Minoxidil for Women: Benefits, Usage, and Side Effects

Hair loss is often considered a men's health concern, but hair loss in women is more common than most people realize, affecting more than 50% of females. It is associated with social stigmas, high healthcare costs, and poor mental health outcomes.  

Minoxidil (Rogaine), the only FDA-approved medication for female pattern hair loss, has gained significant popularity in treating alopecia, highlighting the importance of understanding its benefits, proper usage, and potential side effects for healthcare professionals and patients.

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Understanding Hair Loss in Women

Alopecia is the medical term that refers to any type of hair loss. The first step in treating hair loss is identifying the cause.

Common Causes of Female Hair Loss

Hair loss in women can be categorized into several types:

1. Androgenetic Alopecia (Female Pattern Hair Loss): The most common type of hair loss in women, characterized by diffuse thinning over the mid-frontal scalp while maintaining the frontal hairline. It is often associated with genetic predisposition and hormonal changes. (4, 13)

2. Telogen Effluvium: Diffuse hair shedding due to a shift of hair follicles into the telogen (resting) phase. It can be triggered by physical or emotional stress, illness, surgery, nutritional deficiencies, or hormonal changes such as postpartum state. (38, 50) 

3. Alopecia Areata: This is an autoimmune condition resulting in patchy hair loss on the scalp and other body parts. The hair loss is typically sudden and can be reversible.

4. Traction Alopecia: Caused by prolonged tension on the hair from hairstyles such as tight braids or ponytails, leading to hair breakage and loss.

5. Cicatricial (Scarring) Alopecia: This includes conditions like lichen planopilaris and lupus erythematosus, where inflammation leads to permanent destruction of hair follicles and scarring.

6. Trichotillomania: A psychiatric disorder characterized by compulsive hair pulling, leading to noticeable hair loss.

Types of Hair Loss Treatable with Minoxidil

Minoxidil is the first-line treatment for female pattern hair loss. Both topical and oral formulations have shown efficacy in promoting hair regrowth and improving hair density. Studies have also found minoxidil to be effective for treating other types of non-scarring hair loss, including telogen effluvium, alopecia areata, traction alopecia, and chemotherapy-induced alopecia (44, 54). 

How Minoxidil Works for Women

Minoxidil was initially introduced as an oral antihypertensive medication in the 1970s. The hair growth that was observed as a side effect in balding patients led to the development of a topical formulation aimed at treating hair loss. In 1988, the FDA approved topical minoxidil for treating androgenetic alopecia. (46, 48) 

Mechanism of Action

The way that minoxidil works to promote hair growth isn't completely clear, but it appears to act through two primary mechanisms. 

First, it acts as a vasodilator, widening blood vessels and improving blood flow to hair follicles. A healthy blood supply to hair follicles is necessary for hair follicle growth, maturation, and maintenance. Blood vessels nourish the hair follicle with essential oxygen and nutrients. Loss of this blood supply can lead to hair loss. (33) 

Second, minoxidil affects two of the four stages of hair growth. The hair growth cycle is defined by four stages: anagen (growth), catagen (transition), telogen (rest), and exogen (shedding). Minoxidil extends the length of the anagen phase. It also shortens the length of the telogen phase, which accelerates the transition from telogen to anagen and promotes hair regrowth. (30) 

Other ways in which minoxidil promotes hair regrowth include:

• Minoxidil acts on androgenic receptors and certain enzymes that alter hormonal pathways to reduce dihydrotestosterone and increase estradiol, which prevents hormone-mediated hair loss. 
• Minoxidil increases vascular endothelial growth factor (VEGF) expression, which improves follicular blood flow. 
• Minoxidil increases the secretion of certain growth factors that promote hair follicle proliferation.

Differences Between Men's and Women's Minoxidil

The main differences between minoxidil formulations for men and women are the concentration and frequency of application, with women typically using lower concentrations and less frequent applications to balance efficacy and tolerability. (4, 36) 

Proper Application and Dosage for Women

It is important to apply minoxidil as directed to maximize its benefits and minimize the risk of potential side effects.

Step-by-Step Guide to Using Minoxidil

To apply minoxidil topical solution (31): 

• Dry your hair and scalp completely.
• Use the dropper provided to apply 1 mL of the solution directly to the affected area of the scalp. 
• Wash hands thoroughly after application.
• Repeat this process twice daily (morning and evening).
  

To apply minoxidil topical foam (31):

• Part the hair to expose the affected area of the scalp.
• Hold the can upside down and press nozzle to put one-half capful on your fingers. 
• Use your fingers to spread the foam over the areas of hair loss and gently massage into the scalp.
• Wash your hands immediately after applying the medicine. 
• Apply the foam once daily.

Dosage Guidelines

The recommended dose and frequency of minoxidil varies between the solution and foam formulations: 

• 2% Solution: Apply 1 mL twice daily
• 5% Foam: Apply half a capful once daily

‍Studies have shown that minoxidil solution and foam are equally effective in stimulating hair growth. The 5% foam offers the advantages of once-daily application and reduced risk of scalp irritation,  primarily because it does not contain propylene glycol. However, minoxidil solution is usually less expensive than the foam. (23) 

When to Expect Results

Women who use minoxidil consistently can expect to see visible improvement in hair growth approximately eight weeks after starting treatment. Some studies show that some women will begin to see results as soon as six weeks. Patients typically observe maximum results within 3-6 months of consistent use. (3, 17, 29)

It is important to set realistic expectations for patients, emphasizing that individual results can vary. Approximately 60% of women who use minoxidil will not experience hair growth. Continuous and consistent use is also necessary to maintain the benefits, and discontinuation of the medication will lead to the resumption of hair loss. 

Benefits of Minoxidil for Women

Minoxidil has been shown to improve hair growth and density. Studies have demonstrated that both 2% and 5% topical minoxidil formulations effectively increase hair count on the scalp and improve scalp coverage within 6-12 months. (4, 28, 54)

Beyond the physical benefits, treating hair loss with minoxidil can substantially improve self-esteem and mental health. Women using minoxidil experience a notable improvement in self-esteem, a better sense of attractiveness, and overall satisfaction with their appearance (30). This positive impact on emotional well-being cannot go unrecognized, as alopecia can have a profound effect on mental health, leading to anxiety, depression, and low self-esteem.

Side Effects and Risks

While topical minoxidil is generally well tolerated, its use has been associated with the following possible side effects:

• Minoxidil-Induced Telogen Effluvium (Hair Shedding): The shortened telogen phase of the hair growth cycle can result in excessive hair shedding in some people. Minoxidil shedding is usually temporary, lasting for about 2-8 weeks. 
• Skin Irritation: scalp redness, discomfort, burning, and scaling
• Allergic Contact Dermatitis: localized redness and itching at the site of application
• Hypertrichosis (Excessive Hair Growth): this is a more frequent side effect associated with 5% topical minoxidil solution.

Oral minoxidil is less commonly used to treat hair loss due to its black box warning for pericardial effusion and cardiac tamponade (excessive fluid buildup around the heart that prevents it from working properly). 

Other side effects associated with oral minoxidil include:

• Low blood pressure
• Low platelets and white blood cells
• Breast tenderness and gynecomastia (enlargement of breast tissue)
• Edema (fluid retention)
• Tachycardia (increased heart rate)

Addressing Concerns and Managing Side Effects

To prevent the risk of side effects, patients should adhere to proper application procedures, making sure to only apply the solution or foam to the scalp and avoid spreading it to other areas to prevent unwanted hair growth, skin irritation, and excess systemic absorption. 

If patients experience scalp irritation with minoxidil solution, they should consider switching to the foam formulation, which lacks propylene glycol. Propylene glycol is a common cause of contact dermatitis.

Patients should discontinue minoxidil and seek medical advice if they experience severe side effects, including signs of an allergic reaction or cardiovascular symptoms.

Alternatives to Minoxidil for Women

Alternative treatment options are available for women who are unable to tolerate minoxidil or find it ineffective.

Medications

Spironolactone is a potassium-sparing diuretic with anti-androgenic properties, commonly used off-label to treat female pattern hair loss. It works by reducing androgen production and blocking androgen receptors in target tissues, which helps mitigate the effects of androgens on hair follicles. Evidence shows that it can arrest hair loss progression and, in some cases, promote partial hair regrowth. (42) 

Finasteride helps prevent hair follicle miniaturization and promote hair regrowth by inhibiting the conversion of testosterone to dihydrotestosterone. While some studies have shown that higher doses (2.5 or 5 mg daily) can be effective in postmenopausal women, other studies have found no significant benefit at lower doses (1 mg per day). Due to its teratogenic potential, finasteride should only be prescribed to postmenopausal women. (25, 48, 53) 

Corticosteroids are a standard treatment for alopecia areata. They work by reducing the autoimmune attack on hair follicles, thereby promoting hair regrowth. Corticosteroids can be administered in several ways: topically, intralesionally, and orally. Intralesional injections are typically the preferred method due to their high efficacy and lower risk of systemic side effects. (52) 

Procedures

Low-level light therapy (LLLT) is a non-invasive treatment that utilizes specific wavelengths of light to stimulate hair growth. The absorption of light by hair follicles induces molecular changes that promote cellular proliferation and reduce inflammation to support hair growth. (1, 19) 

‍Hair transplant surgery is a medical procedure used to treat hair loss by relocating hair follicles from a donor area, typically the back or sides of the scalp, to areas experiencing thinning or baldness. Once transplanted, these follicles continue to grow naturally in their new location.

Natural and Lifestyle-Based Approaches

There are many types of supplements that may help support hair health. These formulas often contain the following ingredients:

• Biotin: enhances keratin production
• Iron: delivers oxygen to hair follicles and acts as a cofactor for enzymes involved in DNA and keratin synthesis
• Zinc: reduces intrafollicular inflammation and supports protein synthesis
• Ashwagandha: balances stress hormones
• Saw Palmetto: lowers dihydrotestosterone levels 

Lifestyle changes can also help to support hair health and potentially promote new hair growth:

• Eat a balanced, anti-inflammatory diet to reduce systemic inflammation levels and ensure adequate intake of macro- and micronutrients required for healthy hair.
• Avoid stressors and reduce stress by getting enough sleep, establishing a healthy work-life balance, practicing mind-body therapies, and supplementing with adaptogenic herbs.
• Quit smoking and avoid second-hand smoke. Smoking contributes to hair loss by reducing blood flow to hair follicles, damaging DNA, and inducing inflammation. (2, 35) 

Who Should Use Minoxidil?

Ideal candidates for minoxidil for treating hair loss are women with androgenetic alopecia (female pattern hair loss). Minoxidil is also used off-label for treating telogen effluvium and alopecia areata.

Contraindications and Situations to Avoid

Patients who are not good candidates for minoxidil include (27): 

• Women with hair loss of unknown cause
• Women under the age of 18
• Women with red, inflamed, irritated, or infected scalp conditions
• Women who are pregnant or breastfeeding

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Key Takeaways

• If you are struggling with hair loss, talk to your doctor about minoxidil as one treatment option. Minoxidil is a well-established, FDA-approved treatment for female pattern hair loss. It is also commonly used off-label for treating other types of hair loss in women, including telogen effluvium and alopecia areata.
• Consistent use of minoxidil is required to achieve its full benefits. In as little as six weeks, women can begin seeing hair growth and regain confidence. 
• By working closely with their healthcare providers to address the underlying causes of hair loss, women can adopt an integrative approach that optimizes short- and long-term results in their journey toward healthier, fuller hair.