Medication Fact Sheets
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December 17, 2024

How Voltaren Gel Works for Joint Pain Relief & Inflammation

Medically Reviewed by
Updated On
December 23, 2024

Voltaren® gel is a topical non-steroidal anti-inflammatory drug (NSAID) used for pain relief. It is primarily indicated for joint and muscle pain due to arthritis. Initially available by prescription only, Voltaren was approved for over-the-counter (OTC) use in 2020.

The active ingredient in Voltaren, diclofenac, is available in multiple forms and is used to reduce pain and inflammation. The medication is commonly used for people with pain due to arthritis or other chronic joint pain. This article provides a comprehensive overview of Voltaren Gel.

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What is Voltaren Gel?

Voltaren gel contains 1% diclofenac sodium. Other formulations of diclofenac are available in various concentrations. This medication is an effective option to temporarily relieve pain related to arthritis. Voltaren gel is commonly used for the hands, knees, elbows, and feet, though it can sometimes be used on other joints as well.

Like other anti-inflammatories, Voltaren gel works by inhibiting enzymes known as cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2). Blocking these enzymes decreases the amount of specific inflammatory markers in the blood. This blunts the inflammatory response and leads to less inflammation. 

Decreasing inflammation can improve the range of motion, pain, and stiffness. Voltaren has the advantage of being absorbed through the skin and penetrating into the tissues directly at the site of inflammation, bypassing the stomach.

Benefits and Uses of Voltaren Gel

Voltaren gel is FDA-approved for use in the hands, hips, knees, elbows, and feet to treat osteoarthritis. It is sometimes used off-label for other conditions of inflammation, such as tendonitis, joint sprains, and muscle pain

Discuss your conditions and medications you are considering, including OTC medications, with your healthcare provider, especially if you are considering off-label use.

How to Use Voltaren Gel Safely and Effectively

Using Voltaren gel is straightforward. It comes with a dosing card to ensure that you administer the right amount. Voltaren gel should not be used on more than two body parts at the same time.  

Upper body joints such as the hands, wrist, or elbow typically get a dose of 2.25 inches, while lower body joints such as the foot, ankle, and knee get a dose of 4.5 inches.[23] Voltaren gel can be administered up to four times daily for up to 21 days.

To apply Voltaren gel:

1.   Wash your hands

2.   Using the dosing card to measure out the recommended dose of medication

3.   Rub the gel gently into the affected area

4.   Wash your hands after administration to avoid accidentally putting medication somewhere unintended such as transferring it to food

Using Voltaren gel more than directed or using it with other NSAIDs can increase the risk of side effects. You should never use more medication than recommended by the manufacturer unless you are specifically directed to do so by your healthcare provider.

Like any medication, Voltaren gel has the potential for side effects. Voltaren gel may interact with other medications, such as aspirin or other NSAID medications. In addition, there is the potential for skin rashes and irritation, especially in those with sensitive skin.

Voltaren gel, and other NSAIDs, should not be used during pregnancy due to a lack of studies for safety and the risk of premature closure of the ductus arteriosus in the fetus. It is not known whether Voltaren gel is secreted in breast milk. It should not be applied to the breasts of nursing mothers. It may be acceptable for use on other body parts in people who are breastfeeding if recommended by a healthcare provider.

Comparing Voltaren Gel with Alternative Pain Relief Options

Voltaren gel and other topical NSAID medications have been shown to be at least equivalent to oral NSAIDs for improving pain, decreasing stiffness, and improving physical function in osteoarthritis patients.[18] In addition to being as good for treating symptoms, Voltaren gel has the additional benefit of having fewer side effects, which may allow it to be used safely in some patients who cannot take oral NSAIDs. 

The American College of Rheumatology and the Arthritis Foundation guidelines for treating osteoarthritis in hands, hips, and knees recommend using Voltaren gel and other topical NSAIDs before using oral NSAIDs. This is because Voltra gel and other topical NSAIDs are efficacious, and there is less whole-body exposure with topical medication than with oral medications.

Voltaren gel contains an anti-inflammatory medication, while other topical therapies, such as Biofreeze, contain methanol, lidocaine, salicylates, or capsaicin. Methanol works by cooling the skin, lidocaine by numbing, and capsaicin by heating the skin. Salicylates are also anti-inflammatories but do not have the safe efficacy as Voltaren gel.

Some people use several supplements and alternative therapies, such as turmeric and ice/heat therapy, for pain relief. Voltaren gel is regulated by the FDA, which allows it to be more consistent. Clinical data prove its efficacy and safety.

Side Effects, Risks, and Precautions of Voltaren Gel

The most common side effects of Voltaren gel are skin irritation, dryness, and burning sensation of the skin. People with sensitive skin may be more susceptible to this. To avoid skin irritation, you can do a patch test which involves putting a small amount of medication on a patch of skin and waiting to see if it reacts. Other common side effects of Voltaren gel include headaches, appetite loss, nausea, and upset stomach.

Because Voltaren gel works more locally and is not systemically absorbed like oral medications, it has less potential for causing damage to the kidneys or stomach than oral medications. However, there are still serious side effects possible. Some of these include:

  • Severe allergic reactions
  • Bleeding in the GI tract
  • Cardiovascular problems such as increased blood pressure, heart attack, or heart failure
  • Kidney injuries
  • Liver injuries
  • Stroke

If redness, blistering, or peeling of the skin occurs, it may indicate a severe skin reaction. Stop using the medication and seek immediate medical care if you experience any of these symptoms. 

People with recent heart surgery, bleeding disorders, heart problems, liver disease, or kidney disease should consult their healthcare provider before starting Voltaren gel. Active ulcers and an allergy to NSAIDs are also contraindications to using Voltaren gel. 

People on blood thinners and older adults may be more prone to bleeding with the use of Voltaren gel and shouldn’t use the medication without consulting their healthcare provider.

Cost, Accessibility, and Where to Buy Voltaren Gel

Voltaren gel is available over the counter and does not require a prescription. Some insurance companies may cover the medication with a prescription, while others will not. If you have a flexible spending account (FSA) or health savings account (HSA), you may be able to use this to cover the cost of Voltaren gel

There are five sizes of Voltaren gel available, ranging from 50g to 150g. Prices vary, but Voltaren gel is available at most pharmacies, grocery stores, and department stores. You may also be able to find the medication at online retailers. When buying medications, it is important to ensure that you are buying them from a reputable source to ensure an authentic product.

Frequently Asked Questions about Voltaren Gel

Here are some of the frequently asked questions regarding Voltaren gel.

Can Voltaren Gel Be Used for All Types of Pain?

Voltaren is FDA-approved to treat pain due to osteoarthritis but can be used off-label for other types of pain under the direction of a healthcare provider.

How Quickly Does Voltaren Gel Start Working?

Voltaren gel may start working an hour after use, but with continuous use, pain relief will become more significant within 7 days.[5]

Is it Safe to Use Voltaren Gel Long-Term?

Voltaren gel should not be used for more than 21 days unless directed by a healthcare provider. The risk of side effects with Voltaren gel does increase with time.

Can I Use Voltaren Gel with Other Pain Relief Products?

Using Voltaren gel with other medications can increase the risk of side effects. Do not mix Voltaren gel with other pain relief products without consulting a healthcare provider.

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Key Takeaways

  • Voltaren gel is a relatively safe and effective option for treating osteoarthritis-related pain.
  • People who have heart conditions, are on blood thinners or are pregnant should not use Voltaren gel unless specifically directed by a healthcare provider.
  • Voltaren gel may be a great option for osteoarthritis pain but consult with your healthcare provider to get personalized advice based on your specific healthcare needs before starting a medication regimen.
The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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