Nutrition
|
July 15, 2024

The Top 10 Most Nutrient-Dense Foods: Boost Your Health with These Powerhouses

Medically Reviewed by
Updated On
October 31, 2024

Nutrient-dense foods have a high concentration of essential nutrients relative to their calorie content. Essential nutrients help support metabolic functions, prevent deficiencies, and promote optimal health. According to the Centers for Disease Control and Prevention (CDC), only 1 in 10 adults in America regularly eat the minimal amounts of recommended fruits and vegetables per day. 

The evolving standard American diet, high in ultra-processed foods, leaves little room for anti-inflammatory, nutrient-dense foods, which are vital to maintain health, prevent disease, and promote overall well-being. This article will identify and discuss the top nutrient-dense foods to include in your diet.

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What Are Nutrient-Dense Foods?

Nutrient density describes the concentration of essential nutrients in a food in relation to its total calorie content. Foods that are not only high in vitamins, minerals, antioxidants, phytonutrients, and other beneficial compounds but also relatively low in calories are nutrient-dense. 

Optimal nutrition requires achieving daily nutritional requirements while not consuming excess calories to maintain a healthy weight and reduce chronic disease risk.

Examples of Nutrients Found in Nutrient-Dense Foods

Focusing on nutrient-dense foods must include variety. One popular phrase is "eat the rainbow," which implies the spectrum of nutrients you get from fruits and vegetables of various colors. Here are specific examples of essential nutrients:

Criteria for Ranking Nutrient-Dense Foods

Nutrient density can be assessed and scored using a variety of scales. 

It is important to note that external factors can influence nutrient density.

  • Soil quality impacts the nutrient density of foods and ingredients grown in that soil. The resulting foods may have a lower nutrient density if the soil is depleted of minerals like magnesium, calcium, and potassium.
  • Food processing is known to change the nutrient composition of foods. While some processing techniques fortify foods (like adding minerals to breads and cereals), other processing methods remove nutrients, which is typically the case with ultra-processed foods.
  • Specific cooking methods can make nutrients less available, like boiling, which is known to leach out minerals into the cooking water.

The Top 10 Most Nutrient-Dense Foods

Below are the top 10 most nutrient-dense foods that can significantly enhance your diet, providing a powerhouse of vitamins, minerals, and essential nutrients for optimal health and wellness.

It includes items such as sweet potatoes, quinoa, berries, nuts and seeds, legumes, salmon, cocoa and dark chocolate, dandelion greens, green tea, shiitake mushrooms.

1. Sweet Potatoes

Sweet potatoes offer notable nutrient density, including vitamins, minerals, and fiber. Rich in vitamin A as beta-carotene, sweet potatoes support vision and immune health. They are also high in vitamin C, potassium, and manganese; their high fiber content helps digestion and promotes a healthy gut microbiome

Sweet potatoes are incredibly versatile for use in recipes. Consider baking, roasting, or mashing them. They can also be used in soups, stews, and hearty skillet dishes. Try adding them to salads for a variation of texture. Oven-baked sweet potato fries offer a healthier alternative to traditional white potato fries.

2. Quinoa

Quinoa is exceptionally nutrient-dense. While quinoa is a pseudo-grain compared to other similar grains, quinoa is high in protein. It includes all 9 essential amino acids, making it a complete protein source—a rarity among plant-based proteins. 

Quinoa is also rich in fiber, which improves digestion and helps maintain a healthy weight. In addition to protein and fiber, it contains substantial amounts of essential micronutrients, including magnesium, iron, and B vitamins

To incorporate quinoa into your diet, try incorporating it into a salad for extra texture and nutrition, using it as a base for grain bowls with your favorite vegetables and proteins, or substituting it for rice in various dishes for more protein and fewer carbohydrates.

3. Berries

Berries are rich in polyphenols and antioxidants and provide high amounts of water, fiber, and other micronutrients. Their antioxidant effects allow berries to reduce inflammation. Strawberries, blueberries, raspberries, and blackberries are all potent inflammation-fighters. 

Berries are versatile, and the options are endless. Add them to a smoothie with other whole ingredients, eat them solo, or combine them with protein and healthy fats. They also make delicious additions to drinks or salads. Fruit-based desserts featuring fresh, in-season berries can be the perfect ending to a nutritious meal.

4. Nuts and Seeds

Nuts and seeds provide a blend of healthy fats, including monounsaturated and polyunsaturated fats essential for heart health, protein, and fiber. They also contain plant-based protein, which supports muscle repair and growth. 

The higher fiber content of nuts and seeds helps improve digestion and keep you fuller longer. Chia seeds, walnuts, and flax seeds are rich sources of healthy omega-3 fatty acids.

However, nuts and seeds are also energy-dense, so portion control is essential. A small handful (about 1 ounce) is typically a recommended serving. To keep nuts and seeds fresh, store them in airtight containers in a cool, dark place or refrigerate them to extend their shelf life and preserve their nutrient quality.

5. Legumes

Legumes, like chickpeas and lentils, are loaded with protein and fiber, promoting fullness and supporting digestive health. 

The high protein content in legumes aids in muscle recovery and strength, and their high fiber content improves digestion and helps regulate blood glucose. Additionally, they offer high amounts of B vitamins, iron, folate, zinc, phosphorus, calcium, magnesium, and potassium.

Legumes can be incorporated into soups, stews, snacks, and side dishes. Lentils can make hearty soups or a good base for grain bowls. Chickpeas can be blended to make hummus or roasted for a crunchy snack.

6. Salmon

Salmon is an excellent source of high-quality proteins, omega-3 fatty acids, essential vitamins, and minerals. Omega-3 fatty acids (especially EPA and DHA) improve cardiovascular health, reduce inflammation, and promote brain function.

The high-quality protein available in salmon helps with muscle function and repair, neurotransmitter formation, metabolism regulation, and immune support. You will also get vitamin D, vitamin B12, potassium, magnesium, selenium, and phosphorus from salmon. 

Try roasting or grilling salmon with extra virgin olive oil, herbs, and lemon or lime juice to incorporate salmon into your meals. Consider adding it to salads for healthy fat and protein, stir-frying it, or using it as a healthy protein in whole-grain or vegetable-based bowls.

7. Cocoa and Dark Chocolate

Dark chocolate is highly anti-inflammatory because of the many antioxidants from the flavanols in cacao. Flavanols are highly beneficial for the endothelial cells within your arteries, helping protect against damage and plaque formation, precursors to coronary artery disease. If the endothelial lining of the arteries remains intact, plaque cannot stick to the arterial walls. Instead, it continues to flow through the blood. Dark cacao can also help to reduce blood pressure.

However, many ways dark cacao is incorporated into foods, including heavy cream, trans-fat containing butter, added sugars, dyes, and preservatives, outweigh its actual health benefits. Look for dark chocolate with a high cacao content (70% or higher) and low in added sugars or artificial sweeteners.

8. Dandelion Greens

Dandelion greens are packed with these vitamins, minerals, and antioxidants:

Dandelion greens are well-known for their detoxifying properties, which help liver function.

Dandelion greens are similar to kale, Swiss chard, spinach, and other greens. To incorporate them into your meals, try them in salads for a slightly bitter flavor similar to arugula. You can also roast or saute the greens for a delicious and healthy side dish.

9. Green tea

Green tea is an excellent addition to an anti-inflammatory diet. It offers not only good hydration but also antioxidants and anti-inflammatory compounds that support cellular health and prevent free radical damage. Try drinking it hot or iced and adding fruits to it for additional flavor.

10. Shiitake Mushrooms

Shiitake mushrooms are high in vitamins, minerals, and phytonutrients

As an excellent source of B vitamins, like vitamin B2 (riboflavin) and vitamin B3 (niacin), which promote energy and metabolism, shiitake mushrooms are also an excellent source of vitamin D for optimal bone health. They deliver essential minerals, like selenium, copper, and zinc, and they are rich in polysaccharides (especially lentinan), which boosts immunity

To incorporate shiitake mushrooms into your meals, they are delicious as a side dish sautéed with extra virgin olive oil and garlic. They can also be added to soups and stews for enhanced flavor and nutrition, or their savory flavor and chewy texture will shine in stir-fries and pasta.

Practical Tips for Incorporating Nutrient-Dense Foods into Your Diet

Changing your diet doesn't have to be difficult. Here are some helpful and practical tips!

Substitutions to Enhance Nutrient Density

When you work to incorporate nutrient-dense foods into your diet, aim to crowd out the less healthful options. Start with making nutrient-dense food swaps.

  • Use quinoa in the place of rice in your dinner meal.
  • Opt for sweet potatoes in the place of white potatoes as a side item.
  • Choose berries and dark chocolate instead of ice cream for dessert.
  • Select nuts instead of potato chips for a snack.

Eventually, your diet will consist of all nutrient-dense foods with no room for the less healthful alternatives.

Sample Meal Plans

Breakfast

  • Quinoa Breakfast Bowl: Add 1/2 cup of cooked quinoa to a bowl, top it with 1 cup of fresh berries, 1/4 cup of Greek yogurt, a sprinkle of nuts, and a drizzle of honey.
  • Sweet Potato and Black Bean Breakfast Burrito: Fill a whole-grain tortilla with ¼ cup roasted sweet potatoes, ¼ cup black beans, and 1 scrambled egg. Top it with mashed avocado and fresh salsa.

Lunch

  • Mediterranean Quinoa Salad: Quinoa mixed with chopped cucumbers, tomatoes, red onion, olives, feta cheese, and a lemon-tahini dressing.
  • Sweet Potato and Lentil Soup: Cook a hearty soup made of sweet potatoes, lentils, carrots, celery, and dandelion greens seasoned with salt, garlic, cumin, and turmeric.

Dinner

  • Quinoa and Veggie Stir-Fry: Prepare quinoa, but stop about 5 minutes before the end of the cooking time. Stir-fry the quinoa in avocado oil with a rainbow of vegetables, like bell peppers, broccoli, and snap peas. Add tofu or chicken for extra protein, and top it with coconut aminos and ginger sauce.
  • Roasted Salmon with Sauteed Greens: Drizzle salmon filets with extra virgin olive oil, herbs, fresh lemon juice, and roast in the oven. Saute a rich mixture of kale, dandelion greens, and Swiss chard in extra virgin olive oil, garlic, salt, and pepper.

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Key Takeaways

  • Nutrient-dense foods provide a high concentration of essential nutrients relative to their calorie content.
  • Various assessments can be used to quantify the nutrient density of different foods.
  • The top 10 nutrient-dense foods include sweet potatoes, quinoa, berries, nuts and seeds, legumes, salmon, cocoa and dark chocolate, dandelion greens, green tea, and shiitake mushrooms.

Nutrient-dense foods have a high concentration of essential nutrients relative to their calorie content. Essential nutrients help support metabolic functions, prevent deficiencies, and promote optimal health. According to the Centers for Disease Control and Prevention (CDC), only 1 in 10 adults in America regularly eat the minimal amounts of recommended fruits and vegetables per day. 

The evolving standard American diet, high in ultra-processed foods, leaves little room for anti-inflammatory, nutrient-dense foods, which are vital to maintain health and support overall well-being. This article will identify and discuss the top nutrient-dense foods to consider including in your diet.

[signup]

What Are Nutrient-Dense Foods?

Nutrient density describes the concentration of essential nutrients in a food in relation to its total calorie content. Foods that are not only high in vitamins, minerals, antioxidants, phytonutrients, and other beneficial compounds but also relatively low in calories are nutrient-dense. 

Optimal nutrition requires achieving daily nutritional requirements while not consuming excess calories to maintain a healthy weight and support overall health.

Examples of Nutrients Found in Nutrient-Dense Foods

Focusing on nutrient-dense foods must include variety. One popular phrase is "eat the rainbow," which implies the spectrum of nutrients you get from fruits and vegetables of various colors. Here are specific examples of essential nutrients:

Criteria for Ranking Nutrient-Dense Foods

Nutrient density can be assessed and scored using a variety of scales. 

It is important to note that external factors can influence nutrient density.

  • Soil quality impacts the nutrient density of foods and ingredients grown in that soil. The resulting foods may have a lower nutrient density if the soil is depleted of minerals like magnesium, calcium, and potassium.
  • Food processing is known to change the nutrient composition of foods. While some processing techniques fortify foods (like adding minerals to breads and cereals), other processing methods remove nutrients, which is typically the case with ultra-processed foods.
  • Specific cooking methods can make nutrients less available, like boiling, which is known to leach out minerals into the cooking water.

The Top 10 Most Nutrient-Dense Foods

Below are the top 10 most nutrient-dense foods that can significantly enhance your diet, providing a powerhouse of vitamins, minerals, and essential nutrients for optimal health and wellness.

1. Sweet Potatoes

Sweet potatoes offer notable nutrient density, including vitamins, minerals, and fiber. Rich in vitamin A as beta-carotene, sweet potatoes support vision and immune health. They are also high in vitamin C, potassium, and manganese; their high fiber content supports digestion and promotes a healthy gut microbiome

Sweet potatoes are incredibly versatile for use in recipes. Consider baking, roasting, or mashing them. They can also be used in soups, stews, and hearty skillet dishes. Try adding them to salads for a variation of texture. Oven-baked sweet potato fries offer a healthier alternative to traditional white potato fries.

2. Quinoa

Quinoa is exceptionally nutrient-dense. While quinoa is a pseudo-grain compared to other similar grains, quinoa is high in protein. It includes all 9 essential amino acids, making it a complete protein source—a rarity among plant-based proteins. 

Quinoa is also rich in fiber, which supports digestion and helps maintain a healthy weight. In addition to protein and fiber, it contains substantial amounts of essential micronutrients, including magnesium, iron, and B vitamins

To incorporate quinoa into your diet, try incorporating it into a salad for extra texture and nutrition, using it as a base for grain bowls with your favorite vegetables and proteins, or substituting it for rice in various dishes for more protein and fewer carbohydrates.

3. Berries

Berries are rich in polyphenols and antioxidants and provide high amounts of water, fiber, and other micronutrients. Their antioxidant effects may help manage inflammation. Strawberries, blueberries, raspberries, and blackberries are all potent options to explore. 

Berries are versatile, and the options are endless. Add them to a smoothie with other whole ingredients, eat them solo, or combine them with protein and healthy fats. They also make delicious additions to drinks or salads. Fruit-based desserts featuring fresh, in-season berries can be the perfect ending to a nutritious meal.

4. Nuts and Seeds

Nuts and seeds provide a blend of healthy fats, including monounsaturated and polyunsaturated fats essential for heart health, protein, and fiber. They also contain plant-based protein, which supports muscle repair and growth. 

The higher fiber content of nuts and seeds helps support digestion and keep you fuller longer. Chia seeds, walnuts, and flax seeds are rich sources of healthy omega-3 fatty acids.

However, nuts and seeds are also energy-dense, so portion control is essential. A small handful (about 1 ounce) is typically a recommended serving. To keep nuts and seeds fresh, store them in airtight containers in a cool, dark place or refrigerate them to extend their shelf life and preserve their nutrient quality.

5. Legumes

Legumes, like chickpeas and lentils, are loaded with protein and fiber, promoting fullness and supporting digestive health. 

The high protein content in legumes aids in muscle recovery and strength, and their high fiber content supports digestion and helps regulate blood glucose. Additionally, they offer high amounts of B vitamins, iron, folate, zinc, phosphorus, calcium, magnesium, and potassium.

Legumes can be incorporated into soups, stews, snacks, and side dishes. Lentils can make hearty soups or a good base for grain bowls. Chickpeas can be blended to make hummus or roasted for a crunchy snack.

6. Salmon

Salmon is an excellent source of high-quality proteins, omega-3 fatty acids, essential vitamins, and minerals. Omega-3 fatty acids (especially EPA and DHA) support cardiovascular health, may help manage inflammation, and promote brain function.

The high-quality protein available in salmon helps with muscle function and repair, neurotransmitter formation, metabolism regulation, and immune support. You will also get vitamin D, vitamin B12, potassium, magnesium, selenium, and phosphorus from salmon. 

Try roasting or grilling salmon with extra virgin olive oil, herbs, and lemon or lime juice to incorporate salmon into your meals. Consider adding it to salads for healthy fat and protein, stir-frying it, or using it as a healthy protein in whole-grain or vegetable-based bowls.

7. Cocoa and Dark Chocolate

Dark chocolate is known for its antioxidant properties due to the flavanols in cacao. Flavanols are beneficial for the endothelial cells within your arteries, helping support cardiovascular health. Dark cacao may also help to manage blood pressure.

However, many ways dark cacao is incorporated into foods, including heavy cream, trans-fat containing butter, added sugars, dyes, and preservatives, outweigh its actual health benefits. Look for dark chocolate with a high cacao content (70% or higher) and low in added sugars or artificial sweeteners.

8. Dandelion Greens

Dandelion greens are packed with these vitamins, minerals, and antioxidants:

Dandelion greens are well-known for their properties that support liver function.

Dandelion greens are similar to kale, Swiss chard, spinach, and other greens. To incorporate them into your meals, try them in salads for a slightly bitter flavor similar to arugula. You can also roast or saute the greens for a delicious and healthy side dish.

9. Green tea

Green tea is an excellent addition to an anti-inflammatory diet. It offers not only good hydration but also antioxidants and anti-inflammatory compounds that support cellular health and help manage free radical damage. Try drinking it hot or iced and adding fruits to it for additional flavor.

10. Shiitake Mushrooms

Shiitake mushrooms are high in vitamins, minerals, and phytonutrients

As an excellent source of B vitamins, like vitamin B2 (riboflavin) and vitamin B3 (niacin), which promote energy and metabolism, shiitake mushrooms are also an excellent source of vitamin D for optimal bone health. They deliver essential minerals, like selenium, copper, and zinc, and they are rich in polysaccharides (especially lentinan), which support immune health

To incorporate shiitake mushrooms into your meals, they are delicious as a side dish sautéed with extra virgin olive oil and garlic. They can also be added to soups and stews for enhanced flavor and nutrition, or their savory flavor and chewy texture will shine in stir-fries and pasta.

Practical Tips for Incorporating Nutrient-Dense Foods into Your Diet

Changing your diet doesn't have to be difficult. Here are some helpful and practical tips!

Substitutions to Enhance Nutrient Density

When you work to incorporate nutrient-dense foods into your diet, aim to crowd out the less healthful options. Start with making nutrient-dense food swaps.

  • Use quinoa in the place of rice in your dinner meal.
  • Opt for sweet potatoes in the place of white potatoes as a side item.
  • Choose berries and dark chocolate instead of ice cream for dessert.
  • Select nuts instead of potato chips for a snack.

Eventually, your diet will consist of all nutrient-dense foods with no room for the less healthful alternatives.

Sample Meal Plans

Breakfast

  • Quinoa Breakfast Bowl: Add 1/2 cup of cooked quinoa to a bowl, top it with 1 cup of fresh berries, 1/4 cup of Greek yogurt, a sprinkle of nuts, and a drizzle of honey.
  • Sweet Potato and Black Bean Breakfast Burrito: Fill a whole-grain tortilla with ¼ cup roasted sweet potatoes, ¼ cup black beans, and 1 scrambled egg. Top it with mashed avocado and fresh salsa.

Lunch

  • Mediterranean Quinoa Salad: Quinoa mixed with chopped cucumbers, tomatoes, red onion, olives, feta cheese, and a lemon-tahini dressing.
  • Sweet Potato and Lentil Soup: Cook a hearty soup made of sweet potatoes, lentils, carrots, celery, and dandelion greens seasoned with salt, garlic, cumin, and turmeric.

Dinner

  • Quinoa and Veggie Stir-Fry: Prepare quinoa, but stop about 5 minutes before the end of the cooking time. Stir-fry the quinoa in avocado oil with a rainbow of vegetables, like bell peppers, broccoli, and snap peas. Add tofu or chicken for extra protein, and top it with coconut aminos and ginger sauce.
  • Roasted Salmon with Sauteed Greens: Drizzle salmon filets with extra virgin olive oil, herbs, fresh lemon juice, and roast in the oven. Saute a rich mixture of kale, dandelion greens, and Swiss chard in extra virgin olive oil, garlic, salt, and pepper.

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Key Takeaways

  • Nutrient-dense foods provide a high concentration of essential nutrients relative to their calorie content.
  • Various assessments can be used to quantify the nutrient density of different foods.
  • The top 10 nutrient-dense foods include sweet potatoes, quinoa, berries, nuts and seeds, legumes, salmon, cocoa and dark chocolate, dandelion greens, green tea, and shiitake mushrooms.
The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.

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Stanford, J. (2024, February 15). Pro-Inflammatory Foods: What to Avoid and Why? Rupa Health. https://www.rupahealth.com/post/pro-inflammatory-foods-what-to-avoid-and-why

Stanford, J. (2024, February 13). Top 10 Anti-Inflammatory Foods to Include in Your Diet. Rupa Health. https://www.rupahealth.com/post/top-10-anti-inflammatory-foods-to-include-in-your-diet

Sweetnich, J. (2023, March 28). Calcium 101: Testing, Top Foods, and Supplements. Rupa Health. https://www.rupahealth.com/post/calcium-101-testing-top-foods-supplements

Sweetnich, J. (2023, March 17). Copper 101. Rupa Health. https://www.rupahealth.com/post/copper-101-testing-top-foods-supplements

Sweetnich, J. (2023, April 5). Health Benefits of Zinc. Rupa Health. https://www.rupahealth.com/post/how-to-test-zinc-levels

Sweetnich, J. (2023, May 24). How to Make Sure Your Patients Are Getting Enough Vitamin B3 (Niacin) in Their Diet: Testing, RDAs, and Supplementing. Rupa Health. https://www.rupahealth.com/post/vitamin-b3-niacin-101-testing-rdas-and-supplementing

Sweetnich, J. (2023, March 22). Manganese 101: Health Benefits, Testing, Top Foods. Rupa Health. https://www.rupahealth.com/post/manganese-101-health-benefits-testing-top-foods

Sweetnich, J. (2023, May 19). Overview of the Liver 101: Top Conditions, Specialty Testing, Integrative Medicine Treatment Options. Rupa Health. https://www.rupahealth.com/post/overview-liver-101-top-conditions-and-testing

Sweetnich, J. (2023, April 4). Potassium 101. Rupa Health. https://www.rupahealth.com/post/potassium-101

Sweetnich, J. (2023, March 22). Selenium 101: Testing, Top Foods, and Supplements. Rupa Health. https://www.rupahealth.com/post/selenium-101-testing-top-foods-and-supplements

Sweetnich, J. (2023, June 30). Top 5 Antioxidants That Can Improve Your Health, and How to Test Your Patient's Levels. Rupa Health. https://www.rupahealth.com/post/top-5-antioxidants-to-improve-your-health

Sweetnich, J. (2023, March 24). Vitamin A 101: Health Benefits, Testing, and Top Foods. Rupa Health. https://www.rupahealth.com/post/vitamin-a-101-health-benefits-testing-top-foods

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Sweetnich, J. (2023, May 8). Vitamin B9 (Folate) 101. Rupa Health. https://www.rupahealth.com/post/understanding-the-importance-of-folate-testing-and-proper-supplementation-for-optimal-health

Sweetnich, J. (2023, May 9). Vitamin C 101. Rupa Health. https://www.rupahealth.com/post/vitamin-c-101

Sweetnich, J. (2023, May 4). Vitamin D 101: Testing, RDAs, and Supplementing. Rupa Health. https://www.rupahealth.com/post/vitamin-d-101-testing-rdas-and-supplementing

Sweetnich, J. (2023, May 8). Vitamin E 101: Exploring Testing, Health Benefits, and Sources of This Antioxidant Powerhouse. Rupa Health. https://www.rupahealth.com/post/vitamin-e-101

Teeter, LA. (2023, April 4). Functional Nutrition Strategies for Weight Management and Metabolic Health. Rupa Health. https://www.rupahealth.com/post/functional-nutrition-strategies-for-weight-management-and-metabolic-health

Weinberg, JL. (2023, December 26). The Power of Polyphenols: Functional Medicine's Antioxidant Superstars. Rupa Health. https://www.rupahealth.com/post/the-power-of-polyphenols-functional-medicines-antioxidant-superstars

Yoshimura, H. (2023, October 10). A Root Cause Medicine Approach to Chronic Inflammation. https://www.rupahealth.com/post/a-root-cause-medicine-approach-to-chronic-inflammation

Yoshimura, H. (2023, November 2). From Zinc to Magnesium: Micronutrients that Supercharge Gut Healing. Rupa Health. https://www.rupahealth.com/post/from-zinc-to-magnesium-micronutrients-that-supercharge-gut-healing

Zhang Y, Zhang M, Jiang Y, et al. Lentinan as an immunotherapeutic for treating lung cancer: a review of 12 years clinical studies in China. J Cancer Res Clin Oncol. 2018;144(11):2177-2186. https://pubmed.ncbi.nlm.nih.gov/30043277/

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