.

Ordering Immunoserology of Lyme Disease Panel B with Immunosciences Lab

This is a comprehensive test panel for detecting active and chronic Lyme disease, which may result in Lyme arthritis and neuroborreliosis. It measures antibodies against the spirochete and various components of B. Burgdorferi, its subspecies, and co-infections.

ISL uses both Borrelia antigens grown in culture and the various proteins expressed in vivo, enabling us to improve the accuracy of our determinations.

In this panel, we use both our own patented ELISA methodology (tier one) as well as the Western Blot method (tier two) to measure IgG and IgM antibodies not only against a mixture of Borrelia antigens but

also against proteins or peptides of different molecular sizes, such as Outer Surface Protein A (OspA), Outer Surface Protein B (OspB), Outer Surface Protein C (OspC), Outer Surface Protein E (OspE), Leukocyte Function Associated Antigen (LFA), Variable Major Protein (VMP), and more, each component determined separately. We also measure antibodies against antigens known for their involvement with Lyme disease, including antibodies against the Borrelia subspecies Sensu stricto, Afzelii, Garinii, and Myamotoi, as well as the co-infections Babesia, Ehrlichia, and Bartonella.

It is vital to correctly determine as early as possible whether someone is developing Lyme disease or something else. False positive test results could lead to years of incorrect treatment and unnecessary medications with their side effects, while false negative results could lead to Lyme arthritis, neuroborreliosis, and years or even a lifetime of suffering.

These false positive or false negative results may be avoided by running the Western Blot, which is included in Immunoserology of Lyme Disease Panel B.

According to the CDC/ASTPHLD Working Group:

• An IgG blot is considered positive (reactive) if 5 of the following ten peptide bands are present: p18, p23, p28, p30, p39, p41, p45, p58, p66, p93.
• An IgM blot is considered positive (reactive) if two of the following three peptide bands are present: p23, p39, and p41.
• If the IgG or IgM antibodies against the above peptides are negative, the patient is considered non-reactive.

The Immunoserology of Lyme Disease Panel B is Best Used for Which Patients?

This panel is beneficial for a wide variety of patients with the following:

• Tick bite
• Erythema Migrans positive
• Unclassified autoimmune disease
• Chronic synovitis
• Rheumatoid arthritis
• Lyme arthritis
• Psoriatic arthritis
• Lupus
• Neuroborreliosis
• Lymphocytic meningitis
• Cranial neuritis
• Painful radiculoneuritis
  

Symptoms of Lyme Disease

The Immunoserology of Lyme Disease Panel B should be considered when patients present the following symptoms and conditions, which are represented in the figure below:

• Immune system-swollen glands, fever/chills, weakened immune defenses.
• Heart- irregular heartbeat, inflammation.
• Muscles- weakness, heartbeat, inflammation.
• Rash- flat red rash, not itchy or painful, may have a central clearing.
• Brain- memory loss, inability to concentrate, headache, neck pain. And stiffness, encephalitis or meningitis, psychosis.
• Eyes- blurred vision, floaters, irregular pupil.
• Nerves- Pain, often down an arm or leg, pins, and needles, tingling, burning electric shock sensations, numbness, paralysis, often on one side of the face, twitching, and spasms.
• Joints- joint pain, inflammatory arthritis in one or several joints.

Lyme borreliosis in humans is an inflammatory disease affecting multiple organ systems, including the nervous system, cardiovascular system, joints, and muscles.