While “detox” is often a word linked to fad diets or juice cleanses, the reality of environmental toxicants in our modern world can’t be denied. Chemicals in our water supply, household goods, and the environment in which we live should all be considered when evaluating our exposure to toxic substances.
Functional medicine testing can help bring to light both the body’s detoxification capacity and levels of toxins such as heavy metals, environmental pollutants, or mycotoxins from mold exposure, and can help personalize a game plan to support lowering an individual's toxin burden and relieving their symptoms.
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Signs and Symptoms of Toxicity
A high toxic burden can present in different ways. Some common signs and symptoms include:
- Brain fog
- Low energy
- Mood swings
- Sleep disturbances
- Fatigue
- Bloating and other digestion complaints
- Headaches or migraines
- Skin conditions
- Living or working around known environmental pollutants.
Long-term exposure to heavy metals such as lead, arsenic, mercury, or cadmium can impact kidney and liver function and may affect the nervous system and brain function. The presence of environmental toxins like plastics and other chemicals has been linked to adverse health outcomes, disruption of the endocrine system, impaired immune health, and more. Mycotoxin exposure that can occur in water-damaged buildings and homes can lead to chronic illness, headaches, gastrointestinal complaints, and other frustrating symptoms.
It’s important to test for the presence of various toxins in order to personalize an approach to help bring an individual back into balance, safely eliminating these toxins and promoting optimal health. Functional medicine lab testing provides a means to identify each person’s toxic burden and their unique ability to detoxify and remove these compounds from the body.
Understanding Different Types of Toxin Tests
While “detoxes” are often marketed as quick weight-loss tools and “cleansing agents,” using functional medicine lab testing can help determine if detoxification support is actually needed and if an individual's detox pathways are working optimally.
There are several different avenues to be considered when looking at functional lab testing for toxic load and detoxification ability. Blood, urine, and hair analysis can all provide different insights into various aspects of toxicity. Comprehensive stool testing may also be beneficial to assess an individual’s ability to properly eliminate toxins.
Urine Testing
Urine testing can evaluate for the presence of environmental toxicants, heavy metals, and even mycotoxins that may all be contributing to symptoms of a high toxic burden. Urine tests are simple to complete and can be used to assess for the presence of various toxins and to evaluate the efficacy of any detoxification protocol.
Comprehensive tests like the Total Tox-Burden panel look at heavy metals, environmental toxins, and mycotoxins, making it possible to examine three major toxin groups with one simple at-home test.
Hair Analysis
Hair analysis is a simple way to assess the presence of heavy metals, as well as mineral status, in a non-invasive manner. Unlike blood or urine samples, hair analysis also reflects long-term exposure to toxicants like heavy metals.
Blood Testing
Different blood markers are helpful when testing for toxins and detoxification ability. Liver enzymes such as ALT, AST, and GGT can be elevated or in the high-normal range with a higher toxic burden. To assess kidney function, micronutrient levels (which are important for phase I and II liver detoxification) and inflammatory markers like hs-CRP are also important blood biomarkers to look at.
Taking Action Based On Test Results
Based on test results, a functional medicine practitioner can help you to better support your body’s ability to eliminate toxins and remove any problematic exposures you’ve had. A combination of nutritional interventions, targeted supplements, and lifestyle support may be used for each individual case.
Making Lifestyle Changes to Reduce Toxin Exposure
First, identifying and minimizing exposure to toxins should be addressed. When possible, using water filters, avoiding the use of plastics in cooking and water bottles, using air filters in the home, and eating organic, whole foods with adequate fiber intake are good starting points to minimize toxin exposure. If mycotoxins are present, mold testing of the home or work environment can be important to reduce repeated exposures in the future.
Regular exercise is also important, as exercise promotes lymphatic flow and bowel elimination, both of which are important for everyday detoxification pathways. Dynamic movement has been linked to the excretion of heavy metals that are encountered in daily life for many. Staying hydrated with filtered water, ideally not from plastic water bottles, is also important for proper detoxification and elimination.
Exploring Detoxification Methods Under Medical Guidance
Supporting detoxification is no joke, and medical supervision is advised so that you don’t feel worse or experience negative side effects as you work to remove toxins from your body. Over-the-counter “detox” programs aren’t personalized for each unique case and may not even remove toxins that are stored in various body tissues, as detox programs are often aimed at cleansing the bowels and affecting the makeup of the gut microbiome. It’s possible that doing an unsupervised detox program could result in worsening of your symptoms or unwanted side effects like bloating, rashes, or fatigue.
Helpful supplements may include antioxidants such as glutathione and N-acetyl-cysteine (NAC), any micronutrients that were found to be depleted with lab testing, vitamin C, and milk thistle or other liver-supporting herbs. Other supplements and binders may be necessary depending on an individual’s particular case.
When to Retest Labs
It can take several months for the body to reset after working to remove toxins, and for severe cases, retesting every 3-4 months can be helpful to assess progress.
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Summary
A detox plan should be considered as part of an overall lifestyle change once the major offenders that are contributing to your symptoms are removed. While supporting the body’s ability to detoxify is important, making changes to address exposure to toxins is key to a long, healthy life.
While “detox” is often a word linked to fad diets or juice cleanses, the reality of environmental substances in our modern world can’t be denied. Chemicals in our water supply, household goods, and the environment in which we live should all be considered when evaluating our exposure to various substances.
Functional medicine testing can help bring to light both the body’s detoxification capacity and levels of substances such as heavy metals, environmental pollutants, or mycotoxins from mold exposure, and can help personalize a plan to support lowering an individual's exposure and promoting their overall well-being.
[signup]
Signs and Symptoms of Exposure
A high exposure to certain substances can present in different ways. Some common signs and symptoms include:
- Brain fog
- Low energy
- Mood swings
- Sleep disturbances
- Fatigue
- Bloating and other digestion complaints
- Headaches or migraines
- Skin conditions
- Living or working around known environmental pollutants.
Long-term exposure to heavy metals such as lead, arsenic, mercury, or cadmium can impact kidney and liver function and may affect the nervous system and brain function. The presence of environmental substances like plastics and other chemicals has been linked to various health outcomes, disruption of the endocrine system, and changes in immune health. Mycotoxin exposure that can occur in water-damaged buildings and homes can lead to chronic discomfort, headaches, gastrointestinal complaints, and other symptoms.
It’s important to test for the presence of various substances in order to personalize an approach to help bring an individual back into balance, supporting the body's natural elimination processes and promoting optimal health. Functional medicine lab testing provides a means to identify each person’s exposure level and their unique ability to process and remove these compounds from the body.
Understanding Different Types of Tests
While “detoxes” are often marketed as quick weight-loss tools and “cleansing agents,” using functional medicine lab testing can help determine if detoxification support is actually needed and if an individual's detox pathways are working optimally.
There are several different avenues to be considered when looking at functional lab testing for exposure and detoxification ability. Blood, urine, and hair analysis can all provide different insights into various aspects of exposure. Comprehensive stool testing may also be beneficial to assess an individual’s ability to properly eliminate substances.
Urine Testing
Urine testing can evaluate for the presence of environmental substances, heavy metals, and even mycotoxins that may all be contributing to symptoms of a high exposure. Urine tests are simple to complete and can be used to assess for the presence of various substances and to evaluate the efficacy of any detoxification support.
Comprehensive tests like the Total Tox-Burden panel look at heavy metals, environmental substances, and mycotoxins, making it possible to examine three major groups with one simple at-home test.
Hair Analysis
Hair analysis is a simple way to assess the presence of heavy metals, as well as mineral status, in a non-invasive manner. Unlike blood or urine samples, hair analysis also reflects long-term exposure to substances like heavy metals.
Blood Testing
Different blood markers are helpful when testing for substances and detoxification ability. Liver enzymes such as ALT, AST, and GGT can be elevated or in the high-normal range with a higher exposure. To assess kidney function, micronutrient levels (which are important for phase I and II liver detoxification) and inflammatory markers like hs-CRP are also important blood biomarkers to look at.
Taking Action Based On Test Results
Based on test results, a functional medicine practitioner can help you to better support your body’s ability to process and eliminate substances and reduce any problematic exposures you’ve had. A combination of nutritional interventions, targeted supplements, and lifestyle support may be used for each individual case.
Making Lifestyle Changes to Reduce Exposure
First, identifying and minimizing exposure to substances should be addressed. When possible, using water filters, avoiding the use of plastics in cooking and water bottles, using air filters in the home, and eating organic, whole foods with adequate fiber intake are good starting points to minimize exposure. If mycotoxins are present, mold testing of the home or work environment can be important to reduce repeated exposures in the future.
Regular exercise is also important, as exercise promotes lymphatic flow and bowel elimination, both of which are important for everyday detoxification pathways. Dynamic movement has been linked to the excretion of heavy metals that are encountered in daily life for many. Staying hydrated with filtered water, ideally not from plastic water bottles, is also important for proper detoxification and elimination.
Exploring Detoxification Methods Under Medical Guidance
Supporting detoxification is no joke, and medical supervision is advised so that you don’t feel worse or experience negative side effects as you work to support your body's natural processes. Over-the-counter “detox” programs aren’t personalized for each unique case and may not even support the removal of substances that are stored in various body tissues, as detox programs are often aimed at cleansing the bowels and affecting the makeup of the gut microbiome. It’s possible that doing an unsupervised detox program could result in worsening of your symptoms or unwanted side effects like bloating, rashes, or fatigue.
Helpful supplements may include antioxidants such as glutathione and N-acetyl-cysteine (NAC), any micronutrients that were found to be depleted with lab testing, vitamin C, and milk thistle or other liver-supporting herbs. Other supplements and binders may be necessary depending on an individual’s particular case.
When to Retest Labs
It can take several months for the body to adjust after working to support the removal of substances, and for severe cases, retesting every 3-4 months can be helpful to assess progress.
[signup]
Summary
A detox plan should be considered as part of an overall lifestyle change once the major contributors to your symptoms are addressed. While supporting the body’s ability to process and eliminate substances is important, making changes to address exposure is key to a long, healthy life.
Greenan, S. (2021, December 14). Signs Of Toxic Overload And How To Properly Detox. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-detox
Jan, A., Azam, M., Siddiqui, K., Ali, A., Choi, I., & Haq, Q. (2015). Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants. International Journal of Molecular Sciences, 16(12), 29592–29630. https://doi.org/10.3390/ijms161226183
Kuan, W.-H., Chen, Y.-L., & Liu, C.-L. (2022). Excretion of Ni, Pb, Cu, As, and Hg in Sweat under Two Sweating Conditions. International Journal of Environmental Research and Public Health, 19(7), 4323. https://doi.org/10.3390/ijerph19074323
Liang, G., Pan, L., & Liu, X. (2017). Assessment of Typical Heavy Metals in Human Hair of Different Age Groups and Foodstuffs in Beijing, China. International Journal of Environmental Research and Public Health, 14(8), 914. https://doi.org/10.3390/ijerph14080914
Mokhtari, V., Afsharian, P., Shahhoseini, M., Kalantar, S. M., & Moini, A. (2017). A Review on Various Uses of N-Acetyl Cysteine. Cell Journal (Yakhteh), 19(1), 11–17. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241507/
Omotayo, O. P., Omotayo, A. O., Mwanza, M., & Babalola, O. O. (2019). Prevalence of Mycotoxins and Their Consequences on Human Health. Toxicological Research, 35(1), 1–7. https://doi.org/10.5487/tr.2019.35.1.001
Panda, C., Slavko Komarnytsky, Michelle Norton Fleming, Marsh, C., Barron, K., Sara Le Brun-Blashka, & Metzger, B. (2023). Guided Metabolic Detoxification Program Supports Phase II Detoxification Enzymes and Antioxidant Balance in Healthy Participants. Nutrients, 15(9), 2209–2209. https://doi.org/10.3390/nu15092209
Pillon Barcelos, R., Freire Royes, L. F., Gonzalez-Gallego, J., & Bresciani, G. (2017). Oxidative stress and inflammation: liver responses and adaptations to acute and regular exercise. Free Radical Research, 51(2), 222–236. https://doi.org/10.1080/10715762.2017.1291942
Pizzorno, J. (2015). Conventional Laboratory Tests to Assess Toxin Burden. Integrative Medicine: A Clinician’s Journal, 14(5), 8–16. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712864/
Rustagi, N., Singh, R., & Pradhan, S. (2011). Public health impact of plastics: An overview. Indian Journal of Occupational and Environmental Medicine, 15(3), 100. https://doi.org/10.4103/0019-5278.93198
Vargas-Mendoza, N. (2014). Hepatoprotective effect of silymarin. World Journal of Hepatology, 6(3), 144. https://doi.org/10.4254/wjh.v6.i3.144
Viswanathan , T. (2020, December 13). Toxin Testing 101: The Different Types of Toxin Testing & How to Get Started. Rupa Health. https://www.rupahealth.com/post/toxin-testing-101-the-different-types-of-toxin-testing-how-to-get-started#:~:text=These%20are%20the%20three%20main
Your Body Needs More Fiber: How to Get More Fiber in Your Diet. (2022, June 30). Fullscript. https://fullscript.com/blog/fiber
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