Basic Lab Markers
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February 18, 2025

What Is a CO2 Blood Test? Understanding Levels & Treatments

Written By
Dr. Kristin Robinson ND
Medically Reviewed by
Updated On
February 25, 2025

Have you ever wondered why your doctor checks your blood for carbon dioxide (CO2)? You might think of it as something we simply exhale, but CO2 is essential in maintaining overall health. 

Carbon dioxide is a natural byproduct produced when your body uses oxygen for energy. While it may seem simple, CO2 levels in your blood can provide insights into how well your lungs, kidneys, and metabolism function.

This article explains the CO2 blood test, what the typical CO2 levels are, and what it means if your levels are too high or too low. The information provided is for educational purposes only and can help you better understand how CO2 levels might affect your health and well-being.

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What Is a CO2 Blood Test?

A CO2 blood test measures bicarbonate levels, which reflect the amount of CO2 in your blood. Too much or too little CO2 in your blood can suggest that something is affecting your body's ability to maintain homeostasis or a balanced environment.

The Role of CO2 in the Body

Carbon dioxide is a waste product your body creates when it uses oxygen to turn food into energy. Every cell in your body goes through this process, which is how we stay alive and active. After your cells make energy, they produce CO2, which then travels through the blood to your lungs, where it is exhaled when you exhale.

CO2 plays an important role in keeping your body's internal balance in check, especially the balance between acids and bases. Your body must maintain this balance to work efficiently for nerve signals, muscle movements, and digestion. CO2 helps control this balance, primarily by working with bicarbonate (a substance that helps neutralize acid in the blood).

When CO2 levels get too high or too low, it can cause problems. Too much CO2 can make the blood too acidic, while too little CO2 can make the blood too alkaline. Both conditions can affect how the body functions, making it essential for CO2 to stay within a healthy range.

CO2 also helps control how we breathe. If CO2 levels rise in the blood, your brain signals you to breathe faster and deeper so your body can eliminate the extra CO2. This process helps your body stay balanced.

How the Test Is Performed

The CO2 blood test involves drawing a small blood sample, typically from a vein in your arm. This sample is sent to a lab, where the bicarbonate levels are measured to assess the CO2 concentration in your blood.

The CO2 blood test is usually part of a Comprehensive Metabolic Panel (CMP) or electrolyte panel. It can also be indirectly measured through urine pH tests to assess the body's acid-base balance. In some cases, additional tests, such as an arterial blood gas (APG) test, may be recommended for a more detailed view of your acid-base balance and respiratory health.

This test helps healthcare providers evaluate how well your lungs remove CO2 and how your kidneys manage acid-base balance. High CO2 levels may suggest issues with lung function, while low CO2 levels could indicate problems with acid-base regulation or kidney function.

Understanding CO2 Blood Test Results

Interpreting your CO2 blood test results with your healthcare provider can provide valuable insights into your respiratory and metabolic health.

What Is Measured?

When healthcare providers measure total CO2, they evaluate the combined levels of these components to get a clear picture of your body's overall CO2 balance. This test measures the combined levels of:

  1. Bicarbonate (HCO3-): This is your blood's primary form of CO2. Bicarbonate helps regulate the acid-base balance in your body, acting as a buffer to maintain a stable pH level.

  2. Carbonic acid (H2CO3): This is a form of CO2 that exists briefly in the blood before it is converted into bicarbonate. Though present in small amounts, carbonic acid is important in maintaining pH balance.

  3. Dissolved CO2: This is the CO2 that remains dissolved in the blood and carried to the lungs, where it is eventually exhaled.

Normal Range for CO2 Levels

CO2 levels typically range from 20-29 mmol/L, with slight variations between labs. Staying within this range indicates that your lungs and kidneys maintain optimal CO2 balance.

Low CO2 Blood Test Results

Low CO2 levels in the blood, or hypocapnia, can occur due to:

  • Kidney disease: Impaired kidneys may struggle to regulate bicarbonate, lowering CO2 levels.

  • Metabolic acidosis: Conditions like diabetes or dehydration can lead to excess acid, causing CO2 levels to drop.

Low CO2 can cause fatigue and difficulty concentrating, as the body's systems may not function efficiently. If left untreated, low CO2 could lead to more serious health concerns. If you experience these symptoms, it's essential to consult a healthcare provider to determine the underlying cause and appropriate treatment.

High CO2 Blood Test Results

High CO2 levels in the blood, or hypercapnia, may be caused by:

  • Lung disease: Conditions like chronic obstructive pulmonary disease (COPD) or emphysema can impair the lungs' ability to remove CO2, raising CO2 levels in the blood.

  • Metabolic alkalosis: This occurs when the body becomes too alkaline, often due to acid loss (e.g., from vomiting), which prompts the body to retain CO2.

Symptoms of high CO2 can include shortness of breath and muscle weakness as the body struggles to exhale the excess CO2. Like low CO2, untreated high CO2 can lead to complications, so seeking medical guidance is recommended.

How to Treat Abnormal CO2 Levels

When CO2 levels fall outside the normal range, addressing the underlying causes with appropriate treatments can help restore balance. Treatment generally involves medical care along with lifestyle adjustments.

How to Treat Low CO2 Levels


Treatment for low CO2 levels (hypocapnia) focuses on correcting the underlying causes.

Common medical interventions include:

  • Replenishing lost electrolytes through supplements or intravenous (IV) fluids can help restore balance. Electrolytes like sodium, bicarbonate, and potassium help regulate CO2 levels. If kidney function or other organs are impaired, electrolyte imbalances may occur, leading to low CO2 levels.

  • Treating underlying conditions like metabolic acidosis, diabetes, or high blood pressure can disrupt CO2 balance. Managing these conditions through medications, dietary changes, or proper fluid intake can help support CO2 regulation.

Along with medical treatments, lifestyle changes can support your overall health. These adjustments can help improve kidney function and metabolism. However, a healthcare provider should always guide treatment for abnormal CO2 levels.

Consider the following healthy habits:

  • A balanced diet rich in fruits, vegetables, lean proteins, and whole grains supports kidney health and helps regulate CO2 levels. Foods high in potassium (e.g., bananas, leafy greens) are particularly beneficial, while processed foods and salt may strain kidneys and affect the body's acid-base balance.

  • Proper hydration is key for kidney function, waste filtration, and maintaining a healthy acid-base balance, all influencing CO2 regulation. Dehydration can impair kidney function and lead to low CO2 levels, so drinking enough water throughout the day supports kidney health.

How to Treat High CO2 Levels

Hypercapnia requires interventions to improve ventilation and address the underlying respiratory or metabolic issues. 

Common medical interventions include:

  • Ventilation Support: If the lungs cannot expel enough CO2, mechanical ventilation or non-invasive methods like CPAP may be used to help keep the airways open and assist the lungs in removing excess CO2 from the blood.

  • Medications: Bronchodilators may be prescribed to relax the muscles around the airways, making breathing easier. This can be particularly beneficial for lung conditions where airway constriction makes it difficult to remove CO2.

Once high CO2 levels are treated, lifestyle changes and ongoing monitoring of chronic conditions are important for preventing future imbalances. Consider these preventative strategies:

  • If you smoke, quitting is one of the most effective ways to improve lung health and reduce the risk of respiratory issues. Smoking damages the lungs, impairing their ability to expel CO2 efficiently. Quitting smoking gives your lungs a chance to heal and helps prevent elevated CO2 levels.

  • Monitoring chronic conditions like COPD or Cushing syndrome helps to maintain
    CO2 balance. This includes regular check-ups, medications, and a treatment plan consisting of physical therapy, breathing techniques, or oxygen therapy.

CO2 Blood Test FAQs 

Below are answers to some commonly asked questions about CO2 blood tests, their frequency, and what to do if your levels are outside the normal range.

Is fasting required for a CO2 blood test?

Fasting is generally not required for a CO2 blood test. However, fasting may be necessary if additional tests, such as cholesterol or glucose, are being conducted. Always follow your healthcare provider's instructions before any lab tests.

How often should I monitor my CO2 levels?

The frequency of CO2 testing depends on your health and your healthcare provider's recommendations. Conditions like kidney disease, respiratory issues, or metabolic disorders may require more frequent monitoring. In healthy individuals, CO2 levels are typically checked during routine blood tests.

What happens if CO2 levels remain abnormal?

If CO2 levels stay outside the normal range, this may suggest an imbalance related to the body's acid-base regulation or issues with the lungs, kidneys, or metabolic systems. It's important to consult your healthcare provider to identify the cause and determine the appropriate next steps. Long-term imbalances may require changes in diet, medication, or other treatments as your doctor recommends.

How long does it take to get CO2 blood test results?

Results from a CO2 blood test are usually available within a few days, depending on the lab processing time. Your healthcare provider will review the results with you and discuss any necessary next steps.

Can lifestyle changes help regulate CO2 levels?

Maintaining a balanced diet, staying hydrated, and avoiding smoking can help the body manage CO2 levels. Regular monitoring and lifestyle adjustments can also help maintain balance over time. For personalized advice, consult your healthcare provider.

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Key Takeaways  

  • The CO2 blood test measures the level of carbon dioxide in your blood, helping assess how your body balances acids and bases. It is often part of routine blood work and may provide insight into health conditions such as kidney disease, respiratory issues, or metabolic imbalances.
  • When CO2 levels are abnormal, it's essential to identify the underlying cause through medical evaluation. In addition to medical care, lifestyle habits like maintaining a balanced diet, staying hydrated, and avoiding smoking can support overall health. Early detection and proactive management can help restore balance and reduce the risk of complications.
  • Consult with your healthcare provider if you experience ongoing fatigue, shortness of breath, vomiting, or dizziness, as these may suggest the need for CO2 testing. Your doctor can assess your health and offer tailored advice based on your specific needs. 
The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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