Mental Health
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November 14, 2024

Bipolar 1 vs 2: Clear Comparisons for Better Management

Medically Reviewed by
Updated On
November 19, 2024

Living with bipolar disorder can feel like an emotional rollercoaster, with unpredictable highs and lows that are hard to manage. 

Understanding the differences between Bipolar 1 and Bipolar 2 can help clarify the condition. While both types involve mood swings, they affect people in different ways. Recognizing these differences is essential for both patients and healthcare providers. 

This article explores how these differences influence diagnosis, treatment, and long-term care.

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Understanding Bipolar Disorder

Bipolar disorder is a mood disorder characterized by extreme mood swings, including high-energy periods (mania or hypomania) and deep lows (depression).

These mood shifts can interfere with daily life, relationships, and work, making early diagnosis and treatment necessary for managing the condition effectively.

Mood Episodes: Mania, Hypomania, and Depression

Bipolar disorder involves three main types of mood episodes:

  • Mania: A period of intense euphoria, high energy, and impulsive behavior, often leading to major life disruptions. Mania can be severe enough to impair functioning or require hospitalization and is typically seen in Bipolar 1.
  • Hypomania: A milder form of mania with similar symptoms but less disruptive to daily life. Hypomania is common in Bipolar 2 and can sometimes go unnoticed or be mistaken for high energy.
  • Depression: Persistent sadness, low energy, and a loss of interest in activities once enjoyed. It can be debilitating and have significant impacts on daily functioning. Both Bipolar 1 and Bipolar 2 can include depressive episodes, though they may vary in frequency and severity.

Bipolar 1 vs Bipolar 2: Key Differences

Bipolar 1 and Bipolar 2 share some similarities but differ primarily in the severity of their mood episodes.

Manic Episodes: Full Mania vs. Hypomania

Bipolar 1 is more intense and disruptive. It involves a period of elevated mood, high energy, and impulsive behavior known as mania. Mania in Bipolar 1 can be severe enough to require hospitalization and often impairs daily functioning. In some cases, mania may lead to a break from reality, known as psychosis

Bipolar 2 involves hypomania, a milder form of mania. While symptoms like increased energy and talkativeness are present, they don't lead to significant disruptions in daily functioning. Hypomania is often less noticeable and may be mistaken for a period of high productivity.

Mania lasts at least one week and significantly disrupts daily functioning, whereas hypomania lasts at least four days and does not lead to major impairment.

Depressive Episodes: Intensity and Frequency

Both types involve depressive episodes, but they differ in their intensity and frequency:

  • Bipolar 1 typically has more intense and longer-lasting depressive episodes that can severely affect daily functioning.
  • Bipolar 2 features frequent depressive episodes, but they are generally less intense than those in Bipolar 1.

Diagnosis Criteria: DSM-5 Differences

The Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR) defines the diagnostic criteria for both types:

  • Bipolar 1 requires at least one manic episode, which is severe enough to disrupt daily life and may require hospitalization. Depressive episodes are common but not necessary for diagnosis.
  • Bipolar 2 requires at least one hypomanic episode (milder) and at least one major depressive episode. Hypomania doesn't cause major disruptions and doesn't require hospitalization.

In both types, mania or hypomania cannot be better explained by schizoaffective disorder or other psychotic disorders like schizophrenia.

Symptoms and Behavioral Differences

Bipolar 1 and Bipolar 2 have distinct symptoms and behavioral patterns that can significantly affect daily life.

Behavioral Patterns

In Bipolar 1, manic episodes are marked by:

  • Impulsive behaviors and high-risk actions, such as reckless spending, dangerous driving, or inappropriate social behavior
  • Irritability and aggression, especially when the elevated mood is challenged
  • Grandiose thoughts or an inflated sense of self-importance often leading to unrealistic beliefs in one's abilities

These behaviors can significantly stress relationships, work, and social life.

In Bipolar 2, hypomanic episodes involve increased energy, but the impulsivity and risk-taking behaviors are less extreme. People with hypomania may appear more productive or creative, though irritability and mood swings can still impact relationships and daily functioning.

Symptoms of Mania vs. Hypomania

Long-Term Impact: Relationships, Career, and Life Functioning

Bipolar 1 often has a more significant long-term impact due to the severity of manic episodes. The extreme mood swings can strain relationships, making it challenging to maintain stable connections. 

Career stability may also be affected, as manic episodes may lead to impulsive decisions or erratic work behavior, while depressive episodes can result in extended absences or decreased productivity.

Bipolar 2 is generally less disruptive in the short term, but its long-term effects can still be significant. Although hypomanic episodes tend to be milder and less likely to cause major disruptions, the ongoing depressive episodes can still have a profound impact on relationships, work, and daily life. 

Over time, the cycle of depression and hypomania can disrupt stability in personal relationships and job performance.

Treatment Options for Bipolar 1 and Bipolar 2

Effective treatment for both Bipolar 1 and Bipolar 2 requires a personalized combination of medications, psychotherapy, and lifestyle strategies.

Pharmacological Treatments

Both Bipolar 1 and Bipolar 2 are primarily treated with mood stabilizers (e.g., lithium, valproate) and antidepressants. 

Mood stabilizers help prevent or reduce the severity of mood episodes, while antidepressants target depressive symptoms. For both types, antidepressants must be paired with a mood stabilizer to prevent triggering mania or hypomania.

In Bipolar I, antipsychotics may be added to manage acute mania or psychosis. In severe cases, hospitalization may be warranted, especially when risky behavior or significant detachment from reality occurs. 

Hospitalization for Bipolar II is less common but may be needed for severe depression or suicidal ideation.

Medications for both Bipolar I and 2 can cause side effects like weight gain, drowsiness, tremors, or gastrointestinal issues. Antipsychotics may lead to movement disorders or metabolic changes, while long-term use of mood stabilizers can affect kidney or thyroid function.

Patients must work with their healthcare provider to monitor and adjust medications. Medications should never be stopped or changed without consulting a healthcare provider to avoid withdrawal symptoms or a relapse of mood episodes.

Psychotherapy Approaches

Cognitive Behavioral Therapy (CBT) is effective in both types of bipolar disorder, helping patients identify and change negative thought patterns, manage stress, and improve coping skills. 

A study found that CBT is recommended as an evidence-based adjunctive therapy, except during acute mania.

Interpersonal and Social Rhythm Therapy (IPSRT) is focused on stabilizing sleep, social routines, and relationships. This evidence-based therapy helps reduce mood swings by creating predictable routines and improving interpersonal communication. 

Research indicates that IPSRT significantly improves manic, depressive, and anxious symptoms in patients with bipolar disorder.

Lifestyle and Self-Care

Along with medication and therapy, maintaining healthy lifestyle habits is important for managing bipolar disorder.

Sleep Hygiene

Maintaining a regular sleep schedule and a calming bedtime routine helps regulate mood. In individuals with bipolar disorder, sleep patterns vary depending on their mood. During manic episodes, individuals often feel little need for sleep, while during depressive episodes, they may sleep excessively.

Research shows that sleep disturbances can both trigger and worsen manic and depressive episodes. There is a bidirectional relationship between sleep and bipolar disorder, where poor sleep can worsen symptoms, and the disorder itself can also lead to sleep disturbances.

Treating insomnia can improve mood stability and reduce the impact of bipolar disorder.

Diet and Exercise

Regular exercise and a balanced, nutrient-rich diet support mood stability and overall health. Exercise boosts endorphin levels, which help manage anxiety and depressive symptoms. Additionally, omega-3 fatty acids and zinc have been linked to improved bipolar symptoms.

Stress Management

Chronic stress can trigger or worsen mood episodes. Techniques like mindfulness, yoga, and meditation help manage stress and improve mood stability.

Challenges in Diagnosing and Managing Bipolar 1 and Bipolar 2

Diagnosing bipolar disorder accurately can be difficult, particularly when its symptoms overlap with those of other conditions.

Misdiagnosis Risks

Approximately 69% of patients with bipolar disorder are initially misdiagnosed. 

Bipolar 2 is commonly mistaken for major depressive disorder (MDD) because depressive episodes are more frequent and may mask the hypomanic symptoms. Since MDD doesn't include manic or hypomanic episodes, the broader mood swings in bipolar disorder may be overlooked.

This misdiagnosis can lead to ineffective treatment, as antidepressants prescribed for MDD may trigger hypomania or mania in individuals with Bipolar 2. A complete history of mood episodes is needed for an accurate diagnosis and effective treatment.

Screening Tools and Tests

Diagnosing bipolar disorder generally includes a physical exam and lab tests to exclude other medical conditions, though no single test can provide a definitive diagnosis.

A psychiatrist will perform a mental health assessment, which may include gathering information from the patient as well as from family members or close friends. 

The patient may also be asked to track mood or sleep patterns. Tools like the Mood Disorder Questionnaire (MDQ) and Mini International Neuropsychiatric Interview (MINI) help assess symptoms and differentiate bipolar disorder from other conditions.

Patient Education

Educating patients about the importance of mood tracking helps them identify early signs of change, which can prevent episodes from escalating. It also allows healthcare providers to recognize patterns and determine when intervention is needed.

Practical Tips for Patients and Healthcare Providers

Collaboration between patients and healthcare providers helps create a personalized approach to managing bipolar disorder effectively.

Monitoring Symptoms

Regular mood tracking is critical to managing bipolar disorder, helping patients identify early signs of mood episodes. Patients can use apps or traditional methods, such as journals, to track mood, sleep patterns, and triggers. 

Teaching patients to maintain a routine, manage triggers, and stay consistent with medications can improve long-term outcomes and reduce the risk of relapses. 

Understanding these strategies enables patients to take a more proactive role in their care, resulting in better control of their condition.

Building a Support System

Patients can involve family, friends, and community resources in managing bipolar disorder by educating loved ones about the condition. This includes explaining symptoms, triggers, and treatment plans to ensure everyone is on the same page. Involving family members in therapy or care team discussions can further strengthen support.

Additionally, patients can connect with community resources like mental health organizations and support groups for extra emotional support. Family therapy or peer support can enhance coping strategies and improve overall well-being.

Future Outlook

Researchers are focusing on developing new treatments for bipolar disorder, particularly for cases that don't respond to existing therapies. 

New drug targets are being explored, including inflammatory, oxidative, and mitochondrial pathways. While many of these approaches are still experimental, they offer hope for future breakthroughs.

A study by Harvard Medical School identified AKAP11 as a significant risk factor for bipolar disorder. This gene may also explain how lithium works, as it interacts with a pathway affected by the drug. AKAP11 is the first gene with a significant impact on bipolar disorder risk, offering new insights into its causes and potential treatments.

Additionally, a pilot study is testing a new form of transcranial magnetic stimulation (TMS) for patients with treatment-resistant depression and bipolar 1 disorder. The new technique aims to provide quicker relief than traditional TMS, which usually takes weeks to show results.

These developments bring hope for improved treatments and better outcomes for bipolar disorder in the future.

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Key Takeaways

  • Bipolar 1 involves severe manic episodes, while Bipolar 2 is characterized by hypomania and more frequent depressive episodes.
  • Accurately identifying the type of bipolar disorder helps guide the proper treatment and improves outcomes.
  • Understanding these differences enables individuals to make informed decisions, seek appropriate care, and actively participate in treatment.

Share this article on social media to help spread awareness about Bipolar Disorder.

The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.

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AKAP11 A-kinase anchoring protein 11 [Homo sapiens (human)] - Gene - NCBI. (2024, November 3). Www.ncbi.nlm.nih.gov. https://www.ncbi.nlm.nih.gov/gene/11215

American Psychiatric Association. (2022). Psychiatry.org - DSM-5-TR Fact Sheets. Psychiatry.org. https://www.psychiatry.org/psychiatrists/practice/dsm/educational-resources/dsm-5-tr-fact-sheets

American Psychiatric Association. (2023, January). What Is Psychiatry? Psychiatry.org; American Psychiatric Association. https://www.psychiatry.org/patients-families/what-is-psychiatry

American Psychological Association. (2017). What Is Cognitive Behavioral Therapy? American Psychological Association. https://www.apa.org/ptsd-guideline/patients-and-families/cognitive-behavioral

Anderson, S. (2022, September 21). 10 Commonly Prescribed Medications & The Nutrients They Deplete. Rupa Health. https://www.rupahealth.com/post/10-commonly-prescribed-medications-the-nutrients-they-deplete

Antidepressants. (2023, March 1). Cleveland Clinic; Cleveland Clinic. https://my.clevelandclinic.org/health/treatments/9301-antidepressants-depression-medication

Antipsychotics: A key tool in modern mental health care. (2023). Cleveland Clinic. https://my.clevelandclinic.org/health/treatments/24692-antipsychotic-medications

Biological Insights into Suicidal Depression. (2024, October 7). Rupa Health. https://www.rupahealth.com/post/biological-insights-into-suicidal-depression

Bipolar Disorder | NAMI. (2024). Www.nami.org. https://www.nami.org/about-mental-illness/mental-health-conditions/bipolar-disorder/

Brancati, G. E., Nunes, A., Scott, K., O'Donovan, C., Cervantes, P., Grof, P., & Alda, M. (2023). Differential characteristics of bipolar I and II disorders: A retrospective, cross-sectional evaluation of clinical features, illness course, and response to treatment. Differential Characteristics of Bipolar I and II Disorders: A Retrospective, Cross-Sectional Evaluation of Clinical Features, Illness Course, and Response to Treatment, 11(1). https://doi.org/10.1186/s40345-023-00304-9

Bryant, A. (2024, September 2). How to Have a Good Night Sleep: Top Proven Strategies for Better Rest. Rupa Health. https://www.rupahealth.com/post/how-to-have-a-good-night-sleep-top-proven-strategies-for-better-rest

Caldeira, C., Chen, Y., Chan, L., Pham, V., Chen, Y., & Zheng, K. (2018). Mobile apps for mood tracking: an analysis of features and user reviews. AMIA Annual Symposium Proceedings, 2017, 495. https://pmc.ncbi.nlm.nih.gov/articles/PMC5977660/

Campellone, J., Dugdale, D., & Conaway, B. (2023, June 13). Tardive dyskinesia: MedlinePlus Medical Encyclopedia. Medlineplus.gov. https://medlineplus.gov/ency/article/000685.htm

Christie, J. (2022, December 6). The ultimate guide to thyroid hormones. Rupa Health. https://www.rupahealth.com/post/a-complete-guide-to-thyroid-hormones-a-functional-medicine-approach

Cloyd, J. (2023a, April 20). Top Intestinal Inflammatory Biomarkers Commonly Used In Functional Medicine. Rupa Health. https://www.rupahealth.com/post/top-intestinal-inflammatory-biomarkers-commonly-used-in-functional-medicine

Cloyd, J. (2023b, September 15). Top Labs To Run Bi-Annually On Your Patients Who Suffer From Kidney Disease. Rupa Health. https://www.rupahealth.com/post/top-labs-to-run-bi-annually-on-your-patients-who-suffer-from-kidney-disease

Cloyd, J. (2023c, November 16). The Role of Amino Acids in Mood Regulation: A Functional Medicine Perspective. Rupa Health. https://www.rupahealth.com/post/the-role-of-amino-acids-in-mood-regulation-a-functional-medicine-perspective

Cloyd, J. (2024a, February 27). Sleep Requirements by Age Group & Why It's Important. Rupa Health. https://www.rupahealth.com/post/sleep-requirements-by-age-group-why-its-important

Cloyd, J. (2024b, March 7). The Best Supplements for Sustained Energy Boosts. Rupa Health. https://www.rupahealth.com/post/the-best-supplements-for-sustained-energy-boosts

Cloyd, J. (2024c, June 6). 5 Medications That May Be Interfering with Your Sleep. Rupa Health. https://www.rupahealth.com/post/medications-interfering-with-sleep

Cloyd, K. (2023, December 20). Interpreting Oxidative Stress Markers. Rupa Health. https://www.rupahealth.com/post/interpreting-oxidative-stress-markers

Creedon, K. (2022, August 4). 6 speciality labs that get to the root cause of insomnia. Www.rupahealth.com. https://www.rupahealth.com/post/6-speciality-labs-that-get-to-the-root-cause-of-insomnia

Dailey, M. W., & Saadabadi, A. (2019). Mania. National Library of Medicine; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK493168/

DeCesaris, L. (2023a, July 18). Mitochondria - What They Are, Why We Should Care, and How to Support Them Using Functional Medicine Strategies. Rupa Health. https://www.rupahealth.com/post/mitochondria-what-they-are-why-we-should-care-and-how-to-support-them-using-functional-medicine-strategies

DeCesaris, L. (2023b, December 12). Elevating Mood with Nutraceuticals: A Functional Medicine Perspective. Rupa Health. https://www.rupahealth.com/post/elevating-mood-with-nutraceuticals-a-functional-medicine-perspective

DePorto, T. (2023a, January 6). Omega 3's: The Superfood Nutrient You Need To Know About. Rupa Health. https://www.rupahealth.com/post/omega-3s-the-superfood-nutrient-you-need-to-know-about

DePorto, T. (2023b, January 11). Zinc 101. Rupa Health. https://www.rupahealth.com/post/zinc

Dodd, S., S. Fernandes, B., & M. Dean, O. (2015). Future Directions for Pharmacotherapies for Treatment-resistant Bipolar Disorder. Current Neuropharmacology, 13(5), 656–662. https://doi.org/10.2174/1570159x13666150630175841

EISENSTADT, L. (2022, April 11). Bipolar Breakthrough. Hms.harvard.edu. https://hms.harvard.edu/news/bipolar-breakthrough

Frank, E., Swartz, H. A., & Kupfer, D. J. (2000). Interpersonal and social rhythm therapy: managing the chaos of bipolar disorder. Biological Psychiatry, 48(6), 593–604. https://doi.org/10.1016/s0006-3223(00)00969-0

Gabriel, F. C., Oliveira, M., Martella, B. D. M., Berk, M., Brietzke, E., Jacka, F. N., & Lafer, B. (2022). Nutrition and bipolar disorder: a systematic review. Nutritional Neuroscience, 26(7), 1–15. https://doi.org/10.1080/1028415X.2022.2077031

Guy-Evans, O. (2023, December 13). Grandiosity in Bipolar Disorder - Simply Psychology. Www.simplypsychology.org. https://www.simplypsychology.org/grandiosity-in-bipolar-disorder.html

Harvey, A. G., Kaplan, K. A., & Soehner, A. M. (2015). Interventions for Sleep Disturbance in Bipolar Disorder. Sleep Medicine Clinics, 10(1), 101–105. https://doi.org/10.1016/j.jsmc.2014.11.005

Henry, E. (2022, January 4). How To Reverse Weight Gain And Slowed Metabolism. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-slow-metabolism-middle-age

Hypomania: What Is It, Comparison vs Mania, Symptoms & Treatment. (2021, September 16). Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/21774-hypomania

Information, N. C. for B., Pike, U. S. N. L. of M. 8600 R., MD, B., & Usa, 20894. (2009). Medicines used in bipolar disorders. In www.ncbi.nlm.nih.gov. World Health Organization. https://www.ncbi.nlm.nih.gov/books/NBK143204/

Interpersonal and Social Rhythm Therapy. (2024). Ipsrt.org. https://legacy.ipsrt.org/

Kemp, D. E. (2014). Managing the side effects associated with commonly used treatments for bipolar depression. Journal of Affective Disorders, 169, S34–S44. https://doi.org/10.1016/S0165-0327(14)70007-2

Khakham, C. (2023a, July 20). Exploring the Power of Music Therapy in Easing Anxiety and Depression. Rupa Health. https://www.rupahealth.com/post/exploring-the-power-of-music-therapy-in-easing-anxiety-and-depression

Khakham, C. (2023b, July 28). Top Labs To Run Bi-Annually On Your Depression Patients. Rupa Health. https://www.rupahealth.com/post/top-labs-to-run-bi-annually-on-your-depression-patients

Khakham, C. (2023c, October 6). Physical Activity and Depression In The Older Population. Rupa Health. https://www.rupahealth.com/post/physical-activity-and-depression-in-the-older-population

Kresge, K. (2022a, January 11). Being Deficient In These Nutrients May Be Making Your Depression Worse. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-treating-depression

Kresge, K. (2022b, April 22). 5 Micronutrient Abnormalities That May Make Bipolar Disorder Worse. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-bipolar-disorder

Kresge, K. (2023a, January 31). An Integrative Approach to Mental Health. Rupa Health. https://www.rupahealth.com/post/an-integrative-approach-to-mental-health

Kresge, K. (2023b, February 21). An Integrative Medicine Approach to Depression. Rupa Health. https://www.rupahealth.com/post/an-integrative-medicine-approach-to-depression

Lithium: MedlinePlus Drug Information. (2017). Medlineplus.gov. https://medlineplus.gov/druginfo/meds/a681039.html

LoBisco, S. (2022, September 16). How Food Affects Your Mood Through The Gut-Brain Axis. Rupa Health. https://www.rupahealth.com/post/gut-brain-axis

Maholy, N. (2023, February 17). A functional medicine approach to anxiety: Testing, nutrition, & supplements. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-anxiety

Mania: Screening and Assessment. (2019). CAMH. https://www.camh.ca/en/professionals/treating-conditions-and-disorders/mania/mania---screening-and-assessment

Mania: What is it, causes, triggers, symptoms & treatment. (2021, September 14). Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/21603-mania

Mayo Clinic. (2018, November 27). Transcranial Magnetic Stimulation. Mayoclinic.org. https://www.mayoclinic.org/tests-procedures/transcranial-magnetic-stimulation/about/pac-20384625

Mayo Clinic. (2019). Schizoaffective disorder - Symptoms and causes. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/schizoaffective-disorder/symptoms-causes/syc-20354504

Mayo Clinic. (2021, February 16). Bipolar disorder - Diagnosis and treatment. Mayoclinic.org; Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/bipolar-disorder/diagnosis-treatment/drc-20355961

Mayo Clinic Staff. (2024, August 14). Bipolar disorder. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/bipolar-disorder/symptoms-causes/syc-20355955

Medline Plus. (2019). Valproic Acid: MedlinePlus Drug Information. Medlineplus.gov. https://medlineplus.gov/druginfo/meds/a682412.html

Mental Health and Sleep. (2020, September 18). Sleep Foundation. https://www.sleepfoundation.org/mental-health#references-78566

Mood Stabilizers: What They Are, How They Work & Side Effects. (2024). Cleveland Clinic. https://my.clevelandclinic.org/health/articles/mood-stabilizers

National Institute of Mental Health. (2023). Understanding psychosis. National Institute of Mental Health; U.S. Department of Health and Human Services, National Institutes of Health. https://www.nimh.nih.gov/health/publications/understanding-psychosis

National Institute of Mental Health. (2024). Bipolar Disorder. National Institute of Mental Health. https://www.nimh.nih.gov/health/topics/bipolar-disorder

New Research into Treatment for Bipolar Depression - Johns Hopkins Medicine. (2024). Clinicalconnection.hopkinsmedicine.org. https://clinicalconnection.hopkinsmedicine.org/news/new-research-into-treatment-for-bipolar-depression

Özdel, K., Kart, A., & Türkçapar, M. H. (2021). Cognitive behavioural therapy in treatment of bipolar disorder. Archives of Neuropsychiatry, 58(1). https://doi.org/10.29399/npa.27419

Preston, J. (2023a, May 4). Complementary and Integrative Medicine Treatment for Depression in Teens: Specialty Labs, Herbs, and More. Rupa Health. https://www.rupahealth.com/post/complementary-and-integrative-medicine-testing-and-treatment-for-depression-in-teens

Preston, J. (2023b, December 6). Combatting Holiday Stress: Mind-Body Techniques for Relaxation and Resilience. Rupa Health. https://www.rupahealth.com/post/combatting-holiday-stress-mind-body-techniques-for-relaxation-and-resilience

Rodrigues, G. S., Pellini, G. L., Rocha, R., Lima, A. F., Pio de Almeida Fleck, M., Panzenhagen, A. C., Shansis, F. M., & Capp, E. (2024). Diagnosis of bipolar and major depressive disorders: The appropriateness of MINI compared to the clinical interview in a sample of patients with mood disorders in tertiary mental health care. Journal of Psychiatric Research, 169, 341–346. https://doi.org/10.1016/j.jpsychires.2023.11.012

Singh, T., & Rajput, M. (2006). Misdiagnosis of Bipolar Disorder. Psychiatry (Edgmont), 3(10), 57. https://pmc.ncbi.nlm.nih.gov/articles/PMC2945875/#B13

Steardo, L., Luciano, M., Sampogna, G., Zinno, F., Saviano, P., Staltari, F., Segura Garcia, C., De Fazio, P., & Fiorillo, A. (2020). Efficacy of the interpersonal and social rhythm therapy (IPSRT) in patients with bipolar disorder: results from a real-world, controlled trial. Annals of General Psychiatry, 19(1). https://doi.org/10.1186/s12991-020-00266-7

Substance Abuse and Mental Health Services Administration. (2019, June). Table 12, DSM-IV to DSM-5 Bipolar I Disorder Comparison. Nih.gov; Substance Abuse and Mental Health Services Administration (US). https://www.ncbi.nlm.nih.gov/books/NBK519712/table/ch3.t8/

Support Groups. (2024). NAMI. https://www.nami.org/Support-Education/Support-Groups/

Sweetnich, J. (2023a, March 9). GI specialty lab testing 101: Testing, results interpretation, supplements. Rupa Health. https://www.rupahealth.com/post/gi-specialty-lab-testing-101-broken-down-by-each-section

Sweetnich, J. (2023b, June 20). Top Evidence-Based Supplements and Herbs for Restful Nights, Backed by Specialty Lab Testing to Personalize Treatment. Rupa Health. https://www.rupahealth.com/post/top-evidence-based-supplements-and-herbs-that-help-with-sleep-plus-specialty-lab-testing-that-can-help-identify-which-one-is-best-for-your-patients

Take a Mental Health Test. (2020). Mental Health America Screening 2 Supports. https://screening.mhanational.org/screening-tools/

Taking Control of Your Mental Health: Tips for Talking With Your Health Care Provider. (2023). National Institute of Mental Health (NIMH). https://www.nimh.nih.gov/health/publications/tips-for-talking-with-your-health-care-provider

Teeter, L. A. (2023, April 3). Mental health benefits of yoga and meditation. Rupa Health. https://www.rupahealth.com/post/mental-health-benefits-of-yoga-and-meditation

Tondo, L., Miola, A., Pinna, M., Contu, M., & Baldessarini, R. J. (2022). Differences between bipolar disorder types 1 and 2 support the DSM two-syndrome concept. International Journal of Bipolar Disorders, 10(1). https://doi.org/10.1186/s40345-022-00268-2

Torres, F. (2024). What is schizophrenia? American Psychiatric Association. https://www.psychiatry.org/patients-families/schizophrenia/what-is-schizophrenia

Varanasi-Diaz, S. (2024, March 18). 5 Medications that Should Not be Taken with Dairy. Rupa Health. https://www.rupahealth.com/post/5-medications-that-should-not-be-taken-with-dairy

Weinberg, J. (2022, November 16). 4 Science Backed Health Benefits of The Mediterranean Diet. Rupa Health. https://www.rupahealth.com/post/4-science-backed-health-benefits-of-the-mediterranean-diet

Weinberg, J. (2023, January 11). How To Test Your Patients For Metabolic Syndrome. Rupa Health. https://www.rupahealth.com/post/how-to-test-your-patients-for-metabolic-syndrome-a-functional-medicie-approach

Yoshimura, H. (2023a, May 8). Unlocking the Gut-Brain Connection: How LabTesting Can Personalize Probiotic Treatment for Depression Relief. Rupa Health. https://www.rupahealth.com/post/the-best-probiotics-for-depression-how-to-test-and-supplement

Yoshimura, H. (2023b, June 16). 4 Functional Medicine Labs That Can Help Individualize Treatment Options for Bipolar 2 Disorder. Rupa Health. https://www.rupahealth.com/post/4-functional-medicine-labs-that-can-help-individualize-treatment-options-for-bipolar-2-disorder

Yoshimura, H. (2023c, June 16). Specialty Lab Testing and Integrative Treatment Options for Bipolar 1 Disorder. Rupa Health. https://www.rupahealth.com/post/integrative-approach-to-bipolar-i

Yoshimura, H. (2023d, September 6). Top Labs To Run Bi-Annually On Your Patients Who Suffer From Major Depressive Disorder. Rupa Health. https://www.rupahealth.com/post/top-labs-to-run-bi-annually-on-your-patients-who-suffer-from-major-depressive-disorder

Yoshimura, H. (2023e, October 10). How Integrative Medicine Can Support Those Experiencing Suicidal Ideation. Rupa Health. https://www.rupahealth.com/post/how-integrative-medicine-can-support-those-experiencing-suicidal-ideation

Yoshimura, H. (2023f, November 7). The remarkable power of exercise on our health: A comprehensive overview. Rupa Health. https://www.rupahealth.com/post/the-remarkable-power-of-exercise-on-our-health-a-comprehensive-overview

Yoshimura, H. (2023g, December 27). Epigenetics and Disease Prevention: Harnessing Lifestyle Changes in Clinical Practice. Rupa Health. https://www.rupahealth.com/post/epigenetics-and-disease-prevention-harnessing-lifestyle-changes-in-clinical-practice

Yoshimura, H. (2024, February 27). Exploring collaborative opportunities between functional medicine and conventional medical practitioners. Rupa Health. https://www.rupahealth.com/post/exploring-collaborative-opportunities-between-functional-medicine-and-conventional-medical-practitioners

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