February 6, 2024

The Impact of Regenerative Medicine on Sports Injuries

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Medically Reviewed by

Updated On

September 18, 2024

In the dynamic realm of sports, where athletes constantly push physical boundaries, the prevalence of injuries remains a formidable challenge. Sports injuries can not only hinder performance but also jeopardize the longevity of an athlete's career. The imperative for effective and efficient treatment solutions has never been more critical.

Traditionally, managing sports injuries has been a nuanced endeavor, often accompanied by prolonged recovery periods and the potential for recurrent issues.

Against this backdrop, regenerative therapies, including cutting-edge interventions are revolutionizing the landscape by harnessing the body's innate healing mechanisms. This article will illuminate the potential impact of regenerative medicine on sports injuries for those grappling with the consequences of athletic pursuits. This is a growing field of medicine that is not just addressing symptoms but fundamentally altering the trajectory of sports injury treatment, offering a beacon of hope for enhanced recovery and sustained athletic prowess.

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Common Sports Injuries and Their Traditional Treatments

Common sports injuries include meniscus tears, ligament tears like anterior cruciate ligament (ACL) and ATFL, tendon tears like the rotator cuff tendons of the shoulders and Achilles tendon tears, plantar fasciitis, muscle tears, and labral tears. These injuries pose significant challenges for athletes, as they can eliminate them from the game temporarily or permanently. The arsenal of treatments for these injuries has been limited.

Traditional treatments for sports injuries most often include rest, ice, and initiation of non-steroidal anti-inflammatory medications (NSAIDs) or cortisone injection, both of which have been shown to provide temporary pain relief. Unfortunately, in addition to providing short-term relief, NSAIDs and cortisone injections have been shown in studies to reduce muscle and tendon strength and function in the long term, predisposing athletes to future injuries.

If the athlete does not recover from first-line therapies, physical therapy or surgical intervention is prescribed. While surgery is necessary for severe cases, it comes with inherent risks, extended recovery periods that can result in missing an entire season of their sport, and potential complications that reduce the range of motion within joints and compromise athletic performance forever.

‍Physical therapy is a cornerstone of rehabilitation, aiming to restore functionality and strength, but its effectiveness may vary, and achieving optimal outcomes relies heavily on patient compliance and effort. The limitations of these traditional treatments highlight the need for alternative and complementary approaches in sports injury management. It is these limitations with traditional therapies that have sparked the drive and excitement towards alternative methods for improved functional outcomes which will be reviewed in detail below!

What is Regenerative Medicine?

The principles of regenerative medicine operate on stimulating the body's natural healing mechanisms to restore function and structure at the cellular and molecular levels, aiming to harness the body's innate capacity for self-healing with the fundamental goal of repairing, replacing, or regenerating damaged tissues. Various regenerative therapies are utilized to achieve these objectives. Some therapies include prolotherapy, platelet-rich plasma (PRP), stem cells, and tissue engineering which will all be explained in further detail below!

Regenerative Medicine Therapies for Sports Injuries

Prolotherapy induces controlled inflammation using solutions like dextrose, stimulating tissue strengthening. It is often the least expensive option for regenerative medicine and has a significant impact on tendon overuse injuries and ligament laxity, an overstretched ligament. Ligament laxity often results in reduced stability and chronic pain in joints, especially the ankle, knee, shoulder, and back. Commonly treated injuries include lateral epicondylitis, “tennis elbow”, sacroiliitis, weakened ligaments of the knee, and tears of the anterior talofibular ligament (ATFL) of the ankle. This injection aims at strengthening ligaments and tendons, promoting tissue stability, often benefiting athletes with chronic joint conditions vs more acute conditions.

Platelet-rich plasma (PRP) therapy concentrates platelets from the patient’s blood which stimulates growth factors, accelerating the natural repair processes. PRP injections are utilized to accelerate tissue repair, making it a popular choice for acute injuries such as rotator cuff tears, meniscus damage, partial Achilles rupture, and labral tears. Depending on the severity of the tear it may require several rounds of injections. This option helps the athlete recover without putting the athlete at risk for further degeneration, like NSAIDs & cortisone do, or compromising range of motion, form, and function, as with some surgical outcomes.

Stem cell therapy involves using the regenerative potential of specialized cells to promote tissue healing. Often, mesenchymal stem cells (MSCs) are utilized and harvested from the patient’s adipose (fat) tissue or bone marrow. After harvesting the stem cells with a minor procedure, they are injected directly into damaged tissues. These cells possess the ability to differentiate and change into various cell types, facilitating tissue repair and regeneration. Stem cell therapy aims to accelerate healing and improve functionality and is most often utilized in clinical practice for more severe injuries such as labral tears of the hip or shoulder, meniscus and ACL tears of the knee, or more serious tendon/ligament tears but more research needs to be performed to confirm long term efficacy. Research has shown promising results in combining stem cell therapy followed by PRP injections for faster, longer-lasting results.

In addition to these techniques, regenerative therapies explore the use of growth factor treatments and tissue engineering for comprehensive sports injury management. Tissue engineering explores the creation of functional biological tissues in the laboratory for transplantation or implantation and is currently involved in numerous studies to determine best practices and long-term efficacy within the world of sports medicine and sports injuries. Research trials are underway to determine how to convert stem cells into specific desired cells and tissues once injected into an injury or joint. This will provide more precision in treatment protocols in the future.

These regenerative interventions collectively aim to reduce recovery times, decrease pain, and enhance overall functionality, offering athletes promising and personalized alternatives for the treatment of ligament, tendon, and muscle injuries. As research progresses, the integration of regenerative therapies in sports medicine continues to evolve, providing athletes with innovative solutions for optimal recovery and sustained performance.

The Science Behind Regenerative Medicine

Research in regenerative sports medicine has provided compelling evidence of the efficacy of these therapies in treating sports injuries to accelerate healing, reduce inflammation, and enhance functional recovery in conditions such as ligament tears and muscle strains.

The use of prolotherapy and modern applications of it have been around since the 1950s. It is most often utilized for classic tendinopathies in chronic sports injuries, such as overstrained ACL resulting in laxity. Biopsy of these chronically injured tendons reveals frayed tendons with the absence of inflammatory cells, meaning, the body stopped trying to heal them. The use of dextrose solution or irritating area aggravates the area, causing an inflammatory response, allowing the body to re-address the old injury with a cascade of signals that promote the healing process. Four specific injuries have been well studied for prolotherapy including plantar fasciitis, lateral epicondylitis (aka tennis elbow), Achilles tendonitis, and damage to hip abductor muscles. Athletes who received prolotherapy treatments for these injuries saw improved outcomes compared to control groups. Many of the patients chosen in these studies previously failed traditional therapies including rest, NSAIDs, and cortisone injections.

Platelet-rich plasma (PRP) contains and stimulates growth factors and is often used in more acute injuries. Until more recently, research on PRP injection was variable due to platelet variability within different patients and even within the same patients on different days which can lead to variable results. Currently, researchers are learning to measure platelets to ensure less than 10% variability. Research has shown tremendous efficacy in the treatment of grade I & II muscle tears within the hamstrings with ultrasound guidance with complete resolution of tears on MRI imaging and full regain of function for 52 of the 53 athletes within 30 days. Meniscus injuries, which can be detrimental to athletes, are highly responsive to PRP injections, with one study showing 6 months of MRI follow-up revealing stability in the meniscus for the majority of athletes.

MSC stem cell therapy is currently undergoing widespread clinical investigations for sports injuries. Most current studies suggest that stem cells derived from bone marrow aspirate result in significant improvements in osteoarthritis as well as reductions in pain, which is often a complaint of aging athletes. More clinical trials need to be performed with control groups to best assess treatment comparisons between stem cell-based therapies and traditional treatment protocols.

Advantages and Limitations of Regenerative Medicine

Regenerative medicine presents a promising array of advantages for sports injuries, revolutionizing the approach to treatment. One key advantage of regenerative medicine is the potential for reduced recovery time, which is essential within the athletic realm. Another notable advantage is the potential for promoting tissue regeneration, preventing the athlete from further deterioration and injury some traditional treatments like cortisone injections or NSAIDs do. Additionally, these interventions often result in improved functionality, allowing athletes to regain optimal performance levels.

Regenerative medicine presents a promising array of advantages for sports injuries, revolutionizing the approach to treatment. One key advantage of regenerative medicine is the potential for reduced recovery time, which is essential within the athletic realm. Another notable advantage is the potential for promoting tissue regeneration, preventing the athlete from further deterioration. Additionally, these interventions often result in improved functionality, allowing athletes to regain optimal performance levels.

However, regenerative medicine is not without its limitations and challenges. Availability of these treatments can be a constraint, as not all healthcare providers offer these therapies. Cost is another consideration since these innovative treatments are often not covered by insurance and may pose financial challenges for some patients. This type of therapy may not benefit full-thickness tears, especially if the muscle has retracted.

Moreover, the field of regenerative medicine is still evolving, necessitating further research to establish the long-term efficacy and safety of these interventions. Ongoing scientific exploration is essential to refine protocols, expand the range of treatable conditions, and address any potential risks associated with these therapies. Balancing the advantages with the current limitations, regenerative medicine stands as a promising frontier, necessitating continued research and accessibility enhancements to fully realize its potential in revolutionizing sports injury treatment.

Future Directions in Regenerative Medicine for Sports Injuries

The future of regenerative medicine in sports injuries promises exciting advancements and innovative approaches that could reshape treatment protocols and outcomes. One notable trend is the integration of precision medicine, tailoring regenerative therapies to individual athletes based on genetic, hormonal, molecular, and biomechanical factors. Personalized treatment plans may enhance the efficacy of regenerative interventions, optimizing the healing process for specific injuries. Additionally, advancements in tissue engineering are on the horizon, allowing for the creation of customized biological constructs to replace or repair damaged tissues more effectively.

Technological innovations, such as advanced imaging techniques and three-dimensional bioprinting, hold great potential in refining the delivery and targeting of regenerative therapies. Precise imaging can aid in identifying and assessing injuries, while bioprinting may enable the fabrication of intricate tissue structures. Moreover, ongoing research is exploring the incorporation of innovative biomaterials and nanotechnology to enhance the regenerative potential of therapeutic interventions for sports injuries.

Collaboration between regenerative medicine and other fields, such as artificial intelligence, may further propel advancements in sports injury treatments. AI-driven algorithms could optimize treatment plans and predict patient responses.

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Regenerative Medicine for Sports Injuries: Key Takeaways

Regenerative medicine has emerged as a game-changer in sports injury treatment, offering reduced recovery times, decreased pain, and improved functionality. Its potential to revolutionize sports medicine is evident in its transformative impact on tissue repair and regeneration. However, the journey towards optimal regenerative solutions requires continual research and development, ensuring advancements in treatment protocols and technology. As ongoing innovations unfold, regenerative therapies hold the key to not just treating but elevating the standards of care for athletes, paving the way for a future where sports medicine is defined by personalized, effective, and cutting-edge regenerative interventions with limited downtime for the athlete.

In the dynamic realm of sports, where athletes constantly push physical boundaries, the prevalence of injuries remains a formidable challenge. Sports injuries can not only hinder performance but also impact the longevity of an athlete's career. The need for effective and efficient management solutions has never been more critical.

Traditionally, managing sports injuries has been a nuanced endeavor, often accompanied by prolonged recovery periods and the potential for recurrent issues.

Against this backdrop, regenerative therapies, including innovative interventions, are changing the landscape by supporting the body's natural healing mechanisms. This article will explore the potential impact of regenerative medicine on sports injuries for those dealing with the consequences of athletic pursuits. This is a growing field of medicine that is not just addressing symptoms but may be altering the approach to sports injury management, offering hope for enhanced recovery and sustained athletic performance.

[signup]

Common Sports Injuries and Their Traditional Treatments

Common sports injuries include meniscus tears, ligament tears like anterior cruciate ligament (ACL) and ATFL, tendon tears like the rotator cuff tendons of the shoulders and Achilles tendon tears, plantar fasciitis, muscle tears, and labral tears. These injuries pose significant challenges for athletes, as they can temporarily or permanently affect their ability to participate in sports. The range of treatments for these injuries has been limited.

Traditional treatments for sports injuries most often include rest, ice, and the use of non-steroidal anti-inflammatory medications (NSAIDs) or cortisone injections, both of which have been shown to provide temporary pain relief. However, studies suggest that NSAIDs and cortisone injections may reduce muscle and tendon strength and function in the long term, potentially predisposing athletes to future injuries.

If the athlete does not recover from initial therapies, physical therapy or surgical intervention may be considered. While surgery is necessary for severe cases, it comes with inherent risks, extended recovery periods that can result in missing an entire season of their sport, and potential complications that may reduce the range of motion within joints and affect athletic performance.

‍Physical therapy is a cornerstone of rehabilitation, aiming to restore functionality and strength, but its effectiveness may vary, and achieving optimal outcomes relies heavily on patient compliance and effort. The limitations of these traditional treatments highlight the need for alternative and complementary approaches in sports injury management. It is these limitations with traditional therapies that have sparked interest in alternative methods for improved functional outcomes, which will be reviewed in detail below!

What is Regenerative Medicine?

The principles of regenerative medicine focus on supporting the body's natural healing mechanisms to maintain function and structure at the cellular and molecular levels, aiming to harness the body's innate capacity for self-healing with the goal of repairing, replacing, or regenerating tissues. Various regenerative therapies are utilized to achieve these objectives. Some therapies include prolotherapy, platelet-rich plasma (PRP), stem cells, and tissue engineering, which will all be explained in further detail below!

Regenerative Medicine Therapies for Sports Injuries

Prolotherapy involves inducing controlled inflammation using solutions like dextrose, which may support tissue strengthening. It is often the least expensive option for regenerative medicine and may have a significant impact on tendon overuse injuries and ligament laxity, an overstretched ligament. Ligament laxity often results in reduced stability and chronic pain in joints, especially the ankle, knee, shoulder, and back. Commonly addressed injuries include lateral epicondylitis, “tennis elbow”, sacroiliitis, weakened ligaments of the knee, and tears of the anterior talofibular ligament (ATFL) of the ankle. This injection aims at supporting ligaments and tendons, promoting tissue stability, often benefiting athletes with chronic joint conditions versus more acute conditions.

Platelet-rich plasma (PRP) therapy concentrates platelets from the patient’s blood, which may stimulate growth factors, supporting the natural repair processes. PRP injections are utilized to support tissue repair, making it a popular choice for acute injuries such as rotator cuff tears, meniscus damage, partial Achilles rupture, and labral tears. Depending on the severity of the tear, it may require several rounds of injections. This option helps the athlete recover without putting them at risk for further degeneration, like NSAIDs & cortisone might, or compromising range of motion, form, and function, as with some surgical outcomes.

Stem cell therapy involves using the regenerative potential of specialized cells to support tissue healing. Often, mesenchymal stem cells (MSCs) are utilized and harvested from the patient’s adipose (fat) tissue or bone marrow. After harvesting the stem cells with a minor procedure, they are injected directly into tissues. These cells possess the ability to differentiate and change into various cell types, facilitating tissue repair and regeneration. Stem cell therapy aims to support healing and improve functionality and is most often utilized in clinical practice for more severe injuries such as labral tears of the hip or shoulder, meniscus and ACL tears of the knee, or more serious tendon/ligament tears, but more research needs to be performed to confirm long-term efficacy. Research has shown promising results in combining stem cell therapy followed by PRP injections for potentially faster, longer-lasting results.

These regenerative interventions collectively aim to support recovery times, manage pain, and enhance overall functionality, offering athletes promising and personalized options for the management of ligament, tendon, and muscle injuries. As research progresses, the integration of regenerative therapies in sports medicine continues to evolve, providing athletes with innovative solutions for optimal recovery and sustained performance.

The Science Behind Regenerative Medicine

Research in regenerative sports medicine has provided evidence of the potential of these therapies in supporting sports injuries to aid healing, manage inflammation, and enhance functional recovery in conditions such as ligament tears and muscle strains.

The use of prolotherapy and modern applications of it have been around since the 1950s. It is most often utilized for classic tendinopathies in chronic sports injuries, such as overstrained ACL resulting in laxity. Biopsy of these chronically injured tendons reveals frayed tendons with the absence of inflammatory cells, meaning, the body stopped trying to heal them. The use of dextrose solution or irritating area aggravates the area, causing an inflammatory response, allowing the body to re-address the old injury with a cascade of signals that promote the healing process. Four specific injuries have been well studied for prolotherapy including plantar fasciitis, lateral epicondylitis (aka tennis elbow), Achilles tendonitis, and damage to hip abductor muscles. Athletes who received prolotherapy treatments for these injuries saw improved outcomes compared to control groups. Many of the patients chosen in these studies previously did not respond to traditional therapies including rest, NSAIDs, and cortisone injections.

Platelet-rich plasma (PRP) contains and may stimulate growth factors and is often used in more acute injuries. Until more recently, research on PRP injection was variable due to platelet variability within different patients and even within the same patients on different days, which can lead to variable results. Currently, researchers are learning to measure platelets to ensure less than 10% variability. Research has shown potential efficacy in the management of grade I & II muscle tears within the hamstrings with ultrasound guidance, with complete resolution of tears on MRI imaging and full regain of function for 52 of the 53 athletes within 30 days. Meniscus injuries, which can be detrimental to athletes, are highly responsive to PRP injections, with one study showing 6 months of MRI follow-up revealing stability in the meniscus for the majority of athletes.

MSC stem cell therapy is currently undergoing widespread clinical investigations for sports injuries. Most current studies suggest that stem cells derived from bone marrow aspirate may result in significant improvements in osteoarthritis as well as reductions in pain, which is often a complaint of aging athletes. More clinical trials need to be performed with control groups to best assess treatment comparisons between stem cell-based therapies and traditional treatment protocols.

Advantages and Limitations of Regenerative Medicine

Regenerative medicine presents a promising array of advantages for sports injuries, potentially changing the approach to management. One key advantage of regenerative medicine is the potential for reduced recovery time, which is essential within the athletic realm. Another notable advantage is the potential for supporting tissue regeneration, potentially preventing the athlete from further deterioration and injury that some traditional treatments like cortisone injections or NSAIDs might cause. Additionally, these interventions often result in improved functionality, allowing athletes to regain optimal performance levels.

Regenerative medicine presents a promising array of advantages for sports injuries, potentially changing the approach to management. One key advantage of regenerative medicine is the potential for reduced recovery time, which is essential within the athletic realm. Another notable advantage is the potential for supporting tissue regeneration, potentially preventing the athlete from further deterioration. Additionally, these interventions often result in improved functionality, allowing athletes to regain optimal performance levels.

Future Directions in Regenerative Medicine for Sports Injuries

The future of regenerative medicine in sports injuries promises exciting advancements and innovative approaches that could reshape management protocols and outcomes. One notable trend is the integration of precision medicine, tailoring regenerative therapies to individual athletes based on genetic, hormonal, molecular, and biomechanical factors. Personalized treatment plans may enhance the efficacy of regenerative interventions, optimizing the healing process for specific injuries. Additionally, advancements in tissue engineering are on the horizon, allowing for the creation of customized biological constructs to replace or repair tissues more effectively.

Collaboration between regenerative medicine and other fields, such as artificial intelligence, may further propel advancements in sports injury management. AI-driven algorithms could optimize treatment plans and predict patient responses.

[signup]

Regenerative Medicine for Sports Injuries: Key Takeaways

Regenerative medicine has emerged as a potential game-changer in sports injury management, offering reduced recovery times, managed pain, and improved functionality. Its potential to change sports medicine is evident in its impact on tissue repair and regeneration. However, the journey towards optimal regenerative solutions requires continual research and development, ensuring advancements in management protocols and technology. As ongoing innovations unfold, regenerative therapies hold the key to not just managing but elevating the standards of care for athletes, paving the way for a future where sports medicine is defined by personalized, effective, and cutting-edge regenerative interventions with limited downtime for the athlete.

The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.

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1. Arjmand, B., Goodarzi, P., Mohamadi-Jahani, F., Falahzadeh, K., & Larijani, B. (2017). Personalized Regenerative Medicine. Acta Medica Iranica, 55(3), 144–149. https://pubmed.ncbi.nlm.nih.gov/28282715/

2. Beiner, J. M., Jokl, P., Cholewicki, J., & Panjabi, M. M. (1999). The Effect of Anabolic Steroids and Corticosteroids on Healing of Muscle Contusion Injury. The American Journal of Sports Medicine, 27(1), 2–9. https://doi.org/10.1177/03635465990270011101

3. Bernuzzi, G., Petraglia, F., Pedrini, M. F., De Filippo, M., Pogliacomi, F., Verdano, M. A., & Costantino, C. (2014). Use of platelet-rich plasma in the care of sports injuries: our experience with ultrasound-guided injection. Blood Transfusion, 12(Suppl 1), s229–s234. https://doi.org/10.2450/2013.0293-12

4. Castle, J. P., Cotter, D. L., Jildeh, T. R., Abbas, M. J., Gaudiani, M. A., Ghali, A., Bridges, C., & Moutzouros, V. (2022). Reduced Career Longevity but Return to Baseline Performance After Arthroscopic Shoulder Labral Repair in National Hockey League Players. Arthroscopy, Sports Medicine, and Rehabilitation. https://doi.org/10.1016/j.asmr.2021.11.022

5. Chellini, F., Tani, A., Zecchi-Orlandini, S., & Sassoli, C. (2019). Influence of Platelet-Rich and Platelet-Poor Plasma on endogenous mechanisms of skeletal muscle repair/regeneration. International Journal of Molecular Sciences, 20(3), 683. https://doi.org/10.3390/ijms20030683

6. Costa, J. B., Pereira, H., Espregueira-Mendes, J., Khang, G., Oliveira, J. M., & Reis, R. L. (2017). Tissue engineering in orthopaedic sports medicine: current concepts. Journal of ISAKOS, 2(2), 60–66. https://doi.org/10.1136/jisakos-2016-000080

7. Cusi, M., Saunders, J., Hungerford, B., Wisbey-Roth, T., Lucas, P., & Wilson, S. (2008). The use of prolotherapy in the sacroiliac joint. British Journal of Sports Medicine, 44(2), 100–104. https://doi.org/10.1136/bjsm.2007.042044

8. De Luigi, A. J., Blatz, D., Karam, C., Gustin, Z., & Gordon, A. H. (2019). Use of Platelet-Rich Plasma for the Treatment of Acetabular Labral Tear of the Hip. American Journal of Physical Medicine & Rehabilitation, 98(11), 1010–1017. https://doi.org/10.1097/phm.0000000000001237

9. Ding, D.-C., Shyu, W.-C., & Lin, S.-Z. (2011). Mesenchymal Stem Cells. Cell Transplantation, 20(1), 5–14. https://doi.org/10.3727/096368910x

10. El-Kadiry, A. E.-H., Lumbao, C., Salame, N., Rafei, M., & Shammaa, R. (2022). Bone marrow aspirate concentrate versus platelet-rich plasma for treating knee osteoarthritis: a one-year non-randomized retrospective comparative study. BMC Musculoskeletal Disorders, 23(1). https://doi.org/10.1186/s12891-021-04910-5

11. Engebretsen, L., Steffen, K., Alsousou, J., Anitua, E., Bachl, N., Devilee, R., Everts, P., Hamilton, B., Huard, J., Jenoure, P., Kelberine, F., Kon, E., Maffulli, N., Matheson, G., Mei-Dan, O., Menetrey, J., Philippon, M., Randelli, P., Schamasch, P., & Schwellnus, M. (2010). IOC consensus paper on the use of platelet-rich plasma in sports medicine. British Journal of Sports Medicine, 44(15), 1072–1081. https://doi.org/10.1136/bjsm.2010.079822

12. Guelfi, M., Pantalone, A., Vanni, D., Abate, M., Guelfi, M. G. B., & Salini, V. (2015). Long-term beneficial effects of platelet-rich plasma for non-insertional Achilles tendinopathy. Foot and Ankle Surgery, 21(3), 178–181. https://doi.org/10.1016/j.fas.2014.11.005

13. Guenoun, D., Magalon, J., de Torquemada, I., Vandeville, C., Sabatier, F., Champsaur, P., Jacquet, C., & Ollivier, M. (2020). Treatment of degenerative meniscal tear with intrameniscal injection of platelets rich plasma. Diagnostic and Interventional Imaging, 101(3), 169–176. https://doi.org/10.1016/j.diii.2019.10.003

14. Harley, W., Yoshie, H., & Gentile, C. (2021). Three-Dimensional Bioprinting for Tissue Engineering and Regenerative Medicine in Down Under: 2020 Australian Workshop Summary. ASAIO Journal, 67(4), 363–369. https://doi.org/10.1097/mat.0000000000001389

15. Hauser, R. A., Lackner, J. B., Steilen-Matias, D., & Harris, D. K. (2016). A Systematic Review of Dextrose Prolotherapy for Chronic Musculoskeletal Pain. Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders, 9, 139–159. https://doi.org/10.4137/CMAMD.S39160

16. Kraemer, W., Denegar, C., & Flanagan, S. (2009). Recovery From Injury in Sport: Considerations in the Transition From Medical Care to Performance Care. Sports Health: A Multidisciplinary Approach, 1(5), 392–395. https://doi.org/10.1177/1941738109343156

17. Lai, W.-F., Chang Ho Yoon, Meng Ting Chiang, Hong, Y.-H., Chen, H.-C., Song, W., & Po, Y. (2021). The effectiveness of dextrose prolotherapy in plantar fasciitis. Medicine, 100(51), e28216–e28216. https://doi.org/10.1097/md.0000000000028216

18. Lana, J. F. S. D., da Fonseca, L. F., Macedo, R. da R., Mosaner, T., Murrell, W., Kumar, A., Purita, J., & de Andrade, M. A. P. (2021). Platelet-rich plasma vs bone marrow aspirate concentrate: An overview of mechanisms of action and orthobiologic synergistic effects. World Journal of Stem Cells, 13(2), 155–167. https://doi.org/10.4252/wjsc.v13.i2.155

19. Medina-Porqueres, I., Martin-Garcia, P., Sanz-De-Diego, S., Gomez-Caceres, A., Moya-Torrecilla, F., Reyes-Eldblom, M., & Rosado-Velazquez, D. (2022). Clinical and Functional Outcome of Meniscal Injuries Treated with Platelet-Rich Plasma: A Single-Center Case Series. International Journal of Environmental Research and Public Health, 19(12), 7118–7118. https://doi.org/10.3390/ijerph19127118

20. Middleton, K. K., Barro, V., Muller, B., Terada, S., & Fu, F. H. (2012). Evaluation of the effects of platelet-rich plasma (PRP) therapy involved in the healing of sports-related soft tissue injuries. The Iowa Orthopaedic Journal, 32, 150–163. https://pubmed.ncbi.nlm.nih.gov/23576936/

21. Ntege, E. H., Sunami, H., & Shimizu, Y. (2020). Advances in regenerative therapy: A review of the literature and future directions. Regenerative Therapy, 14, 136–153. https://doi.org/10.1016/j.reth.2020.01.004

22. Paavola, M., Kannus, P., Järvinen, T. A. H., Järvinen, T. L. N., Józsa, L., & Järvinen, M. (2002). Treatment of tendon disorders. Foot and Ankle Clinics, 7(3), 501–513. https://doi.org/10.1016/s1083-7515(02)00056-6

23. Rabago, D., Slattengren, A., & Zgierska, A. (2010). Prolotherapy in Primary Care Practice. Primary Care: Clinics in Office Practice, 37(1), 65–80. https://doi.org/10.1016/j.pop.2009.09.013

24. Ramkumar, P. N., Luu, B. C., Haeberle, H. S., Karnuta, J. M., Nwachukwu, B. U., & Williams, R. J. (2021). Sports Medicine and Artificial Intelligence: A Primer. The American Journal of Sports Medicine, 036354652110086. https://doi.org/10.1177/03635465211008648

25. Razaq, S., Ejaz, A., Rao, S. E., Yasmeen, R., & Arshad, M. A. (2015). The Role of Intraarticular Platelet Rich Plasma (PRP) Injection in Patients with Internal Knee Derangements. Journal of the College of Physicians and Surgeons--Pakistan: JCPSP, 25(9), 699–701. https://pubmed.ncbi.nlm.nih.gov/26374371/

26. Reeves, K. D., & Hassanein, K. M. (2003). Long-term effects of dextrose prolotherapy for anterior cruciate ligament laxity. Alternative Therapies in Health and Medicine, 9(3), 58–62. https://pubmed.ncbi.nlm.nih.gov/12776476/

27. Rockwell, M. S., Oyese, E. G., Singh, E., Vinson, M., Yim, I., Turner, J. K., & Epling, J. W. (2023). A Scoping Review of Interventions to De-implement Potentially Harmful Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Healthcare Settings. MedRxiv: The Preprint Server for Health Sciences, 2023.07.29.23293362. https://doi.org/10.1101/2023.07.29.23293362

28. Rossi, L. A., Agustín Molina Rómoli, Bertona, A., Burgos, A., Scordo, W., & Elizondo, C. (2017). Does platelet-rich plasma decrease time to return to sports in acute muscle tear? A randomized controlled trial. 25(10), 3319–3325. https://doi.org/10.1007/s00167-016-4129-7

29. Sanderson, L. M., & Bryant, A. (2015). Effectiveness and safety of prolotherapy injections for management of lower limb tendinopathy and fasciopathy: a systematic review. Journal of Foot and Ankle Research, 8(1). https://doi.org/10.1186/s13047-015-0114-5

30. Tissue Engineering and Regenerative Medicine. (n.d.). Www.nibib.nih.gov. https://www.nibib.nih.gov/science-education/science-topics/tissue-engineering-and-regenerative-medicine#:~:text=Regenerative%20medicine%20is%20a%20broad

31. Topol, G. A., Reeves, K. D., & Hassanein, K. M. (2005). Efficacy of dextrose prolotherapy in elite male kicking-sport athletes with chronic groin pain. Archives of Physical Medicine and Rehabilitation, 86(4), 697–702. https://doi.org/10.1016/j.apmr.2004.10.007

32. Urzen, J. M., & Fullerton, B. D. (2016). Nonsurgical Resolution of a Bucket Handle Meniscal Tear: A Case Report. PM & R: The Journal of Injury, Function, and Rehabilitation, 8(11), 1115–1118. https://doi.org/10.1016/j.pmrj.2016.05.011

33. Y. Zhu, M. Yuan, H.Y. Meng, A.Y. Wang, Q.Y. Guo, Y. Wang, J. Peng,. (2013). Basic science and clinical application of platelet-rich plasma for cartilage defects and osteoarthritis: a review. Osteoarthritis and Cartilage, 21(11), 1627–1637. https://doi.org/10.1016/j.joca.2013.07.017

34. Yamaguchi, F. S. M., Shams, S., Silva, E. A., & Stilhano, R. S. (2019). PRP and BMAC for Musculoskeletal Conditions via Biomaterial Carriers. International Journal of Molecular Sciences, 20(21). https://doi.org/10.3390/ijms20215328

Author

Dr. Leah Linarelli ND

Naturopathic Physician

Medically Reviewed by