Pediatrics
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January 31, 2025

Understanding Hand, Foot, and Mouth Disease (HFMD)

Written By
Dr. Kristin Robinson ND
Medically Reviewed by
Updated On
February 5, 2025

Did you know 10-15 million Americans contract hand, foot, and mouth disease (HFMD) each year?

HFMD is a viral infection that most commonly affects children under 5, though adults can get it too. Young children are more susceptible because their immune systems are still developing. 

Daycares and preschools also increase the risk due to close contact with others, making it easier for the virus to spread.

This article provides an overview of HFMD, including its early signs, stages, how it spreads, and what to expect during recovery. While HFMD is generally mild and self-limiting, understanding it can help you feel more informed and prepared if your child is affected.

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Understanding Hand, Foot, and Mouth Disease

It's helpful to understand the basic characteristics of hand, foot, and mouth disease (HFMD), including its causes, how it spreads, and who is most at risk.

What Is HFMD?

HFMD is an infectious illness that presents as a rash on the hands and feet and sores in the mouth. Coxsackievirus A16 is the most common cause, though other viral strains can also be involved. While most cases resolve without the need for specific treatment, some individuals may require medical attention, especially if complications arise.

HFMD is highly contagious and most commonly transmitted via respiratory droplets from an infected person’s coughs or sneezes. It can also spread by touching contaminated surfaces, such as toys or doorknobs, and then touching the mouth, nose, or eyes. The virus may also spread through fluid from skin blisters or, in rare cases, stool, especially when proper hand hygiene is not followed.

Who Is Most at Risk?

Children are more likely to contract HFMD due to their developing immune systems and close contact with others in daycare or school settings. The virus spreads easily in these environments, which can lead to outbreaks.

Adults can also become infected, especially if they were not exposed to HFMD during childhood or did not develop immunity to the virus. Additionally, adults with compromised immune systems, such as those undergoing chemotherapy or with autoimmune conditions, may be more vulnerable to infection.

Symptoms and Early Signs of HFMD

Recognizing the early signs of hand, foot, and mouth disease can help track its progression. While symptoms can vary, there are common patterns to look for in both children and adults.

Early Signs: Day-by-Day Breakdown

Here's what to expect in the first few days:

Day 1-3: Initial Symptoms

HFMD often begins with common symptoms such as fever, sore throat, and general fatigue. Children may become fussy or irritable, while adults may feel more tired than usual or have a headache. These early symptoms are usually the most uncomfortable and can last for a few days.

Day 4-6: Rash Development

A rash typically appears around the fourth day. It often starts as small red spots or bumps on the palms of the hands, soles of the feet, and inside the mouth. These can develop into painful blisters. The rash may also spread to other areas, such as the arms, legs, and buttocks.

Although the rash can be uncomfortable, it typically isn’t itchy. This stage marks the most noticeable visual symptoms of the illness. By the end of this period, many individuals begin to feel better, though the rash and mouth sores can last a bit longer.

Symptoms in Adults vs. Children

HFMD symptoms can present differently in children and adults, even though the same viruses cause the illness in both age groups.

Children, especially those under 5, tend to have more noticeable symptoms. The fever is often higher, and the rash spreads more quickly. Mouth sores can be painful, making eating or drinking difficult. Children may also become more irritable due to the discomfort from the rash and sores.

Adults typically experience milder symptoms. The fever is lower, and the rash is less severe. Mouth sores may not be as painful, and adults are generally less affected by the discomfort. However, adults can still pass the virus to others, particularly in close-contact settings.

Stages of HFMD in Adults and Children

HFMD typically progresses through stages, but the timing and severity of symptoms can vary between individuals.

Stage 1: Incubation Period

The incubation period typically lasts 3 to 6 days after exposure to the virus. During this time, there are no visible symptoms, but the virus is still multiplying in the body. While an individual may not feel ill, the virus can still be transmitted to others. Symptoms like fever and sore throat usually appear once the incubation period ends.

Stage 2: Symptomatic Phase

The symptomatic phase begins with mild flu-like symptoms. A rash typically appears on the hands, feet, and inside the mouth. This can develop into blisters, and mouth sores may cause pain when eating or drinking. This phase usually lasts several days, with the rash and sores being the most noticeable symptoms.

Stage 3: Recovery Phase

The recovery phase starts when the fever subsides, and the rash begins to heal. This phase typically lasts 7 to 10 days. As symptoms improve, the rash and mouth sores may remain tender, but discomfort gradually decreases. Energy levels begin to return to normal, and most individuals recover without complications.

Even during recovery, it’s important to continue practicing good hygiene, as the virus can still be contagious for a short period after symptoms improve.

Contagiousness and Recurrence

HFMD is most contagious during the symptomatic phase, especially in the first week. It can still spread for several days after symptoms improve.

It’s possible to get HFMD more than once since multiple viruses cause the illness. After an initial infection, immunity develops to the specific virus that does not protect against other strains. Reinfection may occur, though symptoms are often milder in those who have been previously exposed to a similar virus.

Recovery and Prevention

Preventing the spread of HFMD helps protect others and manage the illness.

Signs of Recovery

HFMD typically follows a clear recovery timeline, though it can vary from person to person.

Post-Illness Care Tips

Once symptoms improve, continue practicing good hygiene, as the virus can still spread. Stay hydrated, eat soft foods if mouth sores remain, and rest to support recovery. It's best to stay home until all symptoms have resolved to avoid spreading the virus.

Preventing HFMD

While it’s hard to avoid exposure in high-risk environments like daycares or schools, you can reduce the risk of transmission with these preventive steps:

  • Wash hands regularly, especially after using the bathroom, eating, or touching shared surfaces.

  • Disinfect commonly shared areas often, including toys, doorknobs, countertops, and bathroom fixtures.

  • Limit contact with infected individuals, especially during the symptomatic phase when they are most contagious.
  • Infected individuals should stay home until symptoms have resolved.

  • Encourage good hygiene by teaching children to wash hands and cover coughs or sneezes.

  • If possible, keep those with HFMD in a separate room and limit sharing personal items, like towels or utensils.

When to Seek Medical Help

Most cases of HFMD are mild, but medical care may be needed if symptoms worsen.

Severe Symptoms That Require Attention

While HFMD symptoms are usually mild, seek medical care if any of these occur:

  • Fever: A fever lasting longer than 3 days that doesn’t improve with OTC medication.

  • Dehydration: If painful mouth sores prevent drinking, dehydration can become a concern. Look for signs like dry mouth, dark urine, dizziness, or lack of urination.

  • Worsening Symptoms: If fever, rash, or mouth sores worsen or don’t improve after several days.

Guidance for Caregivers and Adults

Caregivers should monitor symptoms closely and take the following steps:

  • Monitor Hydration: Encourage frequent small sips to prevent dehydration.

  • Manage Discomfort: Use fever-reducing medications as directed by a healthcare provider. Keep the environment cool and encourage rest..

  • Watch for Changes: Contact a healthcare provider if symptoms worsen or new symptoms appear.

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Key Takeaways

  • HFMD is a viral infection, typically caused by Coxsackievirus A16. It starts with flu-like symptoms, followed by a rash and mouth sores. Most people recover in 7 to 10 days, though medical care may be needed for some.
  • HFMD is most contagious during the first week of symptoms, but the virus can continue to spread for several days after symptoms improve. Practicing good hygiene and isolating during illness helps prevent further spread.
  • Stay hydrated, rest, and manage discomfort during recovery. Seek medical attention if symptoms worsen, especially if signs of dehydration or high fever appear.
  • To limit transmission, wash hands frequently and disinfect shared surfaces. If symptoms worsen or new ones appear, consult a healthcare provider for guidance.

Share this article to help others learn about HFMD and its key prevention tips.

The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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