Cardiology
|
May 31, 2024

Exercise Protocols for Cardiac Rehabilitation and Heart Failure

Medically Reviewed by
Updated On
September 17, 2024

Heart failure is a condition where the heart can't pump blood effectively. It affects millions of people globally and significantly reduces the quality of life. 

Cardiac rehabilitation is one of the strategies healthcare providers can use to help patients with heart failure. It consists of supervised exercise, nutritional counseling, medication management, smoking cessation support, and psychological assistance. 

This article will highlight proven cardiac rehabilitation strategies that you can incorporate into your practice today.

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What is Heart Failure?

Heart failure (HF) is a severe health issue where the heart doesn't pump blood as well as it should, affecting roughly 26 million people globally. The Framingham Heart Study suggests that starting at age 45, people face a 20% to 42% lifetime chance of developing HF. 

This leads to decreased quality of life due to symptoms like tiredness, difficulty breathing, and swelling, which limit physical activities and often result in hospital stays.

The number of HF cases in the U.S. alone is projected to hit 8 million by 2030. The condition not only strains healthcare resources but significantly impacts patients' everyday lives (15). 

The 3 Most Common Causes of Heart Failure

The top 3 causes of heart failure include:

1. Coronary Artery Disease 

Coronary Artery Disease (CAD) is the leading cause of heart failure, accounting for about 70% of cases, highlighting the need for early detection and management.

How CAD Leads to Heart Failure:

Coronary Artery Disease (CAD) leads to heart failure by restricting blood flow to the heart muscle due to plaque buildup in the coronary arteries. This causes ischemia (a condition resulting in a shortage of oxygen and nutrients that leads to tissue damage and impaired function), which weakens the heart muscle over time. 

Acute events like heart attacks result in the death of heart tissue, reducing the heart’s ability to pump blood effectively. Chronic low-grade ischemia and increased workload from conditions like high blood pressure further stress the heart, causing structural changes and impairing its function, ultimately leading to heart failure.

2. High Blood Pressure

High blood pressure, or hypertension, is a condition where the force of blood against the artery walls is consistently too high. This increased pressure can cause the heart to work harder than normal to pump blood. 

How High Blood Pressure Leads to Heart Failure:

Over time, this extra workload can lead to the thickening and stiffening of the heart muscle, particularly the left ventricle, a condition known as left ventricular hypertrophy. The thickened muscle can become less efficient at pumping blood, leading to a decrease in cardiac output. 

Additionally, the high pressure can damage the arteries, making them less elastic and more prone to atherosclerosis, further impairing blood flow. These changes can eventually result in heart failure, as the heart becomes unable to pump enough blood to meet the body’s needs.

3. Chronic Obstructive Pulmonary Disease (COPD), 

Chronic Obstructive Pulmonary Disease (COPD) is a progressive lung disease that obstructs airflow and makes breathing difficult. It includes conditions like emphysema and chronic bronchitis. In COPD, the airways and air sacs lose their elasticity, the walls between air sacs can be destroyed, and the airways can become inflamed and thickened.

How COPD Leads to Heart Failure:

Chronic Obstructive Pulmonary Disease (COPD) can cause heart failure by making it hard for the heart to pump blood through the lungs. When COPD reduces oxygen levels, the blood vessels in the lungs narrow, increasing blood pressure. The right side of the heart has to work harder to push blood through these vessels, which can make it thicker and weaker over time, leading to heart failure. Additionally, inflammation and fluid buildup from COPD put extra stress on the heart, worsening the problem.

How to Measure Heart Failure

Heart failure (HF) is a serious condition where the heart doesn't pump blood as well as it should. The heart's pumping strength is checked by something called the ejection fraction (EF). There are three types of heart failure based on EF:

  • Heart failure with reduced ejection fraction (HFrEF) happens when the EF is 40% or lower, which means the heart muscle isn't squeezing strongly enough.
  • Heart failure with preserved ejection fraction (HFpEF) is when the EF is 50% or higher, meaning the heart squeezes normally but is too stiff to fill up properly.
  • Heart failure with mid-range ejection fraction (HFmrEF) is when the EF is between 41% and 49%, showing signs of both HFrEF and HFpEF.

How to Use Cardiac Rehabilitation for Patients with Heart Failure

Cardiac rehabilitation (CR) is an integral piece in managing heart failure. CR can help to slow disease progression, enhance heart efficiency during physical activities, and improve patients' quality of life. 

Individuals with heart failure often experience a marked reduction in their capacity to perform daily tasks, primarily due to decreased exercise tolerance. CR plays a pivotal role in boosting aerobic fitness and overall health (14,15). 

At its core, CR involves closely supervised exercise training, comprehensive nutritional counseling, effective medication management, support for smoking cessation, and psychological assistance. 

Evidence-Based Exercise Protocols for Cardiac Rehabilitation

Exercise training has demonstrated a decrease in mortality rates by 20%-30% compared to care without exercise intervention. Specifically, aerobic interval training, which alternates between high and low-intensity exercise, has proven more effective in enhancing functional capacity than traditional continuous moderate training. This is because this training method notably improves the efficiency of oxygen and blood flow during exercise (14,15). 

Structured exercise regimens lead to a notable increase in peak oxygen consumption (VO2), which is indicative of improved cardiovascular health and exercise capacity.

Studies confirm exercise's broad impact. For example, research shows that exercise-based rehabilitation reduces mortality and hospitalization rates. Furthermore, resistance training extends benefits to improving muscular strength, functional capacity, and quality of life. Moreover, the reduction in symptoms of depression and anxiety highlights the psychological benefits, reinforcing exercise as a critical component of treatment for HF patients (12). 

Developing Personalized Exercise Protocols

Assessing heart failure patients for participation in cardiac rehabilitation involves a multifaceted approach that includes risk stratification and setting personalized exercise goals. 

Risk stratification models, such as the EXERISK study, have been developed to identify patients at high risk of adverse outcomes during physical training, using variables derived from clinical records, patient evaluations, and stress testing. This process ensures that exercise prescriptions are safely tailored to each patient's risk profile, enhancing the effectiveness of rehabilitation while minimizing the risk of adverse events.

Exercise Protocol for Heart Failure Patients

The following example protocol is referenced from the following research:

Programs typically include moderate-intensity aerobic exercises supplemented with resistance training. All sessions should always be closely supervised by trained personnel, including cardiologists. Safety considerations are of vital importance in exercise prescription for heart failure patients. This example is meant for educational purposes, and this protocol is not intended to replace the guidance or supervision by healthcare professionals: 

Core Components:

  • Aerobic Training
  • Resistance Training
  • High-Intensity Interval Training (HIIT)
  • Inspiratory Muscle Training
  • Localized Muscle Training

Aerobic Exercise:

  1. Intensity: Start with RPE (Rating of Perceived Exertion) 11–13 (light to moderate), progressing to 12–14 (moderate to hard). Target heart rate: Resting Heart Rate (RHR) + 20–30 bpm.
  2. Duration: Begin with 5–10 minutes, increase by 1–5 minutes per session until 30–60 minutes.
  3. Frequency: 3–5 sessions per week.

Resistance Training:

  1. Frequency: 2–3 nonconsecutive days per week.
  2. Intensity: Focus on 8–10 exercises, 1–3 sets of 8–16 repetitions.
  3. Type: Use resistance bands, dumbbells, or bodyweight exercises.

High-Intensity Interval Training (HIIT):

  1. Suitability: Consider for patients who are stable and can tolerate higher intensity.
  2. Frequency: 3 times per week.
  3. Intensity: Short bouts of high-intensity exercise (80–90% HRR) alternated with low-intensity recovery periods.

Inspiratory Muscle Training:

Inspiratory Muscle Training (IMT) strengthens the diaphragm and other muscles involved in breathing using a device that adds resistance to inhalation. This therapy improves respiratory muscle strength, reduces breathlessness, and enhances exercise capacity and quality of life in heart failure patients.

  1. Frequency: Daily.
  2. Duration: 15–20 minutes.
  3. Intensity: Moderate effort.

Localized Muscle Training:

  1. Frequency: Daily, focusing on small muscle groups.
  2. Type: Use small weights or resistance bands.

Exercise Progression:

  1. Initial Phase: Achieve continuous exercise for 10 minutes at RHR + 20–30 bpm, RPE 11–14.
  2. Increase Duration First: Gradually increase to 30–60 minutes.
  3. Increase Intensity: Once duration is achieved, increase exercise intensity, monitoring RPE until it reaches 12–16.
  4. Monitor Symptoms: Watch for exercise-induced symptoms like angina, arrhythmias, or dyspnea.

Safety and Monitoring:

  1. Blood Pressure and Heart Rate: Regularly monitor responses to exercise.
  2. Diabetic Patients: Check blood glucose before and after sessions.
  3. Supervision: Ensure close supervision, especially for patients with advanced HF or complex medical regimens.

Additional Complementary Components: 

Nutritional counseling, lifestyle modification, smoking cessation, and psychosocial support are all fantastic additions to an integrative cardiac rehabilitation program.

Complementary therapies like yoga, tai chi, and aquatic therapy enhance cardiac rehabilitation by offering low-impact, gentle exercises that improve exercise capacity and quality of life. These therapies help by increasing flexibility, reducing stress, and providing alternative ways to achieve rehabilitation goals, particularly for patients who may have limitations with traditional exercise. This holistic approach ensures that the diverse needs of heart failure patients are met, promoting overall well-being (8).

Challenges and Solutions in Implementing Integrative Protocols

One prevalent challenge in implementing integrative protocols for cardiac rehabilitation is patient adherence to exercise regimens. Despite the clear benefits of exercise for heart failure patients, as evidenced by trials like HF-ACTION, many patients struggle with consistently following through with prescribed exercise routines. 

This non-adherence could be attributed to a variety of factors, including physical limitations, lack of motivation, or unclear understanding of the exercise's impact. For example, the HF-ACTION study found that only a minority of participants adhered to the prescribed exercise intensity and frequency (12). 

Health professionals can, therefore, play a pivotal role in bridging this gap through personalized exercise prescriptions, regular monitoring, and motivational support. For instance, creating tailored exercise plans that consider a patient's specific health status, preferences, and lifestyle can increase engagement and adherence. 

Additionally, incorporating technology, such as wearable devices for monitoring exercise intensity and progress, can provide real-time feedback to both patients and healthcare providers. Educating patients about the tangible benefits of regular exercise can also motivate patients (12). 

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Key Takeaways

  • Personalized exercise programs significantly improve recovery in heart failure patients by addressing individual health conditions and preferences.
  • Integrative medicine principles support cardiac rehabilitation by improving physical and mental health.
  • Regular, moderate-intensity exercise linked to heart failure management increases exercise tolerance and quality of life.
  • Resistance training, alongside aerobic exercises, offers comprehensive benefits, including enhanced muscular strength and functional capacity.
  • Addressing patient adherence challenges through personalized care, technology, and education is crucial for the success of cardiac rehabilitation programs.

Heart failure is a condition where the heart can't pump blood effectively. It affects millions of people globally and significantly reduces the quality of life. 

Cardiac rehabilitation is one of the strategies healthcare providers can use to help patients with heart failure. It consists of supervised exercise, nutritional counseling, medication management, smoking cessation support, and psychological assistance. 

This article will highlight cardiac rehabilitation strategies that you can consider incorporating into your practice today.

[signup]

What is Heart Failure?

Heart failure (HF) is a severe health issue where the heart doesn't pump blood as well as it should, affecting roughly 26 million people globally. The Framingham Heart Study suggests that starting at age 45, people face a 20% to 42% lifetime chance of developing HF. 

This leads to decreased quality of life due to symptoms like tiredness, difficulty breathing, and swelling, which limit physical activities and often result in hospital stays.

The number of HF cases in the U.S. alone is projected to hit 8 million by 2030. The condition not only strains healthcare resources but significantly impacts patients' everyday lives (15). 

The 3 Most Common Causes of Heart Failure

The top 3 causes of heart failure include:

1. Coronary Artery Disease 

Coronary Artery Disease (CAD) is the leading cause of heart failure, accounting for about 70% of cases, highlighting the need for early detection and management.

How CAD Leads to Heart Failure:

Coronary Artery Disease (CAD) may contribute to heart failure by restricting blood flow to the heart muscle due to plaque buildup in the coronary arteries. This can cause ischemia (a condition resulting in a shortage of oxygen and nutrients that leads to tissue damage and impaired function), which may weaken the heart muscle over time. 

Acute events like heart attacks can result in the death of heart tissue, reducing the heart’s ability to pump blood effectively. Chronic low-grade ischemia and increased workload from conditions like high blood pressure further stress the heart, potentially causing structural changes and impairing its function, which might lead to heart failure.

2. High Blood Pressure

High blood pressure, or hypertension, is a condition where the force of blood against the artery walls is consistently too high. This increased pressure can cause the heart to work harder than normal to pump blood. 

How High Blood Pressure Leads to Heart Failure:

Over time, this extra workload can lead to the thickening and stiffening of the heart muscle, particularly the left ventricle, a condition known as left ventricular hypertrophy. The thickened muscle can become less efficient at pumping blood, leading to a decrease in cardiac output. 

Additionally, the high pressure can damage the arteries, making them less elastic and more prone to atherosclerosis, further impairing blood flow. These changes can eventually result in heart failure, as the heart becomes unable to pump enough blood to meet the body’s needs.

3. Chronic Obstructive Pulmonary Disease (COPD), 

Chronic Obstructive Pulmonary Disease (COPD) is a progressive lung disease that obstructs airflow and makes breathing difficult. It includes conditions like emphysema and chronic bronchitis. In COPD, the airways and air sacs lose their elasticity, the walls between air sacs can be destroyed, and the airways can become inflamed and thickened.

How COPD Leads to Heart Failure:

Chronic Obstructive Pulmonary Disease (COPD) can make it hard for the heart to pump blood through the lungs. When COPD reduces oxygen levels, the blood vessels in the lungs narrow, increasing blood pressure. The right side of the heart has to work harder to push blood through these vessels, which can make it thicker and weaker over time, potentially leading to heart failure. Additionally, inflammation and fluid buildup from COPD put extra stress on the heart, worsening the problem.

How to Measure Heart Failure

Heart failure (HF) is a serious condition where the heart doesn't pump blood as well as it should. The heart's pumping strength is checked by something called the ejection fraction (EF). There are three types of heart failure based on EF:

  • Heart failure with reduced ejection fraction (HFrEF) happens when the EF is 40% or lower, which means the heart muscle isn't squeezing strongly enough.
  • Heart failure with preserved ejection fraction (HFpEF) is when the EF is 50% or higher, meaning the heart squeezes normally but is too stiff to fill up properly.
  • Heart failure with mid-range ejection fraction (HFmrEF) is when the EF is between 41% and 49%, showing signs of both HFrEF and HFpEF.

How to Use Cardiac Rehabilitation for Patients with Heart Failure

Cardiac rehabilitation (CR) is an integral piece in managing heart failure. CR may help to slow disease progression, enhance heart efficiency during physical activities, and improve patients' quality of life. 

Individuals with heart failure often experience a marked reduction in their capacity to perform daily tasks, primarily due to decreased exercise tolerance. CR plays a pivotal role in boosting aerobic fitness and overall health (14,15). 

At its core, CR involves closely supervised exercise training, comprehensive nutritional counseling, effective medication management, support for smoking cessation, and psychological assistance. 

Evidence-Based Exercise Protocols for Cardiac Rehabilitation

Exercise training has demonstrated a decrease in mortality rates by 20%-30% compared to care without exercise intervention. Specifically, aerobic interval training, which alternates between high and low-intensity exercise, has shown to be more effective in enhancing functional capacity than traditional continuous moderate training. This is because this training method may improve the efficiency of oxygen and blood flow during exercise (14,15). 

Structured exercise regimens can lead to a notable increase in peak oxygen consumption (VO2), which is indicative of improved cardiovascular health and exercise capacity.

Studies confirm exercise's broad impact. For example, research shows that exercise-based rehabilitation may reduce mortality and hospitalization rates. Furthermore, resistance training extends benefits to improving muscular strength, functional capacity, and quality of life. Moreover, the reduction in symptoms of depression and anxiety highlights the psychological benefits, reinforcing exercise as a critical component of treatment for HF patients (12). 

Developing Personalized Exercise Protocols

Assessing heart failure patients for participation in cardiac rehabilitation involves a multifaceted approach that includes risk stratification and setting personalized exercise goals. 

Risk stratification models, such as the EXERISK study, have been developed to identify patients at high risk of adverse outcomes during physical training, using variables derived from clinical records, patient evaluations, and stress testing. This process ensures that exercise prescriptions are safely tailored to each patient's risk profile, enhancing the effectiveness of rehabilitation while minimizing the risk of adverse events.

Exercise Protocol for Heart Failure Patients

The following example protocol is referenced from the following research:

Programs typically include moderate-intensity aerobic exercises supplemented with resistance training. All sessions should always be closely supervised by trained personnel, including cardiologists. Safety considerations are of vital importance in exercise prescription for heart failure patients. This example is meant for educational purposes, and this protocol is not intended to replace the guidance or supervision by healthcare professionals: 

Core Components:

  • Aerobic Training
  • Resistance Training
  • High-Intensity Interval Training (HIIT)
  • Inspiratory Muscle Training
  • Localized Muscle Training

Aerobic Exercise:

  1. Intensity: Start with RPE (Rating of Perceived Exertion) 11–13 (light to moderate), progressing to 12–14 (moderate to hard). Target heart rate: Resting Heart Rate (RHR) + 20–30 bpm.
  2. Duration: Begin with 5–10 minutes, increase by 1–5 minutes per session until 30–60 minutes.
  3. Frequency: 3–5 sessions per week.

Resistance Training:

  1. Frequency: 2–3 nonconsecutive days per week.
  2. Intensity: Focus on 8–10 exercises, 1–3 sets of 8–16 repetitions.
  3. Type: Use resistance bands, dumbbells, or bodyweight exercises.

High-Intensity Interval Training (HIIT):

  1. Suitability: Consider for patients who are stable and can tolerate higher intensity.
  2. Frequency: 3 times per week.
  3. Intensity: Short bouts of high-intensity exercise (80–90% HRR) alternated with low-intensity recovery periods.

Inspiratory Muscle Training:

Inspiratory Muscle Training (IMT) strengthens the diaphragm and other muscles involved in breathing using a device that adds resistance to inhalation. This therapy may improve respiratory muscle strength, reduce breathlessness, and enhance exercise capacity and quality of life in heart failure patients.

  1. Frequency: Daily.
  2. Duration: 15–20 minutes.
  3. Intensity: Moderate effort.

Localized Muscle Training:

  1. Frequency: Daily, focusing on small muscle groups.
  2. Type: Use small weights or resistance bands.

Exercise Progression:

  1. Initial Phase: Achieve continuous exercise for 10 minutes at RHR + 20–30 bpm, RPE 11–14.
  2. Increase Duration First: Gradually increase to 30–60 minutes.
  3. Increase Intensity: Once duration is achieved, increase exercise intensity, monitoring RPE until it reaches 12–16.
  4. Monitor Symptoms: Watch for exercise-induced symptoms like angina, arrhythmias, or dyspnea.

Safety and Monitoring:

  1. Blood Pressure and Heart Rate: Regularly monitor responses to exercise.
  2. Diabetic Patients: Check blood glucose before and after sessions.
  3. Supervision: Ensure close supervision, especially for patients with advanced HF or complex medical regimens.

Additional Complementary Components: 

Nutritional counseling, lifestyle modification, smoking cessation, and psychosocial support are all fantastic additions to an integrative cardiac rehabilitation program.

Complementary therapies like yoga, tai chi, and aquatic therapy may enhance cardiac rehabilitation by offering low-impact, gentle exercises that support exercise capacity and quality of life. These therapies help by increasing flexibility, reducing stress, and providing alternative ways to achieve rehabilitation goals, particularly for patients who may have limitations with traditional exercise. This holistic approach ensures that the diverse needs of heart failure patients are met, promoting overall well-being (8).

Challenges and Solutions in Implementing Integrative Protocols

One prevalent challenge in implementing integrative protocols for cardiac rehabilitation is patient adherence to exercise regimens. Despite the clear benefits of exercise for heart failure patients, as evidenced by trials like HF-ACTION, many patients struggle with consistently following through with prescribed exercise routines. 

This non-adherence could be attributed to a variety of factors, including physical limitations, lack of motivation, or unclear understanding of the exercise's impact. For example, the HF-ACTION study found that only a minority of participants adhered to the prescribed exercise intensity and frequency (12). 

Health professionals can, therefore, play a pivotal role in bridging this gap through personalized exercise prescriptions, regular monitoring, and motivational support. For instance, creating tailored exercise plans that consider a patient's specific health status, preferences, and lifestyle can increase engagement and adherence. 

Additionally, incorporating technology, such as wearable devices for monitoring exercise intensity and progress, can provide real-time feedback to both patients and healthcare providers. Educating patients about the tangible benefits of regular exercise can also motivate patients (12). 

[signup]

Key Takeaways

  • Personalized exercise programs may significantly improve recovery in heart failure patients by addressing individual health conditions and preferences.
  • Integrative medicine principles support cardiac rehabilitation by improving physical and mental health.
  • Regular, moderate-intensity exercise linked to heart failure management may increase exercise tolerance and quality of life.
  • Resistance training, alongside aerobic exercises, offers comprehensive benefits, including enhanced muscular strength and functional capacity.
  • Addressing patient adherence challenges through personalized care, technology, and education is crucial for the success of cardiac rehabilitation programs.
The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.

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  2. Blumenthal, J. A., & Rozanski, A. (2023). Exercise as a therapeutic modality for the prevention and treatment of depression. Progress in Cardiovascular Diseases, 77, 50–58. https://doi.org/10.1016/j.pcad.2023.02.008
  3. Bozkurt, B., Fonarow, G. C., Goldberg, L. R., Guglin, M., Josephson, R., Forman, D. E., Lin, G., Lindenfeld, J., O’Connor, C., Panjrath, G., Piña, I. L., Shah, T., Sinha, S. S., Wolfel, E. E., & Section, T. M. (2021). Cardiac Rehabilitation for Patients With Heart Failure. Journal of the American College of Cardiology (Print), 77(11), 1454–1469. https://doi.org/10.1016/j.jacc.2021.01.030
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  9. Cloyd, J. (2024e, April 5). A Functional Medicine Hypertension Protocol. Rupa Health. https://www.rupahealth.com/post/functional-medicine-hypertension-protocol
  10. DePorto, T. (2024, April 2). What Happens to Our Bodies When We Quit Smoking: A Timeline. Rupa Health. https://www.rupahealth.com/post/what-happens-to-our-bodies-when-we-quit-smoking-a-timeline
  11. Dibben, G., Faulkner, J., Oldridge, N., Rees, K., Thompson, D. R., Zwisler, A., & Taylor, R. S. (2023). Exercise-based cardiac rehabilitation for coronary heart disease: a meta-analysis. European Heart Journal, 44(6), 452–469. https://doi.org/10.1093/eurheartj/ehac747
  12. Downing, J., & Balady, G. J. (2011a). The Role of Exercise Training in Heart Failure. Journal of the American College of Cardiology, 58(6), 561–569. https://doi.org/10.1016/j.jacc.2011.04.020
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  14. Fu, T., Huang, S., Hsu, C., Wang, C., & Wang, J. (2014, September 1). Cardiac Rehabilitation in Patients with Heart Failure. PubMed Central (PMC). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834951/
  15. Hajouli, S., & Ludhwani, D. (2022, December 23). Heart Failure and Ejection Fraction. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK553115/
  16. How Cardiac Rehabilitation Can Help Heal Your Heart | cdc.gov. (2022, September 12). Centers for Disease Control and Prevention. https://www.cdc.gov/heartdisease/cardiac_rehabilitation.htm
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The American Journal of Clinical Nutrition
Peer Reviewed Journal
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The Journal of Bone and Joint Surgery
Peer Reviewed Journal
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Kidney International
Peer Reviewed Journal
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The Journal of Allergy and Clinical Immunology
Peer Reviewed Journal
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Annals of Surgery
Peer Reviewed Journal
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Chest
Peer Reviewed Journal
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The Journal of Neurology, Neurosurgery & Psychiatry
Peer Reviewed Journal
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Blood
Peer Reviewed Journal
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Gastroenterology
Peer Reviewed Journal
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The American Journal of Respiratory and Critical Care Medicine
Peer Reviewed Journal
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The American Journal of Psychiatry
Peer Reviewed Journal
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Diabetes Care
Peer Reviewed Journal
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The Journal of the American College of Cardiology (JACC)
Peer Reviewed Journal
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The Journal of Clinical Oncology (JCO)
Peer Reviewed Journal
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Journal of Clinical Investigation (JCI)
Peer Reviewed Journal
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Circulation
Peer Reviewed Journal
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JAMA Internal Medicine
Peer Reviewed Journal
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PLOS Medicine
Peer Reviewed Journal
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Annals of Internal Medicine
Peer Reviewed Journal
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Nature Medicine
Peer Reviewed Journal
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The BMJ (British Medical Journal)
Peer Reviewed Journal
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The Lancet
Peer Reviewed Journal
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Journal of the American Medical Association (JAMA)
Peer Reviewed Journal
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Pubmed
Comprehensive biomedical database
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Harvard
Educational/Medical Institution
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Cleveland Clinic
Educational/Medical Institution
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Mayo Clinic
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The New England Journal of Medicine (NEJM)
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Johns Hopkins
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