Immune Support
|
March 5, 2025

Immunodeficiency Disorders: A Comprehensive Guide

Medically Reviewed by
Updated On
March 26, 2025

Staying healthy involves more than just eating well and exercising. It also involves supporting your immune system. 

For individuals with immunodeficiency disorders, maintaining immune system function can be an ongoing challenge. Although these conditions may not always be visible, they can significantly affect overall health. For example, a common cold may be a mild inconvenience for most, but even a minor illness can pose a serious risk for someone with a compromised immune system.

This guide discusses immunodeficiency disorders, including their types, diagnosis, management strategies, and preventive measures to help reduce the risk of infections and improve overall quality of life.

[signup]

What Are Immunodeficiency Disorders?

Immunodeficiency disorders occur when the immune system is unable to function effectively. They can affect individuals of all ages and backgrounds. Some are inherited, while others develop later in life. Though living with a weakened immune system can be difficult, many individuals lead fulfilling lives with the proper care and support. These conditions can be classified into two main categories: primary and secondary immunodeficiency.

Primary vs. Secondary Immunodeficiency

  • Primary Immunodeficiency Disorders (PIDs)  are usually inherited and present from birth. These disorders are caused by genetic defects that affect the immune system's ability to function properly.

  • Secondary Immunodeficiency Disorders (SIDs) develop later in life due to external factors, such as infections, medications, or other health conditions.

Common Types of Immunodeficiency Disorders

There are many types of immunodeficiency disorders, each affecting different aspects of the immune system. These conditions can range from mild to severe, and their symptoms vary depending on the condition. Some of the most common ones include:

Severe Combined Immunodeficiency (SCID) 

SCID is a severe primary immunodeficiency that involves defects in both T-cells and B-cells, essential immune system components. Children with SCID are highly vulnerable to infections. Bone marrow transplants may be an option for some individuals with severe forms of SCID.

Common Variable Immunodeficiency (CVID)

CVID is a primary immunodeficiency that typically develops in adulthood. Individuals with CVID have low levels of immunoglobulins (antibodies), increasing their risk of respiratory infections, autoimmune diseases, and some cancers.

X-linked Agammaglobulinemia (XLA)

This primary immunodeficiency mainly affects males because it is associated with the X chromosome. XLA is caused by a genetic mutation that disrupts the development of B-cells. As a result, individuals with this disorder have very low levels of immunoglobulins, which increases their susceptibility to bacterial infections, especially during childhood.

IgA Deficiency

IgA deficiency is the most common type of antibody deficiency. Individuals with this condition have low or absent levels of immunoglobulin A (IgA), an antibody that plays a key role in mucosal immunity. Many with this condition experience few or no symptoms, while others may suffer from frequent respiratory or gastrointestinal infections.

Human Immunodeficiency Virus (HIV) / Acquired Immunodeficiency Syndrome (AIDS)

HIV is a secondary immunodeficiency caused by a virus that targets and destroys CD4 T-cells, weakening the immune system. Without treatment, HIV progresses to AIDS, characterized by severe immune dysfunction and increased susceptibility to opportunistic infections.

Causes and Risk Factors

The causes of immunodeficiency disorders differ depending on the type.

Genetic Factors

There are over 430 primary immunodeficiencies (PIDs), each caused by genetic mutations inherited from one or both parents. These mutations can affect the immune system's ability to produce antibodies, develop white blood cells properly, or coordinate immune responses.

Environmental and Acquired Causes

Secondary immunodeficiencies result from external factors, including:

  • Infections like HIV/AIDS, Hepatitis C, and Tuberculosis (TB)
  • Medications such as immunosuppressants and chemotherapy
  • Chronic medical conditions like autoimmune diseases (e.g., rheumatoid arthritis, lupus), diabetes, chronic kidney disease (CKD), and cancer
  • Exposure to environmental toxins such as cigarette smoke, heavy metals, pesticides, and mold
  • Malnutrition, or inadequate intake of essential nutrients

Symptoms and Diagnosis

Immunodeficiency disorders can present in various ways, and understanding the symptoms helps identify these conditions. However, the signs of immunodeficiency are often subtle and can be mistaken for common illnesses.

Recognizing the Symptoms

The symptoms of immunodeficiency disorders vary depending on the condition. However, common signs of a weakened immune system include recurring infections, which can affect various parts of the body, such as:

  • Respiratory infections (e.g., frequent pneumonia or sinus infections)
  • Skin infections (e.g., abscesses or boils)
  • Gastrointestinal issues (e.g., chronic diarrhea or persistent stomach infections)

In addition to infections, individuals may experience delayed recovery from illnesses, such as a cold that lingers for weeks or a mild infection that worsens. Fatigue, caused by the body's ongoing battle with infections, is also a common symptom. However, these symptoms can also appear in other health conditions. If symptoms persist, it's essential to consult a healthcare provider for proper evaluation.

Each type of immunodeficiency disorder presents unique symptoms depending on the immune system components affected. Here are examples of some common conditions:

  • SCID usually presents in infancy with severe, frequent infections. Affected babies may struggle with even minor infections, often experiencing chronic conditions like skin rashes, diarrhea, and respiratory infections.

  • CVID symptoms can range from frequent sinus and lung infections to autoimmune conditions such as rheumatoid arthritis. GI issues, such as Crohn's disease, are also common.

  • XLA-affected individuals may experience recurrent bacterial infections, especially ear infections, pneumonia, and sepsis, often beginning in childhood.

  • IgA Deficiency may present with no symptoms for some, while others may suffer from recurrent respiratory or GI infections.
  • In the early stages, HIV may present with flu-like symptoms, including fever, swollen lymph nodes, and sore throat. Individuals may experience symptoms like weight loss, persistent diarrhea, and opportunistic infections as the disease progresses.

Diagnostic Procedures

Diagnosing an immunodeficiency disorder typically involves clinical evaluations, lab tests, and sometimes genetic testing. 

Laboratory Tests and Biomarkers

Blood tests are a primary tool for diagnosing immunodeficiency disorders. One standard test measures immunoglobulin levels. Individuals with immunodeficiencies may have low or absent antibody levels. Blood tests can also assess the number and function of white blood cells, such as T-cells and B-cells, which are essential for immune response.

Additional tests may look for signs of chronic infection, inflammation, or biomarkers linked to specific immunodeficiencies. For example, complement protein tests can help diagnose certain primary immunodeficiencies, while blood cultures may identify persistent infections.

Genetic Testing and Imaging

Genetic testing may be necessary to identify mutations in some immunodeficiencies. Since many primary immunodeficiencies are inherited, genetic testing helps confirm the diagnosis and assess any risk to family members.

In addition to blood and genetic tests, imaging may assess organ damage caused by chronic infections or autoimmune responses. For example, chest X-rays can detect lung damage from repeated respiratory infections, and imaging may evaluate GI issues or other affected areas.

Treatment and Management

Managing immunodeficiency disorders requires a combination of medical treatments and lifestyle adjustments to minimize the risk of infections, manage symptoms, and improve quality of life.

Medical Treatments

Effective treatment often requires ongoing care, including medications and therapies to support the immune system and prevent infections.

Immunoglobulin Replacement Therapy

Immunoglobulin replacement therapy (IRT) is commonly used for individuals with conditions like CVID or XLA that result in low antibody levels. Immunoglobulins are proteins that help target infections.

In this therapy, patients receive regular infusions of immunoglobulins from healthy donors to replenish the missing antibodies. Infusion schedules vary depending on the severity of the condition. Depending on individual needs, the therapy can be administered either intravenously (IVIg) or as a subcutaneous injection (SCIg).

Although IRT does not cure the disorder, it helps reduce the frequency and severity of infections.

Antiviral and Antibiotic Treatments

In addition to immunoglobulin therapy, individuals with immunodeficiency disorders often use antiviral, antibiotic, and sometimes antifungal medications to manage infections. These treatments help prevent or address the infections that those with weakened immune systems are more susceptible to. 

For example, individuals with SCID or HIV/AIDS may require antiviral medications to control viral infections, while antibiotics are commonly prescribed for bacterial infections. These medications do not treat the underlying immunodeficiency but are critical in preventing infections and improving overall health.

Lifestyle and Supportive Care

Maintaining a healthy lifestyle through proper nutrition and gentle exercise can help strengthen overall well-being, improve resilience, and reduce complications. This should be part of a comprehensive care plan with a healthcare provider.

Nutritional Support and Exercise

A balanced diet and physical activity are essential for overall health, especially for those with immunodeficiency disorders. Proper nutrition supports the immune system and helps the body recover from illnesses.

Individuals with immunodeficiencies may be at higher risk for malnutrition due to chronic infections or difficulty absorbing nutrients. Nutritional support can be customized to the individual's needs, particularly those with GI issues.

When done appropriately, exercise can improve circulation, support lung function, and reduce stress. It's important to consult with healthcare providers to determine safe physical activity levels, as overexertion may increase the risk of complications. Gentle exercises like walking, yoga, or swimming can be beneficial.

Psychological Support and Counseling

The emotional impact of living with an immunodeficiency disorder is significant. Stress, anxiety, and social isolation can take a toll on mental health. Counseling and therapy offer coping strategies to manage these emotional challenges. Support groups are also valuable, providing opportunities to connect with others who understand the experience of living with a chronic condition.

Addressing mental health concerns through therapy can improve overall well-being, strengthen coping skills, and support a positive outlook on life.

Living with Immunodeficiency Disorders

Living with an immunodeficiency disorder requires managing day-to-day challenges and minimizing the risk of infections. With the right strategies, individuals can maintain a balanced quality of life.

Daily Life and Preventative Measures

For individuals with immunodeficiency disorders, everyday activities often require extra precautions. Key strategies include:

  • Practicing good hygiene (e.g., regular hand washing, using hand sanitizers)
  • Wearing masks in public spaces
  • Avoiding contact with sick individuals
  • Establishing routines for medical care, including medication schedules and doctor visits, to stay on track without becoming overwhelmed.

These practices help reduce the risk of infections and allow individuals to continue leading fulfilling lives while managing their condition.

Vaccinations and Immunizations

Vaccines play an essential role in reducing the risk of infections. Individuals with immunodeficiency disorders should consult their healthcare provider to determine which vaccines are safe and appropriate. Some vaccines, such as live vaccines, may not suit everyone. However, staying current on recommended vaccines, like those for flu and pneumonia, can help reduce the risk of severe infections.

Public Health and Advocacy

Raising awareness and advocating for individuals with immunodeficiency disorders is essential for improving healthcare access, resources, and support. Educational campaigns help reduce stigma, promote understanding, and encourage protective health behaviors.

Organizations like the Immune Deficiency Foundation (IDF) and the Advocacy & Awareness for Immune Disorders Association (AAIDA) are leaders in supporting individuals with immunodeficiencies. The IDF focuses on education, research funding, and policy advocacy, while AAIDA works to increase awareness and research for immune disorders.

Advocacy groups and policymakers are critical in shaping policies that improve healthcare access and protect patient rights. These efforts ensure individuals have the resources to manage their condition and live healthier lives.

Advances in Research and Potential Future Therapies

Recent advances in genetic research, including gene therapy and DNA sequencing technologies, have made diagnosing PIDs more efficient and affordable. While promising, these treatments are still being studied, and results may vary. These developments have helped doctors recognize that PIDs involve infection risks and other health issues, prompting increased collaboration across medical disciplines.

Awareness of PID symptoms, especially in cases with a family history, has led to earlier diagnoses. Newborn screening for severe forms of primary immunodeficiencies allows for early detection and intervention, reducing infection risk. Advocacy efforts have also helped push for the inclusion of PID diagnostic tests on essential healthcare lists.

Ongoing research in stem cell transplants, gene therapy, and enhanced immunoglobulin treatments have improved treatment options. These therapies contribute to a better quality of life for individuals with PIDs by offering more effective options with fewer side effects. However, challenges remain, particularly when patients require immune-suppressing treatments while managing a weakened immune system.

Studies suggest that advances in gene editing and biological drugs have significantly expanded our understanding of inborn errors of immunity (IEIs). As a result, targeted treatments are becoming more widely used alongside traditional therapies. Additionally, innovations in stem cell transplantation and gene therapy are improving treatment outcomes, offering new hope for individuals affected by PIDs.

Gene therapy has shown promise by using a patient's stem cells, modified to correct the genetic defect causing the disorder. Recent advances with lentiviral vectors have made gene therapy safer and more effective, with fewer side effects than earlier methods. Gene therapy has successfully treated several PIDs, including severe immune disorders like SCID and Wiskott-Aldrich Syndrome

Today, gene therapy is as effective, if not more, than traditional stem cell treatments. With continued progress, it is expected to provide even more reliable therapies for a growing list of PIDs.

[signup]

Key Takeaways

  • Immunodeficiency disorders are a range of conditions that impact the immune system, leading to a higher risk of infections and other health complications.
  • Primary immunodeficiencies (PIDs) are inherited at birth due to genetic mutations. In contrast, secondary immunodeficiencies (SIDs) can develop later in life due to other health conditions or treatments that weaken the immune system.
  • Both PIDs and SIDs may cause frequent infections, delayed recovery, and, in some cases, organ-specific issues. Early detection through screening and increased awareness is key for monitoring these conditions and minimizing associated risks.
  • Advancements in treatments, such as gene therapy, stem cell transplants, and immunoglobulin therapies, enhance outcomes for individuals with immunodeficiencies.
The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

Learn more

No items found.

Lab Tests in This Article

No lab tests!

AAIDA  - National Organization for Rare Disorders. (2025). National Organization for Rare Disorders. https://rarediseases.org/organizations/advocacy-awareness-for-immune-disorders-association/

Achuff, J. (2024, March 20). The Gentle Power of Tai Chi: A Promising Approach to Blood Pressure Management. Rupa Health. https://www.rupahealth.com/post/the-gentle-power-of-tai-chi-a-promising-approach-to-blood-pressure-management

Antibodies: Definition, Types & Function. (2022). Cleveland Clinic. https://my.clevelandclinic.org/health/body/22971-antibodies#overview

Bertagna, B. (2024, February 28). Slippery Elm for Sore Throat Relief: Does It Really Work? Rupa Health. https://www.rupahealth.com/post/slippery-elm-for-sore-throat-relief-does-it-really-work

Bryant, A. (2024a, August 26). Secretory IgA: Understanding High and Low Levels, Causes, and Treatment Options. Rupa Health. https://www.rupahealth.com/post/secretory-iga-understanding-high-and-low-levels-causes-and-treatment-options

Bryant, A. (2024b, September 24). Symptoms of rheumatoid arthritis: Recognizing the early signs. Rupa Health. https://www.rupahealth.com/post/symptoms-of-rheumatoid-arthritis-recognizing-the-early-signs

Bryant, A. (2024c, December 9). Cold and Flu Treatment Guide: From Prevention to Recovery. Rupa Health. https://www.rupahealth.com/post/cold-and-flu-treatment-guide-from-prevention-to-recovery

Bucciol, G., & Meyts, I. (2020). Recent advances in primary immunodeficiency: from molecular diagnosis to treatment. F1000Research, 9, 194. https://doi.org/10.12688/f1000research.21553.1

CDC. (2024a). Seasonal Flu Vaccine Basics. Influenza (Flu). https://www.cdc.gov/flu/vaccines/index.html

CDC. (2024b, January 24). About HIV. CDC. https://www.cdc.gov/hiv/about/index.html

Christie, J. (2024, November 29). How Miconazole Nitrate Treats Fungal Infections Effectively. Rupa Health. https://www.rupahealth.com/post/how-miconazole-nitrate-treats-fungal-infections-effectively

Christie, J. (2025, February 25). Fungal Infections: Causes & Treatments. Rupa Health. https://www.rupahealth.com/post/fungal-infections-causes-treatments

Clark, M. (2019). Severe Combined Immunodeficiency (for Parents) - KidsHealth. Kidshealth.org. https://kidshealth.org/en/parents/severe-immunodeficiency.html

Cloyd, J. (2023a, October 2). A Functional Medicine Approach to Stress Management. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-stress-management

Cloyd, J. (2023b, December 1). How to Interpret CBC Results: A Comprehensive Guide. Rupa Health. https://www.rupahealth.com/post/how-to-interpret-cbc-results-a-comprehensive-guide

Cloyd, J. (2024, September 17). Enhancing Psychological Wellbeing Through Exercise: The Role of Self-Esteem. Rupa Health. https://www.rupahealth.com/post/enhancing-psychological-wellbeing-through-exercise-the-role-of-self-esteem

Cloyd, J. (2025, January 28). Your Guide to the Pneumonia Vaccine: What You Should Know. Rupa Health. https://www.rupahealth.com/post/your-guide-to-the-pneumonia-vaccine-what-you-should-know

Common Variable Immunodeficiency (CVID): Cause & Treatment. (2024, July 23). Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/21143-common-variable-immunodeficiency-cvid#overview

Cox, A. (2022, October 18). Diet and autoimmune disease: What’s the connection? Rupa Health. https://www.rupahealth.com/post/the-autoimmune-protocol-diet-who-could-benefit-from-it

Daglis, S. (2024a, September 2). The Impact of Social Isolation and Loneliness on Memory in Aging Populations. Rupa Health. https://www.rupahealth.com/post/the-impact-of-social-isolation-and-loneliness-on-memory-in-aging-populations

Daglis, S. (2024b, December 9). Genetic Mutation Identified as Key Trigger for Early-Onset Lupus. Rupa Health. https://www.rupahealth.com/post/genetic-mutation-identified-as-key-trigger-for-early-onset-lupus

Daglis, S. (2025, February 5). What Is Mycoplasma Pneumoniae? Causes, Symptoms, & Solutions. Rupa Health. https://www.rupahealth.com/post/what-is-mycoplasma-pneumoniae-causes-symptoms-solutions

DeCesaris, L. (2023, June 7). 4 Genetic Tests That Can Help Individualize Treatment Options for Patients With Autoimmune Disease. Rupa Health. https://www.rupahealth.com/post/the-role-of-genetics-in-autoimmune-diseases

Foglesong Stabile , J. (2025a, January 22). TB Test Guide: Types, Results, and Free Testing Options. Rupa Health. https://www.rupahealth.com/post/tb-test-guide-types-results-and-free-testing-options

Foglesong Stabile , J. (2025b, February 10). Living with Stage 3 Kidney Disease: Expert Advice and Tips. Rupa Health. https://www.rupahealth.com/post/living-with-stage-3-kidney-disease-expert-advice-and-tips

Friedmann, J. (2024, September 20). What is the Lymphatic System, and What Does it Do? Rupa Health. https://www.rupahealth.com/post/what-is-the-lymphatic-system-and-what-does-it-do

Friedmann, J. (2025, January 24). Stem Cells and Cord Blood Banking: How They May Shape Medical Research. Rupa Health. https://www.rupahealth.com/post/stem-cells-and-cord-blood-banking-how-they-may-shape-medical-research

Get Support | Immune Deficiency Foundation. (2025). Primaryimmune.org. https://primaryimmune.org/living-primary-immunodeficiency/get-support

Healthy diet, exercise key in general care for PI | Immune Deficiency Foundation. (2022). Primaryimmune.org. https://primaryimmune.org/resources/news-articles/healthy-diet-exercise-key-general-care-pi

Ho, H., & Cunningham-Rundles, C. (2022). Seeking Relevant Biomarkers in Common Variable Immunodeficiency. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.857050

Ilaria Saltarella, Altamura, C., Solimando, A. G., D’Amore, S., Ria, R., Vacca, A., Jean-François Desaphy, & Frassanito, M. A. (2024). Immunoglobulin Replacement Therapy: Insights into Multiple Myeloma Management. Cancers, 16(18), 3190–3190. https://doi.org/10.3390/cancers16183190

Khakham, C. (2023a, July 10). Understanding Environmental Toxins and Their Impact on Health. Rupa Health. https://www.rupahealth.com/post/understanding-environmental-toxins-and-their-impact-on-health

Khakham, C. (2023b, August 2). Top Labs To Run Bi-Annually On Your Patients Experiencing Fatigue. Rupa Health. https://www.rupahealth.com/post/top-labs-to-run-bi-annually-on-your-patients-experiencing-fatigue

Khakham, C. (2023c, August 11). Top Functional Medicine Labs To Run Bi-Annually On Your Crohn’s Patients. Rupa Health. https://www.rupahealth.com/post/top-functional-medicine-labs-to-run-bi-annually-on-your-crohns-patients

Khakham, C. (2023d, September 11). Top Labs To Run Bi-Annually On Your Gastroenteritis Patients. Rupa Health. https://www.rupahealth.com/post/top-labs-to-run-bi-annually-on-your-gastroenteritis-patients

Khakham, C. (2023e, September 26). Top Labs To Run On Your Patients Who Suffer From Mold Toxicity. Rupa Health. https://www.rupahealth.com/post/top-labs-to-run-bi-annually-on-your-patients-who-suffer-from-mold-toxicity

Kohn, L. A., & Kohn, D. B. (2021). Gene Therapies for Primary Immune Deficiencies. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.648951

Magryta, C. (2024, December 12). Understanding Immune Health Through Complete Blood Count and Inflammatory Markers . Rupa Health. https://www.rupahealth.com/post/understanding-immune-health-through-complete-blood-count-and-inflammatory-markers

Mayo Clinic. (2022a, May 12). Primary immunodeficiency - Diagnosis and treatment - Mayo Clinic. Mayoclinic.org. https://www.mayoclinic.org/diseases-conditions/primary-immunodeficiency/diagnosis-treatment/drc-20376910

Mayo Clinic. (2022b, May 12). Primary immunodeficiency - Symptoms and causes. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/primary-immunodeficiency/symptoms-causes/syc-20376905

Mayo Clinic. (2023). Selective IgA deficiency - Symptoms and causes. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/selective-iga-deficiency/symptoms-causes/syc-20362236

Mayo Clinic. (2024, January 10). X-linked agammaglobulinemia - Symptoms and causes. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/x-linked-agammaglobulinemia/symptoms-causes/syc-20361635

MedlinePlus. (2022). Wiskott-Aldrich syndrome: MedlinePlus Genetics. Medlineplus.gov. https://medlineplus.gov/genetics/condition/wiskott-aldrich-syndrome/

MedlinePlus. (2024a). T-cell count: MedlinePlus Medical Encyclopedia. Medlineplus.gov. https://medlineplus.gov/ency/article/003516.htm

MedlinePlus. (2024b, March 31). B-cell leukemia/lymphoma panel: MedlinePlus Medical Encyclopedia. Medlineplus.gov. https://medlineplus.gov/ency/article/003518.htm

MedlinePlus. (2024c, March 31). Immunodeficiency disorders: MedlinePlus Medical Encyclopedia. Medlineplus.gov. https://medlineplus.gov/ency/article/000818.htm

Meyts, I., Bousfiha, A., Duff, C., Singh, S., Lau, Y. L., Condino-Neto, A., Bezrodnik, L., Ali, A., Adeli, M., & Drabwell, J. (2022). Primary Immunodeficiencies: A Decade of Progress and a Promising Future. Frontiers in Immunology, 11, 625753. https://doi.org/10.3389/fimmu.2020.625753

Neibling, K. (2023, March 24). Why Functional Medicine Practitioners Focus on Gut Health. Rupa Health. https://www.rupahealth.com/post/why-functional-medicine-practitioners-focus-on-gut-health

Preston, J. (2022, December 20). How To Build Natural Immunity During A Bad Flu Season. Rupa Health. https://www.rupahealth.com/post/building-immunity-during-flu-season

Preston, J. (2023, April 12). A Functional Medicine Approach to Loose Stool in Pediatrics. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-loose-stool-in-pediatrics

Primary Immunodeficiency: Types & Symptoms. (2023a, September 8). Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/17964-primary-immunodeficiency#diagnosis-and-tests

Primary Immunodeficiency: Types & Symptoms. (2023b, September 8). Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/17964-primary-immunodeficiency#outlook-prognosis

Robinson, K. (2025, January 6). Immunosuppressants: A Comprehensive Guide. Rupa Health. https://www.rupahealth.com/post/immunosuppressants-a-comprehensive-guide

Stauffer, K. (2024, October 4). Sinus Infection vs. Cold: How to Tell the Difference and Get the Right Treatment. Rupa Health. https://www.rupahealth.com/post/sinus-infection-vs-cold-how-to-tell-the-difference-and-get-the-right-treatment

Sweetnich, J. (2023, March 9). Top Micronutrient Imbalances That Can Cause Diarrhea. Rupa Health. https://www.rupahealth.com/post/top-micronutrient-imbalances-that-can-cause-diarrhea

Teeter, L. A. (2023, April 3). Mental health benefits of yoga and meditation. Rupa Health. https://www.rupahealth.com/post/mental-health-benefits-of-yoga-and-meditation

Tuano, K. S., Seth, N., & Chinen, J. (2021). Secondary immunodeficiencies. Annals of Allergy, Asthma & Immunology, 127(6). https://doi.org/10.1016/j.anai.2021.08.413

U.S. Department of Health and Human Services. (2022, December 22). Vaccine Types. U.S. Department of Health and Human Services. https://www.hhs.gov/immunization/basics/types/index.html

Wilson, E. (2024, December 20). Quick Relief for Ear Pain with These Expert Tips for Kids and Adults. Rupa Health. https://www.rupahealth.com/post/quick-relief-for-ear-pain-with-these-expert-tips-for-kids-and-adults

Wilson, E. (2025a, January 6). Antibiotics 101: A medical guide to usage and safety. Rupa Health. https://www.rupahealth.com/post/antibiotics-101-a-medical-guide-to-usage-and-safety

Wilson, E. (2025b, January 20). Antiviral Drugs 101: Uses, Benefits, and Side Effects. Rupa Health. https://www.rupahealth.com/post/antiviral-drugs-101-uses-benefits-and-side-effects

World Health Organization. (2024, July 22). HIV and AIDS. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/hiv-aids

Order from 30+ labs in 20 seconds (DUTCH, Mosaic, Genova & More!)
We make ordering quick and painless — and best of all, it's free for practitioners.

Latest Articles

View more on Immune Support
Subscribe to the magazine for expert-written articles straight to your inbox
Join the thousands of savvy readers who get root cause medicine articles written by doctors in their inbox every week!
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Are you a healthcare practitioner?
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Subscribe to the Magazine for free to keep reading!
Subscribe for free to keep reading, If you are already subscribed, enter your email address to log back in.
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Are you a healthcare practitioner?
Thanks for subscribing!
Oops! Something went wrong while submitting the form.

Hey practitioners! 👋 Join Dr. Chris Magryta and Dr. Erik Lundquist for a comprehensive 6-week course on evaluating functional medicine labs from two perspectives: adult and pediatric. In this course, you’ll explore the convergence of lab results across different diseases and age groups, understanding how human lab values vary on a continuum influenced by age, genetics, and time. Register Here! Register Here.

Hey practitioners! 👋 Join Dr. Robert Silverman for an insightful webinar, "Food Sensitivities, GLP-1, and Gut Health" on April 2nd at 2 PM EST / 11 AM PST. In this session, you'll gain insight into how GLP-1 may play a role in gut function, metabolism, and immune response, how food sensitivities may be linked to digestive discomfort, and practical strategies to help support gut health and overall well-being. Register now to secure your spot!