GI Health
|
August 28, 2024

IBS-M: Understanding the Mixed Type of Irritable Bowel Syndrome

Written By
Medically Reviewed by
Updated On
December 13, 2024

Living with Irritable Bowel Syndrome (IBS) can be a daily struggle filled with discomfort and uncertainty. IBS is a common digestive disorder that causes symptoms like stomach pain, bloating, and unpredictable bowel habits, which can disrupt your routine and affect your well-being. 

IBS isn’t the same for everyone. There are different types including IBS-C, where constipation is the main issue, IBS-D, which involves frequent diarrhea, IBS-M, the mixed type that combines both constipation and diarrhea,  and IBS-U (unclassified). 

This article will guide you through understanding IBS-M. We’ll break down what it is, how it’s diagnosed, and the steps you can take to manage it effectively, to help you regain control and live more comfortably.

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What is IBS-M?

IBS-M, or Irritable Bowel Syndrome-Mixed, involves both constipation and diarrhea, with symptoms that can alternate unpredictably. This variability makes IBS-M distinct from other IBS subtypes like IBS-C (constipation-predominant) and IBS-D (diarrhea-predominant). 

While IBS-C is marked by infrequent, hard stools, and IBS-D involves frequent, loose stools, IBS-M includes both, making it challenging to manage.

Traditional treatments targeting just constipation or diarrhea may not be effective for IBS-M and could even worsen symptoms. For example, increasing fiber may help constipation but trigger more diarrhea, while anti-diarrheal medications could lead to more constipation. 

Managing IBS-M often requires a personalized approach focused on balanced dietary adjustments, stress management, and tailored medication use.

Symptoms of IBS-M

People with IBS-M experience a range of symptoms, most commonly the following:

  • Constipation: This involves having infrequent bowel movements, often with hard, dry stools that can be difficult to pass.
  • Diarrhea: This is the opposite problem, where stools are loose, watery, and you might feel an urgent need to go to the bathroom.
  • Abdominal Pain: Many people with IBS-M feel pain or discomfort in their abdomen. This pain can come and go and is often linked to bowel movements.
  • Bloating and gas: Many patients with IBS-M report feelings of bloating, gas, and abdominal distension, which can be both uncomfortable and embarrassing.

The symptom patterns in IBS-M are often unpredictable. Some patients may have several days of constipation followed by sudden diarrhea, while others might experience both within the same day. This variability adds to the challenge of managing the condition.

The severity and frequency of symptoms can also differ, with some experiencing mild, occasional flare-ups and others facing persistent, severe symptoms that disrupt daily life.

The unpredictability of IBS-M can make planning difficult. Not knowing whether you'll face constipation, diarrhea, or both, can make everyday tasks like running errands or attending meetings feel overwhelming.

IBS-M symptoms can also affect work, as frequent bathroom breaks or discomfort might hinder your focus. Social activities become challenging too, as the fear of sudden symptoms or needing a bathroom can lead to avoiding outings or limiting social interactions.

Causes and Triggers of IBS-M

The exact cause of IBS-M isn’t fully understood, but several factors are believed to contribute to its development:

  • Gut-Brain Interaction: one of the key factors of IBS is the gut-brain communication. In people with IBS-M, this communication might be disrupted, leading to abnormal bowel movements and pain [26., 29.].
  • Stress: stress plays a significant role in IBS-M. When you're stressed, your body produces chemicals that affect how your intestines function, which can worsen symptoms.
  • Diet: certain foods can trigger symptoms, and some people with IBS-M might be more sensitive to specific foods, like those high in fat or certain carbohydrates.
  • Genetics: There’s also some evidence that IBS-M can run in families, suggesting that genetics might play a role.

Common Triggers

While the causes of IBS-M are complex, several common triggers can make symptoms worse:

  • Certain Foods: foods that are high in fat, spicy foods, dairy products, and certain types of carbohydrates (like those found in beans, lentils, and some fruits) can trigger symptoms in people with IBS-M.
  • Stress: emotional stress or anxiety can trigger or worsen symptoms. Stress management techniques like relaxation exercises can sometimes help reduce symptom flare-ups.
  • Hormonal Changes: some people notice that their IBS-M symptoms worsen during their menstrual cycle or in early menopause, suggesting that hormones might also play a role.
  • Medications: certain medications, especially those that affect the digestive system, can trigger symptoms [43., 48.]. It’s important to talk to your healthcare provider about any medications you’re taking to ensure they are not contributing to your symptoms.

The Role of Gut Microbiota

Your gut is home to trillions of bacteria, known as gut microbiota, which play a crucial role in digestion and overall health. 

In people with IBS-M, there may be an imbalance in these gut bacteria, which can contribute to symptoms. When the balance of these bacteria is disrupted, it can lead to inflammation, altered gut motility, and increased sensitivity, all of which are associated with IBS symptoms.

In IBS-M, specific patterns of gut bacteria may be linked to the alternating symptoms of constipation and diarrhea. For example, an overgrowth of certain types of bacteria may contribute to diarrhea, while a lack of beneficial bacteria could be associated with constipation. 

Probiotics, which are supplements containing beneficial bacteria, may help restore a healthy balance of gut microbiota and alleviate some symptoms of IBS-M.

Diagnosing IBS-M

The diagnosis of IBS-M (Irritable Bowel Syndrome with mixed bowel habits) is primarily based on the Rome IV criteria. These criteria are used to identify functional gastrointestinal disorders, including IBS, by focusing on symptom patterns rather than specific test results. 

For IBS-M, the Rome IV criteria require the presence of recurrent abdominal pain, on average, at least one day per week in the last three months, associated with two or more of the following:

  • Pain related to defecation
  • Change in stool frequency
  • Change in stool form (appearance)

In the case of IBS-M, patients experience a mix of both constipation and diarrhea, distinguishing it from other IBS subtypes.

Differential Diagnosis

Given the overlapping symptoms between IBS-M and other gastrointestinal disorders, it is crucial to rule out conditions with similar presentations before confirming a diagnosis of IBS-M. 

Some conditions that may mimic IBS-M include:

Inflammatory Bowel Disease (IBD): this includes Crohn's disease and ulcerative colitis, both of which cause inflammation in the digestive tract and can lead to symptoms like diarrhea, abdominal pain, and weight loss. Unlike IBS-M, IBD can cause significant damage to the intestines and is often associated with blood in the stool.

Celiac Disease: celiac disease is an autoimmune disorder where ingestion of gluten leads to damage in the small intestine, causing symptoms like diarrhea, weight loss, and malnutrition. Celiac disease can be differentiated from IBS-M through specific blood tests and biopsy.

Infections or Parasites: certain infections or parasitic infestations can cause symptoms similar to IBS-M, including alternating diarrhea and constipation. These conditions often require stool tests for proper diagnosis.

Lactose Intolerance: Difficulty digesting lactose can lead to bloating, diarrhea, and abdominal pain, which may be mistaken for IBS-M. A hydrogen breath test can help diagnose lactose intolerance.

Tests and Procedures

To diagnose IBS-M, healthcare providers may recommend several tests and procedures to rule out other conditions and confirm the diagnosis:

  • Stool Tests: These tests can help detect infections, parasites, or blood in the stool, which could indicate a condition other than IBS. Stool tests are particularly useful in ruling out IBD and infections. Here are some examples offered through Rupa Health:
  • Blood Tests: Blood tests can be used to check for anemia, inflammation, and celiac disease. Elevated inflammatory markers may suggest IBD, while specific antibodies could indicate celiac disease. Examples offered through Rupa Health are:
  • Celiac Disease Evaluation - Access Labcorp Draw
  • Colonoscopy: A colonoscopy involves inserting a flexible tube with a camera into the colon to examine the lining for signs of inflammation, polyps, or other abnormalities. This procedure is particularly important if there are red flags such as unexplained weight loss, rectal bleeding, or a family history of colorectal cancer.
  • Lactose Intolerance Tests: If lactose intolerance is suspected, a hydrogen breath test may be performed to confirm the diagnosis. Here are some examples offered through Rupa Health:

Treatment Options for IBS-M

Many treatment options are available for IBS including diet, lifestyle, and medications. It is essential to work with a healthcare provider to create the best treatment plan for your unique presentation, particularly if you have been diagnosed with IBS-M.

Dietary Management

One of the most effective ways to manage IBS-M is through dietary changes. Identifying foods that trigger symptoms such as bloating, constipation, or diarrhea is crucial. 

Keeping a food diary can help you track what you eat and how it affects your symptoms. Once you identify your trigger foods, avoiding them can reduce the frequency and severity of symptoms.

The low FODMAP diet is a popular approach for managing IBS symptoms. FODMAPs are certain types of carbohydrates that can be hard to digest and may trigger IBS symptoms. 

The low FODMAP diet involves temporarily eliminating high-FODMAP foods (like certain fruits, vegetables, and dairy products) and then gradually reintroducing them to see which ones cause problems. Many people with IBS-M find that this diet helps reduce their symptoms.

Medications

In some cases, doctors may prescribe medications to help manage the symptoms of IBS-M:

  • Antispasmodics: these help relieve gut spasms and cramps, such as dicyclomine and hyoscyamine.
  • Laxatives: used to manage constipation, these medications help regulate bowel movements.
  • Antidiarrheal Agents: medications like loperamide can help control diarrhea by slowing intestinal transit.
  • Antidepressants: low-dose antidepressants may be used to reduce pain and improve gut motility.

Stress Management

Stress is a known trigger for IBS-M symptoms, so managing stress is an important part of treatment. Stress can affect how your gut functions, leading to more frequent or severe symptoms. 

Strategies for managing stress include practicing mindfulness techniques such as meditation or deep breathing, and activities like yoga, progressive muscle relaxation, and gentle exercise.

Probiotics and Supplements

Probiotics are beneficial bacteria that can help restore balance in your gut microbiota, which might be disrupted in people with IBS-M. Taking a probiotic supplement or eating probiotic-rich foods like yogurt can sometimes help reduce symptoms like bloating and irregular bowel movements. 

Other supplements such as fiber supplements may be recommended to help manage constipation or diarrhea.

Behavioral Therapies

Behavioral therapies are another option for managing IBS-M symptoms, particularly when stress and anxiety play a significant role. 

Cognitive Behavioral Therapy (CBT) is a type of therapy that helps you change negative thought patterns and behaviors that may be contributing to your symptoms. It has been shown to be effective in reducing the severity of IBS symptoms.

Gut-Directed Hypnotherapy is a specialized form of hypnotherapy that focuses on the gut-brain connection and uses relaxation techniques to help reduce symptoms. Studies have shown that it can be particularly helpful for people with IBS.

Living with IBS-M

Living with IBS-M can be challenging, but there are practical ways to manage symptoms and maintain a good quality of life:

  • Meal Planning: plan your meals and snacks around foods that you know are safe for you. Eating smaller, more frequent meals can help prevent overeating, which may trigger symptoms.
  • Stay Hydrated: drinking plenty of water throughout the day can help with both constipation and diarrhea. Avoiding caffeinated and carbonated beverages, which can irritate the gut, is also helpful.
  • Exercise Regularly: regular physical activity can aid digestion and reduce stress, both of which are important in managing IBS-M. Gentle exercises like walking, swimming, or yoga can be particularly beneficial.
  • Mindful Eating: paying attention to how you eat is just as important as what you eat. Eating slowly, chewing thoroughly, and avoiding distractions during meals can help your digestion work more smoothly.

Dealing with IBS-M can feel isolating, but connecting with others who understand can make a big difference. Joining a support group, whether in-person or online, offers a community where you can share experiences, gain practical advice, and find emotional support.

Talk to your friends and family about your condition so they can offer support during tough times. Regular check-ins with your healthcare provider are crucial to keep your treatment plan effective and address any new concerns. Be open about how your treatment is working and discuss any needed adjustments.

Even with careful management, flare-ups can happen. Having a plan and knowing which medications or strategies work best for you can help manage these episodes more effectively. Stay informed about new treatments and strategies for IBS-M to better control your condition.

[signup]

Key Takeaways 

​​IBS-M, or Mixed Irritable Bowel Syndrome, is a form of IBS characterized by alternating symptoms of constipation and diarrhea. It can be challenging to manage due to the unpredictable nature of these symptoms, but understanding the condition is the first step in taking control. 

While IBS-M is a chronic condition, it's important to remember that it can be managed effectively. With the right approach, including identifying and avoiding triggers, managing stress, and working closely with healthcare providers to create an individualized treatment plan including diet, lifestyle, and possibly medications, you can significantly reduce symptoms and improve your quality of life. 

You're not alone in this journey, and support is available.

Living with Irritable Bowel Syndrome (IBS) can be a daily struggle filled with discomfort and uncertainty. IBS is a common digestive disorder that causes symptoms like stomach pain, bloating, and unpredictable bowel habits, which can disrupt your routine and affect your well-being. 

IBS isn’t the same for everyone. There are different types including IBS-C, where constipation is the main issue, IBS-D, which involves frequent diarrhea, IBS-M, the mixed type that combines both constipation and diarrhea,  and IBS-U (unclassified). 

This article will guide you through understanding IBS-M. We’ll break down what it is, how it’s diagnosed, and the steps you can take to manage it effectively, to help you regain control and live more comfortably.

[signup]

What is IBS-M?

IBS-M, or Irritable Bowel Syndrome-Mixed, involves both constipation and diarrhea, with symptoms that can alternate unpredictably. This variability makes IBS-M distinct from other IBS subtypes like IBS-C (constipation-predominant) and IBS-D (diarrhea-predominant). 

While IBS-C is marked by infrequent, hard stools, and IBS-D involves frequent, loose stools, IBS-M includes both, making it challenging to manage.

Traditional approaches targeting just constipation or diarrhea may not be effective for IBS-M and could even worsen symptoms. For example, increasing fiber may help constipation but trigger more diarrhea, while anti-diarrheal medications could lead to more constipation. 

Managing IBS-M often requires a personalized approach focused on balanced dietary adjustments, stress management, and tailored medication use.

Symptoms of IBS-M

People with IBS-M experience a range of symptoms, most commonly the following:

  • Constipation: This involves having infrequent bowel movements, often with hard, dry stools that can be difficult to pass.
  • Diarrhea: This is the opposite problem, where stools are loose, watery, and you might feel an urgent need to go to the bathroom.
  • Abdominal Pain: Many people with IBS-M feel pain or discomfort in their abdomen. This pain can come and go and is often linked to bowel movements.
  • Bloating and gas: Many patients with IBS-M report feelings of bloating, gas, and abdominal distension, which can be both uncomfortable and embarrassing.

The symptom patterns in IBS-M are often unpredictable. Some patients may have several days of constipation followed by sudden diarrhea, while others might experience both within the same day. This variability adds to the challenge of managing the condition.

The severity and frequency of symptoms can also differ, with some experiencing mild, occasional flare-ups and others facing persistent, severe symptoms that disrupt daily life.

The unpredictability of IBS-M can make planning difficult. Not knowing whether you'll face constipation, diarrhea, or both, can make everyday tasks like running errands or attending meetings feel overwhelming.

IBS-M symptoms can also affect work, as frequent bathroom breaks or discomfort might hinder your focus. Social activities become challenging too, as the fear of sudden symptoms or needing a bathroom can lead to avoiding outings or limiting social interactions.

Causes and Triggers of IBS-M

Key topics highlighted include Gut-Brain Interaction, Diet, Stress, and Genetics.

The exact cause of IBS-M isn’t fully understood, but several factors are believed to contribute to its development:

  • Gut-Brain Interaction: one of the key factors of IBS is the gut-brain communication. In people with IBS-M, this communication might be disrupted, leading to abnormal bowel movements and pain [26., 29.].
  • Stress: stress plays a significant role in IBS-M. When you're stressed, your body produces chemicals that affect how your intestines function, which can worsen symptoms.
  • Diet: certain foods can trigger symptoms, and some people with IBS-M might be more sensitive to specific foods, like those high in fat or certain carbohydrates.
  • Genetics: There’s also some evidence that IBS-M can run in families, suggesting that genetics might play a role.

Common Triggers

While the causes of IBS-M are complex, several common triggers can make symptoms worse:

  • Certain Foods: foods that are high in fat, spicy foods, dairy products, and certain types of carbohydrates (like those found in beans, lentils, and some fruits) can trigger symptoms in people with IBS-M.
  • Stress: emotional stress or anxiety can trigger or worsen symptoms. Stress management techniques like relaxation exercises can sometimes help reduce symptom flare-ups.
  • Hormonal Changes: some people notice that their IBS-M symptoms worsen during their menstrual cycle or in early menopause, suggesting that hormones might also play a role.
  • Medications: certain medications, especially those that affect the digestive system, can trigger symptoms [43., 48.]. It’s important to talk to your healthcare provider about any medications you’re taking to ensure they are not contributing to your symptoms.

The Role of Gut Microbiota

Your gut is home to trillions of bacteria, known as gut microbiota, which play a crucial role in digestion and overall health. 

In people with IBS-M, there may be an imbalance in these gut bacteria, which can contribute to symptoms. When the balance of these bacteria is disrupted, it can lead to inflammation, altered gut motility, and increased sensitivity, all of which are associated with IBS symptoms.

In IBS-M, specific patterns of gut bacteria may be linked to the alternating symptoms of constipation and diarrhea. For example, an overgrowth of certain types of bacteria may contribute to diarrhea, while a lack of beneficial bacteria could be associated with constipation. 

Probiotics, which are supplements containing beneficial bacteria, may help support a healthy balance of gut microbiota and contribute to digestive comfort.

Diagnosing IBS-M

The diagnosis of IBS-M (Irritable Bowel Syndrome with mixed bowel habits) is primarily based on the Rome IV criteria. These criteria are used to identify functional gastrointestinal disorders, including IBS, by focusing on symptom patterns rather than specific test results. 

For IBS-M, the Rome IV criteria require the presence of recurrent abdominal pain, on average, at least one day per week in the last three months, associated with two or more of the following:

  • Pain related to defecation
  • Change in stool frequency
  • Change in stool form (appearance)

In the case of IBS-M, patients experience a mix of both constipation and diarrhea, distinguishing it from other IBS subtypes.

Differential Diagnosis

Given the overlapping symptoms between IBS-M and other gastrointestinal disorders, it is crucial to rule out conditions with similar presentations before confirming a diagnosis of IBS-M. 

Some conditions that may mimic IBS-M include:

Inflammatory Bowel Disease (IBD): this includes Crohn's disease and ulcerative colitis, both of which cause inflammation in the digestive tract and can lead to symptoms like diarrhea, abdominal pain, and weight loss. Unlike IBS-M, IBD can cause significant damage to the intestines and is often associated with blood in the stool.

Celiac Disease: celiac disease is an autoimmune disorder where ingestion of gluten leads to damage in the small intestine, causing symptoms like diarrhea, weight loss, and malnutrition. Celiac disease can be differentiated from IBS-M through specific blood tests and biopsy.

Infections or Parasites: certain infections or parasitic infestations can cause symptoms similar to IBS-M, including alternating diarrhea and constipation. These conditions often require stool tests for proper diagnosis.

Lactose Intolerance: Difficulty digesting lactose can lead to bloating, diarrhea, and abdominal pain, which may be mistaken for IBS-M. A hydrogen breath test can help diagnose lactose intolerance.

Tests and Procedures

To diagnose IBS-M, healthcare providers may recommend several tests and procedures to rule out other conditions and confirm the diagnosis:

  • Stool Tests: These tests can help detect infections, parasites, or blood in the stool, which could indicate a condition other than IBS. Stool tests are particularly useful in ruling out IBD and infections. Here are some examples offered through Rupa Health:
  • Blood Tests: Blood tests can be used to check for anemia, inflammation, and celiac disease. Elevated inflammatory markers may suggest IBD, while specific antibodies could indicate celiac disease. Examples offered through Rupa Health are:
  • Celiac Disease Evaluation - Access Labcorp Draw
  • Colonoscopy: A colonoscopy involves inserting a flexible tube with a camera into the colon to examine the lining for signs of inflammation, polyps, or other abnormalities. This procedure is particularly important if there are red flags such as unexplained weight loss, rectal bleeding, or a family history of colorectal cancer.
  • Lactose Intolerance Tests: If lactose intolerance is suspected, a hydrogen breath test may be performed to confirm the diagnosis. Here are some examples offered through Rupa Health:

Treatment Options for IBS-M

Many treatment options are available for IBS including diet, lifestyle, and medications. It is essential to work with a healthcare provider to create the best treatment plan for your unique presentation, particularly if you have been diagnosed with IBS-M.

Dietary Management

One of the most effective ways to manage IBS-M is through dietary changes. Identifying foods that trigger symptoms such as bloating, constipation, or diarrhea is crucial. 

Keeping a food diary can help you track what you eat and how it affects your symptoms. Once you identify your trigger foods, avoiding them can reduce the frequency and severity of symptoms.

The low FODMAP diet is a popular approach for managing IBS symptoms. FODMAPs are certain types of carbohydrates that can be hard to digest and may trigger IBS symptoms. 

The low FODMAP diet involves temporarily eliminating high-FODMAP foods (like certain fruits, vegetables, and dairy products) and then gradually reintroducing them to see which ones cause problems. Many people with IBS-M find that this diet helps reduce their symptoms.

Medications

In some cases, doctors may prescribe medications to help manage the symptoms of IBS-M:

  • Antispasmodics: these help relieve gut spasms and cramps, such as dicyclomine and hyoscyamine.
  • Laxatives: used to manage constipation, these medications help regulate bowel movements.
  • Antidiarrheal Agents: medications like loperamide can help control diarrhea by slowing intestinal transit.
  • Antidepressants: low-dose antidepressants may be used to reduce pain and improve gut motility.

Stress Management

Stress is a known trigger for IBS-M symptoms, so managing stress is an important part of treatment. Stress can affect how your gut functions, leading to more frequent or severe symptoms. 

Strategies for managing stress include practicing mindfulness techniques such as meditation or deep breathing, and activities like yoga, progressive muscle relaxation, and gentle exercise.

Probiotics and Supplements

Probiotics are beneficial bacteria that can help support balance in your gut microbiota, which might be disrupted in people with IBS-M. Taking a probiotic supplement or eating probiotic-rich foods like yogurt can sometimes help support digestive health. 

Other supplements such as fiber supplements may be recommended to help manage constipation or diarrhea.

Behavioral Therapies

Behavioral therapies are another option for managing IBS-M symptoms, particularly when stress and anxiety play a significant role. 

Cognitive Behavioral Therapy (CBT) is a type of therapy that helps you change negative thought patterns and behaviors that may be contributing to your symptoms. It has been shown to be effective in reducing the severity of IBS symptoms.

Gut-Directed Hypnotherapy is a specialized form of hypnotherapy that focuses on the gut-brain connection and uses relaxation techniques to help reduce symptoms. Studies have shown that it can be particularly helpful for people with IBS.

Living with IBS-M

Living with IBS-M can be challenging, but there are practical ways to manage symptoms and maintain a good quality of life:

  • Meal Planning: plan your meals and snacks around foods that you know are safe for you. Eating smaller, more frequent meals can help prevent overeating, which may trigger symptoms.
  • Stay Hydrated: drinking plenty of water throughout the day can help with both constipation and diarrhea. Avoiding caffeinated and carbonated beverages, which can irritate the gut, is also helpful.
  • Exercise Regularly: regular physical activity can aid digestion and reduce stress, both of which are important in managing IBS-M. Gentle exercises like walking, swimming, or yoga can be particularly beneficial.
  • Mindful Eating: paying attention to how you eat is just as important as what you eat. Eating slowly, chewing thoroughly, and avoiding distractions during meals can help your digestion work more smoothly.

Dealing with IBS-M can feel isolating, but connecting with others who understand can make a big difference. Joining a support group, whether in-person or online, offers a community where you can share experiences, gain practical advice, and find emotional support.

Talk to your friends and family about your condition so they can offer support during tough times. Regular check-ins with your healthcare provider are crucial to keep your treatment plan effective and address any new concerns. Be open about how your treatment is working and discuss any needed adjustments.

Even with careful management, flare-ups can happen. Having a plan and knowing which medications or strategies work best for you can help manage these episodes more effectively. Stay informed about new treatments and strategies for IBS-M to better control your condition.

[signup]

Key Takeaways 

​​IBS-M, or Mixed Irritable Bowel Syndrome, is a form of IBS characterized by alternating symptoms of constipation and diarrhea. It can be challenging to manage due to the unpredictable nature of these symptoms, but understanding the condition is the first step in taking control. 

While IBS-M is a chronic condition, it's important to remember that it can be managed effectively. With the right approach, including identifying and avoiding triggers, managing stress, and working closely with healthcare providers to create an individualized treatment plan including diet, lifestyle, and possibly medications, you can significantly reduce symptoms and improve your quality of life. 

You're not alone in this journey, and support is available.

The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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  1. Aziz, I., Whitehead, W. E., Palsson, O. S., Törnblom, H., & Simrén, M. (2020). An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation. Expert Review of Gastroenterology & Hepatology, 14(1), 39–46. https://doi.org/10.1080/17474124.2020.1708718  
  2. Calprotectin by Diagnostic Solutions. (n.d.). Rupa Health. https://www.rupahealth.com/lab-tests/diagnostic-solutions-calprotectin  
  3. Celiac Disease Evaluation by Access Labcorp Draw. (n.d.). https://www.rupahealth.com/lab-tests/labcorp-celiac-disease-evaluation  
  4. Chong, P. P., Chin, V. K., Looi, C. Y., Wong, W. F., Madhavan, P., & Yong, V. C. (2019). The Microbiome and Irritable Bowel Syndrome – A Review on the Pathophysiology, Current Research and Future Therapy. Frontiers in Microbiology, 10(10). https://doi.org/10.3389/fmicb.2019.01136  
  5. Christie, J. (2023, January 26). 5 Lab Test Can That Help Diagnose The Root Cause of Chronic Bloating. Rupa Health. https://www.rupahealth.com/post/5-lab-test-that-help-diagnose-the-root-cause-of-chronic-bloating  
  6. Christie, J. (2024, January 9). The Science Behind Mindful Eating: How It Impacts Digestion and Overall Health. Rupa Health. https://www.rupahealth.com/post/the-science-behind-mindful-eating-how-it-impacts-digestion-and-overall-health  
  7. Cloyd, J. (2022, December 15). Fatigue, Brain Fog, And Headaches Are Signs Of This Gastrointestinal Disorder. Rupa Health. https://www.rupahealth.com/post/ibs-c-diagnosis-and-natural-treatments-options  
  8. Cloyd, J. (2023a, March 29). Top 5 Differential Diagnosis for Abdominal Pain and How to Treat With Functional Medicine. Rupa Health. https://www.rupahealth.com/post/top-5-differential-diagnoses-for-abdominal-pain-and-how-to-treat-with-functional-medicine  
  9. Cloyd, J. (2023b, April 19). What’s the Difference Between Prebiotics vs. Probiotics vs. Postbiotics? Rupa Health. https://www.rupahealth.com/post/whats-the-difference-between-prebiotics-vs-probiotics-vs-postbiotics  
  10. Cloyd, J. (2023c, April 20). Top Intestinal Inflammatory Biomarkers Commonly Used In Functional Medicine. Rupa Health. https://www.rupahealth.com/post/top-intestinal-inflammatory-biomarkers-commonly-used-in-functional-medicine  
  11. Cloyd, J. (2023d, May 17). A Functional Medicine Constipation Protocol: Testing, Nutrition, and Supplements. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-constipation-protocol-testing-nutrition-and-supplements  
  12. Cloyd, J. (2023e, June 8). A Functional Medicine IBS-D Protocol: Testing, Differential Diagnosis, and Treatment. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-ibs-d-protocol-testing-nutrition-and-supplements  
  13. Cloyd, J. (2023f, June 15). A Functional Medicine Lactose Intolerance Protocol: Specialty Testing, Elimination Diet, and Supplement Suggestions. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-lactose-intolerance-protocol-specialty-testing-elimination-diet-and-supplement-suggestions  
  14. Cloyd, J. (2023g, July 28). A functional medicine diarrhea protocol: Comprehensive lab testing, therapeutic diet, and supplements. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-diarrhea-protocol-comprehensive-lab-testing-therapeutic-diet-and-supplements  
  15. Cloyd, J. (2024a, January 8). The Science of Hydration: How Water Intake Affects Overall Health. Rupa Health. https://www.rupahealth.com/post/the-science-of-hydration-how-water-intake-affects-overall-health  
  16. Cloyd, J. (2024b, February 2). Navigating dietary management for IBS: A functional medicine perspective. Rupa Health. https://www.rupahealth.com/post/navigating-dietary-management-for-ibs-a-functional-medicine-perspective  
  17. Complete Blood Count by BostonHeart Diagnostics. (n.d.). Rupa Health. https://www.rupahealth.com/lab-tests/bostonheart-complete-blood-count  
  18. Comprehensive Stool Analysis by Access Medical Laboratories. (n.d.). Rupa Health. https://www.rupahealth.com/lab-tests/access-medical-labs-comprehensive-stool-analysis  
  19. Comprehensive Stool Analysis by Mosaic Diagnostics (formerly Great Plains). (n.d.). Rupa Health. https://www.rupahealth.com/lab-tests/mosaic-diagnostics-comprehensive-stool-analysis  
  20. GI-MAP + Zonulin by Diagnostic Solutions. (n.d.). Rupa Health. https://www.rupahealth.com/lab-tests/diagnostic-solutions-gi-map-zonulin  
  21. Greenan, S. (2021a, November 5). A Functional Medicine Approach To IBS. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-ibs  
  22. Greenan, S. (2021b, November 18). How To Do A Low FODMAP Elimination Diet. Rupa Health. https://www.rupahealth.com/post/what-are-fodmaps  
  23. Greenan, S. (2021c, December 8). 5 Probiotic-Rich Foods To Eat Instead Of Taking Supplements. Rupa Health. https://www.rupahealth.com/post/the-different-types-of-probiotics-health-benefits  
  24. Heitkemper MM, Chang L. Do fluctuations in ovarian hormones affect gastrointestinal symptoms in women with irritable bowel syndrome?. Gend Med. 2009;6 Suppl 2(Suppl 2):152-167. doi:10.1016/j.genm.2009.03.004  
  25. High Sensitivity C-Reactive Protein (hsCRP) by ZRT Laboratory. (n.d.). Rupa Health. https://www.rupahealth.com/lab-tests/zrt-laboratory-high-sensitivity-c-reactive-protein-hscrp  
  26. Hillestad EMR, van der Meeren A, Nagaraja BH, et al. Gut bless you: The microbiota-gut-brain axis in irritable bowel syndrome. World J Gastroenterol. 2022;28(4):412-431. doi:10.3748/wjg.v28.i4.412  
  27. Jadallah, K. A., Nimri, L. F., & Ghanem, R. A. (2017). Protozoan parasites in irritable bowel syndrome: A case-control study. World Journal of Gastrointestinal Pharmacology and Therapeutics, 8(4), 201–207. https://doi.org/10.4292/wjgpt.v8.i4.201
  28. Jayasinghe M, Karunanayake V, Mohtashim A, et al. The Role of Diet in the Management of Irritable Bowel Syndrome: A Comprehensive Review. Cureus. 2024;16(2):e54244. Published 2024 Feb 15. doi:10.7759/cureus.54244  
  29. Kennedy PJ, Cryan JF, Dinan TG, Clarke G. Irritable bowel syndrome: a microbiome-gut-brain axis disorder?. World J Gastroenterol. 2014;20(39):14105-14125. doi:10.3748/wjg.v20.i39.14105  
  30. Kibune Nagasako C, Garcia Montes C, Silva Lorena SL, Mesquita MA. Irritable bowel syndrome subtypes: Clinical and psychological features, body mass index and comorbidities. Rev Esp Enferm Dig. 2016;108(2):59-64. doi:10.17235/reed.2015.3979/2015  
  31. Kim, G.-H., Lee, K., & Shim, J. O. (2023). Gut Bacterial Dysbiosis in Irritable Bowel Syndrome: a Case-Control Study and a Cross-Cohort Analysis Using Publicly Available Data Sets. Microbiology Spectrum, 11(1). https://doi.org/10.1128/spectrum.02125-22  
  32. Lactose Intolerance Breath Test by Aerodiagnostics LLC. (2020). Rupa Health. https://www.rupahealth.com/lab-tests/aerodiagnostics-lactose-intolerance-breath-test  
  33. Lactose Malabsorption Breath Test by Commonwealth Diagnostics International, Inc. (2020). Rupa Health. https://www.rupahealth.com/lab-tests/cdi-lactose-malabsorption-breath-test  
  34. Maholy, N. (2023a, April 14). How to reduce stress through mind-body therapies. Rupa Health. https://www.rupahealth.com/post/how-to-reduce-stress-through-mind-body-therapies  
  35. Maholy, N. (2023b, June 29). The Role of Probiotics and Prebiotics in Gut Health: An Integrative Perspective. Rupa Health. https://www.rupahealth.com/post/the-role-of-probiotics-and-prebiotics-in-gut-health-an-integrative-perspective  
  36. McDowell, C., Farooq, U., & Haseeb, M. (2023, August 4). Inflammatory Bowel Disease (IBD). PubMed; StatPearls Publishing. https://www.ncbi.nlm
  37. .nih.gov/books/NBK470312/  
  38. Nakao, M., Shirotsuki, K., & Sugaya, N. (2021). Cognitive–behavioral Therapy for Management of Mental Health and stress-related disorders: Recent Advances in Techniques and Technologies. BioPsychoSocial Medicine, 15(1), 1–4. https://doi.org/10.1186/s13030-021-00219-w  
  39. National Institute of Diabetes and Digestive and Kidney Diseases. (2019, May 28). Colonoscopy | NIDDK. National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/diagnostic-tests/colonoscopy  
  40. Perera, H. (2024, February 7). How to Rebalance the Gut Microbiome: A Functional Medicine Protocol. Rupa Health. https://www.rupahealth.com/post/how-to-rebalance-the-gut-microbiome-a-functional-medicine-protocol  
  41. Qin HY, Cheng CW, Tang XD, Bian ZX. Impact of psychological stress on irritable bowel syndrome. World J Gastroenterol. 2014;20(39):14126-14131. doi:10.3748/wjg.v20.i39.14126  
  42. Rogers MAM, Aronoff DM. The influence of non-steroidal anti-inflammatory drugs on the gut microbiome. Clin Microbiol Infect. 2016;22(2):178.e1-178.e9. doi:10.1016/j.cmi.2015.10.003  
  43. Rome Foundation. Rome IV Criteria. Rome Foundation. Published January 16, 2021. https://theromefoundation.org/rome-iv/rome-iv-criteria/  
  44. Saito, Y. A. (2011). The Role of Genetics in IBS. Gastroenterology Clinics of North America, 40(1), 45–67. https://doi.org/10.1016/j.gtc.2010.12.011  
  45. Sanna Nybacka, Törnblom H, Axel Josefsson, et al. A low FODMAP diet plus traditional dietary advice versus a low-carbohydrate diet versus pharmacological treatment in irritable bowel syndrome (CARBIS): a single-centre, single-blind, randomised controlled trial. ˜The œLancet Gastroenterology & hepatology. Published online April 1, 2024. doi:https://doi.org/10.1016/s2468-1253(24)00045-1  
  46. Satish Kumar, L., Pugalenthi, L. S., Ahmad, M., Reddy, S., Barkhane, Z., & Elmadi, J. (2022). Probiotics in Irritable Bowel Syndrome: a Review of Their Therapeutic Role. Cureus, 14(4). https://doi.org/10.7759/cureus.24240  
  47. Schmulson MJ, Frati-Munari AC. Bowel symptoms in patients that receive proton pump inhibitors. Results of a multicenter survey in Mexico. Síntomas intestinales en pacientes que reciben inhibidores de bomba de protones (IBP). Resultados de una encuesta multicéntrica en México. Rev Gastroenterol Mex (Engl Ed). 2019;84(1):44-51. doi:10.1016/j.rgmx.2018.02.008  
  48. Shaikh, S. D., Sun, N., Canakis, A., Park, W. Y., & Weber, H. C. (2023). Irritable Bowel Syndrome and the Gut Microbiome: A Comprehensive Review. Journal of Clinical Medicine, 12(7), 2558. https://doi.org/10.3390/jcm12072558  
  49. Sweetnich, J. (2023, June 30). Exploring the Role of Stress in IBS and the 3 Specialty Tests That Can Help Personalized Treatment. Rupa Health. https://www.rupahealth.com/post/the-role-of-stress-and-ibs  
  50. The Rome Foundation. (2021, January 16). Rome IV Criteria. Rome Foundation. https://theromefoundation.org/rome-iv/rome-iv-criteria/  
  51. van der Schoot, A., Drysdale, C., Whelan, K., & Dimidi, E. (2022). The effect of fiber supplementation on chronic constipation in adults: an updated systematic review and meta-analysis of randomized controlled trials. The American Journal of Clinical Nutrition, 116(4). https://doi.org/10.1093/ajcn/nqac184  
  52. Weinberg, J. (2022, February 28). An Integrative Medicine Approach to Celiac Disease. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-celiac-disease  
  53. Winfried Häuser. (2024). Gut-directed hypnosis and hypnotherapy for irritable bowel syndrome: a mini-review. Frontiers in Psychology, 15. https://doi.org/10.3389/fpsyg.2024.1389911  
  54. Yoshimura, H. (2023, November 7). The remarkable power of exercise on our health: A comprehensive overview. Rupa Health. https://www.rupahealth.com/post/the-remarkable-power-of-exercise-on-our-health-a-comprehensive-overview

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