Nutrition
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April 8, 2024

Evidence-Based Review: The Role of Anti-Inflammatory Foods

Written By
Heather Yoshimura AGNP-PC
Medically Reviewed by
Updated On
January 14, 2025

Inflammation is often at the heart of what makes us feel under the weather, from the swelling and redness that accompanies a sprained ankle to more invisible battles within, like the fight against chronic illnesses. Science shows that this natural immune response, while essential for healing, can tip the scales against us when it becomes a persistent visitor. 

Reducing inflammation relies heavily on what we eat, and it is a necessary part of maintaining good health. Certain foods, armed with natural compounds, stand out as supporters of a healthy inflammatory response. In this article, we will cover what types of foods we might consider eating to help manage our inflammatory load - and why this is so important to health. 

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What is Inflammation?

Inflammation is the body's defense mechanism to protect itself from infections, injuries, or toxins, initiating a process that allows healing and recovery. It's categorized into two types: acute and chronic. Acute inflammation is an immediate, short-term response where the body quickly responds to an injury or infection, mobilizing white blood cells to the affected area to facilitate healing. For example, the redness and swelling following a cut or scrape are signs of acute inflammation working to repair your body.

Chronic inflammation, in contrast, is a long-term, often harmful response. It occurs when the inflammatory process continues even after the initial threat (like an infection or injury) has been eliminated. Unlike acute inflammation, which is direct and resolves upon healing, chronic inflammation is persistent and can fluctuate in intensity over time. Chronic inflammation can arise from ongoing issues such as autoimmune diseases, where the body's immune system mistakenly attacks healthy cells, or from long-term exposure to irritants, such as pollutants or industrial chemicals. Over time, this continual cascade can damage the body and may contribute to diseases like arthritis, heart disease, and diabetes (20). 

The Nutritional Science of Anti-Inflammatory Foods

Bioactive compounds significantly contribute to supporting a healthy inflammatory response, acting much like nature's pharmacists by dispensing natural chemicals that interact with our biological systems. These compounds help maintain health, support a balanced inflammatory response, and may help manage health conditions, mainly through polyphenols and omega-3 fatty acids.

Polyphenols, antioxidants found in a vast array of plant foods, act as protective agents that neutralize free radicals, support a healthy inflammatory response, and promote health. They are instrumental in fostering the growth of beneficial gut microbes, which in turn produce molecules such as short-chain fatty acids (SCFAs) that support a healthy inflammatory response. Similarly, omega-3 fatty acids, especially those found in fish oil like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may help maintain a balanced gut microbiota while also supporting the gut barrier's integrity.

This integrity is vital for maintaining the body’s health. A dysfunctional gut can lead to dysbiosis—a disruption in the balance of gut microbes—or weaken the gut barrier, creating a "leaky gut" scenario where toxins and pathogens can leak into the bloodstream. This can escalate systemic inflammation and may trigger various health issues. 

Top Anti-Inflammatory Foods and Their Mechanisms

Fatty fish are highly valued for their health benefits, particularly for their potential to support a healthy inflammatory response, thanks to omega-3 fatty acids like EPA and DHA found in varieties such as salmon, mackerel, and sardines. These specific types of fats may help manage the processes that lead to inflammation. They do this by supporting the body's natural response to inflammation. Additionally, EPA and DHA help generate compounds known as resolvins and protectins, which are beneficial in supporting a healthy inflammatory response.

Berries are packed with polyphenols. This type of antioxidant plays a key role in supporting a healthy inflammatory response and promoting the immune system. This beneficial effect is mainly attributed to anthocyanins, compounds that give berries their vibrant colors and are recognized for their supportive effects on inflammation. These compounds help improve the body’s defense against chronic inflammation and support the immune system's functioning.

Leafy green vegetables, such as spinach and kale, are rich in antioxidants. These vegetables contain an array of bioactive compounds, including phenolic compounds and flavonoids, which are known for their antioxidant and supportive effects on inflammation. They work by neutralizing harmful molecules in the body, thereby supporting a healthy inflammatory response and promoting overall health.

Nuts and seeds, including almonds, walnuts, flaxseeds, and chia seeds, are excellent sources of beneficial fats that help support a healthy inflammatory response. Flaxseeds and chia seeds are rich in omega-3 fatty acids, while walnuts and almonds contain polyunsaturated fatty acids (PUFAs). These fats have been shown to support the body's natural inflammatory response, which can lead to improved heart health. Their supportive effects on inflammation are partly due to their ability to help manage the production of cytokines (substances produced by the immune system) and to alter the composition of cell membranes in a way that supports a healthy inflammatory response. Including these nuts and seeds regularly can thus play a role in supporting a healthy inflammatory response.

Turmeric and ginger are known for their supportive properties on inflammation, thanks to curcumin in turmeric and gingerols in ginger. Curcumin may help manage the body's inflammation response, which is connected to many chronic conditions. Gingerols may help manage the body's production of substances that lead to inflammation. These compounds are particularly effective when used together, as they more efficiently support the body's natural response to inflammation. This combination offers potential support in conditions characterized by inflammation.

Scientific Evidence and Research

If you're looking to add more foods that support a healthy inflammatory response to your diet, the Mediterranean diet is a good place to start. It focuses on eating lots of fruits, vegetables, whole grains, and olive oil, and it includes some fish and poultry. Studies have found that this diet may help support a healthy inflammatory response, which is good news for people who have or want to avoid chronic diseases.

Research shows the Mediterranean diet may help support a healthy inflammatory response in the body; eating foods like fruits, vegetables, and olive oil can not only support a healthy inflammatory response but also help the immune system work better and improve gut health. This can lead to a lower chance of experiencing health issues. Further, clinical trials have suggested that the Mediterranean diet can support health by using its supportive and antioxidant benefits. Together, these studies suggest that the Mediterranean diet can be an effective way to support a healthy inflammatory response, making it a great choice for healthy eating.

Considerations and Balancing a Healthy Diet

When considering individual dietary needs and restrictions, it's important to seek advice from healthcare professionals before making significant changes. Every person's body reacts differently to food, which means dietary plans must be customized to meet nutritional needs and health conditions. Consulting with professionals ensures safety and long-term benefits. Finally, it’s important to remember that diet changes are part of a comprehensive plan to improve health. 

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Key Takeaways

  • The Mediterranean diet, rich in fruits, vegetables, whole grains, and olive oil, may help support a healthy inflammatory response and is beneficial for promoting overall health.
  • Differentiating between acute and chronic inflammation is important, with chronic inflammation being a factor in several serious health conditions.
  • Polyphenols and omega-3 fatty acids play significant roles in supporting a healthy inflammatory response by neutralizing free radicals and promoting gut health.
  • Consuming fatty fish, berries, leafy greens, nuts, and seeds can support a healthy inflammatory response and contribute to better heart health and overall wellness.
  • Turmeric and ginger contain compounds that may help manage inflammation pathways, offering potential support against conditions related to chronic inflammation.
The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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