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The Chemistry of Cravings

Why This Was Updated?

Our specialists regularly review advancements in health and wellness, ensuring our articles are updated with the newest information as it becomes accessible.
Medically Reviewed by
Updated On
August 29, 2024
The Chemistry of Cravings

We've all felt the magnetic pull of cravings while standing in front of an open pantry, whether the cravings be for chocolate, chips, or cheese. The experience leaves us wrestling with guilt after giving in. 

Studies have shown that over 90% of us experience cravings on a regular basis, suggesting that these cravings may not only be moments of weakness but may also be meaningful signals from our bodies - indicating an unmet need. 

Recent advances in nutritional science reveal that our cravings may not only be about indulging in empty calories for pleasure. Instead, these desires could be our body’s intelligent way of communicating specific nutritional deficiencies. This perspective encourages us to consider the underlying reasons our bodies send these signals, transforming how we respond to them.

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Cravings Unleashed: The Biochemical Indicators

Human food cravings are governed by a network of biochemical signals. Like a city bus system, our hormones deliver messages from the gut to the brain and back again. The main drivers of these messages are neurotransmitters and hormonal signals:

Neurotransmitters:

  • Dopamine:
    • Known as the “pleasure” chemical
    • Crucial to the brain’s reward pathways
    • Dopamine is released in response to fulfilling survival behaviors
    • Teaches the brain to repeat actions that trigger its release, promoting a continuous pursuit of satisfaction

Hormonal Signals:

  • Ghrelin:
    • Commonly referred to as the “hunger hormone”.
    • Ghrelin signals the brain when the stomach is empty, prompting the urge to eat.
  • Leptin:
    • Acts as a satiety regulator.
    • Informs the brain when enough food has been consumed, thus preventing over-eating.
    • When leptin signals are disrupted, it can lead to a cycle of constant cravings, fulfillment, and then cravings again.

It is crucial to understand these signals to disrupt this pattern. Knowing the mechanisms of hormones and neurotransmitters that cause strong cravings can help you take control of them. Understanding this can help you differentiate between real and fake hunger – a desire for food or a desire for fulfillment. It’s about understanding the ‘what’ of our wants and the ‘why’ at a cellular scale.

The Why Behind the Desire

Our bodies are intelligent creations that express their wants and needs through multiple modes of communication, including cravings. Did you know that the depletion of certain nutrients in our diets might be linked to certain cravings? These intentional cravings could be our body’s attempt to get the nutrients it needs, like the body's distress signals in disguise. Understanding the potential reasons behind these cravings can offer insights into our nutritional and emotional needs:

Nutritional Deficiencies:

  • Iron Deficiency
    • A lack of iron might cause cravings for non-food items like dirt or ice
    • These cravings are scientifically recognized as signals of deficiency
  • Magnesium Deficiency
    • Chocolate cravings may signal a magnesium deficiency, as chocolate is high in this vital mineral.
    • Magnesium is crucial for numerous biochemical processes, including blood sugar regulation and mood stabilization, which can influence cravings.
    • Consuming magnesium-rich foods may help satisfy cravings and restore magnesium levels in the body.

Emotional Eating: 

  • Cortisol and Stress
    • Under emotional stress, cortisol levels increase.
    • Increased cortisol can also trigger the desire for sugary, fatty, and/or salty foods.
  • Dopamine and Reward
    • As we satisfy cravings, dopamine is released, reinforcing the pleasure and reward of eating the craved foods.
    • This creates a cycle of emotional eating, where we seek foods that create emotional comfort rather than those that fulfill us nutritionally (encouraging more emotional eating).

Understanding this emotional-biochemical connection can help us identify the root cause of cravings and surely emphasizes the importance of managing both emotional and nutritional health. 

By appreciating the relationship between cravings and our body’s nutritional demands, we gain valuable insights. Instead of feeling guilty about yielding to cravings, we can explore their underlying causes, respond more effectively to our body’s signals, and make dietary choices that satisfy cravings and provide essential nutrients. 

A Smarter Way of Managing Cravings

Understanding the root cause of cravings involves more than just willpower. As the field of health science continues to evolve, the more we understand how an individual's biochemistry, genetics, lifestyle, and especially nutrition impact overall wellness. 

Recent studies outline the importance of a personalized approach to nutrition to aid in the effective management of food cravings:

  • Protein-Rich Breakfasts:
    • Research published in Current Developments in Nutrition in 2018 found that a high-protein breakfast reduced food cravings throughout the day, emphasizing the importance of dietary adjustments tailored to an individual’s metabolic responses.
  • Mindfulness Techniques:
    • A 2018 review article in The Harvard Review of Psychiatry demonstrated that mindfulness practices significantly diminish food cravings by improving awareness and self-regulation.

To better manage cravings, modern nutrition science advocates for a transition to a personalized approach to nutrition and health, which could transform how we think about diet and wellness and help to move away from the “one-size-fits-all” approach to tailored dietary recommendations. 

Here are five recommended tests that could help to understand your cravings better:

1. Complete Blood Count (CBC) and Serum Iron Levels

CBC and serum iron tests provide critical insights into overall iron status and blood health. Since iron deficiency can lead to specific (and sometimes strange) cravings, these tests can help identify deficiencies.

Suggested Tests:

  1. CBC
    1. CBC with Differential – Boston Heart Diagnostics
    2. CBC – Access Medical Labs 
  1. Serum Iron
    1. Iron, Total–Access Medical Labs
    2. Iron – Boston Heart Diagnostics
    3. Serum Elements – Doctor’s Data

2. Magnesium Levels

Magnesium plays a role in hundreds of biochemical reactions, including those contributing to blood sugar control and mood, which could lead to cravings.

Suggested tests:

  1. Magnesium – Access Medical Labs
  2. Magnesium (Mg2+) – Boston Heart Diagnostics 
  3. Red Blood Cell (RBC) Elements – Doctor’s Data

3. DUTCH Test (Dried Urine Test for Comprehensive Hormones) 

The DUTCH test provides a comprehensive view of hormonal balance, particularly stress and sex hormones, which influence cravings – especially those related to emotional eating.

Suggested Tests:

  1. DUTCH Complete – Precision Analytical
  2. DUTCH Cycle Mapping – Precision Analytical
  3. DUTCH Plus – Precision Analytical

4. Blood Glucose and Insulin Levels

Monitoring blood glucose and insulin levels could help to identify patterns related to blood sugar instability, which can lead to sugar cravings as the body seeks a “quick energy fix". Managing blood glucose and insulin levels can help to reduce these cravings.

Suggested Tests:

  1. Blood Glucose:
    1. Glucose – Access Medical Labs
    2. Glucose – Boston Heart Diagnostics
  1. Insulin:
    1. Insulin, Fasting – Access Medical Labs
    2. Insulin – Boston Heart Diagnostics

5. Leptin Hormone Assay

Since leptin helps regulate appetite and fat storage, imbalances in leptin could lead to constant hunger or cravings despite adequate food intake. Testing leptin levels can provide insight and help you manage your appetite.

Suggested Tests:

  1. Leptin
    1. Leptin – Access Medical Labs
    2. Leptin – Boston Heart Diagnostics

Cravings are not the enemy; they are more like messages sent between our body and mind to help us better understand our health. When we appreciate ‘The Chemistry of Cravings', we can recognize why we crave what we crave and make more empowering choices based on the signals our bodies send us. Instead of fighting cravings, maybe we can work with them to help give our bodies what they need.

By transitioning to an evidence-based approach to understanding cravings and realizing what our bodies tell us on a molecular level, we can work with our cravings on the journey to optimal health.

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Key Takeaways:

  • Cravings are a common experience, with over 90% of people experiencing them regularly.
  • They can result from interactions between our body’s biochemistry, including hormones and neurotransmitters.
  • Ghrelin and leptin are hormones that play significant roles in hunger and satiety, which can affect craving patterns.
  • Dopamine is a neurotransmitter that is crucial in the brain’s reward system, which encourages behaviors that meet our needs.
  • Understanding the science behind why we have cravings can help us to make better health decisions.
  • Some cravings may be linked to nutritional deficiencies, while others are not.
  • Recommended tests for better understanding cravings include the DUTCH test and testing levels for CBC and serum iron, magnesium, blood glucose, insulin, and leptin.
The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.
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Borgna-Pignatti, C., & Zanella, S. (2016). Pica as a manifestation of iron deficiency. Expert Review of Hematology, 9(11), 1075–1080. https://doi.org/10.1080/17474086.2016.1245136

Campfield, L. A., & Smith, F. J. (2003). Blood Glucose Dynamics and Control of Meal Initiation: A Pattern Detection and Recognition Theory. Physiological Reviews, 83(1), 25–58. https://doi.org/10.1152/physrev.00019.2002

Cloyd, J. (2023a, February 2). Top Lab Test to Run on Your Iron Deficiency Anemia Patients. Rupa Health. https://www.rupahealth.com/post/top-lab-test-to-run-on-your-iron-deficiency-anemia-patients

Cloyd, J. (2023b, December 1). How to Interpret CBC Results: A Comprehensive Guide. Rupa Health. https://www.rupahealth.com/post/how-to-interpret-cbc-results-a-comprehensive-guide

Cloyd, J. (2024, February 27). Exploring Neurotransmitter Testing: A Functional Medicine Perspective on Mental Health. Rupa Health. https://www.rupahealth.com/post/exploring-neurotransmitter-testing-a-functional-medicine-perspective-on-mental-health

Cloyd, K. (2023, September 7). Unlocking Hormonal Health: A Comprehensive Guide to Understanding and Choosing the Right Hormonal Testing for Your Patients. Rupa Health. https://www.rupahealth.com/post/unlocking-hormonal-health-a-comprehensive-guide-to-understanding-and-choosing-the-right-hormonal-testing-for-your-patients

Daglis, S. (2024, February 21). Decoding the Glucose Level in Your Basic Metabolic Panel. Rupa Health. https://www.rupahealth.com/post/decoding-the-glucose-level-in-your-basic-metabolic-panel

Gwin, J. A., & Leidy, H. J. (2018). Breakfast Consumption Augments Appetite, Eating Behavior, and Exploratory Markers of Sleep Quality Compared with Skipping Breakfast in Healthy Young Adults. Current Developments in Nutrition, 2(11). https://doi.org/10.1093/cdn/nzy074

Hallam, J., Boswell, R. G., DeVito, E. E., & Kober, H. (2016). Gender-related Differences in Food Craving and Obesity. The Yale Journal of Biology and Medicine, 89(2), 161–173. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918881/

Henry, E. (2021, September 29). Are Your Patients Insulin Resistant? 4 Ways To Test. Rupa Health. https://www.rupahealth.com/post/insulin-resistance-testing

Khakham, C. (2023, October 13). The DUTCH Plus Test: A Comprehensive Overview. Rupa Health. https://www.rupahealth.com/post/the-dutch-plus-test-a-comprehensive-overview

Klok, M. D., Jakobsdottir, S., & Drent, M. L. (2007). The role of leptin and ghrelin in the regulation of food intake and body weight in humans: A review. Obesity Reviews : An Official Journal of the International Association for the Study of Obesity, 8(1), 21–34. https://doi.org/10.1111/j.1467-789X.2006.00270.x

Pradhan, G., Samson, S. L., & Sun, Y. (2013). Ghrelin. Current Opinion in Clinical Nutrition and Metabolic Care, 16(6), 619–624. https://doi.org/10.1097/mco.0b013e328365b9be

Rogers, P. J., & Smit, H. J. (2000). Food Craving and Food “Addiction.” Pharmacology Biochemistry and Behavior, 66(1), 3–14. https://doi.org/10.1016/s0091-3057(00)00197-0

Schuman-Olivier, Z., Trombka, M., Lovas, D. A., Brewer, J. A., Vago, D. R., Gawande, R., Dunne, J. P., Lazar, S. W., Loucks, E. B., & Fulwiler, C. (2020). Mindfulness and Behavior Change. Harvard Review of Psychiatry, 28(6), 371–394. https://doi.org/10.1097/HRP.0000000000000277

Tarleton, E. K., & Littenberg, B. (2015). Magnesium intake and depression in adults. Journal of the American Board of Family Medicine : JABFM, 28(2), 249–256. https://doi.org/10.3122/jabfm.2015.02.140176

Vazquez, K. (2022, September 9). This Is How Much Magnesium You Should Take Based On Your Age. Rupa Health. https://www.rupahealth.com/post/magnesium-101

Volkow, N. D., Wise, R. A., & Baler, R. (2017). The dopamine motive system: implications for drug and food addiction. Nature Reviews Neuroscience, 18(12), 741–752. https://doi.org/10.1038/nrn.2017.130

Vollmert, C. (2012). Association of Leptin With Food Cue–Induced Activation in Human Reward Pathways. Archives of General Psychiatry, 69(5), 529. https://doi.org/10.1001/archgenpsychiatry.2011.1586

Wise, R. A. (2013). Dual roles of dopamine in food and drug seeking: The drive-reward paradox. Biological Psychiatry, 73(9), 819–826. https://doi.org/10.1016/j.biopsych.2012.09.001

Wolf, O. T., Schommer, N. C., Hellhammer, D. H., McEwen, B. S., & Kirschbaum, C. (2001). The relationship between stress induced cortisol levels and memory differs between men and women. Psychoneuroendocrinology, 26(7), 711–720. https://doi.org/10.1016/s0306-4530(01)00025-7

Yoshimura, H. (2023a, November 17). Sugar Cravings: Unraveling the Mystery of Our Sweet Addiction. Rupa Health. https://www.rupahealth.com/post/sugar-cravings-unraveling-the-mystery-of-our-sweet-addiction

Yoshimura, H. (2023b, December 11). Personalized Nutrition: Tailoring Diet Plans to Genetic Profiles. Rupa Health. https://www.rupahealth.com/post/personalized-nutrition-tailoring-diet-plans-to-genetic-profiles

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