A Root Cause Medicine Approach
|
April 12, 2023

The Best of Genetic Testing in Functional Medicine: Personalized Treatment Plans for Patients

Written By
Dr. Kristin Neibling ND
Medically Reviewed by
Updated On
January 14, 2025

What if you could learn more about the nutrients your body might benefit from or the conditions you may be more likely to experience? Understanding our genetic risk factors can be both challenging and empowering. On one hand, it might feel overwhelming. On the other, having this knowledge can offer choices that may help support healthier lifestyle decisions.

Genetics is just one part of the complex puzzle of health. However, it can be a useful tool for personalizing wellness strategies and supporting preventative care.

[signup]

What is Genetic Testing?

Genetic testing involves examining the DNA found in our cells. In practical applications, only specific sections of DNA are analyzed. Sometimes, variations in genes can affect the proteins they produce, which may influence how these proteins function in the body.

Research has shown that specific changes in DNA can indicate potential health risk factors. Many genetic tests available today can highlight areas where there might be increased risk for certain health issues, such as how the body processes caffeine or maintains cardiovascular health.

Who Benefits from Genetic Testing?

Many people might find value in personalizing their lifestyle based on insights from genetic testing. It depends on how interested someone is in optimizing their health strategies and whether they have the resources to make informed choices based on this information.

Everyone has genetic patterns that may create areas of vulnerability. Genetic testing can be a helpful option for those comfortable with exploring these patterns and considering actions that may help manage potential risks.

Reasons for Genetic Testing

With current knowledge of genetic variants, some common reasons for genetic testing include having known genetic variants and a personal or family history of health challenges in specific areas.

Weight management can be complex, and genetic insights might help clarify areas to focus on for maintaining a healthy weight. Similarly, mental health challenges often have familial patterns, and genetic variants can play a role. Simple lifestyle and nutrition changes may support mental well-being.

Histamine issues are also linked to genetic variants, and additional information from genetic testing can provide useful insights for managing these challenges.

Some individuals may be genetically predisposed to conditions like celiac disease. Knowing one's genetic status can help streamline testing for digestive concerns related to gluten sensitivity.

There are also associations between genetic variants and increased risk of heart disease, diabetes, and Alzheimer's. Understanding one's genetic status may encourage proactive lifestyle choices to support heart and brain health.

The Best Functional Medicine Labs for Genetic Testing

3x4 Genetics and Blueprint

This test offers a broad overview of genetic variants and suggests lifestyle adjustments for optimal health. It examines over 36 genes related to weight management, mental health, histamine responses, and chronic disease risk.

Other Tests for Supporting Heart Health

For those with identified risk factors for heart disease, additional genetic tests can help tailor wellness strategies.

Statins are often used to support cardiovascular health, but responses vary. People with the KIF6 genetic variant may find statins more beneficial. Those with the SLCO1B1 variant might need alternative statins to reduce the risk of muscle discomfort.

Cell Science System's MethylDetox Profile

This test focuses on gene variants involved in methyl detox pathways, which are important for mental and cardiovascular health.

Additional Labs or Tests to Consider

Based on clinical presentation and genetics, it may be useful to explore micronutrient, gluten sensitivity, comprehensive lipid panels, and glucose testing. Micronutrient testing can sometimes be combined with genetic tests.

Personalized Functional Medicine Treatment Plans

Personalized functional medicine treatment plans are tailored based on individual factors, including genetic variants.

Diet for Healthy Living

Genetics can influence dietary needs, but a general healthy diet for most people includes plenty of fresh fruits and vegetables, is plant-based, and low in sugar, refined carbs, and alcohol.

Those with a genetic predisposition to celiac disease may want to be mindful of symptoms and consider early dietary adjustments to support digestive health.

A diet supporting cardiovascular, metabolic, and brain health may emphasize antioxidant-rich foods and healthy fats.

Individuals with histamine challenges might benefit from identifying and avoiding food sensitivities.

Supplements & Herbs for Healthy Living

People with MTHFR and related genetic variants may find L-methylfolate supplementation supportive. This may be particularly important during the prenatal period to support heart health in developing babies. B-12 and L-methylfolate may help manage homocysteine levels, supporting cardiovascular health.

Those with histamine issues might consider supplements like diamine oxidase (DAO) and histamine blockers such as quercetin and curcumin. Other supplements to consider include B Vitamins, Magnesium, omega-3 fatty acids, and probiotics.

For weight management with a genetic component, targeted supplementation might include fiber, probiotics, multivitamins, Vitamin D, omega-3 fatty acids, and antioxidants.

Complementary and Alternative Medicine for Healthy Living

Research suggests that regular yoga practice may influence the expression of certain genes, potentially supporting overall well-being.

[signup]

Summary

We now have the ability to learn about our personal risk factors for various health conditions. While this information can feel overwhelming, it can also empower those who are ready to make lifestyle adjustments to support a healthier life.

The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

Learn more

No items found.

Lab Tests in This Article

Order from 30+ labs in 20 seconds (DUTCH, Mosaic, Genova & More!)
We make ordering quick and painless — and best of all, it's free for practitioners.

Latest Articles

View more on A Root Cause Medicine Approach
Subscribe to the magazine for expert-written articles straight to your inbox
Join the thousands of savvy readers who get root cause medicine articles written by doctors in their inbox every week!
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Are you a healthcare practitioner?
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Subscribe to the Magazine for free to keep reading!
Subscribe for free to keep reading, If you are already subscribed, enter your email address to log back in.
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Are you a healthcare practitioner?
Thanks for subscribing!
Oops! Something went wrong while submitting the form.

Hey practitioners! 👋 Join Dr. Chris Magryta and Dr. Erik Lundquist for a comprehensive 6-week course on evaluating functional medicine labs from two perspectives: adult and pediatric. In this course, you’ll explore the convergence of lab results across different diseases and age groups, understanding how human lab values vary on a continuum influenced by age, genetics, and time. Register Here! Register Here.