Herbal Medicine Fact Sheets
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February 14, 2024

The Top 4 Herbal Antimicrobials for Your Functional Medicine Toolkit

Written By
Dr. Rachel Magerman ND
Medically Reviewed by
Updated On
January 17, 2025

The use of herbal medicine to support the body's defense against microbial challenges has gained significant attention over the years. Although antibiotics are necessary for saving lives when used correctly, they are also recognized for various negative side effects. As modern medicine continues to address antimicrobial resistance, the exploration of effective natural and herbal options is on the rise. In this article, we will discuss the rise of antibiotic resistance and herbal approaches that may help support the body's natural defenses against microbial challenges. 

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The Rise of Antibiotic Resistance 

While antibiotic medications are a central component of conventional medicine, the rise of antimicrobial resistance is a pressing global health concern. According to the CDC, antimicrobial resistance is associated with significant health impacts worldwide. The implications of antibiotic resistance are profound. Antimicrobial resistance develops due to the overuse and misuse of antibiotics leading to drug-resistant pathogens. As drug-resistant pathogens continue to evolve, physicians confront challenges in managing life-threatening infectious diseases. Due to the ongoing threat of antibiotic resistance, practitioners and researchers have turned to herbal and natural options for potential support. (11, 47

The Top 4 Herbal Options

Herbal medicine offers promising benefits in supporting the body's defense against microbial challenges. Plants contain multiple bioactive compounds that can work together to support the body's natural defenses, making them a valuable complement to conventional approaches. Among the herbal options studied extensively are Echinacea, Garlic, Oregano, and Goldenseal. (3

The Top 4 Herbal Antimicrobials are Garlic, Echinacea, Oregano Oil, and Goldenseal.

1. Garlic (Allium sativa)

For centuries, garlic has been admired as an edible plant renowned for its potential to support the body's defense against microbial challenges. Allicin, the main constituent in garlic, is believed to contribute to its supportive effects. Garlic may help support immune function and maintain overall health, making it a popular choice for those looking to support their body's natural defenses. (4).

2. Echinacea (Echinacea purpurea)

Echinacea is a flowering plant native to North America. It is used to support the immune system and maintain respiratory health. Echinacea is believed to help support the body's natural response to microbial challenges. Due to its properties, echinacea is often used to support urinary tract health, maintain vaginal health, support ear health, and promote overall well-being. (20, 27, 45).

3. Oregano Oil (Origanum vulgare)

Oregano is a common herb used widely to support the body's defense against microbial challenges. The medicinal part of oregano lies within the essential oil, which contains carvacrol and thymol. These constituents are believed to support the body's natural defenses and maintain overall health. Oregano oil is often used to support respiratory health, skin health, and digestive well-being. (12, 16, 46).

4. Goldenseal (Hydrastis canadensis)

Goldenseal is a plant native to North America known for its potential to support the body's defense against microbial challenges. The active constituent in goldenseal is berberine, which studies suggest may have supportive properties for overall health. Goldenseal is often used to support seasonal health, maintain sinus health, support digestive well-being, and promote skin health. (10, 18, 21, 52)

Evidence-Based Applications of Herbal Options

Over the years, clinical studies have highlighted the potential benefits of herbal options in supporting the body's defense against microbial challenges. When deciding which option may be most supportive, we can look at the numerous clinical studies and research performed on these herbal allies. 

A study conducted on the potential of goldenseal (Hydrastis canadensis) to support the body's defense against methicillin-resistant Staphylococcus aureus (MRSA) showed that the alkaloids and flavonoids of the plant may offer supportive benefits. MRSA is known to be resistant to many pharmaceutical antibiotics, and the emerging study suggests that goldenseal may be a supportive option. (10, 24).

Our next highlighted herb, backed by ample clinical research, is garlic. One study examined the potential benefits of using garlic extract to support oral health against streptococcus bacteria, the microbe responsible for strep throat. The study examined 30 subjects using a garlic-prepared mouthwash over 5 weeks. Results suggested that the garlic mouthwash may help support oral health by reducing oral streptococci organisms. (17, 23).

As previously mentioned, Echinacea is a preferred herbal option for supporting respiratory health. One study examined the effects of Echinacea purpura against common bacteria that may affect upper respiratory tract health. The results of the study suggested that Echinacea may help support the body's natural response to microbial challenges. (8, 9, 45).

Incorporating Herbal Options into Wellness Plans

The integration of herbal medicine into wellness plans requires careful attention to dosing, potential interactions with pharmaceuticals, and consideration of the individual's overall health profile. When formulating a wellness plan, it is important to consider the whole person and any underlying health conditions. Considering individual allergies, sensitivities, and preferences is key to success. 

When selecting an herbal option for a specific wellness plan, it is important to consider the bioavailability of different herbal preparations. Most herbal medicines come in capsule, tincture, or tea format. It is best to select herbal options with standardized extracts to ensure adequate concentration of active constituents. Lastly, proper education is needed to ensure individuals understand how to incorporate herbal medicine into their daily lives. (14, 19)

Addressing Safety and Quality Concerns

While herbal options offer promising benefits in supporting the body's defense against microbial challenges, it is important to consider the safety and quality of products. When sourcing any herbal medicine, it is crucial to obtain herbs from reputable companies that follow quality control standards. When searching for reputable companies, it is advised to look for products that have been third-party tested and follow Good Manufacturing Practices (GMP). Using products that lack standardized regulations can cause undesired side effects and variability in the effectiveness of the product. (53).

Of the herbs discussed in this article, the two that may cause undesired side effects are Echinacea and Oregano oil. When considering Echinacea, it is important to avoid using this herb in individuals with autoimmune conditions such as multiple sclerosis due to its immunostimulant properties. While oregano oil is generally considered safe for most people, it is imperative to mix the oil with a carrier oil or water to avoid side effects such as burning or internal irritation. (6).

Role of Diet and Lifestyle in Supporting Wellness

Optimizing the effectiveness of wellness plans involves not only herbal medicine but also the incorporation of nutritional and lifestyle practices. In functional medicine, a comprehensive approach is needed to enhance immune function and support overall health while addressing the root cause of wellness concerns. A balanced diet rich in essential nutrients is key to building a strong immune system. 

For optimal results with your wellness plan, consider including foods rich in vitamins C, D, A, and E as well as zinc and omega-3 fatty acids. Including plentiful phytonutrients commonly found in colorful fruits and vegetables is also beneficial. It is important to avoid inflammatory foods such as saturated fats and processed sugars. For more information on how to follow these diet recommendations, please read up on the Mediterranean Diet. (22).

Often, the foundation of good health lies in our daily lifestyle choices. This is where the importance of lifestyle factors becomes apparent. The keys to supporting your body through wellness plans lie in sound sleep, stress management, proper aerobic exercise, and good hydration. (5, 29).

For best immune health, it is suggested to aim for 7-9 hours of sleep per night. In addition, monitoring stress levels is crucial for immune health when following wellness plans. Chronic stress may affect immune function and contribute to higher levels of inflammation. By practicing stress management techniques, such as mindfulness meditation, individuals can improve their overall well-being and support their immune systems. (13).

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Functional Lab Testing in Identifying and Monitoring Wellness

Functional lab testing plays a crucial role in identifying and monitoring wellness. In the context of wellness plans, functional lab tests allow healthcare practitioners to assess changes in imbalances and support overall health over time. Among the most important tests include comprehensive stool analysis such as the GI-MAP by Diagnostic Solutions and the Microbial Analysis by Genova Diagnostics, which provide detailed information about microbial balance and overall health.

The GI Map test by Diagnostic Solutions is a valuable tool to gain insight into gastrointestinal microbial balance. This test uses PCR technology to screen for various microbes in the stool that may contribute to health concerns. (26).

The Microbial Analysis lab by Genova Diagnostics provides a thorough culture of the individual's gut flora while also providing possible supportive interventions. This test provides the practitioner with insight into which pharmaceutical or botanical options may be most supportive for the individual. (32).

The growing concern of antibiotic resistance has led functional medicine practitioners to research and utilize herbal and natural options. Additionally, lifestyle factors and functional lab testing play key roles in supporting wellness plans and monitoring health progression. As clinical research continues to grow, the use of herbal medicine in supporting the body's natural defenses presents a promising avenue for addressing health concerns.  

The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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