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An Evidence-Based Approach To Blood Detoxing

Why This Was Updated?

Our specialists regularly review advancements in health and wellness, ensuring our articles are updated with the newest information as it becomes accessible.
Medically Reviewed by
Updated On
August 19, 2024

Environmental toxins are substances from our surroundings that can harm our health and often enter our bodies through air, water, food, and skin contact. Blood detoxification, the process of removing these harmful substances from the bloodstream, is primarily managed by the liver, kidneys, and other bodily systems.Β 

However, misconceptions about blood detoxing abound, with many people believing in quick fixes and miracle cures that lack scientific support. This article will discuss detoxification with evidence-based methods to ensure safety and effectiveness.Β 

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What Is a Blood Detox?

Exposure to environmental toxins in the air, food, water, health products, and prescribed pharmaceuticals is a significant contributor to autoimmunity and chronic disease.Β 

Chronic exposure to environmental toxins can cause several health issues, such as endocrine dysfunction, ADHD, autism, asthma, COPD, cancer, arthritis, cardiovascular problems, chronic fatigue, and more. Implementing blood purification techniques through diet, lifestyle, or medical interventions helps remove drugs and toxins from the body.Β 

Blood detox can be accomplished through natural strategies, including lifestyle, nutrition, herbal medicine, and nutraceuticals. In cases of more severe toxicity or poisoning, medical interventions such as plasmapheresis, dialysis, or chelation therapy may be needed.Β 

These procedures require the guidance of a trained physician to assess which treatment is appropriate.Β 

How Does the Body Detox the Blood?

Different parts of the body participate in the detoxification praocess:

The Role of the Liver

The liver helps detoxify the blood by removing toxins, drugs, metals, and metabolic waste products through enzymatic reactions.Β 

During phase 1 detoxification, the liver activates toxins, making them water-soluble for proper bodily removal.Β 

During phase 2 detoxification, the liver neutralizes toxins through sulfation, glucuronidation, methylation, acetylation, glutathione conjugation, and glycination. These processes help facilitate the excretion of toxins through the urine and bowels.Β 

Each step of liver detoxification requires adequate antioxidants, minerals, and enzymes. If the body becomes overburdened with toxins or depleted of essential nutrients, liver detoxification starts slowing down, leading to disease (14).Β 

The Function of the Kidneys

The kidneys are an often overlooked organ of detoxification. After toxins have passed through phase 2 liver detoxification, unfiltered blood enters the kidneys. It is filtered through the nephrons, the kidney's functional units that filter blood and form urine.Β 

If the kidneys have been damaged, toxins can be reabsorbed into the blood. Heavy metals such as cadmium and mercury, persistent organic pollutants (POPs), glyphosate, smoking, and endotoxins from the gut can impair kidney function. Maintaining proper kidney function is vital when undergoing blood detoxification (55).Β 

Other Detoxification Mechanisms

The lungs, skin, and gastrointestinal tract are also crucial in detoxification.Β 

The lungs filter out carbon dioxide, fumes, and airborne toxins like mold. Over time, environmental toxins such as cigarette smoking, molds, and dust can interfere with the lung's ability to facilitate gas exchange from the environment into the bloodstream. This leads to decreased oxygen transport and the buildup of metabolic toxins in the lungs and blood.Β 

The gastrointestinal tract plays a role in detoxification by breaking down food, absorbing nutrients, and eliminating waste products from the body. If dysbiosis or leaky gut develops, toxins from the gut can enter circulation.Β 

By addressing gut inflammation, gut permeability, and malabsorption through targeted therapies, we can enhance the overall elimination of harmful substances from the body.Β 

The skin is the body's largest organ and is crucial in detoxifying harmful substances. Through sweat glands, the skin helps excrete small amounts of metabolic toxins from the body. Sweating through exercise or sauna helps detoxify heavy metals, xenobiotics (chemicals that disrupt the endocrine system), ammonia, urea, and lactic acid from the body.

Signs Your Patient's Blood Detoxing Systems Need Support

If your patients experience the following, it may be a sign the their detoxification systems are in need of support:

Symptoms of Blood Toxin Buildup

Signs and symptoms of toxins in the blood include:

  • Diarrhea
  • Nausea and/or vomiting
  • Abdominal pain
  • Shortness of breath
  • Tingling in the hands and feet
  • Chills
  • General weakness and/or muscle weakness
  • Vision changes
  • Lack of coordination

Risk Factors for Blood Toxin Accumulation

Lifestyle factors that lead to toxin accumulation include:

Environmental factors that lead to toxin accumulation:

When to Consider a Blood Detox

The following situations prompt a blood detox:

  • Recent antibiotic usage
  • Exposure to mold/mycotoxins
  • Heavy metal exposure (lead, mercury, cadmium, arsenic)
  • Long-term use of plastics
  • History of handling toxic chemicals, herbicides, pesticides
  • Heavy alcohol use

If you have any of the above situations, it is imperative that you work alongside a licensed health professional who can guide you. Not doing so can potentially lead to further complications.

Lab Testing for Patients with Blood Toxin Symptoms

The following labs can be helpful for understanding the current toxic burden on the body:

Comprehensive Metabolic Panel (CMP)

A CMP is a blood test that measures substances involved in chemical balance and metabolism. The following are parts of CMP that may signal the need for a blood detox:

  • Liver Enzymes (ALT & AST): If elevated, these enzymes indicate liver damage and inflammation, leading to impaired detoxification. Liver enzymes increase due to toxic chemicals and metals such as polychlorinated biphenyls, lead, and mercury.Β 
  • Bilirubin is a waste product made from the breakdown of red blood cells and is an essential marker for liver and blood health. Elevated levels suggest liver and gallbladder stress, which interferes with the body's ability to detox properly. Research shows that bilirubin levels can increase in response to persistent organic pollutants (POPs) and pesticide exposure.
  • Blood Urea Nitrogen (BUN) is a marker for kidney function. It represents the concentration of urea, a waste product generated by the liver. Elevations in BUN mean that the kidneys are not functioning correctly.Β 
  • Creatinine is a waste product filtered and removed from the blood by the kidneys. The concentration of creatinine in the blood and the rate at which it is removed are key indicators of health.Β 

Complete Blood Count (CBC)

A CBC is a group of tests that measure the amount and size of red blood cells, white blood cells, hemoglobin, and platelets.Β 

  • White Blood Cells: The primary function of WBC is to fight infections. An abnormal CBC count can be due to several underlying factors. After emergent conditions are ruled out, abnormal WBC may warrant a blood detox due to the possibility of infection, inflammation, or chronic conditions impairing detox. WBC count can also decrease in response to polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs).Β 
  • Platelet Count: The measure of the number of platelets in your blood that indicates how well you can clot. Low platelet levels can indicate infection, cancer, heavy drinking, and certain medications. Chronic exposure to solvents can decrease platelet counts, warranting a blood detox.Β 

Specific Toxicology Tests

Specific toxicology tests may be needed to identify the toxins in the body. The following are helpful tests to determine the exact toxin:

Evidence-Based Blood Detoxing Approaches

Diet and Nutrition

Blood detoxification starts with incorporating a healthy diet filled with nutrients and vitamins that support detoxification. The following nutrients have been shown to accelerate phase 1 and 2 liver detoxification:

Exercise and Hydration

Lifestyle changes such as exercise, hydration, and sweating help promote blood detoxification. The following are suggestions you can implement:

  • Regular physical exercise increases blood flow, reduces inflammation, and improves antioxidant defenses, aiding detoxification.
  • Proper hydration helps alleviate constipation and improves kidney health, aiding blood detox.
  • Infrared sauna therapy helps promote the detoxification of heavy metals and mold from the blood.

Herbal Medicine

Herbal medicine can support waste elimination in the kidneys, liver, lungs, and skin.Β  The following herbs have been shown to support the elimination of toxins and impurities from the blood:

  • Burdock Root (Arcticum lappa) helps eliminate toxins from the body by enhancing liver and kidney function. This herb contains antioxidants that neutralize free radicals, promoting healthier blood.Β 
  • Dandelion leaf (Taraxacum officinale) aids blood purification by stimulating bile and enhancing liver function.
  • Red Clover (Trifolium pratense) is commonly used in menopause. However, it helps improve circulation, stimulates lymphatic flow, increases blood circulation, and enhances the elimination of metabolic waste and toxins.Β 

Avoiding Harmful Substances

Toxin avoidance is imperative during a blood detox. The following are strategies to avoid environmental toxins:

Medical Treatments and Interventions

The following medical interventions can be used in more severe toxin exposure:

  • Chelation therapy binds and removes heavy metals from the body. Natural supplements that promote chelation include cilantro, alpha lipoic acid, NAC, and glutathione. Synthetic agents used for chelation include DMSA, DMPS, and CaEDTA.Β 
  • Hemoperfusion (HP) is a blood purification therapy that removes poisons or drugs from the body.
  • Plasmapheresis involves removing, returning, or exchanging blood plasma to remove toxic substances from the blood.Β 
  • Ozone therapy promotes detoxification by increasing oxygen content in the blood, stimulating the immune system, and breaking down toxic substances in the blood.

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Key Takeaways

  • Blood detox through nutrition, lifestyle, herbal medicine, and medical interventions significantly decreases levels of environmental toxins in the body.
  • Utilizing conventional laboratory tests and specialized functional medicine tests is helpful in the diagnosis of environmental toxicity.
  • Always consult a trusted healthcare provider for a proper diagnosis of environmental toxicity and proper elimination techniques for your current health goals.
The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.
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  80. Yoshimura, H. (2023c, November 2). Interpreting Intestinal Permeability: Lab Assessments for "Leaky Gut" and Beyond. Rupa Health. https://www.rupahealth.com/post/interpreting-intestinal-permeability-lab-assessments-for-leaky-gut-and-beyond
  81. Yoshimura, H. (2023d, November 7). The remarkable power of exercise on our health: A comprehensive overview. Rupa Health. https://www.rupahealth.com/post/the-remarkable-power-of-exercise-on-our-health-a-comprehensive-overview
  82. Yoshimura, H. (2023e, November 13). Sweat It Out: The Powerful Connection Between Exercise and Insulin Sensitivity. Rupa Health. https://www.rupahealth.com/post/sweat-it-out-the-powerful-connection-between-exercise-and-insulin-sensitivity
  83. Yoshimura, H. (2024, January 16). What is Methylation: An Introduction to Its Role in Health and Disease for Functional Medicine Practitioners. Rupa Health. https://www.rupahealth.com/post/what-is-methylation-an-introduction-to-its-role-in-health-and-disease-for-functional-medicine-practitioners
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