Autoimmune Viral Trio Panel

Ordering Autoimmune Viral Trio Panel with Immunosciences Lab

The Autoimmune Viral Trio Panel is known for detecting three major viruses (EBV, HHV-6, and Sars-Cov-2) that contribute to long COVID and autoimmunity.

Studies reported increased levels of antibodies against EBV as well as HHV-6 A and B antigens not only in patients with various autoimmune disorders but in patients with long COVID or post-acute COVID-19 sequelae (PACS).

Similar to EBV and HHV-6, SARS-CoV-2 and its disease COVID-19 have been associated with various autoimmune disorders, including type 1 diabetes, Grave’s disease, autoimmune hemolytic anemia, polyneuritis cranialis, post-orthostatic tachycardia syndrome, systemic lupus erythematosus, antiphospholipid syndrome, Guillain- Barré syndrome, rheumatoid arthritis, immune thrombocytopenic purpura, Miller-Fisher syndrome, Kawasaki disease, and vasculitis.

This is because these three viruses share a significant homology with various human tissue antigens that are targets for major autoimmune disorders, as shown in the figure below.

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Some of the autoimmune disorders that are associated with SARS-CoV-2. Note that many of these autoimmune diseases are induced by EBV and HHV-6.

Furthermore, titers and antibodies against EBV EAD and HHV-6 were found to correlate with the severity of long COVID. That is because the reactivation of EBV and HHV-6 from latency by infecting epithelial cells increase the expression of the ACE2 receptor for SARS-CoV-2, enhancing the infection, replicating and spreading the cycle of SARS-CoV-2, thus increasing the severity and duration of the infection.

The Autoimmune Viral Trio Panel is Best Used for Which Patients?

This EBV, HHV-6, and Sars-COV-2 antibody panel is beneficial for a wide variety of patients with the following:

1. Long COVID or post-acute COVID-19 sequelae

2. Many autoimmune diseases induced by the Viral Trio (EBV, HHV-6, and SARS-CoV-2)

3. Myalgic encephalomyelitis/chronic fatigue syndrome

4. Autonomic nervous system dysfunction

The awareness of the association between EBV, HHV-6 reactivation, and SARS-CoV-2 creates new opportunities for long COVID diagnosis, management, and possible treatment.

The Autoimmune Viral Trio Panel Should be Considered When Patients Present the Following Symptoms and Conditions:

Symptoms

• Shortness of breath
• Memory loss
• Fatigue
• Anosmia
• Flu-like symptoms
• Low fever
• GI distress
• Autoimmune factors
• Muscle pain
• Enlarged tonsils
• Nasal congestion

Conditions

• Small fiber neuropathy
• Orthostatic intolerance
• Orthostatic hypotension
• Neurally mediated syncope
• Digestive issues
• Swollen lymph nodes
• Chronic fatigue
• Fibromyalgia
• Autoinflammation

Due to cross-reactivity with human tissue components, these three viruses contribute the most towards inflammation and autoimmunity.