Medication Fact Sheets
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February 13, 2025

Nasal Spray 101: Uses, Benefits, and Tips

Written By
Erin Coleman RD
Medically Reviewed by
Updated On
February 21, 2025

We all know that feeling—stuffiness, sneezing, congestion. You’re tired of tissues, and the usual remedies just aren’t cutting it. Imagine breathing freely without the constant discomfort of nasal congestion. Nasal sprays target congestion at its source to provide relief. Whether it’s seasonal allergies or a cold or flu that’s got you down, these sprays help clear things up.

Nasal sprays are common remedies for various nasal issues and super easy to use; just spray, breathe, and get back to your daily activities. This article provides an in-depth exploration of nasal sprays, their types, benefits, proper usage, and considerations to help you make informed decisions about your respiratory health.

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Understanding Nasal Sprays

Learning more about nasal sprays helps you make educated choices about their use.

What Are Nasal Sprays?

Nasal sprays often contain medicine you spray in your nasal passages to ease stuffiness caused by:

Numerous nasal sprays are available to choose from, depending on the severity of your congestion and its cause.  

How Nasal Sprays Work

Nasal sprays have several mechanisms of action. The spray absorbs into your nasal passages and clears stuffiness by reducing swelling, narrowing blood vessels in your nose, opening your airways, or clearing mucus.

Types of Nasal Sprays

Some of the most common forms of nasal sprays include:

Saline Nasal Sprays

Saline sprays contain a saline (salt and water) solution They keep your nose moist, but may or may not help with nasal congestion. Saline sprays are often beneficial for individuals with epistaxis (nosebleeds) and dry nasal passages.

Decongestant Nasal Sprays

Nasal decongestant sprays offer temporary relief from congestion by constricting nose blood vessels and reducing nasal swelling. Examples include phenylephrine (Neo-Synephrine®) and oxymetazoline hydrochloride (Afrin®, Dristan® and Sinex™). 

Such sprays are available over-the-counter and are useful for short periods of congestion due to a cold, the flu, or bad allergy flare-ups. 

However, avoid using decongestants for more than 3-4 days in a row as they can be addictive or cause rebound nasal congestion. 

This rebound effect can lead to worsening or long-lasting congestion, sneezing, a bitter taste or smell, nasal irritation, stinging, burning, and runny nose. Major side effects like tremors, persistent nosebleeds, unusual sweating, or heart rate changes warrant a consultation with a doctor. 

Steroid Nasal Sprays

Nasal steroid sprays are often a first line of defense for treating allergies. They work by reducing inflammation within your nasal passages and offering relief from congestion, watery eyes, runny nose, sneezing, and more. Examples include triamcinolone (Nasacort®), fluticasone (Flonase®), budesonide (Rhinocort®), and mometasone (Nasonex®).

Many steroid sprays are available over-the-counter and it’s important to use them once or twice daily for several weeks to be most effective. These sprays are non habit-forming. Begin using them a few weeks before allergy season. While steroids may cause side effects, such as cataracts, the risks from nasal sprays are lower than with oral steroids. 

Antihistamine Nasal Sprays

Antihistamine nasal sprays are similar to oral antihistamines. They block histamine receptors to ease unpleasant allergy symptoms. Examples include olopatadine (Patanase®) that requires a prescription and azelastine (Astepro® and Astelin®). 

Similar to steroid sprays, antihistamine sprays aren’t habit-forming and you can use them daily for optimal allergy-reducing results. But some require a prescription. A potential side effect is a bitter taste. 

Combination Sprays

Combination sprays may contain both antihistamines and nasal steroids and are available by prescription. 

Nasal Cromolyn Sodium Spray

Cromolyn sodium is a mast cell inhibitor that helps prevent symptoms of allergies and eases nasal congestion, a runny nose, and sneezing in individuals with allergies. Its method of action is to prevent mast cells from releasing allergic mediators. 

Cromolyn sodium spray works best when treatment begins before exposure to allergens. It’s available over-the-counter and a common side effect is a bad taste or nasal burning. 

Anticholinergic Nasal Spray

Anticholinergic sprays treat a runny nose in individuals with allergic and nonallergic reactions. They block acetylcholine, decreasing nasal passage gland secretions. Side effects include a bad taste or dry mouth. 

Prescription vs. Over-the-Counter Sprays

Over-the-counter nasal sprays are often as effective as many prescription sprays to reduce nasal congestion. If you must use these sprays for more than a few months at a time, let your healthcare provider know and ask which sprays are best suited for your individualized needs.

Prescription nasal sprays may be a good option if your insurance covers them, you require combination sprays, you have nasal polyps, or over-the-counter sprays haven’t been effective.

Over-the-counter antihistamine and steroid sprays often work well for treating allergy symptoms and are safe for everyday use when sprayed in suggested dosages. Decongestant nasal sprays help relieve temporary congestion, but aren’t ideal for allergies as they should only be used for up to 3-4 days at a time. 

Benefits of Using Nasal Sprays

The benefits of using nasal sprays include:

Relief from Nasal Congestion

Nasal sprays alleviate congestion by constricting blood vessels in your nose to reduce nasal swelling. They help you breathe easier, feel better, and enjoy simple daily activities without debilitating symptoms.

Allergy Management

Many nasal sprays help control allergic reactions, particularly a runny or stuffy nose due to seasonal allergies. Sprays designed for allergies are approved for everyday use and work most effectively when used on a regular basis.

Enhanced Breathing and Sleep Quality

Because nasal sprays can help you breathe easier, they have a beneficial impact on overall respiratory health and sleep quality. Better sleep leaves you feeling more energized and may reduce the risk of certain chronic diseases — such as dementia, type 2 diabetes, heart disease, obesity, and some cancers (colon, breast, prostate, ovarian, etc.).

Convenience and Accessibility

Nasal sprays are easy to use and convenient, making them a popular choice among many children, teeangers, and adults struggling with allergies or nasal congestion caused by colds and flu. Side effects are usually minimal. 

Proper Usage of Nasal Sprays

Using nasal sprays exactly as directed is vital to ensure they work as designed and avoid bothersome side effects or complications — such as irritation, burning, and worsening or long-lasting nasal congestion. 

Step-by-Step Guide to Using Nasal Sprays

To use nasal sprays effectively, follow these simple step-by-step instructions:

  1. Gently blow your nose to clear the nasal passages.
  2. Shake the nasal spray bottle (if the instructions ask you to) or squirt out a tiny amount of the spray.
  3. Place the bottle’s opening under one of your nostrils. Point the spray upward toward the back of your nose.
  4. Gently pump or squeeze the bottle and inhale gently while keeping your mouth closed.
  5. Repeat with the other nostril. 

Avoid sharing nasal sprays with other people and keep the bottle clean. Wipe it down after each use before placing the cap back on. 

Dosage and Frequency

It’s important to use nasal sprays exactly as instructed on the packaging. Some are designed for once or twice daily use, but use decongestants just a few days at a time. Some mast cell inhibitors can be used up to six times daily. Look at the age requirements and check with your doctor before offering nasal sprays to children. 

Common Mistakes to Avoid

It’s helpful to understand common mistakes people make to ensure optimal nasal spray effectiveness. For example, avoid aiming the spray at the middle part of your nose and don’t tilt your head back when spraying. Don’t sniff deeply when spraying medicine into your nasal passages and avoid blowing your nose right after using the spray. 

Storing and Handling Nasal Sprays

To maximize effectiveness, store nasal sprays with the cap on as instructed on the product’s packaging. Keep them at room temperature away from moisture, heat, and direct light. Don’t freeze nasal sprays and keep them out of the reach of children. Throw these medicines away after the expiration date.

Potential Side Effects and Risks

Side effects and compilations to be aware of include:

Common Side Effects

Common side effects of using nasal sprays vary by the type and quantity you use and may include:

  • Temporary discomfort
  • Irritation
  • Cataracts or glaucoma
  • Bitter or bad taste
  • Dry mouth
  • Rebound nasal congestion (decongestants)
  • Headaches
  • Nose stinging, burning, or dryness
  • Nausea
  • Vomiting
  • Diarrhea
  • Sore throat
  • Dizziness
  • Bloody nasal mucus

Persistent nosebleeds, sweating, tremors, changes in heart rate, or signs of an allergic reaction (itching, skin rash, swelling of the face or throat, hives, etc.) are side effects that warrant a visit to your healthcare provider. 

Long-Term Risks

Potential long-term risks associated with some nasal spray include children growing at a slower rate and rebound effects (chronic stuffiness) due to overusing decongestants. Cataracts and glaucoma are eye diseases that are more likely in individuals using some types of nasal sprays, including steroid sprays. 

Who Should Avoid Certain Nasal Sprays

Not everyone is a candidate for nasal sprays. People who may need to avoid them include those with high blood pressure, diabetes, hyperthyroidism — and individuals taking certain medications. 

Check in with your doctor to ensure nasal sprays are safe for you or your child and which are likely the most effective. Avoid sprays if your nasal passages become damaged from overuse.

Addressing Counter Arguments

Decongestant nasal sprays can become habit-forming when overusing them, meaning your body builds up a tolerance over time. When you stop using these sprays after overuse, the nasal passages begin to swell and become more congested. It’s difficult to stop using decongestants after overuse, and you might need medical supervision to effectively wean off. 

Choosing the Right Nasal Spray for Your Needs

Numerous sprays are available to choose from based on your individualized needs.

Assessing Your Symptoms

Identifying your symptoms and their cause helps determine which nasal sprays are the best option for you. If you experience constant nasal congestion because of seasonal allergies, you may need steroid sprays or antihistamines. 

When you have symptoms of cold or flu (congestion paired with coughing, a sore throat, fever, or body aches) or a severe allergy flare-up, using a decongestant for a few days may be your best bet. Some nasal sprays are fast-acting, while others may take several hours, days, or weeks to provide full relief. 

Consulting Healthcare Professionals

It’s helpful to consult with a healthcare provider before using nasal sprays, partially for children and for individuals requiring daily use to treat allergies. 

See a doctor immediately if you experience changes in heart rate, unusual sweating, frequent nosebleeds, tremors, signs of an allergic reaction — or allergy symptoms that haven’t subsided after a week or two of using nasal sprays.

Comparing Popular Brands and Products

Examples of popular nasal spray options on the market and their uses include:

The best choice for you is based on your symptoms, their cause, and a discussion with your doctor.

Cost vs. Effectiveness

The cost of various nasal sprays depends on whether they’re over-the-counter or prescription, generic vs. name brand, where you buy them, and the type of nasal spray you purchase. Prices may range from $10-$600. If your health insurance pays for prescription nasal sprays, this may be the cheapest, most effective option. Chat with your healthcare provider to be sure. 

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Key Takeaways

  • Nasal sprays’ key benefits include easier breathing, convenience, effectiveness, and a better quality of life in people struggling with seasonal allergies, colds, flu, and other common causes of nasal congestion. Such sprays are widely available over-the-counter and via prescription. 
  • However, overuse of some sprays is a concern, leading to chronic congestion or other complications. It’s vital to use nasal sprays exactly as instructed for best results and to avoid worsening symptoms or bothersome side effects.
  • It’s highly important to make informed choices regarding your nasal health and overall well-being.
  • Consult with a medical professional to determine the best nasal spray for your specific needs and share your experiences or questions in the comments below!
The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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