Estradiol

High levels of estradiol, or E2, might mean that your body is producing more of this hormone than usual. This can happen for various reasons, such as natural hormonal changes, certain medications (like hormone replacement therapy or birth control pills), or lifestyle factors like your diet and exercise habits. Sometimes, high E2 levels can be linked to specific health conditions that affect hormone production, like polycystic ovary syndrome (PCOS) or certain ovarian tumors. Additionally, liver disease could cause elevated E2 levels, since the liver helps break down excess hormones. Keep in mind that these are just some possible reasons for high E2 levels, and there could be other factors at play.

Symptoms of high levels of E2 could include bloating, breast tenderness, mood swings, heavy or irregular periods, and changes in weight.

Low levels of estradiol, or E2, might suggest that there's an imbalance in the body's hormone levels. This could be caused by a variety of factors, such as getting older and entering menopause, or lifestyle issues like too much stress, not eating well, or working out too much. Some medications, like hormone treatments or chemotherapy drugs, could also lead to lower E2 levels. Additionally, certain health conditions like polycystic ovary syndrome (PCOS), hypopituitarism, or hypothalamic amenorrhea might be contributing factors. Keep in mind that these are just possible causes, and the exact reason for low E2 levels can be different for each person.

Symptoms of low levels of E2 might include irregular or missed periods, hot flashes, night sweats, mood swings, difficulty concentrating, and decreased bone density.