Medication Fact Sheets
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January 29, 2025

Nystatin Cream: Understanding Its Uses and Considerations

Written By
Medically Reviewed by
Updated On
February 19, 2025

Fungal infections can affect anyone and develop in warm, moist areas of the body. They often cause itching, redness, and irritation, leading to discomfort in daily life.

These infections can start small but quickly become uncomfortable. Peeling skin, persistent itching, and redness can make everyday activities frustrating. Whether it's yeast infection or athlete's foot, finding relief is a priority.

Nystatin cream is a topical antifungal that helps stop fungal growth. When used correctly, it can ease symptoms and support skin recovery.

This guide covers how nystatin cream works, its benefits, proper use, and key safety tips to help you get the best results.

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What Is Nystatin Cream?

Nystatin cream is a topical antifungal medication used to manage fungal or yeast infections of the skin. 

Its active ingredient, nystatin, works by disrupting the cell membranes of fungi, preventing their growth and spread. This targeted action helps manage infections and relieve associated symptoms like itching, redness, and irritation.

Unlike broad-spectrum antifungals, nystatin is specifically effective against Candida, a yeast that commonly causes skin infections. 

It is commonly used for yeast-related conditions rather than other fungal infections, such as ringworm or nail fungus

Always consult your healthcare provider to determine the appropriate treatment.

Application Guidelines, Dosage, and Precautions

Using this medication correctly is essential for its effectiveness and safety. Follow these guidelines to ensure correct usage and minimize potential complications.

How to Use This Medication

This medication is for external use only—do not swallow or take it by mouth.

  • Thoroughly wash your hands before and after applying the medication. If you are treating an infection on your hands, wash them before applying the medication, but not after, so the medication remains effective.
  • Apply a thin, even layer to the affected area as directed by your healthcare provider.
  • Use it at the same time each day to maintain consistent treatment.
  • Do not apply more than prescribed or use it more frequently than instructed.
  • Continue the medication for the entire prescribed course, even if symptoms improve. Stopping too soon may reduce its effectiveness—only discontinue early if your healthcare provider advises.
  • If necessary, you may apply a sterile gauze dressing over the treated area. Avoid airtight or plastic-covered bandages, which can interfere with absorption and cause irritation.
  • If the medication accidentally gets into your eyes, rinse immediately with plenty of cool water.

Additional Considerations

Consult your healthcare provider before applying this medication to children, as they may require special care.

This medication is prescribed for you alone. Do not share it with others, even if they have similar symptoms.

If you suspect an overdose or if the medication is swallowed, seek immediate medical attention or contact a poison control center right away.

Follow your healthcare provider's instructions for optimal results and use the medication exactly as prescribed.

Potential Side Effects

This medication may cause some side effects, but not everyone will experience them. Some are mild and temporary, while others may require medical attention.

Common Side Effects

The most common side effect is mild irritation at the application site. This may include slight redness, itching, or discomfort. These symptoms usually go away on their own. 

However, inform your healthcare provider if the irritation becomes persistent or bothersome.

Serious Side Effects

Although rare, some reactions require urgent medical attention. Contact your healthcare provider right away if you experience:

  • A skin rash, severe itching, or hives
  • Swelling of the face, tongue, lips, or throat
  • Intense burning, peeling, or crusting of the treated area

If you have any concerns about side effects, speak with your provider for further guidance.

Frequently Asked Questions (FAQs)

Here are answers to common questions about nystatin cream to help ensure safe and effective use.

Can nystatin cream be used on children?

Healthcare providers may recommend nystatin cream for children, but a medical professional should guide its use.

What should I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed one and continue as usual. Do not apply additional cream to make up for a missed dose.

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Key Takeaways

  • Nystatin cream is an antifungal medication commonly used for Candida infections. It may help alleviate symptoms such as itching, redness, and discomfort when applied correctly.
  • For best outcomes, apply a thin layer as directed, complete the entire course of treatment, and avoid airtight bandages that may interfere with absorption.
  • Consult your trusted healthcare provider before using this medication to confirm it is appropriate for your condition.
  • Always follow your doctor's guidance and consult them if you have concerns about its use.
The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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Lab Tests in This Article

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Bethesda. (2012). Nystatin. PubMed; National Institute of Diabetes and Digestive and Kidney Diseases. https://www.ncbi.nlm.nih.gov/books/NBK548581/

Cleveland Clinic. (n.d.). Nystatin cream or ointment. Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/19293-nystatin-cream-or-ointment

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Cleveland clinic. (2022). Fungal infection (mycosis): Types, causes & treatments. Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/24401-fungal-infections-mycosis

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NHS. (2023, August 8). Who can and cannot take or use nystatin. Nhs.uk. https://www.nhs.uk/medicines/nystatin/who-can-and-cannot-take-or-use-nystatin/

Sweetnich, J. (2023, May 17). 3 natural treatments for ringworm. Rupa Health. https://www.rupahealth.com/post/3-natural-treatments-for-ringworm

Weinberg, J. L. (2023a, September 18). Integrative dermatology approach to urticaria (hives). Rupa Health. https://www.rupahealth.com/post/integrative-dermatology-approach-to-urticaria-hives

Weinberg, J. L. (2023b, September 25). Getting to the root cause of athlete's foot. Rupa Health. https://www.rupahealth.com/post/getting-to-the-root-cause-of-athletes-foot

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