Research Studies
|
December 21, 2023

Study Reveals Brain's Remarkable Recovery from Alcohol Abuse: Insights into Cortical Thickness Improvements with Abstinence

Medically Reviewed by
Updated On
September 18, 2024

A recent study, spearheaded by Timothy C. Durazzo, has brought to light encouraging news about the brain's ability to recover from the adverse effects of prolonged alcohol consumption. The study, which used magnetic resonance imaging (MRI) to monitor changes in the brain, focused on individuals with alcohol use disorder (AUD). It revealed significant improvements in brain structure, particularly in cortical thicknessβ€”a crucial aspect of cognitive function. This improvement was observed in participants who maintained about 7.3 months of abstinence from alcohol.

[signup]

The core of the study's methodology revolved around the use of Magnetic Resonance Imaging (MRI), a non-invasive imaging technology that produces detailed images of the brain. MRI is particularly adept at showing contrasts between different soft tissues of the body, making it ideal for studying changes in the brain's structure.

For this study, the researchers employed MRI to analyze changes in cortical thickness. The cortex is the brain's outer layer, responsible for many complex cognitive functions such as memory, attention, thought, and consciousness. Cortical thickness, which refers to the thickness of this outer layer, can be an important indicator of brain health. Changes in cortical thickness are often associated with various neurological and psychiatric conditions.

The participants in the study, comprising 88 individuals with alcohol use disorder (AUD) and a control group of 45 people, underwent MRI scans. These scans were critical for measuring the cortical thickness in various regions of the brain. The study particularly focused on tracking changes in these measurements over the period of abstinence from alcohol, averaging about 7.3 months.

By comparing the MRI data from the start of the study to the data collected after this period of abstinence, the researchers were able to observe and quantify the changes in cortical thickness. This approach provided a clear picture of how abstaining from alcohol impacted the brain's structure, particularly in terms of recovery and improvement in cortical thickness.

This methodology, with its emphasis on precise, quantifiable measurements of brain structure, offered a robust way to assess the impact of alcohol abstinence on brain health, especially in comparison to previous research that might have relied more on subjective assessments or less direct methods of measuring brain health.

However, the recovery rate varied among participants, influenced by factors like the amount and duration of previous alcohol consumption and the presence of cardiovascular risk factors, which seemed to impede recovery in some brain regions.

While these findings are promising, the study's relatively small sample size does pose limitations. It suggests the need for further research to fully understand how improvements in cortical thickness relate to other factors, such as psychiatric conditions, cognitive function, and overall quality of life. Nonetheless, this research underscores the brain's remarkable capacity to heal from the impacts of alcohol abuse and the critical importance of sustained abstinence for optimal brain health.

A recent study, led by Timothy C. Durazzo, has provided encouraging insights into the brain's potential to recover from the effects of prolonged alcohol consumption. The study utilized magnetic resonance imaging (MRI) to observe changes in the brain, focusing on individuals with alcohol use disorder (AUD). It noted improvements in brain structure, particularly in cortical thicknessβ€”an important aspect of cognitive function. These improvements were observed in participants who maintained approximately 7.3 months of abstinence from alcohol.

[signup]

The core of the study's methodology involved the use of Magnetic Resonance Imaging (MRI), a non-invasive imaging technology that produces detailed images of the brain. MRI is particularly effective at showing contrasts between different soft tissues of the body, making it suitable for studying changes in the brain's structure.

For this study, the researchers used MRI to analyze changes in cortical thickness. The cortex is the brain's outer layer, responsible for many complex cognitive functions such as memory, attention, thought, and consciousness. Cortical thickness, which refers to the thickness of this outer layer, can be an important indicator of brain health. Changes in cortical thickness are often associated with various neurological and psychiatric conditions.

The participants in the study, comprising 88 individuals with alcohol use disorder (AUD) and a control group of 45 people, underwent MRI scans. These scans were essential for measuring the cortical thickness in various regions of the brain. The study particularly focused on tracking changes in these measurements over the period of abstinence from alcohol, averaging about 7.3 months.

By comparing the MRI data from the start of the study to the data collected after this period of abstinence, the researchers were able to observe and quantify the changes in cortical thickness. This approach provided insights into how abstaining from alcohol might impact the brain's structure, particularly in terms of recovery and improvement in cortical thickness.

This methodology, with its emphasis on precise, quantifiable measurements of brain structure, offered a robust way to assess the potential impact of alcohol abstinence on brain health, especially in comparison to previous research that might have relied more on subjective assessments or less direct methods of measuring brain health.

However, the recovery rate varied among participants, influenced by factors like the amount and duration of previous alcohol consumption and the presence of cardiovascular risk factors, which seemed to affect recovery in some brain regions.

While these findings are promising, the study's relatively small sample size suggests the need for further research to fully understand how improvements in cortical thickness relate to other factors, such as psychiatric conditions, cognitive function, and overall quality of life. Nonetheless, this research highlights the brain's potential to recover from the impacts of alcohol use and the importance of sustained abstinence for supporting brain health.

The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

Learn more

No items found.

Lab Tests in This Article

No lab tests!

Cleveland Clinic. (2022, May 23). Cerebral cortex: What it is, function & location. Cleveland Clinic. https://my.clevelandclinic.org/health/articles/23073-cerebral-cortex

Durazzo, T. C., Stephens, L. H., & Meyerhoff, D. J. (2023). Regional cortical thickness recovery with extended abstinence after treatment in those with alcohol use disorder. Alcohol. https://doi.org/10.1016/j.alcohol.2023.08.011

Mayo Clinic. (2021, September 4). MRI. Mayoclinic.org. https://www.mayoclinic.org/tests-procedures/mri/about/pac-20384768

Order from 30+ labs in 20 seconds (DUTCH, Mosaic, Genova & More!)
We make ordering quick and painless β€” and best of all, it's free for practitioners.

Latest Articles

View more on Research Studies
Subscribe to the magazine for expert-written articles straight to your inbox
Join the thousands of savvy readers who get root cause medicine articles written by doctors in their inbox every week!
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Are you a healthcare practitioner?
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Subscribe to the Magazine for free to keep reading!
Subscribe for free to keep reading, If you are already subscribed, enter your email address to log back in.
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Are you a healthcare practitioner?
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Trusted Source
Rupa Health
Medical Education Platform
Visit Source
Visit Source
American Cancer Society
Foundation for Cancer Research
Visit Source
Visit Source
National Library of Medicine
Government Authority
Visit Source
Visit Source
Journal of The American College of Radiology
Peer Reviewed Journal
Visit Source
Visit Source
National Cancer Institute
Government Authority
Visit Source
Visit Source
World Health Organization (WHO)
Government Authority
Visit Source
Visit Source
The Journal of Pediatrics
Peer Reviewed Journal
Visit Source
Visit Source
CDC
Government Authority
Visit Source
Visit Source
Office of Dietary Supplements
Government Authority
Visit Source
Visit Source
National Heart Lung and Blood Institute
Government Authority
Visit Source
Visit Source
National Institutes of Health
Government Authority
Visit Source
Visit Source
Clinical Infectious Diseases
Peer Reviewed Journal
Visit Source
Visit Source
Brain
Peer Reviewed Journal
Visit Source
Visit Source
The Journal of Rheumatology
Peer Reviewed Journal
Visit Source
Visit Source
Journal of the National Cancer Institute (JNCI)
Peer Reviewed Journal
Visit Source
Visit Source
Journal of Cardiovascular Magnetic Resonance
Peer Reviewed Journal
Visit Source
Visit Source
Hepatology
Peer Reviewed Journal
Visit Source
Visit Source
The American Journal of Clinical Nutrition
Peer Reviewed Journal
Visit Source
Visit Source
The Journal of Bone and Joint Surgery
Peer Reviewed Journal
Visit Source
Visit Source
Kidney International
Peer Reviewed Journal
Visit Source
Visit Source
The Journal of Allergy and Clinical Immunology
Peer Reviewed Journal
Visit Source
Visit Source
Annals of Surgery
Peer Reviewed Journal
Visit Source
Visit Source
Chest
Peer Reviewed Journal
Visit Source
Visit Source
The Journal of Neurology, Neurosurgery & Psychiatry
Peer Reviewed Journal
Visit Source
Visit Source
Blood
Peer Reviewed Journal
Visit Source
Visit Source
Gastroenterology
Peer Reviewed Journal
Visit Source
Visit Source
The American Journal of Respiratory and Critical Care Medicine
Peer Reviewed Journal
Visit Source
Visit Source
The American Journal of Psychiatry
Peer Reviewed Journal
Visit Source
Visit Source
Diabetes Care
Peer Reviewed Journal
Visit Source
Visit Source
The Journal of the American College of Cardiology (JACC)
Peer Reviewed Journal
Visit Source
Visit Source
The Journal of Clinical Oncology (JCO)
Peer Reviewed Journal
Visit Source
Visit Source
Journal of Clinical Investigation (JCI)
Peer Reviewed Journal
Visit Source
Visit Source
Circulation
Peer Reviewed Journal
Visit Source
Visit Source
JAMA Internal Medicine
Peer Reviewed Journal
Visit Source
Visit Source
PLOS Medicine
Peer Reviewed Journal
Visit Source
Visit Source
Annals of Internal Medicine
Peer Reviewed Journal
Visit Source
Visit Source
Nature Medicine
Peer Reviewed Journal
Visit Source
Visit Source
The BMJ (British Medical Journal)
Peer Reviewed Journal
Visit Source
Visit Source
The Lancet
Peer Reviewed Journal
Visit Source
Visit Source
Journal of the American Medical Association (JAMA)
Peer Reviewed Journal
Visit Source
Visit Source
Pubmed
Comprehensive biomedical database
Visit Source
Visit Source
Harvard
Educational/Medical Institution
Visit Source
Visit Source
Cleveland Clinic
Educational/Medical Institution
Visit Source
Visit Source
Mayo Clinic
Educational/Medical Institution
Visit Source
Visit Source
The New England Journal of Medicine (NEJM)
Peer Reviewed Journal
Visit Source
Visit Source
Johns Hopkins
Educational/Medical Institution
Visit Source
Visit Source

Hey practitioners! πŸ‘‹ Join Dr. Chris Magryta and Dr. Erik Lundquist for a comprehensive 6-week course on evaluating functional medicine labs from two perspectives: adult and pediatric. In this course, you’ll explore the convergence of lab results across different diseases and age groups, understanding how human lab values vary on a continuum influenced by age, genetics, and time. Register Here! Register Here.

Hey practitioners! πŸ‘‹ Join Dr. Terry Wahls for a 3-week bootcamp on integrating functional medicine into conventional practice, focusing on complex cases like Multiple Sclerosis. Learn to analyze labs through a functional lens, perform nutrition-focused physical exams, and develop personalized care strategies. Register Here.