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Reference Guide
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Antithrombin Activity
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Antithrombin Activity
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Antithrombin Activity

What's 
Antithrombin Activity
?
Antithrombin Activity is a test that measures the level of antithrombin, a protein in your blood that helps control blood clotting. Produced in the liver, antithrombin is like a natural 'brake' in your body, preventing excessive clotting and ensuring your blood flows smoothly. When a potential clot is detected, antithrombin springs into action, blocking certain enzymes to stop the clot from growing too large. This is crucial because while clotting is necessary to stop bleeding when you're injured, too much clotting can lead to serious health problems. So, the Antithrombin Activity test is a way to check if this important 'brake' system in your body is working properly.
If Your Levels Are High
High levels of Antithrombin Activity could indicate that your body is overactive in preventing blood clotting. This might be due to a condition called Antithrombin III deficiency, where your body doesn't produce enough of this protein, leading to an increased risk of blood clots. Alternatively, it could be a sign of liver disease, as the liver is responsible for producing antithrombin. Certain medications, such as anabolic steroids or oral contraceptives, can also increase Antithrombin Activity levels. High levels could also be due to malnutrition or a high vitamin K intake, as these factors can affect how your body produces and uses antithrombin. It's important to note that these are potential causes and further investigation would be needed to confirm a diagnosis.
Symptoms of High Levels
Symptoms of high levels of Antithrombin Activity could include unusual bleeding or bruising, blood in urine or stool, or swelling and pain in one leg (usually the calf), which could indicate a deep vein thrombosis. Other symptoms might include chest pain or discomfort, which could be a sign of a blood clot in the lungs.
If Your Levels are Low
Low levels of Antithrombin Activity could suggest that your body isn't effectively preventing blood clots as it should. This could be due to a condition called Antithrombin Deficiency, which is a rare inherited disorder. It could also be a result of liver disease, as the liver is responsible for producing antithrombin. Certain medications, such as L-asparaginase, which is used in chemotherapy, or oral contraceptives, can also lower Antithrombin Activity. Additionally, low levels can occur due to a high consumption of dietary vitamin K, which plays a role in blood clotting. It's important to note that low Antithrombin Activity could increase the risk of developing harmful blood clots.
Symptoms of Low Levels
Symptoms of low levels of Antithrombin Activity may include unexplained or excessive bleeding, blood clots in veins or arteries, and in severe cases, a sudden blockage of blood flow to the lungs or brain.

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