Mental Health
|
December 29, 2023

Saffron For Depression: How This Beautiful Spice Can Help Manage Low Mood

Written By
Brittney Bertagna RN
Medically Reviewed by
Dr. Jessica Christie ND, CNS
Updated On
January 14, 2025

Is it possible to consider saffron as a complementary option to anti-depressants? This question has captivated the attention of many, as the search for effective and natural ways to support mental health continues. Depression affects millions of people worldwide, and while pharmacological treatments exist, their efficacy and side effects have raised concerns.

In fact, saffron has shown promising results in multiple studies, demonstrating a large positive effect size in supporting mood improvement when compared to placebo. However, before rushing to add saffron to your wellness routine, it is essential to approach it with caution and seek guidance from a healthcare professional. 

[signup]

What is Saffron?

Saffron is the dried stigma, or thread-like parts, of the flower Crocus sativus L. It has a long history of use as a spice, coloring agent, and in traditional practices. Saffron is considered one of the world's most expensive spices due to its cultivation and harvesting process, which is largely done by hand.

Traditionally, saffron has been used for thousands of years in various cultures. It has been used in contexts such as addressing cramps, asthma, menstruation disorders, liver health, and discomfort. 

The properties of saffron are attributed to its compounds, such as crocetin, crocins, and safranal, which have antioxidant and radical scavenger properties. These compounds may help support the body's defense against reactive oxygen species and pro-inflammatory cytokines, making saffron potentially beneficial in supporting overall health.

In recent years, there has been increased scientific attention given to saffron as a potential supportive agent for various health conditions, including cancer, cardiovascular health, and mood support. 

Research has shown that saffron has potential properties that may support antioxidant, mood-enhancing, and memory functions. It may also influence levels of certain neurotransmitters in the brain, such as serotonin, which can support mood balance.

Can Saffron Help With Mood Support?

The exact mechanism through which saffron supports mood is not fully understood, but it is believed to influence levels of certain neurotransmitters in the brain, including serotonin, which is involved in regulating mood. By potentially affecting serotonin reuptake, saffron may help maintain balanced levels of serotonin in the brain, contributing to mood support.

Can Saffron Help With Mood Support? Saffron may influence serotonin levels in the brain, supporting mood balance.

While saffron shows promise as a natural supplement for mood support, it is essential to consult with a healthcare professional before starting any new supplement. A functional medicine provider can provide personalized guidance based on your specific situation and help determine the best course of action.

How Does Saffron Support Mood?

Saffron is believed to support mood through its effects on neurotransmitters in the brain, particularly serotonin. Serotonin is a neurotransmitter that plays a crucial role in regulating mood. 

Low levels of serotonin have been associated with mood imbalances, and many mood-supporting medications work by influencing serotonin levels in the brain.

Saffron may influence serotonin levels by affecting its reuptake, which means that it helps keep serotonin in the brain for a longer period of time. This is similar to how some mood-supporting medications work, as they also influence serotonin reuptake.

Animal studies suggest that saffron can influence serotonin levels in the brain, and this mechanism of action is likely responsible for its mood-supporting effects. However, it is important to note that the exact mechanism through which saffron supports mood states in humans is still not fully understood.

By influencing serotonin levels, saffron may help support mood balance. It is worth mentioning that more research is needed to fully elucidate the physiological mechanisms involved in saffron's mood-supporting effects.

An Overview of The Current Research Findings 

Current research findings suggest that saffron shows promise as a potential support for mood balance. Several clinical trials have demonstrated that saffron supplementation can support mood in individuals with mood imbalances.

Several studies have demonstrated that saffron supplementation can produce similar support for mood balance compared to certain medications. A meta-analysis by Hausenblas et al. found that saffron supplementation significantly supported mood balance compared to a placebo. 

Another meta-analysis by Lopresti and Drummond confirmed these findings, showing that saffron had large supportive effects and similar efficacy when compared to certain medications.

Moreover, another study compared the effects of saffron supplementation in individuals with mood imbalances. The researchers found that saffron supplementation produced similar support for mood balance as certain medications.

Safety Profile of Saffron for Mental Health Support

When considering saffron supplementation for mood support, there are several safety considerations that should be taken into account. While saffron has demonstrated potential in supporting mood balance, it is important to be aware of potential risks and precautions.

Quality and Source: It is crucial to ensure that you are using a high-quality saffron supplement from a reputable source. This can help minimize the risk of contamination or adulteration.

Dosage: Adhering to the recommended dosage is important to avoid any potential adverse effects. Saffron is typically dosed at 30 mg/day to 60 mg/day. Always follow the instructions provided by the manufacturer or consult a healthcare professional for appropriate dosing guidance.

Allergies and Sensitivities: Individuals with known allergies or sensitivities to saffron or other related plants, such as the iris family, should exercise caution when considering saffron supplementation. It is recommended to consult with a healthcare professional if you have any known allergies or sensitivities.

Drug Interactions: Saffron may interact with certain medications, such as mood-supporting drugs, anti-anxiety drugs, or sedatives. It is important to inform your healthcare provider about any medications you are currently taking to assess potential interactions. They can help determine if saffron supplementation is appropriate for you.

Pregnancy and Breastfeeding: Limited information is available regarding the safety of saffron supplementation during pregnancy and breastfeeding. It is advised to exercise caution and consult with a healthcare professional before starting saffron supplementation if you are pregnant or breastfeeding.

Adverse Effects: While saffron is generally well-tolerated, some commonly reported adverse effects include anxiety, appetite fluctuation, sedation, nausea, headache, and hypomania. If you experience any unusual or severe side effects while taking saffron, it is important to discontinue use and seek medical attention.

Long-Term Safety: Longer-term trials are needed to more fully evaluate the safety of saffron for human consumption, especially in the context of mental health support. It is important to monitor for any potential long-term effects and consult with a healthcare professional for ongoing evaluation and guidance.

[signup]

Saffron For Mood Support: Key Takeaways

Saffron holds promise as a potential herbal option to support mood balance. Its bioactive compounds have demonstrated positive effects in supporting mood, and it may have a similar efficacy to some conventional mood-supporting medications. However, caution must be exercised when considering saffron supplementation for mental health support.

Before incorporating saffron into your wellness routine, it is crucial to consult with a healthcare professional. They can provide personalized guidance based on your specific situation, help determine the appropriate dosage, and assess any potential interactions or risks. 

The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

Learn more

No items found.

Lab Tests in This Article

No lab tests!

1. 2023, J. D. (n.d.). Saffron allergy | allergy resources. Www.allergyresources.co.uk. Retrieved December 29, 2023, from https://www.allergyresources.co.uk/Saffron.php

2. Ann Hausenblas, H., Heekin, K., Mutchie, H. L., & Anton, S. (2015). A systematic review of randomized controlled trials examining the effectiveness of saffron (Crocus sativus L.) on psychological and behavioral outcomes. Journal of Integrative Medicine, 13(4), 231–240. https://doi.org/10.1016/s2095-4964(15)60176-5

3. Brown, W. (2022). Saffron research analysis. Examine.com. https://examine.com/supplements/saffron/

4. Cloyd, J. (2023a, August 9). A root cause medicine protocol for patients with depression: Comprehensive lab testing, therapeutic diet, and supplements. Rupa Health. https://www.rupahealth.com/post/a-root-cause-medicine-protocol-for-patients-with-depression-comprehensive-lab-testing-therapeutic-diet-and-supplements

5. Cloyd, J. (2023b, December 15). How to interpret a neurotransmitter test. Rupa Health. https://www.rupahealth.com/post/how-to-interpret-a-neurotransmitter-test

6. Diorio, B. (2022, September 6). How to increase your serotonin levels naturally. Rupa Health. https://www.rupahealth.com/post/how-to-increase-your-serotonin-naturally

7. El Midaoui, A., Ghzaiel, I., Vervandier-Fasseur, D., Ksila, M., Zarrouk, A., Nury, T., Khallouki, F., El Hessni, A., Ibrahimi, S. O., Latruffe, N., Couture, R., Kharoubi, O., Brahmi, F., Hammami, S., Masmoudi-Kouki, O., Hammami, M., Ghrairi, T., Vejux, A., & Lizard, G. (2022). Saffron (Crocus sativus L.): A source of nutrients for health and for the treatment of neuropsychiatric and age-related diseases. Nutrients, 14(3), 597. https://doi.org/10.3390/nu14030597

8. Greenan, S. (2021, November 19). What is functional medicine? How do I find A functional medicine practitioner? Rupa Health. https://www.rupahealth.com/post/what-is-functional-medicine

9. Griffin, R. M. (n.d.). Saffron: Uses and risks. WebMD. https://www.webmd.com/vitamins-and-supplements/saffron-uses-and-risks

10. Hausenblas, H. A., Saha, D., Dubyak, P. J., & Anton, S. D. (2013). Saffron (Crocus sativus L.) and major depressive disorder: A meta-analysis of randomized clinical trials. Journal of Integrative Medicine, 11(6), 377–383. https://doi.org/10.3736/jintegrmed2013056

11. Health benefits of saffron. (2023, August 2). WebMD. https://www.webmd.com/diet/health-benefits-saffron

12. Henry, K. (2023, February 21). An integrative medicine approach to depression. Rupa Health. https://www.rupahealth.com/post/an-integrative-medicine-approach-to-depression

13. Lopresti, A. L., & Drummond, P. D. (2014). Saffron (Crocus sativus) for depression: A systematic review of clinical studies and examination of underlying antidepressant mechanisms of action. Human Psychopharmacology: Clinical and Experimental, 29(6), 517–527. https://doi.org/10.1002/hup.2434

14. Monchaux De Oliveira, C., Pourtau, L., Vancassel, S., Pouchieu, C., Capuron, L., Gaudout, D., & Castanon, N. (2021). Saffron extract-induced improvement of depressive-like behavior in mice is associated with modulation of monoaminergic neurotransmission. Nutrients, 13(3), 904. https://doi.org/10.3390/nu13030904

15. Siddiqui, M., Saleh, M. M., Basharuddin, S. B. B., Zamri, S. B., Mohd Najib, M. bin, Che Ibrahim, M., binti Mohd Noor, N., Binti Mazha, H., Mohd Hassan, N., & Khatib, A. (2018). Saffron (Crocus sativus L.): As an antidepressant. Journal of Pharmacy and Bioallied Sciences, 10(4), 173. https://doi.org/10.4103/jpbs.jpbs_83_18

16. Yoshimura, H. (2023a, April 10). Integrative medicine approaches to managing anxiety and depression naturally. Rupa Health. https://www.rupahealth.com/post/integrative-medicine-approaches-to-managing-anxiety-and-depression-naturally

17. Yoshimura, H. (2023b, July 17). Using functional medicine as personalized medicine. Rupa Health. https://www.rupahealth.com/post/using-functional-medicine-as-personalized-medicine

18. Yoshimura, H. (2023c, September 6). Top labs to run bi-annually on your patients who suffer from major depressive disorder. Rupa Health. https://www.rupahealth.com/post/top-labs-to-run-bi-annually-on-your-patients-who-suffer-from-major-depressive-disorder

Order from 30+ labs in 20 seconds (DUTCH, Mosaic, Genova & More!)
We make ordering quick and painless — and best of all, it's free for practitioners.

Latest Articles

View more on Mental Health
Subscribe to the magazine for expert-written articles straight to your inbox
Join the thousands of savvy readers who get root cause medicine articles written by doctors in their inbox every week!
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Are you a healthcare practitioner?
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Subscribe to the Magazine for free to keep reading!
Subscribe for free to keep reading, If you are already subscribed, enter your email address to log back in.
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Are you a healthcare practitioner?
Thanks for subscribing!
Oops! Something went wrong while submitting the form.

Hey practitioners! 👋 Join Dr. Chris Magryta and Dr. Erik Lundquist for a comprehensive 6-week course on evaluating functional medicine labs from two perspectives: adult and pediatric. In this course, you’ll explore the convergence of lab results across different diseases and age groups, understanding how human lab values vary on a continuum influenced by age, genetics, and time. Register Here! Register Here.