Endocrinology
|
July 3, 2024

8 Potential Benefits of Clomid for Low Testosterone

Medically Reviewed by
Updated On
September 17, 2024

Clomid (clomiphene citrate) is a medication typically known for its use in female fertility, but it’s also prescribed off-label for men with low testosterone. Low T can diminish quality of life in men because it may lead to fatigue, sexual dysfunction, and other bothersome symptoms.

This article addresses the use of Clomid for low testosterone and the potential benefits of prescribing this medication to ease negative symptoms and optimize male fertility.Β 

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What is Testosterone?

Testosterone is a sex hormone that plays a role in male reproduction, and overall health and well-being. It is vital for maintaining strong bones, muscle mass, sexual function, fertility, red blood cell formation, mood, and much more.Β 

Symptoms of Low Testosterone

Common symptoms associated with low testosterone include:

Fortunately, lifestyle changes and medical interventions can boost testosterone levels and diminish undesirable symptoms.Β 

What is Clomid?

Clomiphene (brand name Clomid) is a selective estrogen receptor modulator (SERM). Traditionally, it has been used to treat infertility in women, as it increases the chance of becoming pregnant by aiding in egg production.Β 

FDA Approval and Off-label Use

While Clomid is FDA-approved to treat female infertility, its off-label use can treat low testosterone (male hypogonadism) in men. Studies show that while testosterone therapy is often a first-line treatment for low testosterone in men, Clomid is an alternative off-label therapy for hypogonadal men wishing to have children.Β 

The researchers found that men with low T treated with Clomid had higher levels of total testosterone, free testosterone, luteinizing hormone, and follicle-stimulating hormone. They report that while on Clomid treatment, 74% of study subjects experienced symptom relief.Β Β 

8 Potential Benefits of Clomid for Low Testosterone

The benefits for men of using Clomid for hypogonadism include:

1. Natural Testosterone Enhancement

Clomid is a natural treatment for low T, stimulating the pituitary gland to produce more luteinizing and follicle-stimulating hormone. This, in turn, enhances the body’s natural ability to make more testosterone.Β 

2. Fertility Preservation

Unlike traditional testosterone therapy (TRT), Clomid doesn’t adversely affect sperm production, which makes it a preferred option for men desiring maximum fertility.

A review found that study subjects who took Clomid had higher sperm concentrations, total sperm motility, total testosterone, luteinizing hormone, and follicle-stimulating hormone without any serious adverse side effects. The researchers concluded that taking Clomid is a safe therapy for improving sperm function in infertile men.

3. Improves Sexual Function

Clomid can improve sexual function, including erectile function and sex drive, by increasing testosterone levels without administering testosterone during TRT. A review reports that studies examining the effects of four months of Clomid treatment on men with hypogonadism found that testosterone increased and 75% of subjects experienced improvements in sexual functioning.Β 

4. Mood Improvements

Because low testosterone levels can cause depression and other mood changes, using Clomid to boost testosterone in men might improve the mood of hypogonadal men. Patients may experience fewer mood swings, reduced depression, and less irritability after starting Clomid treatment. Studies demonstrate that men with low T who took Clomid were happier and experienced more enjoyment.Β 

5. Enhanced Body CompositionΒ 

Increasing testosterone levels using Clomid or other methods can improve body composition, particularly in men carrying excess body weight. A study found that men with obesity-related hypogonadism who took Clomid showed improvements in lean body mass, including more muscle mass. Higher testosterone levels also contribute to reduced body fat.

6. Improved Physical PerformanceΒ 

Researchers showed that hypogonadal men who took Clomid and experienced higher testosterone levels developed increased strength, more energy, and overall improvements in sports performance. Healthy athletes (including bodybuilders and other weightlifters) have used Clomid for performance enhancement, though this is not its intended use.Β 

7. Better Sleep

Clomid treatment that increases testosterone levels can help individuals struggling with low T get a better night’s rest. Studies show that Clomid treatment for men increases energy, restores hormone balance, and contributes to a consistent, restful night’s sleep.Β 

8. Enhanced Cognitive Function

Since low T can affect cognitive functioning, one sign that Clomid is working to treat low testosterone is improved cognition, including better concentration and memory.

The Link Between Clomid and Testosterone

There is a link between treatment with Clomid in men and improved testosterone levels.Β 

Clomid and Testosterone Levels

Because clomid stimulates the pituitary gland to boost luteinizing and follicle-stimulating hormone, testosterone production also increases. Numerous research studies support this claim. Luteinizing hormone stimulates testosterone production and follicle-stimulating hormone enhances testosterone’s action.Β 

Research and Efficacy

Research has consistently shown that Clomid is effective at increasing testosterone in men. A review examined 18 research studies. The researchers found that taking Clomid for male infertility led to an increase in total sperm motility, sperm concentration, follicular-stimulating hormone, total testosterone, and luteinizing hormone.Β 

According to one study, the median length of time for low T symptom relief is three months. Therefore, it might take several months to experience the beneficial effects of Clomid treatment, such as more energy, reduced ED, and a stronger sex drive.

Potential Side Effects and Considerations

Many potential benefits exist for men taking Clomid to balance testosterone and maintain fertility, but it’s important to take note of possible side effects and considerations.Β 

Common Side Effects

Clomid side effects may include:

One study found that the side effects reported by 8% of men treated with Clomid for more than three years were blurred vision, mood changes, and breast tenderness.Β 

Adverse reactions occur mainly in people taking doses that are too high. These include vomiting, nausea, visual disturbances, high triglycerides, pancreatitis, abdominal pain, and liver or kidney damage.Β 

TRT is also linked to side effects and potential complications. Examples include worsening sleep apnea, acne, other skin reactions, benign prostatic hyperplasia (BPH), prostate cancer complications, enlarged breasts, reduced sperm production, and a risk of blood clots.Β 

Monitoring and Managing Side Effects

It’s vital to monitor testosterone levels and other health indicators when taking Clomid or any other medication that affects hormone balance. Healthcare providers can manage any side effects via dosage adjustments or other medical interventions.

Comparing Clomid to Testosterone Replacement Therapy

Several studies have examined the effects of testosterone replacement therapy (TRT) vs. Clomid treatment.Β 

Effectiveness

One study found that both TRT (injections, gels, etc.) and Clomid effectively treated hypogonadism, but TRT was more effective at diminishing low T symptoms, particularly low libido. The researchers found that TRT improved the following health indicators slightly more than Clomid:

  • Libido
  • Energy
  • Strength
  • Enjoyment
  • Happiness
  • Erections
  • Work performanceΒ 
  • Sports
  • SleepΒ 
  • HeightΒ 

However, another study demonstrated that Clomid was more effective than testosterone replacement therapy (53.2% vs. 46.8%) for normalizing testosterone in men with secondary hypogonadism, which is low T caused by conditions that affect the hypothalamus or pituitary gland. Secondary hypogonadism is congenital (present at birth) or acquired (occurs later in life).

Patient Suitability

Patients who might benefit more from Clomid vs. TRT are typically younger men who want to preserve their fertility because of a desire to have children. Men who aren’t candidates for TRT due to underlying conditions might be eligible to take Clomid instead. Furthermore, Clomid may be more effective at treating secondary hypogonadism.

However, the following conditions may make an individual ineligible for Clomid treatment:

Providers must thoroughly assess patients’ medical histories before prescribing Clomid.

Implementing Clomid in a Treatment Plan

Before beginning Clomid for low testosterone, patients require an initial assessment that addresses their medical history, symptoms, lifestyle habits, current medications, treatment preferences, and goals – such as whether or not they plan to have children.Β 

Lab testing helps evaluate their current hormone and cholesterol levels to establish which treatment and dosages are likely the most effective.Β 

Typical dosages for men include taking 25 milligrams (half tablet) daily for 25 days, followed by five off days, or 25 milligrams every other day. Dosages might gradually increase to 50 milligrams daily for 25 days (followed by five days off). Routine hormone testing, fertility testing, and symptom reviews determine if a patient’s treatment and dosing are safe and effective.Β 

Expectations and Follow-up

It’s vital to set realistic expectations for patients regarding the onset of low testosterone symptom relief, as it could take several months. It’s also important to schedule routine follow-up appointments to monitor the efficacy of treatment and adjust medications or dosages as needed to optimize patient outcomes.Β 

[signup]

Key Takeaways

There are numerous benefits associated with using Clomid for low testosterone in men, particularly those concerned with fertility and side effects linked to testosterone replacement therapy.

Based on various research studies, Clomid appears to be a highly effective alternative to TRT. Individualized treatment plans for low T vary from patient to patient based on their medical history, treatment preferences, and lifestyle goals.Β 

Clomid (clomiphene citrate) is a medication typically known for its use in female fertility, but it’s also prescribed off-label for men with low testosterone. Low T can affect quality of life in men because it may lead to fatigue, sexual dysfunction, and other bothersome symptoms.

This article addresses the use of Clomid for low testosterone and the potential benefits of prescribing this medication to help manage negative symptoms and support male fertility.Β 

[signup]

What is Testosterone?

Testosterone is a sex hormone that plays a role in male reproduction, and overall health and well-being. It is vital for maintaining strong bones, muscle mass, sexual function, fertility, red blood cell formation, mood, and much more.Β 

Symptoms of Low Testosterone

Common symptoms associated with low testosterone include:

Fortunately, lifestyle changes and medical interventions may help support testosterone levels and manage undesirable symptoms.Β 

What is Clomid?

Clomiphene (brand name Clomid) is a selective estrogen receptor modulator (SERM). Traditionally, it has been used to treat infertility in women, as it increases the chance of becoming pregnant by aiding in egg production.Β 

FDA Approval and Off-label Use

While Clomid is FDA-approved to treat female infertility, its off-label use may help manage low testosterone (male hypogonadism) in men. Studies show that while testosterone therapy is often a first-line treatment for low testosterone in men, Clomid is an alternative off-label therapy for hypogonadal men wishing to have children.Β 

The researchers found that men with low T treated with Clomid had higher levels of total testosterone, free testosterone, luteinizing hormone, and follicle-stimulating hormone. They report that while on Clomid treatment, 74% of study subjects experienced symptom relief.Β Β 

8 Potential Benefits of Clomid for Low Testosterone

The benefits for men of using Clomid for hypogonadism may include:

1. Natural Testosterone Enhancement

Clomid is considered a natural option for low T, as it may stimulate the pituitary gland to produce more luteinizing and follicle-stimulating hormone. This, in turn, may enhance the body’s natural ability to make more testosterone.Β 

2. Fertility Preservation

Unlike traditional testosterone therapy (TRT), Clomid doesn’t adversely affect sperm production, which makes it a preferred option for men desiring maximum fertility.

A review found that study subjects who took Clomid had higher sperm concentrations, total sperm motility, total testosterone, luteinizing hormone, and follicle-stimulating hormone without any serious adverse side effects. The researchers concluded that taking Clomid is a safe therapy for supporting sperm function in infertile men.

3. Supports Sexual Function

Clomid may support sexual function, including erectile function and sex drive, by increasing testosterone levels without administering testosterone during TRT. A review reports that studies examining the effects of four months of Clomid treatment on men with hypogonadism found that testosterone increased and 75% of subjects experienced improvements in sexual functioning.Β 

4. Mood Support

Because low testosterone levels can be associated with depression and other mood changes, using Clomid to boost testosterone in men might support mood in hypogonadal men. Patients may experience fewer mood swings, reduced depression, and less irritability after starting Clomid treatment. Studies demonstrate that men with low T who took Clomid were happier and experienced more enjoyment.Β 

5. Enhanced Body CompositionΒ 

Increasing testosterone levels using Clomid or other methods may support improved body composition, particularly in men carrying excess body weight. A study found that men with obesity-related hypogonadism who took Clomid showed improvements in lean body mass, including more muscle mass. Higher testosterone levels also contribute to reduced body fat.

6. Supports Physical PerformanceΒ 

Researchers showed that hypogonadal men who took Clomid and experienced higher testosterone levels developed increased strength, more energy, and overall improvements in sports performance. Healthy athletes (including bodybuilders and other weightlifters) have used Clomid for performance enhancement, though this is not its intended use.Β 

7. Better Sleep

Clomid treatment that increases testosterone levels may help individuals struggling with low T get a better night’s rest. Studies show that Clomid treatment for men increases energy, restores hormone balance, and contributes to a consistent, restful night’s sleep.Β 

8. Supports Cognitive Function

Since low T can affect cognitive functioning, one sign that Clomid is working to help manage low testosterone is improved cognition, including better concentration and memory.

The Link Between Clomid and Testosterone

There is a link between treatment with Clomid in men and improved testosterone levels.Β 

Clomid and Testosterone Levels

Because Clomid may stimulate the pituitary gland to boost luteinizing and follicle-stimulating hormone, testosterone production may also increase. Numerous research studies support this claim. Luteinizing hormone stimulates testosterone production and follicle-stimulating hormone enhances testosterone’s action.Β 

Research and Efficacy

Research has consistently shown that Clomid is effective at increasing testosterone in men. A review examined 18 research studies. The researchers found that taking Clomid for male infertility led to an increase in total sperm motility, sperm concentration, follicular-stimulating hormone, total testosterone, and luteinizing hormone.Β 

According to one study, the median length of time for low T symptom relief is three months. Therefore, it might take several months to experience the beneficial effects of Clomid treatment, such as more energy, reduced ED, and a stronger sex drive.

Potential Side Effects and Considerations

Many potential benefits exist for men taking Clomid to help balance testosterone and maintain fertility, but it’s important to take note of possible side effects and considerations.Β 

Common Side Effects

Clomid side effects may include:

One study found that the side effects reported by 8% of men treated with Clomid for more than three years were blurred vision, mood changes, and breast tenderness.Β 

Adverse reactions occur mainly in people taking doses that are too high. These include vomiting, nausea, visual disturbances, high triglycerides, pancreatitis, abdominal pain, and liver or kidney damage.Β 

TRT is also linked to side effects and potential complications. Examples include worsening sleep apnea, acne, other skin reactions, benign prostatic hyperplasia (BPH), prostate cancer complications, enlarged breasts, reduced sperm production, and a risk of blood clots.Β 

Monitoring and Managing Side Effects

It’s vital to monitor testosterone levels and other health indicators when taking Clomid or any other medication that affects hormone balance. Healthcare providers can manage any side effects via dosage adjustments or other medical interventions.

Comparing Clomid to Testosterone Replacement Therapy

Several studies have examined the effects of testosterone replacement therapy (TRT) vs. Clomid treatment.Β 

Effectiveness

One study found that both TRT (injections, gels, etc.) and Clomid effectively managed hypogonadism, but TRT was more effective at managing low T symptoms, particularly low libido. The researchers found that TRT improved the following health indicators slightly more than Clomid:

  • Libido
  • Energy
  • Strength
  • Enjoyment
  • Happiness
  • Erections
  • Work performanceΒ 
  • Sports
  • SleepΒ 
  • HeightΒ 

However, another study demonstrated that Clomid was more effective than testosterone replacement therapy (53.2% vs. 46.8%) for normalizing testosterone in men with secondary hypogonadism, which is low T caused by conditions that affect the hypothalamus or pituitary gland. Secondary hypogonadism is congenital (present at birth) or acquired (occurs later in life).

Patient Suitability

Patients who might benefit more from Clomid vs. TRT are typically younger men who want to preserve their fertility because of a desire to have children. Men who aren’t candidates for TRT due to underlying conditions might be eligible to take Clomid instead. Furthermore, Clomid may be more effective at managing secondary hypogonadism.

However, the following conditions may make an individual ineligible for Clomid treatment:

Providers must thoroughly assess patients’ medical histories before prescribing Clomid.

Implementing Clomid in a Treatment Plan

Before beginning Clomid for low testosterone, patients require an initial assessment that addresses their medical history, symptoms, lifestyle habits, current medications, treatment preferences, and goals – such as whether or not they plan to have children.Β 

Lab testing helps evaluate their current hormone and cholesterol levels to establish which treatment and dosages are likely the most effective.Β 

Typical dosages for men include taking 25 milligrams (half tablet) daily for 25 days, followed by five off days, or 25 milligrams every other day. Dosages might gradually increase to 50 milligrams daily for 25 days (followed by five days off). Routine hormone testing, fertility testing, and symptom reviews determine if a patient’s treatment and dosing are safe and effective.Β 

Expectations and Follow-up

It’s vital to set realistic expectations for patients regarding the onset of low testosterone symptom relief, as it could take several months. It’s also important to schedule routine follow-up appointments to monitor the efficacy of treatment and adjust medications or dosages as needed to optimize patient outcomes.Β 

[signup]

Key Takeaways

There are numerous benefits associated with using Clomid for low testosterone in men, particularly those concerned with fertility and side effects linked to testosterone replacement therapy.

Based on various research studies, Clomid appears to be a highly effective alternative to TRT. Individualized treatment plans for low T vary from patient to patient based on their medical history, treatment preferences, and lifestyle goals.Β 

The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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  1. Christie, J. (2022, March 25). The most common causes of infertility in men and women. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-infertility
  1. Christie, J. (2023, January 31). 7 functional medicine labs to test for root cause of infertility in women. Rupa Health. https://www.rupahealth.com/post/7-functional-medicine-labs-to-test-for-root-cause-of-infertility-in-women
  1. Cleveland Clinic. (2018, October 4). Low testosterone (low T): Causes, symptoms, diagnosis & treatment. Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/15603-low-testosterone-male-hypogonadism
  1. Clomiphene: Uses & side effects. (2024). Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/19178-clomiphene-tablets
  1. Cloyd, J. (2023b, April 4). Integrative medicine approach to patients with sleep apnea. Rupa Health. https://www.rupahealth.com/post/integrative-medicine-approach-to-patients-with-sleep-apnea
  1. Cloyd, J. (2023d, November 17). The gut-based approach to healing your acne. Rupa Health. https://www.rupahealth.com/post/the-gut-based-approach-to-healing-your-acne
  1. Cloyd, J. (2023a, March 29). Top 5 differential diagnosis for abdominal pain and how to treat with functional medicine. Rupa Health. https://www.rupahealth.com/post/top-5-differential-diagnoses-for-abdominal-pain-and-how-to-treat-with-functional-medicine
  1. Cloyd, J. (2023b, August 25). A root cause medicine protocol for patients with insomnia: Testing, therapeutic diet, and supportive supplements. Rupa Health. https://www.rupahealth.com/post/a-root-cause-medicine-protocol-for-patients-with-insomnia-testing-therapeutic-diet-and-supportive-supplements
  1. Cloyd, J. (2023c, December 27). Hormone testing 101: How to test and interpret your results. Rupa Health. https://www.rupahealth.com/post/hormone-testing-101-how-to-test-and-interpret-your-results
  1. Cloyd, J. (2024a, February 28). The link between erectile dysfunction and cardiovascular disease: Understanding the connection. Rupa Health. https://www.rupahealth.com/post/the-link-between-erectile-dysfunction-and-cardiovascular-disea
  2. se-understanding-the-connection
  1. Cloyd, J. (2024b, March 1). Optimizing sperm health for male fertility outcomes. Rupa Health. https://www.rupahealth.com/post/optimizing-sperm-health-for-male-fertility-outcomes
  1. Cloyd, J. (2024c, March 1). What is hyperlipidemia? Symptoms, testing, and treatments. Rupa Health. https://www.rupahealth.com/post/what-is-hyperlipidemia-symptoms-testing-and-treatments
  1. Creedon, K. (2022, March 18). 8 ways to prevent osteoporosis as you age. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-osteoporosis
  1. Dadhich, P., Ramasamy, R., Scovell, J., Wilken, N., & Lipshultz, L. (2017). Testosterone versus clomiphene citrate in managing symptoms of hypogonadism in men. Indian Journal of Urology : IJU : Journal of the Urological Society of India, 33(3), 236–240. https://doi.org/10.4103/iju.IJU_372_16
  1. DeCesaris, L. (2023, December 12). Elevating mood with nutraceuticals: A functional medicine perspective. Rupa Health. https://www.rupahealth.com/post/elevating-mood-with-nutraceuticals-a-functional-medicine-perspective
  1. Diorio, B. (2023, January 27). Functional medicine labs that are important for longevity and cognition. Rupa Health. https://www.rupahealth.com/post/functional-medicine-labs-that-are-important-to-longevity-and-cognition
  1. Easthope, A. (2022, April 26). 11 common causes of low male testosterone (and how to fix them). Rupa Health. https://www.rupahealth.com/post/an-integrative-medicine-approach-to-low-male-testosterone-hypogonadism
  1. Garcia-Touza, M. (2021). Safety and efficacy of clomiphene citrate in the treatment of secondary hypogonadism. A retrospective study. Journal of the Endocrine Society, 5(Supplement_1), A761–A761. https://doi.org/10.1210/jendso/bvab048.1548
  1. Huijben, M., Huijsmans, R. L. N., Lock, M. T. W. T., de Kemp, V. F., de Kort, L. M. O., & van Breda, J. H. M. K. (2023). Clomiphene citrate for male infertility: A systematic review and meta-analysis. Andrology, 11(6). https://doi.org/10.1111/andr.13388
  2. Jake. (2023, November 6). Low T solutions: Signs clomid is working. Austin Urology Institute. https://austinurologyinstitute.com/blog/low-t-solutions-signs-clomid-is-working/
  1. Kresge, K. (2023, February 21). An integrative medicine approach to depression. Rupa Health. https://www.rupahealth.com/post/an-integrative-medicine-approach-to-depression
  1. Krzastek, S. C., Sharma, D., Abdullah, N., Sultan, M., Machen, G. L., Wenzel, J. L., Ells, A., Chen, X., Kavoussi, M., Costabile, R. A., Smith, R. P., & Kavoussi, P. K. (2019). Long-Term safety and efficacy of clomiphene citrate for the treatment of hypogonadism. Journal of Urology, 202(5), 1029–1035. https://doi.org/10.1097/ju.0000000000000396
  1. Lin, B., & Twigg, S. M. (2023). Dose-dependent response to long-term clomiphene citrate in male functional hypogonadotropic hypogonadism. Endocrinology, Diabetes & Metabolism Case Reports, 2023(1). https://doi.org/10.1530/EDM-22-0242
  1. Manou Huijben, Lock, M. T. W. T., Vincent, Beck, J., de, M. O., & Jetske van Breda. (2023). Clomiphene citrate: A potential alternative for testosterone therapy in hypogonadal males. Endocrinology, Diabetes & Metabolism, 6(3). https://doi.org/10.1002/edm2.416
  1. Mayo Clinic. (2017). Testosterone therapy: Potential benefits and risks as you age. Mayo Clinic. https://www.mayoclinic.org/healthy-lifestyle/sexual-health/in-depth/testosterone-therapy/art-20045728
  1. Mbi Feh, M. K., & Wadhwa, R. (2020). Clomiphene. PubMed; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK559292/
  1. Neibling, K. (2023, February 27). Integrative medicine treatment for headaches. Rupa Health. https://www.rupahealth.com/post/integrative-medicine-treatment-for-headaches
  1. Oduwole, O. O., Huhtaniemi, I. T., & Misrahi, M. (2021). The roles of luteinizing hormone, follicle-stimulating hormone and testosterone in spermatogenesis and folliculogenesis revisited. International Journal of Molecular Sciences, 22(23), 12735. https://doi.org/10.3390/ijms222312735
  1. Perera, H. (2024, March 11). Anterior pituitary (its hormones, functions, & more). Rupa Health. https://www.rupahealth.com/post/hormones-by-anterior-pituitary
  1. Preston, J. (2023, September 13). A functional medicine protocol for fatigue: Lab testing, nutrition, and helpful supplements. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-protocol-for-fatigue-lab-testing-nutrition-and-helpful-supplements
  1. Ros, C. T. D., Ros, L. U. D., & Ros, J. P. U. D. (2022). The role of clomiphene citrate in late onset male hypogonadism. International Braz J Urol, 48(5), 850–856. https://doi.org/10.1590/s1677-5538.ibju.2021.0724
  1. Soares, A. H., Horie, N. C., Chiang, L. A. P., Caramelli, B., Matheus, M. G., Campos, A. H.,Β 
  2. Marti, L. C., Rocha, F. A., Mancini, M. C., Costa, E. M. F., & Cercato, C. (2018). Effects of clomiphene citrate on male obesity-associated hypogonadism: A randomized, double-blind, placebo-controlled study. International Journal of Obesity (2005), 42(5), 953–963. https://doi.org/10.1038/s41366-018-0105-2
  1. Sizar, O., & Pico, J. (2022). Androgen replacement. PubMed; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK534853/
  1. Sweetnich, J. (2023, April 17). A functional medicine protocol for low libido in men. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-protocol-for-low-libido-in-men
  1. Teeter, L. A. (2023, April 13). Using functional nutrition to address hormone imbalances. Rupa Health. https://www.rupahealth.com/post/using-functional-nutrition-to-address-hormone-imbalances
  1. Varanasi-Diaz, S. (2024, April 1). Integrative approaches to enhanced focus and concentration. Rupa Health. https://www.rupahealth.com/post/integrative-approaches-to-enhanced-focus-and-concentration
  1. Weinberg, J. (2022a, May 3). Tiredness, weight loss, and itching are signs of this dangerous liver disease. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-non-alcoholic-fatty-liver-disease
  1. Weinberg, J. (2022b, October 4). Pancreatitis: Causes, risk factors, and treatments. Www.rupahealth.com. https://www.rupahealth.com/post/pancreatitis-causes-risk-factors-and-treatments
  1. Weinberg, J. L. (2022, September 7). An integrative medicine approach to hypothyroidism. Rupa Health. https://www.rupahealth.com/post/understanding-hypothyroidism-and-how-to-treat-it-naturally
  1. Yoshimura, H. (2024, January 22). Functional medicine and hormone therapy in aging male populations. Rupa Health. https://www.rupahealth.com/post/functional-medicine-and-hormone-therapy-in-aging-male-populations
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Kidney International
Peer Reviewed Journal
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The Journal of Allergy and Clinical Immunology
Peer Reviewed Journal
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Annals of Surgery
Peer Reviewed Journal
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Chest
Peer Reviewed Journal
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The Journal of Neurology, Neurosurgery & Psychiatry
Peer Reviewed Journal
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Blood
Peer Reviewed Journal
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Gastroenterology
Peer Reviewed Journal
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The American Journal of Respiratory and Critical Care Medicine
Peer Reviewed Journal
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The American Journal of Psychiatry
Peer Reviewed Journal
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Diabetes Care
Peer Reviewed Journal
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The Journal of the American College of Cardiology (JACC)
Peer Reviewed Journal
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The Journal of Clinical Oncology (JCO)
Peer Reviewed Journal
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Journal of Clinical Investigation (JCI)
Peer Reviewed Journal
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Circulation
Peer Reviewed Journal
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JAMA Internal Medicine
Peer Reviewed Journal
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PLOS Medicine
Peer Reviewed Journal
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Annals of Internal Medicine
Peer Reviewed Journal
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Nature Medicine
Peer Reviewed Journal
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The BMJ (British Medical Journal)
Peer Reviewed Journal
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The Lancet
Peer Reviewed Journal
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Journal of the American Medical Association (JAMA)
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Pubmed
Comprehensive biomedical database
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Harvard
Educational/Medical Institution
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Cleveland Clinic
Educational/Medical Institution
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Mayo Clinic
Educational/Medical Institution
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The New England Journal of Medicine (NEJM)
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Johns Hopkins
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