IBS is a chronic condition affecting the large intestine, characterized by symptoms like abdominal pain, bloating, and changes in bowel movements [40.]
Its exact causes are unclear which makes it difficult to manage, although factors like diet, stress, and genetics play a role.
Understanding the connection between the gut microbiome and IBS is vital for improving diagnosis and treatment.
Exploring how microbiome disruptions can influence IBS symptoms could lead to more effective and personalized management strategies, addressing the root causes rather than just the symptoms.
[signup]
Understanding the Gut Microbiome
The gut microbiome is a complex ecosystem of microorganisms in the digestive tract, including bacteria, viruses, fungi, and other microbes [41.]
These microorganisms interact closely with each other and the host to support essential functions like digestion, immune defense, and metabolism.
The composition of the microbiome is unique to each person and influenced by diet, lifestyle, and environment.
Bacteria are the dominant organisms in this ecosystem, with up to 1000 species and 100 trillion organisms fulfilling various roles. The most common bacterial groups are Firmicutes and Bacteroidetes, along with Actinobacteria and Proteobacteria.
Viruses, particularly bacteriophages, and fungi also play roles in regulating bacterial dynamics and breaking down complex carbohydrates [21.]. This microbial community is dynamic, continually adapting to shifts in diet, lifestyle, and environment to maintain stability and support health.
The gut microbiome supports immune regulation by preventing the immune system from attacking the body’s own tissues, reducing the risk of autoimmune diseases.
It also facilitates the synthesis of essential nutrients like vitamins B12 and K, which are crucial for blood clotting and nerve function, as well as neurotransmitters like serotonin, which impacts mood and gut function.
Disruptions in the microbiome affect immune regulation and impair the synthesis of important compounds like vitamins and neurotransmitters, as well as having other negative health effects. This can lead to increased risks of autoimmune conditions and other health issues, especially in the setting of IBS [37.].
The Gut Microbiome and Digestive Health
A healthy gut microbiome is essential for optimal digestive health. Essential functions of a healthy microbiome include:
Nutrient Production and Extraction: Microbiota play a crucial role in extracting energy and nutrients from food, including the digestion of complex carbohydrates, proteins, and lipids. It also produces some essential vitamins.
Metabolic Contributions: the microbiome is involved in the biosynthesis of essential bioactive molecules, such as vitamins, amino acids, and lipids.
Immune System Regulation: microbiota contribute to the development and regulation of the immune system, protecting the host from pathogens by producing antimicrobial substances and influencing immune cell differentiation.
Colonization Resistance: the microbiome helps resist the colonization of harmful pathogens by outcompeting them for nutrients and space and by producing bacteriocins and other antimicrobial agents.
Gut-Brain Axis Modulation: the microbiome influences the gut-brain axis which influences behavior, stress response, and neurophysiology through the production of neurotransmitters and neuromodulatory metabolites.
Development of Immune Tolerance: the microbiome aids in the development of immune tolerance by influencing the maturation of immune cells and maintaining a balanced immune response.
Maintenance of Homeostasis: by maintaining a balance between beneficial and potentially harmful bacteria, the microbiome plays a critical role in maintaining homeostasis within various organ systems, supporting general health and preventing disease.
A well-balanced microbiome supports regular bowel movements, maintains proper immune function, helps prevent gastrointestinal discomfort, and contributes to overall gut health.
Dysbiosis: Disruption of the Gut Microbiome
When the balance of the gut microbiome is disrupted, a condition known as dysbiosis can occur.
Dysbiosis is characterized by an imbalance where harmful bacteria, viruses, or fungi outnumber beneficial ones, leading to a range of digestive and systemic issues.
Causes of Gut Microbiome Imbalance
Gut microbiome imbalance, or dysbiosis, can arise from various factors that disrupt the natural balance of microorganisms in the digestive tract. Here are some key causes:
Poor Diet
A diet high in processed foods, sugars, and unhealthy fats and low in fiber can significantly reduce the diversity of beneficial bacteria.
Fiber, which is abundant in fruits, vegetables, and whole grains, is essential for nourishing healthy gut bacteria. Without adequate fiber, harmful bacteria can thrive and promote microbial imbalance.
Frequent Antibiotic Use
While antibiotics are effective for treating bacterial infections, they can also inadvertently kill beneficial bacteria in the gut. This loss of good bacteria creates an environment where harmful bacteria and fungi can overgrow, contributing to dysbiosis.
Stress
Stress has a detrimental impact on gut health by altering gut motility and increasing the permeability of the gut lining, commonly known as "leaky gut." This condition allows harmful substances to enter the bloodstream and further disrupts the balance of the gut microbiome.
Lack of Sleep
Poor sleep quality and irregular sleep patterns can disturb the natural rhythms of the gut microbiome. Certain beneficial bacteria thrive during restful sleep periods, and disruption in sleep can lead to an imbalance in gut bacteria.
Excessive Alcohol Consumption
Alcohol can be harmful to the gut microbiome by promoting the growth of harmful bacteria and reducing beneficial bacteria.
Excessive alcohol intake also increases gut permeability, exacerbating dysbiosis.
Environmental Toxins
Exposure to environmental toxins such as pesticides, pollutants, and heavy metals can promote dysbiosis.
These toxins can kill beneficial bacteria and encourage the growth of harmful ones, leading to imbalance.
Infections
Gastrointestinal infections caused by bacteria, viruses, or parasites can directly introduce harmful microorganisms into the gut, depleting beneficial bacteria and causing dysbiosis [26.].
Acute gastrointestinal infections can cause significant changes in the gut microbiome, resulting in persistent dysbiosis. These alterations can also disrupt the gut-brain axis, increase visceral sensitivity, and cause low-grade inflammation, contributing to the development and persistence of post-infectious IBS.
Studies have shown a significant connection between the gut microbiome and Irritable Bowel Syndrome (IBS). Research indicates that individuals with IBS often have notable differences in their gut microbiome composition compared to healthy individuals.
A study published in Wiener Medizinische Wochenschrift found that altered gut microbiota in IBS patients is often linked to increased intestinal permeability, or "leaky gut," contributing to typical IBS symptoms like bloating, abdominal pain, and irregular bowel movements.
This study also noted that gut microbiota play a significant role in visceral hypersensitivity, stress response, and emotional regulation, which emphasizes the gut-brain axis and its connection with the microbiome in IBS [32.].
Another study in Nutrients emphasized the role of diet in modulating the gut microbiome, which can either exacerbate or alleviate IBS symptoms depending on dietary patterns.
Mechanisms of Interaction
The gut microbiome influences IBS symptoms through several mechanisms.
One key pathway is its impact on gut motility. Dysbiosis, or an imbalance in the gut microbiome, can lead to altered motility, causing diarrhea or constipation, which are hallmark symptoms of IBS.
An imbalanced microbiome can also increase gut inflammation, contributing to pain and discomfort.
This inflammation is often driven by harmful bacteria that produce toxins and pro-inflammatory compounds, leading to heightened gut sensitivity and the visceral hypersensitivity commonly seen in IBS.
Additionally, the gut microbiome interacts with the nervous system through the gut-brain axis, influencing gut sensitivity and the stress response. This interaction can exacerbate IBS symptoms, particularly under stress, by increasing intestinal permeability and triggering immune responses.
Factors Affecting the Gut Microbiome in IBS
The following are the top factors that can influence the gut microbiome and therefore IBS:
Diet and Nutrition
Diet plays a crucial role in influencing the gut microbiome, especially in individuals with IBS.
The microbiome is highly responsive to what we eat. Diets rich in fiber from fruits, vegetables, and whole grains encourage the growth of beneficial bacteria, which are essential for a healthy gut environment.
On the other hand, diets high in processed foods, sugars, and unhealthy fats can reduce microbial diversity and promote the growth of harmful bacteria, worsening IBS symptoms.
Prebiotics, found in fiber-rich foods like garlic, onions, and bananas, nourish beneficial gut bacteria. Probiotics, found in fermented foods like yogurt, kefir, and sauerkraut, are live beneficial bacteria that help restore balance to the gut microbiome.
Antibiotics and Medications
Antibiotics, though essential for treating bacterial infections, can significantly impact the gut microbiome.
They do not distinguish between harmful and beneficial bacteria, leading to a reduction in microbial diversity. This disruption can create conditions for pathogenic bacteria to overgrow, contributing to dysbiosis and worsening IBS symptoms.
The effects of antibiotics on the gut can be long-lasting, with some research showing that recovery can take months or years.
Other medications also influence the gut microbiome.
For example, nonsteroidal anti-inflammatory drugs (NSAIDs), commonly used for pain relief, can increase gut permeability and alter the microbiome, potentially leading to inflammation and IBS symptoms.
Proton pump inhibitors (PPIs), used to treat acid reflux, can reduce stomach acidity, leading to an overgrowth of bacteria in the small intestine, a condition known as small intestinal bacterial overgrowth (SIBO), which is often associated with IBS.
Stress and Lifestyle
Stress significantly impacts the gut microbiome, especially in those with IBS.
The gut-brain axis, a communication system between the gut and the brain, plays a critical role in how stress affects gut health.
Chronic stress can alter gut motility, increase gut permeability, and change the gut microbiome’s composition, leading to an overgrowth of harmful bacteria and a reduction in beneficial ones.
This imbalance can exacerbate IBS symptoms, including pain, bloating, and irregular bowel movements.
Lifestyle factors including exercise, sleep, and wellness practices such as meditation and yoga, significantly impact the gut microbiome in individuals with IBS.
Regular physical activity promotes microbial diversity and supports beneficial bacteria, while poor sleep patterns can lead to dysbiosis, worsening IBS symptoms.
Maintaining a healthy lifestyle is crucial for supporting gut health and managing IBS.
Managing IBS Through Gut Microbiome Modulation
Here are some ways that IBS can be managed by altering the makeup of the gut microbiome:
Probiotics and Prebiotics
To manage IBS symptoms, incorporating probiotics can be highly effective, although the effectiveness of probiotics varies, and their benefits are often strain-specific [34.].
These probiotics may work by replenishing beneficial bacteria in the gut, enhancing microbial diversity, and strengthening the gut barrier, which helps alleviate IBS symptoms.
Prebiotics are equally important in IBS management. These non-digestible fibers, found in foods like garlic, onions, asparagus, and bananas, feed beneficial gut bacteria, promoting their growth and activity.
By fostering a healthy gut environment, prebiotics help reduce harmful bacteria and support overall gut health, which can mitigate IBS symptoms.
Dietary Interventions
One of the most effective dietary approaches for managing IBS is the Low FODMAP diet. This strategy involves reducing certain poorly absorbed carbohydrates, like fermentable oligosaccharides, disaccharides, monosaccharides, and polyols, which are common triggers for IBS symptoms.
Individuals with IBS may experience symptom relief, including reduced bloating, gas, and diarrhea, by following a low FODMAP diet.
Beyond the Low FODMAP diet, integrating foods that support a healthy gut microbiome is important.
Consuming fiber-rich foods, fermented foods like yogurt and sauerkraut, and polyphenol-rich foods such as berries, green tea, and dark chocolate can nourish beneficial bacteria and maintain a balanced gut environment, aiding in the effective management of IBS.
Lifestyle Changes
Managing IBS through gut microbiome modulation also involves making key lifestyle adjustments.
Stress management is vital, as stress can disrupt the gut microbiome and worsen IBS symptoms. Techniques like mindfulness practice, meditation, deep breathing exercises, and yoga are effective for reducing stress and promoting a healthier gut.
Incorporating regular exercise is another crucial element, as it supports gut motility and microbial diversity. Activities like walking or cycling can positively impact gut health.
Additionally, ensuring adequate sleep is essential, as poor sleep patterns can disrupt the gut microbiome. Establishing a regular sleep routine and prioritizing quality rest are critical components of effective IBS management.
[signup]
Key Takeaways
The gut microbiome is deeply connected to IBS, influencing symptoms through its role in digestion, inflammation, and gut-brain interactions. Recognizing the impact of diet, medications, stress, and lifestyle choices on the microbiome is key to managing IBS effectively.
Maintaining a balanced and healthy gut microbiome is essential for reducing IBS symptoms and improving overall digestive health. Strategies such as dietary adjustments, probiotics, prebiotics, and healthy lifestyle practices can significantly enhance quality of life for those with IBS.
As our knowledge of the gut microbiome expands, there is a growing need for further research and the development of personalized treatment approaches. Tailoring IBS management to each individual’s unique microbiome composition offers the potential for more effective and long-lasting relief.
IBS is a chronic condition affecting the large intestine, characterized by symptoms like abdominal pain, bloating, and changes in bowel movements [40.]
Its exact causes are unclear which makes it difficult to manage, although factors like diet, stress, and genetics play a role.
Understanding the connection between the gut microbiome and IBS is vital for improving diagnosis and management strategies.
Exploring how microbiome disruptions can influence IBS symptoms could lead to more effective and personalized management strategies, addressing the root causes rather than just the symptoms.
[signup]
Understanding the Gut Microbiome
The gut microbiome is a complex ecosystem of microorganisms in the digestive tract, including bacteria, viruses, fungi, and other microbes [41.]
These microorganisms interact closely with each other and the host to support essential functions like digestion, immune defense, and metabolism.
The composition of the microbiome is unique to each person and influenced by diet, lifestyle, and environment.
Bacteria are the dominant organisms in this ecosystem, with up to 1000 species and 100 trillion organisms fulfilling various roles. The most common bacterial groups are Firmicutes and Bacteroidetes, along with Actinobacteria and Proteobacteria.
Viruses, particularly bacteriophages, and fungi also play roles in regulating bacterial dynamics and breaking down complex carbohydrates [21.]. This microbial community is dynamic, continually adapting to shifts in diet, lifestyle, and environment to maintain stability and support health.
The gut microbiome supports immune regulation by helping the immune system function properly, which may reduce the risk of autoimmune diseases.
It also facilitates the synthesis of essential nutrients like vitamins B12 and K, which are crucial for blood clotting and nerve function, as well as neurotransmitters like serotonin, which impacts mood and gut function.
Disruptions in the microbiome may affect immune regulation and impair the synthesis of important compounds like vitamins and neurotransmitters, as well as having other negative health effects. This can lead to increased risks of autoimmune conditions and other health issues, especially in the setting of IBS [37.].
The Gut Microbiome and Digestive Health
A healthy gut microbiome is essential for optimal digestive health. Essential functions of a healthy microbiome include:
Nutrient Production and Extraction: Microbiota play a crucial role in extracting energy and nutrients from food, including the digestion of complex carbohydrates, proteins, and lipids. It also produces some essential vitamins.
Metabolic Contributions: the microbiome is involved in the biosynthesis of essential bioactive molecules, such as vitamins, amino acids, and lipids.
Immune System Regulation: microbiota contribute to the development and regulation of the immune system, supporting the body's defense against pathogens by producing antimicrobial substances and influencing immune cell differentiation.
Colonization Resistance: the microbiome helps resist the colonization of potentially harmful pathogens by outcompeting them for nutrients and space and by producing bacteriocins and other antimicrobial agents.
Gut-Brain Axis Modulation: the microbiome influences the gut-brain axis which influences behavior, stress response, and neurophysiology through the production of neurotransmitters and neuromodulatory metabolites.
Development of Immune Tolerance: the microbiome aids in the development of immune tolerance by influencing the maturation of immune cells and maintaining a balanced immune response.
Maintenance of Homeostasis: by maintaining a balance between beneficial and potentially harmful bacteria, the microbiome plays a critical role in maintaining homeostasis within various organ systems, supporting general health and preventing disease.
A well-balanced microbiome supports regular bowel movements, maintains proper immune function, helps manage gastrointestinal discomfort, and contributes to overall gut health.
Dysbiosis: Disruption of the Gut Microbiome
When the balance of the gut microbiome is disrupted, a condition known as dysbiosis can occur.
Dysbiosis is characterized by an imbalance where harmful bacteria, viruses, or fungi outnumber beneficial ones, leading to a range of digestive and systemic issues.
Causes of Gut Microbiome Imbalance
Gut microbiome imbalance, or dysbiosis, can arise from various factors that disrupt the natural balance of microorganisms in the digestive tract. Here are some key causes:
Poor Diet
A diet high in processed foods, sugars, and unhealthy fats and low in fiber can significantly reduce the diversity of beneficial bacteria.
Fiber, which is abundant in fruits, vegetables, and whole grains, is essential for nourishing healthy gut bacteria. Without adequate fiber, harmful bacteria can thrive and promote microbial imbalance.
Frequent Antibiotic Use
While antibiotics are effective for managing bacterial infections, they can also inadvertently reduce beneficial bacteria in the gut. This loss of good bacteria creates an environment where harmful bacteria and fungi can overgrow, contributing to dysbiosis.
Stress
Stress has a detrimental impact on gut health by altering gut motility and increasing the permeability of the gut lining, commonly known as "leaky gut." This condition allows harmful substances to enter the bloodstream and further disrupts the balance of the gut microbiome.
Lack of Sleep
Poor sleep quality and irregular sleep patterns can disturb the natural rhythms of the gut microbiome. Certain beneficial bacteria thrive during restful sleep periods, and disruption in sleep can lead to an imbalance in gut bacteria.
Excessive Alcohol Consumption
Alcohol can be harmful to the gut microbiome by promoting the growth of harmful bacteria and reducing beneficial bacteria.
Excessive alcohol intake also increases gut permeability, exacerbating dysbiosis.
Environmental Toxins
Exposure to environmental toxins such as pesticides, pollutants, and heavy metals can promote dysbiosis.
These toxins can reduce beneficial bacteria and encourage the growth of harmful ones, leading to imbalance.
Infections
Gastrointestinal infections caused by bacteria, viruses, or parasites can directly introduce harmful microorganisms into the gut, depleting beneficial bacteria and causing dysbiosis [26.].
Acute gastrointestinal infections can cause significant changes in the gut microbiome, resulting in persistent dysbiosis. These alterations can also disrupt the gut-brain axis, increase visceral sensitivity, and cause low-grade inflammation, contributing to the development and persistence of post-infectious IBS.
Studies have shown a significant connection between the gut microbiome and Irritable Bowel Syndrome (IBS). Research indicates that individuals with IBS often have notable differences in their gut microbiome composition compared to healthy individuals.
A study published in Wiener Medizinische Wochenschrift found that altered gut microbiota in IBS patients is often linked to increased intestinal permeability, or "leaky gut," contributing to typical IBS symptoms like bloating, abdominal pain, and irregular bowel movements.
This study also noted that gut microbiota play a significant role in visceral hypersensitivity, stress response, and emotional regulation, which emphasizes the gut-brain axis and its connection with the microbiome in IBS [32.].
Another study in Nutrients emphasized the role of diet in modulating the gut microbiome, which can either exacerbate or alleviate IBS symptoms depending on dietary patterns.
Mechanisms of Interaction
The gut microbiome influences IBS symptoms through several mechanisms.
One key pathway is its impact on gut motility. Dysbiosis, or an imbalance in the gut microbiome, can lead to altered motility, causing diarrhea or constipation, which are hallmark symptoms of IBS.
An imbalanced microbiome can also increase gut inflammation, contributing to pain and discomfort.
This inflammation is often driven by harmful bacteria that produce toxins and pro-inflammatory compounds, leading to heightened gut sensitivity and the visceral hypersensitivity commonly seen in IBS.
Additionally, the gut microbiome interacts with the nervous system through the gut-brain axis, influencing gut sensitivity and the stress response. This interaction can exacerbate IBS symptoms, particularly under stress, by increasing intestinal permeability and triggering immune responses.
Factors Affecting the Gut Microbiome in IBS
The following are the top factors that can influence the gut microbiome and therefore IBS:
Diet and Nutrition
Diet plays a crucial role in influencing the gut microbiome, especially in individuals with IBS.
The microbiome is highly responsive to what we eat. Diets rich in fiber from fruits, vegetables, and whole grains encourage the growth of beneficial bacteria, which are essential for a healthy gut environment.
On the other hand, diets high in processed foods, sugars, and unhealthy fats can reduce microbial diversity and promote the growth of harmful bacteria, potentially worsening IBS symptoms.
Prebiotics, found in fiber-rich foods like garlic, onions, and bananas, nourish beneficial gut bacteria. Probiotics, found in fermented foods like yogurt, kefir, and sauerkraut, are live beneficial bacteria that help maintain balance in the gut microbiome.
Antibiotics and Medications
Antibiotics, though essential for managing bacterial infections, can significantly impact the gut microbiome.
They do not distinguish between harmful and beneficial bacteria, leading to a reduction in microbial diversity. This disruption can create conditions for pathogenic bacteria to overgrow, contributing to dysbiosis and potentially worsening IBS symptoms.
The effects of antibiotics on the gut can be long-lasting, with some research showing that recovery can take months or years.
Other medications also influence the gut microbiome.
For example, nonsteroidal anti-inflammatory drugs (NSAIDs), commonly used for pain relief, can increase gut permeability and alter the microbiome, potentially leading to inflammation and IBS symptoms.
Proton pump inhibitors (PPIs), used to manage acid reflux, can reduce stomach acidity, leading to an overgrowth of bacteria in the small intestine, a condition known as small intestinal bacterial overgrowth (SIBO), which is often associated with IBS.
Stress and Lifestyle
Stress significantly impacts the gut microbiome, especially in those with IBS.
The gut-brain axis, a communication system between the gut and the brain, plays a critical role in how stress affects gut health.
Chronic stress can alter gut motility, increase gut permeability, and change the gut microbiome’s composition, leading to an overgrowth of harmful bacteria and a reduction in beneficial ones.
This imbalance can exacerbate IBS symptoms, including pain, bloating, and irregular bowel movements.
Lifestyle factors including exercise, sleep, and wellness practices such as meditation and yoga, significantly impact the gut microbiome in individuals with IBS.
Regular physical activity promotes microbial diversity and supports beneficial bacteria, while poor sleep patterns can lead to dysbiosis, potentially worsening IBS symptoms.
Maintaining a healthy lifestyle is crucial for supporting gut health and managing IBS.
Managing IBS Through Gut Microbiome Modulation
Here are some ways that IBS can be managed by altering the makeup of the gut microbiome:
Probiotics and Prebiotics
To manage IBS symptoms, incorporating probiotics can be helpful, although the effectiveness of probiotics varies, and their benefits are often strain-specific [34.].
These probiotics may work by replenishing beneficial bacteria in the gut, enhancing microbial diversity, and supporting the gut barrier, which may help alleviate IBS symptoms.
Prebiotics are equally important in IBS management. These non-digestible fibers, found in foods like garlic, onions, asparagus, and bananas, feed beneficial gut bacteria, promoting their growth and activity.
By fostering a healthy gut environment, prebiotics help reduce harmful bacteria and support overall gut health, which can help manage IBS symptoms.
Dietary Interventions
One of the most effective dietary approaches for managing IBS is the Low FODMAP diet. This strategy involves reducing certain poorly absorbed carbohydrates, like fermentable oligosaccharides, disaccharides, monosaccharides, and polyols, which are common triggers for IBS symptoms.
Individuals with IBS may experience symptom relief, including reduced bloating, gas, and diarrhea, by following a low FODMAP diet.
Beyond the Low FODMAP diet, integrating foods that support a healthy gut microbiome is important.
Consuming fiber-rich foods, fermented foods like yogurt and sauerkraut, and polyphenol-rich foods such as berries, green tea, and dark chocolate can nourish beneficial bacteria and maintain a balanced gut environment, aiding in the effective management of IBS.
Lifestyle Changes
Managing IBS through gut microbiome modulation also involves making key lifestyle adjustments.
Stress management is vital, as stress can disrupt the gut microbiome and worsen IBS symptoms. Techniques like mindfulness practice, meditation, deep breathing exercises, and yoga are effective for reducing stress and promoting a healthier gut.
Incorporating regular exercise is another crucial element, as it supports gut motility and microbial diversity. Activities like walking or cycling can positively impact gut health.
Additionally, ensuring adequate sleep is essential, as poor sleep patterns can disrupt the gut microbiome. Establishing a regular sleep routine and prioritizing quality rest are critical components of effective IBS management.
[signup]
Key Takeaways
The gut microbiome is deeply connected to IBS, influencing symptoms through its role in digestion, inflammation, and gut-brain interactions. Recognizing the impact of diet, medications, stress, and lifestyle choices on the microbiome is key to managing IBS effectively.
Maintaining a balanced and healthy gut microbiome is essential for reducing IBS symptoms and improving overall digestive health. Strategies such as dietary adjustments, probiotics, prebiotics, and healthy lifestyle practices can significantly enhance quality of life for those with IBS.
As our knowledge of the gut microbiome expands, there is a growing need for further research and the development of personalized management approaches. Tailoring IBS management to each individual’s unique microbiome composition offers the potential for more effective and long-lasting relief.
The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.
[1.] Adrijana D'Silva, Marshall, D. A., Vallance, J., Nasser, Y., Rajagopalan, V., Szostakiwskyj, J. H., & Raman, M. (2022). Meditation and yoga for irritable bowel syndrome: A randomized clinical trial. The American Journal of Gastroenterology, 118(2), 329–337. https://doi.org/10.14309/ajg.0000000000002052
[2.] Ali OM. THE ROLE OF GUT MICROBIOTA IN IMMUNOMODULATION AND AUTOIMMUNE DISEASES: A COMPREHENSIVE REVIEW. International Journal of Medical Science and Dental Health. 2023;09(12):47-61. doi:https://doi.org/10.55640/ijmsdh-09-12-09
[3.] Allen-Vercoe E, Petrof EO. The microbiome: what it means for medicine. Br J Gen Pract. 2014 Mar;64(620):118-9. doi: 10.3399/bjgp14X677374. PMID: 24567626; PMCID: PMC3933839.
[4.] Altomare, A., Di Rosa, C., Imperia, E., Emerenziani, S., Cicala, M., & Guarino, M. P. L. (2021). Diarrhea predominant-irritable bowel syndrome (IBS-D): Effects of different nutritional patterns on intestinal dysbiosis and symptoms. Nutrients, 13(5), 1506. https://doi.org/10.3390/nu13051506
[5.] Barone M, D'Amico F, Brigidi P, Turroni S. Gut microbiome-micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins? Biofactors. 2022 Mar;48(2):307-314. doi: 10.1002/biof.1835. Epub 2022 Mar 16. PMID: 35294077; PMCID: PMC9311823.
[6.] Brown K, DeCoffe D, Molcan E, Gibson DL. Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease. Nutrients. 2012;4(8):1095-1119. doi:https://doi.org/10.3390/nu4081095
[7.] Calleja-Conde J, Echeverry-Alzate V, Bühler KM, et al. The Immune System through the Lens of Alcohol Intake and Gut Microbiota. International Journal of Molecular Sciences. 2021;22(14):7485. doi:https://doi.org/10.3390/ijms22147485
[8.] Chen J, Li Y, Tian Y, Huang C, Li D, Zhong Q, Ma X. Interaction between Microbes and Host Intestinal Health: Modulation by Dietary Nutrients and Gut-Brain-Endocrine-Immune Axis. Curr Protein Pept Sci. 2015;16(7):592-603. doi: 10.2174/1389203716666150630135720. PMID: 26122779.
[9.] Chiu K, Warner G, Nowak RA, Flaws JA, Mei W. The Impact of Environmental Chemicals on the Gut Microbiome. Toxicol Sci. 2020 Aug 1;176(2):253-284. doi: 10.1093/toxsci/kfaa065. PMID: 32392306; PMCID: PMC7416318.
[10.] Cloyd, J. (2023, March 29). Top 5 differential diagnosis for abdominal pain and how to treat with functional medicine. Rupa Health. https://www.rupahealth.com/post/top-5-differential-diagnoses-for-abdominal-pain-and-how-to-treat-with-functional-medicine
[11.] Cloyd, J. (2024a, January 25). What is the gut microbiome? Rupa Health. https://www.rupahealth.com/post/what-is-the-gut-microbiome
[12.] Cloyd, J. (2024b, February 2). Navigating dietary management for IBS: A functional medicine perspective. Rupa Health. https://www.rupahealth.com/post/navigating-dietary-management-for-ibs-a-functional-medicine-perspective
[13.] Cloyd, J. (2024c, February 20). Deciphering diarrhea: Top 5 differential diagnoses every healthcare practitioner should consider. Rupa Health. https://www.rupahealth.com/post/deciphering-diarrhea-top-5-differential-diagnoses-every-healthcare-practitioner-should-consider
[14.] Cloyd, J. (2024d, February 27). Sleep requirements by age group & why it’s important. Rupa Health. https://www.rupahealth.com/post/sleep-requirements-by-age-group-why-its-important
[15.] Cloyd, J. (2024e, February 28). Dietary strategies for bloating: Understanding and alleviating digestive discomfort. Rupa Health. https://www.rupahealth.com/post/dietary-strategies-for-bloating-understanding-and-alleviating-digestive-discomfort
[16.] DeCesaris, L. (2022, June 6). What is gut dysbiosis? 7 signs to watch for. Rupa Health. https://www.rupahealth.com/post/how-your-gut-bacteria-affects-your-overall-health
[17.] Greenan, S. (2021a, November 2). Constant burping is A sign of this harmful bacterial overgrowth. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-sibo
[18.] Greenan, S. (2021b, November 5). A functional medicine approach to IBS. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-ibs
[19.] Greenan, S. (2021c, November 18). How to do A low FODMAP elimination diet. Rupa Health. https://www.rupahealth.com/post/what-are-fodmaps
[20.] Greenan, S. (2021d, December 8). 5 probiotic-rich foods to eat instead of taking supplements. Rupa Health. https://www.rupahealth.com/post/the-different-types-of-probiotics-health-benefits
[21.] Han M, Yuan S, Zhang J. The interplay between sleep and gut microbiota. Brain Res Bull. 2022 Mar;180:131-146. doi: 10.1016/j.brainresbull.2021.12.016. Epub 2022 Jan 13. PMID: 35032622.
[22.] Hou, K., Wu, ZX., Chen, XY. et al. Microbiota in health and diseases. Sig Transduct Target Ther 7, 135 (2022). https://doi.org/10.1038/s41392-022-00974-4
[23.] Imhann, F., Vich Vila, A., Bonder, M. J., Lopez Manosalva, A. G., Koonen, D. P. Y., Fu, J., … Weersma, R. K. (2017). The influence of proton pump inhibitors and other commonly used medication on the gut microbiota. Gut Microbes, 8(4), 351–358. https://doi.org/10.1080/19490976.2017.1284732
[24.] Jernberg C, Lofmark S, Edlund C, Jansson JK. Long-term impacts of antibiotic exposure on the human intestinal microbiota. Microbiology. 2010;156(11):3216-3223. doi:https://doi.org/10.1099/mic.0.040618-0
[25.] Khan I. Microbiome. Indian Journal of Medical and Paediatric Oncology. 2021;42(05):461-465. doi:https://doi.org/10.1055/s-0041-1735599
[26.] LoBisco, S. (2022, September 16). How food affects your mood through the gut-brain axis. Rupa Health. https://www.rupahealth.com/post/gut-brain-axis
[27.] Lupu VV, Cristina Mihaela Ghiciuc, Stefanescu G, et al. Emerging role of the gut microbiome in post-infectious irritable bowel syndrome: A literature review. World Journal of Gastroenterology. 2023;29(21):3241-3256. doi:https://doi.org/10.3748/wjg.v29.i21.3241
[28.] Lyra A, Sampo Lahtine. Dysbiosis of the Intestinal Microbiota in IBS. InTech eBooks. Published online January 5, 2012. doi:https://doi.org/10.5772/25759
[29.] Madison A, Kiecolt-Glaser JK. Stress, depression, diet, and the gut microbiota: human-bacteria interactions at the core of psychoneuroimmunology and nutrition. Curr Opin Behav Sci. 2019 Aug;28:105-110. doi: 10.1016/j.cobeha.2019.01.011. Epub 2019 Mar 25. PMID: 32395568; PMCID: PMC7213601.
[30.] Magge S, Lembo A. Low-FODMAP Diet for Treatment of Irritable Bowel Syndrome. Gastroenterol Hepatol (N Y). 2012 Nov;8(11):739-45. PMID: 24672410; PMCID: PMC3966170.
[31.] Maholy, N. (2023a, February 22). Improving gut health with exercise. Rupa Health. https://www.rupahealth.com/post/improving-gut-health-with-exercise
[32.] Maholy, N. (2023b, June 29). The role of probiotics and prebiotics in gut health: An integrative perspective. Rupa Health. https://www.rupahealth.com/post/the-role-of-probiotics-and-prebiotics-in-gut-health-an-integrative-perspective
[33.] Moser, G., Fournier, C., & Peter, J. (2018). Intestinal microbiome-gut-brain axis and irritable bowel syndrome. Wiener Medizinische Wochenschrift (1946), 168(3-4), 62–66. https://doi.org/10.1007/s10354-017-0592-0
[34.] Ng, Q.X., Soh, A.Y., Loke, W., Lim, D.Y., & Yeo, W. (2018). The role of inflammation in irritable bowel syndrome (IBS). Journal of Inflammation Research, 11, 345 - 349.
[35.] Parkes GC, Sanderson JD, Whelan K. Treating irritable bowel syndrome with probiotics: the evidence. Proceedings of the Nutrition Society. 2010;69(2):187-194. doi:10.1017/S002966511000011X
[36.] Patel, N. V. (2021). “Let food be thy medicine”: Diet and supplements in irritable bowel syndrome. Clinical and Experimental Gastroenterology, Volume 14, 377–384. https://doi.org/10.2147/ceg.s321054
[37.] Petersen C, Round JL. Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol. 2014 Jul;16(7):1024-33. doi: 10.1111/cmi.12308. Epub 2014 Jun 2. PMID: 24798552; PMCID: PMC4143175.
[38.] Postler TS, Ghosh S. Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System. Cell Metabolism. 2017;26(1):110-130. doi:https://doi.org/10.1016/j.cmet.2017.05.008
[39.] Preston, J. (2023, October 11). An integrative medicine approach to gastrointestinal motility disorders. Rupa Health. https://www.rupahealth.com/post/an-integrative-medicine-approach-to-gastrointestinal-motility-disorders
[40.] Rogers MAM, Aronoff DM. The influence of non-steroidal anti-inflammatory drugs on the gut microbiome. Clin Microbiol Infect. 2016 Feb;22(2):178.e1-178.e9. doi: 10.1016/j.cmi.2015.10.003. Epub 2015 Oct 16. PMID: 26482265; PMCID: PMC4754147.
[41.] Rome Foundation. Rome IV Criteria. Rome Foundation. Published January 16, 2021. https://theromefoundation.org/rome-iv/rome-iv-criteria/
[42.] Scarpellini E, Ianiro G, Attili F, Bassanelli C, De Santis A, Gasbarrini A. The human gut microbiota and virome: Potential therapeutic implications. Digestive and Liver Disease. 2015;47(12):1007-1012. doi:https://doi.org/10.1016/j.dld.2015.07.008
[43.] Sweetnich, J. (2023a, February 17). 6 health benefits of prebiotics. Rupa Health. https://www.rupahealth.com/post/6-health-benefits-of-prebiotics
[44.] Sweetnich, J. (2023b, February 22). How stress affects our gut health. Rupa Health. https://www.rupahealth.com/post/how-stress-affects-our-gut-health
[45.]Sweetnich, J. (2023c, June 30). Exploring the role of stress in IBS and the 3 specialty tests that can help personalized treatment. Rupa Health. https://www.rupahealth.com/post/the-role-of-stress-and-ibs
[46.] Szopa S, Szymonik J. Gut microbiota in professional and amateur athletes: the impact of physical activity on microbiota - what do we know? A literature review. Quality in Sport. 2024;15:50532-50532. doi:https://doi.org/10.12775/qs.2023.15.002
[47.] Takakura W, Pimentel M. Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome – An Update. Frontiers in Psychiatry. 2020;11(11). doi:https://doi.org/10.3389/fpsyt.2020.00664
[48.] Teeter, L. A. (2023, March 16). Mind-Body techniques for IBS relief. Rupa Health. https://www.rupahealth.com/post/mind-body-techniques-for-ibs-relief
[49.] Tidjani Alou M, Lagier JC, Raoult D. Diet influence on the gut microbiota and dysbiosis related to nutritional disorders. Human Microbiome Journal. 2016;1:3-11. doi:https://doi.org/10.1016/j.humic.2016.09.001
[50.] Zhang, S., & Chen, D.-C. (2019). Facing a new challenge: The adverse effects of antibiotics on gut microbiota and host immunity. Chinese Medical Journal, 132(10), 1135–1138. https://doi.org/10.1097/cm9.0000000000000245
[51.] Zhang, Y.-J., Li, S., Gan, R.-Y., Zhou, T., Xu, D.-P., & Li, H.-B. (2015). Impacts of gut bacteria on human health and diseases. International Journal of Molecular Sciences, 16(12), 7493–7519. https://doi.org/10.3390/ijms16047493
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