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Episode #
270
Hosted by
Dr. Carrie Jones
Dr. Kate Kresge
March 4, 2025
 ・ 
59
 mins

The Story of 3x4 Nutrigenomic Testing and Dr. Yael Joffe

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In today's episode of The Root Cause Medicine Podcast, Dr. Yael Joffe joins Dr. Kate Kresge to discuss her remarkable journey from architecture student to nutrigenomics pioneer, driven by a personal loss that left her searching for answers. You’ll hear us discuss:

  • The role of genetic insights in supporting personalized wellness approaches

  • 3X4 Genetics innovative approach to genetic testing

  • The challenges of bringing genetics into clinical practice

  • How AI might reshape the field

Dr. Joffe is a pioneering figure in nutrigenomics and the founder of 3X4 Genetics. Originally from South Africa, she began her career studying architecture before pivoting to dietetics following her grandmother's battle with cancer. Driven to understand the intersection of genetics and nutrition more deeply, she pursued a PhD in genetics while working full-time. Throughout her career, Dr. Joffe has been instrumental in developing nutrigenomic testing methodologies, including the Darwin methodology used by 3X4 Genetics to analyze genetic markers for potential insights in personalized wellness. Additionally, Dr. Joffe is the author of The Power Of Genetics.

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Timestamps

03:07 - From Art to Science

16:24 - Why PhDs Deserve More Credit

33:56 - The Birth of 3X4 Genetics

47:21 - AI’s Role in Genetics, Healthcare, and Research

53:55 - How 3X4 Chooses the Right Genes

01:05:27 - Why Every Clinician Should Consider Genetic Testing

01:08:14 - Clinical Application: A Detoxification Case Study

01:11:16 - The Future of Genetics


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