Clomid (clomiphene citrate) is a medication typically known for its use in female fertility, but it’s also prescribed off-label for men with low testosterone. Low T can diminish quality of life in men because it may lead to fatigue, sexual dysfunction, and other bothersome symptoms.
This article addresses the use of Clomid for low testosterone and the potential benefits of prescribing this medication to ease negative symptoms and optimize male fertility.
[signup]
What is Testosterone?
Testosterone is a sex hormone that plays a role in male reproduction, and overall health and well-being. It is vital for maintaining strong bones, muscle mass, sexual function, fertility, red blood cell formation, mood, and much more.
Symptoms of Low Testosterone
Common symptoms associated with low testosterone include:
- Erectile dysfunction (ED)
- Lower sex drive
- Reduced sperm count
- Infertility
- Depression
- Mood changes
- Reduced muscle mass, endurance, and strength
- Increased body fat
- Enlarged breast tissue
- Weight gain
- Reduced body hair
- Hot flashes
- Shrinking testicles
- Decreased concentration and memory
Fortunately, lifestyle changes and medical interventions can boost testosterone levels and diminish undesirable symptoms.
What is Clomid?
Clomiphene (brand name Clomid) is a selective estrogen receptor modulator (SERM). Traditionally, it has been used to treat infertility in women, as it increases the chance of becoming pregnant by aiding in egg production.
FDA Approval and Off-label Use
While Clomid is FDA-approved to treat female infertility, its off-label use can treat low testosterone (male hypogonadism) in men. Studies show that while testosterone therapy is often a first-line treatment for low testosterone in men, Clomid is an alternative off-label therapy for hypogonadal men wishing to have children.
The researchers found that men with low T treated with Clomid had higher levels of total testosterone, free testosterone, luteinizing hormone, and follicle-stimulating hormone. They report that while on Clomid treatment, 74% of study subjects experienced symptom relief.
8 Potential Benefits of Clomid for Low Testosterone
The benefits for men of using Clomid for hypogonadism include:
1. Natural Testosterone Enhancement
Clomid is a natural treatment for low T, stimulating the pituitary gland to produce more luteinizing and follicle-stimulating hormone. This, in turn, enhances the body’s natural ability to make more testosterone.
2. Fertility Preservation
Unlike traditional testosterone therapy (TRT), Clomid doesn’t adversely affect sperm production, which makes it a preferred option for men desiring maximum fertility.
A review found that study subjects who took Clomid had higher sperm concentrations, total sperm motility, total testosterone, luteinizing hormone, and follicle-stimulating hormone without any serious adverse side effects. The researchers concluded that taking Clomid is a safe therapy for improving sperm function in infertile men.
3. Improves Sexual Function
Clomid can improve sexual function, including erectile function and sex drive, by increasing testosterone levels without administering testosterone during TRT. A review reports that studies examining the effects of four months of Clomid treatment on men with hypogonadism found that testosterone increased and 75% of subjects experienced improvements in sexual functioning.
4. Mood Improvements
Because low testosterone levels can cause depression and other mood changes, using Clomid to boost testosterone in men might improve the mood of hypogonadal men. Patients may experience fewer mood swings, reduced depression, and less irritability after starting Clomid treatment. Studies demonstrate that men with low T who took Clomid were happier and experienced more enjoyment.
5. Enhanced Body Composition
Increasing testosterone levels using Clomid or other methods can improve body composition, particularly in men carrying excess body weight. A study found that men with obesity-related hypogonadism who took Clomid showed improvements in lean body mass, including more muscle mass. Higher testosterone levels also contribute to reduced body fat.
6. Improved Physical Performance
Researchers showed that hypogonadal men who took Clomid and experienced higher testosterone levels developed increased strength, more energy, and overall improvements in sports performance. Healthy athletes (including bodybuilders and other weightlifters) have used Clomid for performance enhancement, though this is not its intended use.
7. Better Sleep
Clomid treatment that increases testosterone levels can help individuals struggling with low T get a better night’s rest. Studies show that Clomid treatment for men increases energy, restores hormone balance, and contributes to a consistent, restful night’s sleep.
8. Enhanced Cognitive Function
Since low T can affect cognitive functioning, one sign that Clomid is working to treat low testosterone is improved cognition, including better concentration and memory.
The Link Between Clomid and Testosterone
There is a link between treatment with Clomid in men and improved testosterone levels.
Clomid and Testosterone Levels
Because clomid stimulates the pituitary gland to boost luteinizing and follicle-stimulating hormone, testosterone production also increases. Numerous research studies support this claim. Luteinizing hormone stimulates testosterone production and follicle-stimulating hormone enhances testosterone’s action.
Research and Efficacy
Research has consistently shown that Clomid is effective at increasing testosterone in men. A review examined 18 research studies. The researchers found that taking Clomid for male infertility led to an increase in total sperm motility, sperm concentration, follicular-stimulating hormone, total testosterone, and luteinizing hormone.
According to one study, the median length of time for low T symptom relief is three months. Therefore, it might take several months to experience the beneficial effects of Clomid treatment, such as more energy, reduced ED, and a stronger sex drive.
Potential Side Effects and Considerations
Many potential benefits exist for men taking Clomid to balance testosterone and maintain fertility, but it’s important to take note of possible side effects and considerations.
Common Side Effects
Clomid side effects may include:
- Headaches
- Hot flashes
- Gynecomastia
- Fatigue
- Dizziness
- Gastrointestinal disturbances
- Psychiatric illness exacerbation
One study found that the side effects reported by 8% of men treated with Clomid for more than three years were blurred vision, mood changes, and breast tenderness.
Adverse reactions occur mainly in people taking doses that are too high. These include vomiting, nausea, visual disturbances, high triglycerides, pancreatitis, abdominal pain, and liver or kidney damage.
TRT is also linked to side effects and potential complications. Examples include worsening sleep apnea, acne, other skin reactions, benign prostatic hyperplasia (BPH), prostate cancer complications, enlarged breasts, reduced sperm production, and a risk of blood clots.
Monitoring and Managing Side Effects
It’s vital to monitor testosterone levels and other health indicators when taking Clomid or any other medication that affects hormone balance. Healthcare providers can manage any side effects via dosage adjustments or other medical interventions.
Comparing Clomid to Testosterone Replacement Therapy
Several studies have examined the effects of testosterone replacement therapy (TRT) vs. Clomid treatment.
Effectiveness
One study found that both TRT (injections, gels, etc.) and Clomid effectively treated hypogonadism, but TRT was more effective at diminishing low T symptoms, particularly low libido. The researchers found that TRT improved the following health indicators slightly more than Clomid:
- Libido
- Energy
- Strength
- Enjoyment
- Happiness
- Erections
- Work performance
- Sports
- Sleep
- Height
However, another study demonstrated that Clomid was more effective than testosterone replacement therapy (53.2% vs. 46.8%) for normalizing testosterone in men with secondary hypogonadism, which is low T caused by conditions that affect the hypothalamus or pituitary gland. Secondary hypogonadism is congenital (present at birth) or acquired (occurs later in life).
Patient Suitability
Patients who might benefit more from Clomid vs. TRT are typically younger men who want to preserve their fertility because of a desire to have children. Men who aren’t candidates for TRT due to underlying conditions might be eligible to take Clomid instead. Furthermore, Clomid may be more effective at treating secondary hypogonadism.
However, the following conditions may make an individual ineligible for Clomid treatment:
- Hypersensitivity to Clomid
- Liver disease
- Uncontrolled thyroid disease or adrenal dysfunction
- Intracranial lesions
- Pituitary tumor
- Risk of high triglycerides
Providers must thoroughly assess patients’ medical histories before prescribing Clomid.
Implementing Clomid in a Treatment Plan
Before beginning Clomid for low testosterone, patients require an initial assessment that addresses their medical history, symptoms, lifestyle habits, current medications, treatment preferences, and goals – such as whether or not they plan to have children.
Lab testing helps evaluate their current hormone and cholesterol levels to establish which treatment and dosages are likely the most effective.
Typical dosages for men include taking 25 milligrams (half tablet) daily for 25 days, followed by five off days, or 25 milligrams every other day. Dosages might gradually increase to 50 milligrams daily for 25 days (followed by five days off). Routine hormone testing, fertility testing, and symptom reviews determine if a patient’s treatment and dosing are safe and effective.
Expectations and Follow-up
It’s vital to set realistic expectations for patients regarding the onset of low testosterone symptom relief, as it could take several months. It’s also important to schedule routine follow-up appointments to monitor the efficacy of treatment and adjust medications or dosages as needed to optimize patient outcomes.
[signup]
Key Takeaways
There are numerous benefits associated with using Clomid for low testosterone in men, particularly those concerned with fertility and side effects linked to testosterone replacement therapy.
Based on various research studies, Clomid appears to be a highly effective alternative to TRT. Individualized treatment plans for low T vary from patient to patient based on their medical history, treatment preferences, and lifestyle goals.
%201.svg){kind=logo}
Ready to become a world class gut health expert? Join Jeannie Gorman, MS, CCN, for a 
