Title
Subscribe to the Magazine for free
Subscribe for free to keep reading! If you are already subscribed, enter your email address to log back in.
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Are you a healthcare practitioner?
Thanks for subscribing!
Oops! Something went wrong while submitting the form.

What Is Amino Acid Therapy?

Why This Was Updated?

Our specialists regularly review advancements in health and wellness, ensuring our articles are updated with the newest information as it becomes accessible.
Medically Reviewed by
Updated On
July 25, 2024
What Is Amino Acid Therapy?

Amino acid therapy is a growing focus for medical treatment. It focuses on using amino acids to improve various health problems, especially related to neurologic, psychiatric, and oncologic health.Β 

Amino acid therapy is gaining popularity for its therapeutic potential in balancing neurotransmitter levels for conditions such as depression, anxiety, and sleep disorders. It is becoming an important element of holistic health strategies, although additional research is necessary to understand the specific scope of its benefits, dosages, and risks.

This article aims to present the many successful applications of amino acid therapy, how it is given, and the potential risks of its use.

[signup]

What Is Amino Acid Therapy?

Amino acids are organic molecules that serve as the building blocks of proteins, which are vital for physiologic functions like tissue repair, neurotransmitter regulation, enzyme production, and metabolic processing.Β 

Amino acid therapy involves using amino acids as medical treatment, particularly in metabolic, oncologic, neurologic, and mental health disorders. Amino acid therapy helps restore balance in basic biochemical processes by correcting amino acid deficiencies.

Types of Amino Acids

There are 20 different amino acids grouped into essential and non-essential categories. The body cannot make essential amino acids, and must be obtained through diet. Non-essential amino acids are produced by the body through various compounds.

Essential amino acids include these:

1. Histidine

2. Isoleucine

3. Leucine

4. Lysine

5. Methionine

6. Phenylalanine

7. Threonine

8. Tryptophan

9. Valine

Non-essential amino acids include these:

1. Alanine

2. Arginine

3. Asparagine

4. Aspartic acid

5. Cysteine

6. Glutamic acid

7. Glutamine

8. Glycine

9. Proline

10. Serine

11. Tyrosine

Forms of Amino Acid Therapy

Amino acid therapy can be administered as oral supplements, intravenous (IV) therapy, or obtained from dietary sources. Oral supplements are convenient and thus widely used. IV therapy is administered directly for immediate absorption, giving it a faster onset of action. Dietary sources are the most natural way to incorporate amino acid therapy, yet this form offers less precise dosing, given the variability in digestion and absorption.Β 

Each form varies in its most suitable applications and efficacy, with additional variability depending on patients’ specific health concerns.

What Is Amino Acid Therapy Used For?

There are several common uses for amino acid therapy:

Medical and Therapeutic Uses

Amino acid therapy is utilized to treat a variety of health conditions. Common uses include the following:

Amino acids are essential to form neurotransmitters, and amino acid therapy can help restore optimal neurotransmitter levels. Restoring neurotransmitter balance helps treat chronic fatigue by improving mood and boosting energy levels.Β 

Athletes and avid exercisers experience the benefits of improved muscle repair, less soreness, and improved athletic performance. Amino acid therapy can target immune cells to alter the progression of various cancers. Outside of specific indications, amino acid therapy has been shown to improve general well-being by improving sleep, metabolism, and immunity.

Specific Roles in Mental Health

Amino acids are exceptionally important for mental health because of their role in neurotransmitter production. While not all substances can be taken up into the brain, amino acids can move across the blood-brain barrier. By supplementing specific amino acids, amino acid therapy can alleviate symptoms of mood disorders such as depression and anxiety. It also supports cognitive health by enhancing focus, memory, and overall brain function.

Tryptophan is required to form serotonin, an important neurotransmitter that regulates mood, sleep, and appetite.Β 

Tyrosine is necessary to produce dopamine, a crucial neurotransmitter for motivation, satisfaction, and pleasure, and norepinephrine, which is crucial to the body’s stress response.Β 

Supplementation of ten amino acids demonstrates improvements in cognitive functioning:Β 

  • Arginine
  • Glutamine
  • Histidine
  • Isoleucine
  • Leucine
  • Lysine
  • Phenylalanine
  • Tryptophan
  • Tyrosine
  • Valine

Nutritional Deficiencies

Amino acid therapy is effective in correcting nutritional deficiencies. Deficiencies in essential amino acids can lead to a number of health problems, including impaired immunity, reduced muscle strength, and decreased cognitive functioning.Β 

Correcting amino acid deficiencies improves physical and mental health, optimizes the body’s stress response, increases energy levels, and bolsters immunity.Β 

How Does Amino Acid Therapy Work?

Amino acids are the building blocks of protein and are required for protein synthesis. Protein synthesis is necessary for muscle growth, repair, and recovery. Amino acids allow for new protein formation, muscle hypertrophy, and muscle recovery after physical exercise. Amino acids are also required components of neurotransmitters and hormones, which play important physiologic roles.

Dosage and Administration

Typical dosages of amino acid supplements vary depending on specific amino acids and the intended therapeutic use. Branched-chain amino acids (BCAAs) are often used for muscle growth and recovery and are usually taken in doses ranging from 5 to 20 grams per day. However, dosages should be personalized to individual needs, considering age, weight, other health conditions, and activity level.Β 

Personalizing dosages promotes the highest efficacy balanced with patient safety, reducing unintended side effects from doses that are inappropriate. Consulting with a healthcare provider is vital in developing personalized treatment strategies.

The Science Behind Amino Acid Therapy

Numerous studies support amino acid therapy to treat depression, anxiety, certain cancers, chronic fatigue, and muscle recovery. Extensive evidence also demonstrates improvements in mood, cognition, and physical performance with supplemental amino acids. Nonetheless, additional randomized controlled trials and other peer-reviewed multi-institutional clinical trials are needed to understand the full potential of amino acid therapy and other potential adverse effects.Β 

Risks of Amino Acid Therapy

There are potential risks of amino acid therapy, especially with high doses or inappropriate use. Side effects include nausea, abdominal pain, constipation, fluid retention, and nutritional imbalances.

[signup]

Key Takeaways

  • Amino acid therapy utilizes specific amino acids to treat various conditions, including depression, anxiety, chronic fatigue, cancers, and athletic recovery.
  • Amino acid therapy also promotes overall wellness by improving sleep, metabolism, and immunity.
  • Various administration methods include dietary sources, oral amino acid supplements, and intravenous therapy.
  • Potential adverse effects are possible with inappropriate dosing and intolerance.
  • Seeking guidance from a knowledgeable healthcare professional allows for the formation of a personalized treatment plan to ensure optimal outcomes.
The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.
Learn More
No items found.

Lab Tests in This Article

No items found.

Achuff, J. (2024, February 12). The Impact of the Midlife Dietary Protein Intake on Healthy Aging: Insights from the Nurses’ Health Study. Rupa Health. https://www.rupahealth.com/post/the-impact-of-midlife-dietary-protein-intake-on-healthy-aging-insights-from-the-nurses-health-study

Azhar G, Wei JY, Schutzler SE, et al. Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning. J Gerontol A Biol Sci Med Sci. 2021;76(7):1184-1191. https://pubmed.ncbi.nlm.nih.gov/33475727/

Christie, J. (2023, February 14). How to Test Your Patients’ Amino Acid Levels. Rupa Health. https://www.rupahealth.com/post/how-to-test-your-patients-amino-acid-levels

Cloyd, J. (2024, January 25). L-Tyrosine Supplementation: Supporting Thyroid Health and Adrenal Function. Rupa Health. https://www.rupahealth.com/post/l-tyrosine-supplementation-supporting-thyroid-health-and-adrenal-function

Cloyd, J. (2024, March 7). The Best Supplements for Sustained Energy Boosts. Rupa Health. https://www.rupahealth.com/post/the-best-supplements-for-sustained-energy-boosts

Cloyd, J. (2023, November 16). The Role of Amino Acids in Mood Regulation: A Functional Medicine Perspective. Rupa Health. https://www.rupahealth.com/post/the-role-of-amino-acids-in-mood-regulation-a-functional-medicine-perspective

DeCesaris, L. Depression and Sleep Disorders: Strategies for Improving Sleep Quality. Rupa Health. https://www.rupahealth.com/post/depression-and-sleep-disorders-strategies-for-improving-sleep-quality

Diorio, B. (2022, August 11). Anxiety, GI Discomfort, Irritability, and Poor Memory Are All Signs of These Neurotransmitter Imbalances. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-understanding-neurotransmitters-101

Friedman M. Analysis, Nutrition, and Health Benefits of Tryptophan. Int J Tryptophan Res. 2018;11:1178646918802282. https://pubmed.ncbi.nlm.nih.gov/30275700/

Holeček M. Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements. Nutr Metab (Lond). 2018;15:33. https://pubmed.ncbi.nlm.nih.gov/29755574/

Holeček M. Side effects of amino acid supplements. Physiol Res. 2022;71(1):29-45. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997670/

Institute of Medicine (US) Committee on Military Nutrition Research. The Role of Protein and Amino Acids in Sustaining and Enhancing Performance. Washington (DC): National Academies Press (US); 1999. 14, Amino Acid and Protein Requirements: Cognitive Performance, Stress, and Brain Function. Available from:Β  https://www.ncbi.nlm.nih.gov/books/NBK224629/

James SC, Fraser K, Cooney J, et al. Concentrations of Plasma Amino Acids and Neurotransmitters in Participants with Functional Gut Disorders and Healthy Controls. Metabolites. 2023;13(2):313. https://pubmed.ncbi.nlm.nih.gov/36837931/

Khemtong C, Kuo CH, Chen CY, Jaime SJ, Condello G. Does Branched-Chain Amino Acids (BCAAs) Supplementation Attenuate Muscle Damage Markers and Soreness after Resistance Exercise in Trained Males? A Meta-Analysis of Randomized Controlled Trials. Nutrients. 2021;13(6):1880. https://pubmed.ncbi.nlm.nih.gov/34072718/

Kresge, K. (2023, February 21). An Integrative Medicine Approach to Depression. Rupa Health. https://www.rupahealth.com/post/an-integrative-medicine-approach-to-depression

Kresge, K. (2023, March 21). An Integrative Medicine Team Approach to Treating Anxiety. Rupa Health. https://www.rupahealth.com/post/an-integrative-medicine-team-approach-to-treating-anxiety

Ling ZN, Jiang YF, Ru JN, Lu JH, Ding B, Wu J. Amino acid metabolism in health and disease. Signal Transduct Target Ther. 2023;8(1):345. https://pubmed.ncbi.nlm.nih.gov/37699892/

Madsen TE, Liu S. Amino acid neurotransmitters and prognosis after stroke: nutrition as a modifiable factor to improve stroke outcomes. Am J Clin Nutr. 2023;118(4):737-738. https://pubmed.ncbi.nlm.nih.gov/37793741/

Maholy, N. (2023, May 20). A Functional Medicine Immune Support Protocol. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-immune-support-protocol

Rajagopal S, Sangam SR, Singh S, Joginapally VR. Modulatory Effects of Dietary Amino Acids on Neurodegenerative Diseases. Adv Neurobiol. 2016;12:401-414. https://pubmed.ncbi.nlm.nih.gov/27651266/

Salvadore G, van der Veen JW, Zhang Y, et al. An investigation of amino-acid neurotransmitters as potential predictors of clinical improvement to ketamine in depression. Int J Neuropsychopharmacol. 2012;15(8):1063-1072. https://pubmed.ncbi.nlm.nih.gov/22040773/

Teeter, LA. (2023, April 4). Functional Nutrition Strategies for Weight Management and Metabolic Health. Rupa Health. https://www.rupahealth.com/post/functional-nutrition-strategies-for-weight-management-and-metabolic-health

Varanasi-Diaz, S. (2024, April 1). Integrative Approaches to Enhanced Focus and Concentration. Rupa Health. https://www.rupahealth.com/post/integrative-approaches-to-enhanced-focus-and-concentration

Weinberg, JL. (2024, February 29). The Neurobiology of Stress: Cortisol and Beyond. Rupa Health. https://www.rupahealth.com/post/the-neurobiology-of-stress-cortisol-and-beyond

Winter, K. (2023, November 27). Maximizing Muscle Recovery: The Role of Post-Workout Nutrition. Rupa Health. https://www.rupahealth.com/post/maximizing-muscle-recovery-the-role-of-post-workout-nutrition

Yang L, Chu Z, Liu M, et al. Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy. J Hematol Oncol. 2023;16(1):59. https://pubmed.ncbi.nlm.nih.gov/37277776/

Yoo HC, Han JM. Amino Acid Metabolism in Cancer Drug Resistance. Cells. 2022;11(1):140. https://pubmed.ncbi.nlm.nih.gov/35011702/

Yoshimura, H. (2023, April 26). Complementary and Integrative Medicine Approaches to Oncology and Gerontology. Rupa Health. https://www.rupahealth.com/post/complementary-and-integrative-medicine-approaches-to-oncology-in-gerontology

Yoshimura, H. (2023, April 3). Functional Medicine Approach to Treatment of Chronic Fatigue Syndrome Symptoms. Rupa Health. https://www.rupahealth.com/post/functional-medicine-approach-to-treatment-of-chronic-fatigue-syndrome-symptoms

Subscribe to the Magazine for free to keep reading!
Subscribe for free to keep reading, If you are already subscribed, enter your email address to log back in.
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Are you a healthcare practitioner?
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
See All Magazine Articles
Trusted Source
The Journal of Pediatrics
Peer Reviewed Journal
Visit Source
CDC
Government Authority
Visit Source
Office of Dietary Supplements
Government Authority
Visit Source
National Heart Lung and Blood Institute
Government Authority
Visit Source
National Institutes of Health
Government Authority
Visit Source
Clinical Infectious Diseases
Peer Reviewed Journal
Visit Source
Brain
Peer Reviewed Journal
Visit Source
The Journal of Rheumatology
Peer Reviewed Journal
Visit Source
Journal of the National Cancer Institute (JNCI)
Peer Reviewed Journal
Visit Source
Journal of Cardiovascular Magnetic Resonance
Peer Reviewed Journal
Visit Source
Hepatology
Peer Reviewed Journal
Visit Source
The American Journal of Clinical Nutrition
Peer Reviewed Journal
Visit Source
The Journal of Bone and Joint Surgery
Peer Reviewed Journal
Visit Source
Kidney International
Peer Reviewed Journal
Visit Source
The Journal of Allergy and Clinical Immunology
Peer Reviewed Journal
Visit Source
Annals of Surgery
Peer Reviewed Journal
Visit Source
The Journal of Neurology, Neurosurgery & Psychiatry
Peer Reviewed Journal
Visit Source
Chest
Peer Reviewed Journal
Visit Source
Blood
Peer Reviewed Journal
Visit Source
Gastroenterology
Peer Reviewed Journal
Visit Source
The American Journal of Respiratory and Critical Care Medicine
Peer Reviewed Journal
Visit Source
The American Journal of Psychiatry
Peer Reviewed Journal
Visit Source
Diabetes Care
Peer Reviewed Journal
Visit Source
The Journal of the American College of Cardiology (JACC)
Peer Reviewed Journal
Visit Source
The Journal of Clinical Oncology (JCO)
Peer Reviewed Journal
Visit Source
Journal of Clinical Investigation (JCI)
Peer Reviewed Journal
Visit Source
Circulation
Peer Reviewed Journal
Visit Source
JAMA Internal Medicine
Peer Reviewed Journal
Visit Source
PLOS Medicine
Peer Reviewed Journal
Visit Source
Annals of Internal Medicine
Peer Reviewed Journal
Visit Source
Nature Medicine
Peer Reviewed Journal
Visit Source
The BMJ (British Medical Journal)
Peer Reviewed Journal
Visit Source
The Lancet
Peer Reviewed Journal
Visit Source
Journal of the American Medical Association (JAMA)
Peer Reviewed Journal
Visit Source
Pubmed
Comprehensive biomedical database
Visit Source
Harvard
Educational/Medical Institution
Visit Source
Cleveland Clinic
Educational/Medical Institution
Visit Source
Mayo Clinic
Educational/Medical Institution
Visit Source
The New England Journal of Medicine (NEJM)
Peer Reviewed Journal
Visit Source
Johns Hopkins
Educational/Medical Institution
Visit Source