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Reference Guide
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Lp-PLA2
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Lp-PLA2

What's 
Lp-PLA2
?
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that travels in your bloodstream, mainly connected to low-density lipoproteins (LDL), which are often called 'bad cholesterol'. This enzyme is made by various cells in your body, including those in your blood vessels. Lp-PLA2 has a special role in your body's response to inflammation, particularly in the development of atherosclerosis, a condition where plaque accumulates inside your arteries. By checking the levels of Lp-PLA2, we can learn more about the inflammation happening in your body, especially in relation to your heart and blood vessels.
If Your Levels Are High
Elevated Lp-PLA2 levels might mean that there's more inflammation happening in your body, especially in your heart and blood vessels. This could be caused by various factors such as eating too many processed foods and unhealthy fats, not getting enough exercise, or dealing with ongoing stress. Some medications, like blood pressure or cholesterol-lowering drugs, could also affect your Lp-PLA2 levels. High levels could be linked to conditions like atherosclerosis, where plaque builds up in your arteries, or metabolic syndrome, which is a group of conditions that raise your risk for heart disease, stroke, and type 2 diabetes.
Symptoms of High Levels
Symptoms of high levels of Lp-PLA2 may not be immediately noticeable, as this enzyme primarily indicates internal inflammation and cardiovascular risk. However, if associated conditions like atherosclerosis or metabolic syndrome are present, one might experience symptoms such as chest pain, fatigue, shortness of breath, or increased thirst and urination.
If Your Levels are Low
Low levels of Lp-PLA2 might mean that there's less inflammation happening in your body, especially in your heart and blood vessels. This enzyme is involved in your body's response to inflammation and plays a part in the buildup of plaque in your arteries, a condition called atherosclerosis. Having lower levels could be a result of living a healthy lifestyle, like eating well, exercising regularly, and managing stress. Some medications, such as anti-inflammatory drugs or cholesterol-lowering medications like statins, might also contribute to lower Lp-PLA2 levels.
Symptoms of Low Levels
Symptoms of low levels of Lp-PLA2 are typically not noticeable as this condition often doesn't present with any specific signs.

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