Medication Fact Sheets
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February 6, 2025

Scopolamine Patch: Benefits, Uses, and Key Safety Tips

Written By
Dr. Ayesha Bryant MSPH, MD
Medically Reviewed by
Updated On
February 24, 2025

Imagine setting off on a long-awaited cruise only to be sidelined by relentless nausea and dizziness. Similarly, some patients wake up from surgery experiencing severe nausea due to anesthesia. Fortunately, the scopolamine patch provides an effective way to prevent and manage these symptoms.

First developed in the mid-20th century, scopolamine has been used for decades to treat motion sickness and postoperative nausea. This article explores the scopolamine patch, how it works, its benefits, proper usage, potential side effects, and safety considerations. 

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What Is a Scopolamine Patch?

The scopolamine patch is a prescription medication used to prevent nausea and vomiting caused by motion sickness, surgery, or certain medical conditions. This small, skin-worn patch delivers medication through the skin and into the bloodstream, providing long-lasting relief with minimal effort.

Overview of Scopolamine

Scopolamine is an anticholinergic medication. It blocks certain nerve signals in the brain that cause nausea, vomiting, and dizziness. The scopolamine patch delivers this medication slowly over time, making it an effective option for people who need long-lasting relief from motion sickness or post-surgical nausea.

Chemical Composition and How It Works

The patch's active ingredient is scopolamine hydrobromide, which is derived from certain plant species, including the nightshade family. When applied to the skin, the patch gradually releases scopolamine, allowing the body to absorb it through the skin and into the bloodstream.

Scopolamine blocks acetylcholine, a neurotransmitter that sends signals related to balance and nausea from the inner ear to the brain. By reducing these signals, the patch helps prevent motion sickness and nausea before symptoms start.

FDA Approval and Common Applications

The U.S. Food and Drug Administration (FDA) has approved the scopolamine patch for preventing:

  • Motion sickness in adults and children over 12 years old
  • Nausea and vomiting caused by anesthesia during surgery
  • Vestibular disorders (conditions affecting the inner ear and balance) 

Scopolamine has been studied for potential off-label uses, including chemotherapy-induced nausea. Patients should consult their healthcare provider before considering such uses.

How to Use the Scopolamine Patch

Proper use of the scopolamine patch ensures that patients receive the full benefit of the medication while minimizing side effects.

Step-by-Step Guide

Applying the scopolamine patch correctly helps ensure it delivers a steady dose of medication for maximum effectiveness. Steps for applying the patch:

Where to Apply the Patch

  • Choose a clean, dry, and hairless area behind one ear.
  • Avoid placing the patch on irritated, broken, or sensitive skin.
  • Do not touch the adhesive side with your fingers; this may transfer medication to your hands.
  • Press the patch firmly onto the skin for at least 10 seconds to ensure it sticks properly.

Duration and Frequency of Use

  • Each patch lasts for up to 72 hours (3 days).
  • For motion sickness, apply the patch at least 4 hours before travel for best results.
  • If nausea continues, replace the old patch with a new one behind the opposite ear.
  • After surgery, doctors will instruct when to apply and remove the patch based on recovery needs.

Tips for Maximizing Effectiveness

  • Wash hands thoroughly before and after handling the patch to avoid getting medication in your eyes or mouth.
  • Avoid cutting or trimming the patch, as this can alter how the medication is released.
  • Do not cover the patch with a bandage or dressing.
  • If the patch falls off, consult your healthcare provider for guidance on reapplication.

Dos and Don’ts

Using the scopolamine patch correctly includes understanding what to do and what to avoid while wearing it.

What to Avoid While Using the Patch

  • Do not drink alcohol while using the patch, as it may increase drowsiness and dizziness.
  • After handling the patch, avoid touching your eyes or mouth. If contact occurs, wash thoroughly with water to prevent blurred vision or irritation.
  • Do not drive or operate heavy machinery until you know how the patch affects you. Some people experience drowsiness or confusion.
  • Avoid swimming or bathing in hot water for long periods, as excessive moisture may cause the patch to loosen.

Storage and Disposal Tips

  • Store the patch at room temperature, away from heat and moisture.
  • Keep out of reach of children and pets.
  • When disposing of the patch, fold it in half (sticky sides together) and throw it in a secure trash bin. Do not flush it down the toilet.
  • Wash your hands after handling a used patch to prevent accidental exposure to medication.

As with any medication, consult a healthcare provider before using the patch, especially if you have underlying health conditions or take other medications.

Benefits of the Scopolamine Patch

Scopolamine is most commonly used to prevent nausea and vomiting caused by motion sickness and surgery. 

Motion Sickness Relief

Motion sickness occurs when the brain receives mixed signals about movement from the inner ear, eyes, and body. It often occurs during car rides, boat trips, or air travel. The scopolamine patch helps prevent these symptoms before they start by:

  • Reducing nausea and vomiting while traveling
  • Providing sustained symptom relief for up to 72 hours, reducing the need for multiple doses.

Because of its long-lasting effects, the patch is especially useful for people going on cruises, long flights, or extended road trips.

Postoperative Nausea Management

After surgery, some people experience nausea and vomiting due to anesthesia. The scopolamine patch is often used in hospitals to reduce these symptoms, particularly for patients at high risk of postoperative nausea, such as those undergoing:

  • Abdominal surgery
  • Gynecologic procedures
  • Certain types of chemotherapy

Applying the patch before surgery can help control nausea for up to 72 hours, making recovery more comfortable.

Advantages Over Alternative Treatments

While other medications for motion sickness and nausea exist, the scopolamine patch offers several advantages.

Comparison with Oral Medications

Unlike oral motion sickness pills, which must be taken multiple times a day, the scopolamine patch works continuously for three days with just one application. Oral medications like meclizine (Dramamine) or diphenhydramine (Benadryl) may cause drowsiness and require frequent dosing. 

The patch provides:

  • Longer-lasting relief without the need for multiple doses.
  • Less sedation compared to some oral medications.
  • Bypasses the gastrointestinal tract, which may benefit people with difficulty tolerating oral medications.

Long-Lasting Effects and Convenience

One of the biggest benefits of the scopolamine patch is its ease of use. Instead of remembering to take a pill every few hours, patients simply apply the patch and forget about it. Other advantages include:

  • Water-resistant properties, allowing for showers and swimming.
  • Minimal interference with daily activities.
  • Better tolerance in people who cannot swallow pills.

Side Effects and Safety Considerations

While the scopolamine patch is effective for many people, it can cause side effects ranging from mild to serious. Knowing what to expect can help users manage symptoms and recognize when medical attention is needed.

Common Side Effects

Side effects vary among individuals, with many experiencing mild and temporary symptoms.

Dry Mouth, Dizziness, and Blurred Vision

Since scopolamine blocks certain nerve signals, it can cause:

  • Dry mouth, which may be relieved by drinking water or sucking on sugar-free candy
  • Dizziness or drowsiness, especially when first using the patch
  • Blurred vision, particularly if the medication accidentally gets into the eyes

To reduce these side effects, avoid touching your eyes after handling the patch and stay hydrated.

Skin Irritation at the Application Site

Some people experience redness, itching, or mild swelling where the patch is applied. To minimize irritation:

  • Rotate application sites between ears with each use
  • Ensure skin is clean and dry before applying
  • Avoid placing the patch on broken or irritated skin

If irritation persists, consult a healthcare provider.

Rare But Serious Reactions

Although uncommon, some people may experience serious side effects that require immediate medical attention.

Allergic Reactions

Severe allergic reactions to scopolamine are rare but possible. Symptoms may include:

  • Severe itching or rash
  • Swelling of the face, lips, or throat
  • Difficulty breathing

If any of these symptoms occur, seek emergency medical help immediately.

When to Seek Medical Attention

While mild side effects usually go away on their own, contact a doctor if you experience:

  • Severe confusion, agitation, or hallucinations
  • Extreme drowsiness or trouble waking up
  • Painful urination or difficulty passing urine

These symptoms may indicate a serious reaction that requires medical care.

Safety Precautions

Before using the scopolamine patch, certain individuals should consult their doctor to avoid potential risks.

Who Should Avoid Using the Patch?

The scopolamine patch may not be safe for everyone. People with the following conditions should talk to their doctor before use:

  • Glaucoma, as scopolamine can increase eye pressure
  • Enlarged prostate or urinary retention, which may worsen with anticholinergic drugs
  • Severe kidney or liver disease, which can affect how the medication is processed

Additionally, the patch is not recommended for children under 12 years old without a doctor’s approval.

Interactions with Other Medications

Scopolamine can interact with certain medications, increasing the risk of side effects. Examples of medications that may interact with it include: 

Combining these drugs with scopolamine may cause excessive drowsiness or confusion. Always inform your healthcare provider about all medications you take.

Frequently Asked Questions (FAQs)

The scopolamine patch is designed to provide long-lasting relief from nausea and motion sickness. Understanding how and when to use it can help ensure the best results.

How Quickly Does It Start Working?

The scopolamine patch begins working within 4 to 6 hours of application. However, it is most effective when applied at least 4 to 8 hours before exposure to motion, such as traveling by car, boat, or plane. For surgery-related nausea, the patch is usually applied the evening before surgery or at least 1 hour before anesthesia.  

Can It Be Used During Pregnancy?

There is limited data on the safety of scopolamine use during pregnancy. Some doctors may prescribe it if the benefits outweigh the risks, especially for women with severe nausea and vomiting (such as hyperemesis gravidarum).

Pregnant women should always consult their healthcare provider before using the patch to discuss potential risks and alternatives.

What Happens If I Forget to Remove It?

If you forget to remove the scopolamine patch after 72 hours:

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Key Takeaways

  • Long-lasting nausea prevention: The scopolamine patch provides up to 72 hours of continuous relief from motion sickness and postoperative nausea.
  • Gradual absorption through the skin: The patch slowly releases medication into the bloodstream, helping to block nausea signals from the inner ear to the brain.
  • More convenient than oral medications: Unlike pills that require frequent dosing, the scopolamine patch is a once-every-three-day solution.
  • Common side effects are mild: Most people experience dry mouth, dizziness, or slight skin irritation, which usually improves over time.
  • Not suitable for everyone: People with glaucoma, urinary retention, or certain medical conditions should consult a doctor before using the patch.
  • Pregnant or breastfeeding women should check with a doctor: Limited safety data means medical guidance is needed before use.
  • Proper handling and disposal are important: Users should wash their hands after applying or removing the patch and dispose of it properly to prevent accidental exposure.
The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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