GI Health
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February 7, 2025

How Phenylephrine, Pramoxine & Petrolatum Heal Hemorrhoids

Written By
Medically Reviewed by
Updated On
February 24, 2025

Sitting hurts. Walking stings. Even bathroom trips feel like a battle. Hemorrhoid discomfort isn’t just annoying—it can take over your day.

Hemorrhoids, swollen veins in the lower rectum or around the anus, affect millions of people, causing pain, itching, and irritation that can disrupt daily life. They’re common, but that doesn’t make them any less challenging to manage.

Phenylephrine, pramoxine, and petrolatum are commonly used to help manage hemorrhoid symptoms and support relief. This article explores how these ingredients work individually and together to reduce discomfort and effectively promote comfort.

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What Are Hemorrhoids?

Hemorrhoids occur when the anal cushions—structures in the anal canal that help control bowel movements and protect the sphincter muscles—become swollen and inflamed. These cushions naturally contain blood vessels and connective tissue, but excessive pressure can cause them to enlarge, leading to discomfort and other symptoms.

Types of Hemorrhoids

Hemorrhoids are categorized based on their location:

  • Internal Hemorrhoids: Located inside the rectum, these are usually painless but may cause bright red bleeding during bowel movements. In some cases, they can prolapse (push out of the anus), leading to discomfort.
  • External Hemorrhoids: Found under the skin around the anus, these can cause itching, swelling, pain, and irritation. They may also bleed when aggravated.
  • Thrombosed Hemorrhoids: A blood clot (thrombus) can form in an external hemorrhoid, leading to severe pain, swelling, and a hard lump near the anus.

Each type varies in severity, but all can cause discomfort and may require treatment if symptoms persist.

Common Causes

Hemorrhoids develop when increased pressure affects the veins in the rectum and anus. Several factors contribute to their formation, including:

  • Straining during bowel movements, often due to constipation.
  • Pregnancy and childbirth put additional stress on pelvic blood vessels.
  • Chronic constipation or diarrhea leads to ongoing irritation.
  • Aging, as tissues supporting the anal veins weaken over time.
  • Prolonged sitting, particularly on the toilet, which increases pressure in the anal region.
  • Obesity adds strain to the lower body.
  • Frequent heavy lifting or activities that require excessive straining.

Symptoms

Hemorrhoid symptoms vary based on type and severity but commonly include:

  • Bright red blood in the stool, on toilet paper, or in the toilet
  • Pain or discomfort around the anus
  • Swelling or a lump near the anal opening
  • Itching or irritation, especially with external hemorrhoids

Because these symptoms can overlap with other medical conditions, consulting a healthcare provider is essential for an accurate diagnosis.

Why Proper Treatment Matters

While hemorrhoids are common, leaving them untreated can lead to ongoing discomfort and potential complications.

Potential Risks of Untreated Hemorrhoids

Without appropriate care, hemorrhoids may worsen over time, increasing the risk of:

  • Prolapsed hemorrhoids: Internal hemorrhoids that extend outside the anus, potentially leading to pain and requiring medical intervention.
  • Chronic bleeding and anemia: Recurrent blood loss from hemorrhoids can reduce red blood cell levels, resulting in fatigue.
  • Persistent inflammation and irritation: Ongoing swelling can make daily activities and bowel movements uncomfortable.

Key Ingredients for Hemorrhoid Relief

Effective hemorrhoid treatments combine ingredients that target different symptoms. Phenylephrine, pramoxine, and petrolatum work together to reduce swelling, relieve discomfort, and protect irritated skin. Here’s how each ingredient contributes to relief:

Phenylephrine: Reducing Swelling

Phenylephrine is a vasoconstrictor, meaning it tightens blood vessels to decrease swelling and discomfort. By reducing blood flow to the affected area, it helps shrink hemorrhoids and ease pressure.

Pramoxine: Relieving Pain and Itching

Pramoxine is a topical anesthetic that blocks nerve signals to temporarily numb the affected area, providing relief from pain and itching.

Petrolatum: Protecting and Healing Skin

Petrolatum, also known as petroleum jelly, is a skin protectant that creates a barrier that locks in moisture and shields the skin from further irritation. It helps soothe sensitive areas, supports healing, and is widely used in wound care and dermatology.

Dosage, Side Effects, and Drug Interactions

Apply the phenylephrine-pramoxine-petrolatum cream up to four times daily—in the morning, at bedtime, and after bowel movements. 

Tips:

  • Clean the area with mild soap and water, rinse well, and pat dry before applying. 
  • If applying inside the lower rectum, use the applicator tip, but do not insert it deeply.
  • Do not use it on children under 12 years without a healthcare provider’s approval.

Side Effects

Most people tolerate this medication well, but some may experience:

  • Mild irritation or stinging at the application site
  • Redness or dryness of the skin

Serious side effects are rare but may include:

  • Nervousness 
  • Tremor
  • Difficulty sleeping

Consult your healthcare provider for persistent, worsening (e.g., increased pain or bleeding), or severe side effects.  

Drug Interactions

Avoid using the cream with monoamine oxidase inhibitors (MAOIs) like phenelzine or selegiline, as they may increase side effects.

Pregnant or breastfeeding individuals should check with a doctor before using. Follow dosage instructions carefully, and do not mix with other medications without medical approval.

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Key Takeaways

  • Hemorrhoids are a common condition that can cause pain, itching, swelling, and bleeding, disrupting daily life.
  • Phenylephrine, pramoxine, and petrolatum work together to reduce swelling, relieve discomfort, and protect irritated skin.
  • Proper treatment is essential to prevent complications like prolapsed hemorrhoids, persistent irritation, and chronic bleeding.
  • Using the cream as directed—up to four times daily—helps manage symptoms effectively and supports healing.
The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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Lab Tests in This Article

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Bryant, A. (2024, August 2). Understanding arrhythmias: Types, symptoms, diagnosis, and treatment. Rupa Health. https://www.rupahealth.com/post/arrhythmias-basics-types-symptoms-diagnosis-treatment

Christie, J. (2023, January 6). A functional medicine approach to obesity and weight management. Rupa Health. https://www.rupahealth.com/post/an-integrative-approach-to-obesity

Cleveland Clinic. (2022, July 18). Hemorrhoids while pregnant: Causes, prevention & treatment. Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/23498-pregnancy-hemorrhoids

Cloyd, J. (2023a, May 17). A functional medicine constipation protocol: Testing, nutrition, and supplements. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-constipation-protocol-testing-nutrition-and-supplements

Cloyd, J. (2023b, July 28). A functional medicine diarrhea protocol: Comprehensive lab testing, therapeutic diet, and supplements. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-diarrhea-protocol-comprehensive-lab-testing-therapeutic-diet-and-supplements

Cloyd, J. (2023c, October 2). A functional medicine approach to treating hemorrhoids. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-treating-hemorrhoids

John Hopkins Medicine. (2024). Hemorrhoids. Www.hopkinsmedicine.org. https://www.hopkinsmedicine.org/health/conditions-and-diseases/hemorrhoids

Kaiser Permanente. (2021). Phenylephrine 0.25 %-pramoxine 1 %-glycerin-wh.petrolatum rectal cream. @Kpthrive. https://healthy.kaiserpermanente.org/health-wellness/drug-encyclopedia/drug.phenylephrine-0-25-pramoxine-1-glycerin-wh-petrolatum-rectal-cream.546407

Kamrani, P., Hedrick, J., Marks, J. G., & Zaenglein, A. L. (2023). Petroleum jelly: A comprehensive review of its history, uses, and safety. Journal of the American Academy of Dermatology, 90(4). https://doi.org/10.1016/j.jaad.2023.06.010

Mayo Clinic. (2018). Hemorrhoids - symptoms and causes. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/hemorrhoids/symptoms-causes/syc-20360268

MedlinePlus. (n.d.). Pramoxine: MedlinePlus drug information. Medlineplus.gov. https://medlineplus.gov/druginfo/meds/a682429.html

Neibling, K. (2023, February 27). Integrative medicine treatment for headaches. Rupa Health. https://www.rupahealth.com/post/integrative-medicine-treatment-for-headaches

Richards, E., & Maani, C. V. (2023, October 30). Phenylephrine. Nih.gov; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK534801/

Tahrier Sub Laban, & Abdolreza Saadabadi. (2023, July 17). Monoamine oxidase inhibitors (MAOI). Nih.gov; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK539848/

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