Metabolic Management
|
May 22, 2024

5 Effective Strategies for Losing Weight with Insulin Resistance

Medically Reviewed by
Updated On
October 31, 2024

Insulin resistance, a condition that affects the body's ability to use the hormone insulin effectively, may contribute to weight loss challenges. This condition affects 40% of adults aged 18-44. Fortunately, natural and conventional treatments can promote improved hormone balance and weight management.Β 

This article focuses on practical strategies for losing weight when dealing with insulin resistance to minimize the risk of type 2 diabetes.Β 

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What Is Insulin Resistance And How Does It Affect Weight?

Insulin resistance describes impaired insulin sensitivity, a problem that occurs when cells in fat, muscles, and the liver don't respond appropriately to insulin (a hormone produced by the pancreas).

Insulin is responsible for moving sugar (obtained from foods consumed) from the bloodstream into other cells within the body. Insulin resistance causes the pancreas to make too much insulin in response to high blood sugar levels, upsetting hormone balance. Fortunately, insulin resistance is treatable, and people with this condition can effectively achieve weight loss goals.Β 

The Relationship Between Insulin Resistance and Weight Gain

Research has discovered a link between weight gain and insulin resistance. Studies show that increased body weight often appears with excessive insulin production. However, evidence suggests that this phenomenon might be related to overeating rather than hyperinsulinemia (high insulin levels) itself.

Weight gain eventually slows after tissues become more resistant to insulin and the body can't make enough insulin to meet its needs. Prolonged insulin resistance may become prediabetes (affecting 1 in 3 adults in the United States) and eventually diabetes. Unintentional weight loss is a sign of type 2 diabetes.

The Link Between Insulin Resistance and Body Fat

Where an individual carries their body weight may also affect the risk of insulin irregularities, as research suggests that excess abdominal fat and around the organs (visceral fat) is a leading cause of insulin resistance.Β 

A waist circumference of 40 inches or greater in men and 35 inches or more in women is associated with impaired insulin sensitivity. Additionally, abdominal fat alters hormones that promote inflammation, potentially leading to insulin resistance.

Some forms of diabetes, such as prediabetes and gestational diabetes (diabetes that appears during pregnancy), for example, are potentially reversible by adopting healthy lifestyle habits. Studies show that a 7% weight loss in overweight or obese individuals decreases the onset of type 2 diabetes by 58%.Β 

5 Effective Strategies for Losing Weight with Insulin Resistance

The following strategies can help people struggling with insulin resistance lose excess body weight and potentially reverse insulin abnormalities:

It outlines various strategies, including physical activity, improved hydration, medication and medical interventions, dietary changes, and supplement use.

#1. Dietary Changes

Consider the following dietary changes to boost weight loss with insulin resistance.

Eat these nutritious foods:

  • Lean proteins: Eggs, organic meats, chicken, fish, seafood, Greek yogurt, and low-fat cottage.
  • High-fiber foods: Beans, peas, other legumes, whole grains, fruits, vegetables, nuts, and seeds.
  • Non-starchy vegetables: Leafy greens, asparagus, mushrooms, broccoli, and cauliflower.
  • Heart-healthy fats: Avocados, nuts, seeds, nut butters, olive oil, and other plant-based oils.
  • Whole grains: Brown rice, quinoa, oatmeal, whole-grain pasta, wild rice, and barley.

Eating a healthy, balanced diet consisting of recommended portions of each food group is crucial.Β 

Focus on plant-based foods, as studies show that plant-based diets decrease the risk of type 2 diabetes and diabetes-related complications.

Reduce the intake of:

  • Added sugars
  • Highly processed foods, such as pre-packaged snacks and microwavable dinnersΒ 
  • Refined carbohydrates (white bread, sugary cereals, white rice, regular pasta)
  • Alcohol
  • Saturated fats (animal fats)
  • High-fat meats
  • Highly processed meats (hot dogs, salami, sausage)
  • Fried foods
  • Cookies, cakes, pies, and ice cream
  • Sugar-sweetened drinks (sweet tea, soda, lemonade, fruit juice, and other sugar-sweetened beverages)
  • Sugar-sweetened breakfast cereals
  • Sugar-sweetened sauces and condiments
  • Fruits canned in syrup

These foods can negatively affect insulin resistance by causing the pancreas to produce excess insulin.

#2. Physical Activity

Exercise improves insulin sensitivity by moving sugar into the muscles. A single session of moderate-intensity exercise can increase glucose uptake by at least 40%. Researchers suggest that 30-45 minutes of moderate-intensity exercise daily or shorter bouts of high-intensity interval training (HIIT) is an effective strategy for improving insulin resistance.Β 

Regular exercise aids in weight loss by increasing calorie expenditure and metabolism, boosting muscle mass, reducing body fat, and supporting a better night's sleep – an essential component of healthy weight management and improved insulin sensitivity.

#3. Medication and Medical Interventions

If lifestyle interventions have been unsuccessful in facilitating weight loss, medications may be a solution. Some medicines aid in weight loss by improving insulin sensitivity or reducing appetite, while others help manage coexisting medical conditions.

Taking dietary supplements (under the direction of a healthcare provider) or undergoing hormone therapy for hormone imbalance can speed up metabolism, making weight loss easier. Weight loss surgery might also be an option for some obese individuals.Β 

#4. Improved Hydration

About 75% of individuals in the United States are chronically dehydrated, which can hinder weight loss in those struggling with insulin resistance. Drinking more water aids in weight loss in people with and without insulin resistance by reducing hunger and the risk of overeating.

Studies show that drinking more water increases satiety, and consuming 2 cups of water before meals optimizes weight loss in overweight or obese people. Increasing water consumption can also improve blood sugar levels, reducing the risk of type 2 diabetes.

#5. Supplement Use

Taking certain supplements may help reduce insulin resistance during weight loss. Examples of supplements to consider:

  • Cinnamon: Taking 4 grams of cinnamon daily (about 1 teaspoon) may reduce blood glucose in people with prediabetes and obesity.Β 
  • Fenugreek: Studies show that fenugreek may reduce the risk of type 2 diabetes.Β 
  • Ginseng: Research suggests that ginseng may optimize glycemic control.
  • Biotin: Studies show that taking at least 9 milligrams of biotin daily may improve blood sugar levels.
  • Banaba: One study demonstrated supplementing with 500 milligrams of banaba twice daily improved insulin sensitivity.
  • Flavonoids: Studies suggest that flavonoid supplements may decrease insulin resistance in overweight and obese study subjects.Β 
  • Fiber supplements: Taking 17 grams of NUTRIOSE fiber supplements twice daily may improve insulin resistance.Β 
  • Alpha-lipoic acid (ALA): Researchers found 400 milligrams of ALA improved insulin resistance.
  • Omega-3 fatty acids: Studies demonstrate that omega-3 supplementation boosts insulin sensitivity among individuals with metabolic disorders.
  • Magnesium and vitamin D: Studies show that combining magnesium with vitamin D improves blood sugar control.
  • Vitamin K: Vitamin K supplementation may improve insulin sensitivity and reduce the risk of related conditions.Β 
  • Probiotics: Probiotic supplements may benefit insulin resistance in women with polycystic ovary syndrome (PCOS).
  • Resveratrol: Researchers found that resveratrol supplementation reduced blood sugar and significantly improved insulin sensitivity.Β 

Individuals should always consult with a medical provider before taking dietary supplements and to establish appropriate dosing, especially if they take medications or have a chronic disease.

Why Is Losing Weight Harder with Insulin Resistance?

Insulin resistance makes weight loss more challenging because the body's impaired ability to use insulin for energy increases fat storage. However, losing weight with insulin resistance is still entirely possible with the proper lifestyle habits or treatment plan.

Factors Contributing to Weight Retention

Factors that contribute to weight retention in people with insulin resistance include:

Additional Tips for Weight Loss Success

Here are some other tips for success in losing weight with insulin resistance:

Prioritize SleepΒ 

Getting plenty of sleep is vital for optimizing insulin sensitivity and losing weight with insulin resistance. Sleeping more than seven hours per night can improve insulin resistance, lower the risk of type 2 diabetes, and enhance weight loss and fat loss in overweight or obese individuals.

Β To achieve a better night's sleep, consider the following recommendations:

  • Set a regular sleep schedule that allows at least seven sleep hours per night.
  • Sleep in a relaxing, quiet, dark, and cool room.
  • Participate in regular exercise, but avoid physical activity right before bed.
  • Avoid screen time (televisions, computers, phones) before bedtime.
  • Avoid smoking, large meals, caffeine, and alcohol before you go to sleep.

Individuals with sleep apnea or other sleep disorders should seek treatment from their provider if they're not able to get a good night's rest using natural methods.

Manage Stress

Studies show that stress increases insulin resistance, promotes inflammation, and increases the risk of obesity through its effects on behaviors, cognition, and physiology.Β 

Ways to minimize stress to lose weight with insulin resistance include:

These techniques can enhance insulin utilization, balance hormone levels, and maximize fat loss.

Seek Professional Guidance

Individuals should consult a healthcare provider, dietitian, or diabetes educator to create a personalized weight loss plan based on their health history, lifestyle, treatment preferences, and goals.

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Key Takeaways

It's vital to understand the impact of insulin resistance on weight loss. To recap, the effective strategies for losing weight with insulin resistance include:

Patience, consistency, and professional guidance are the keys to weight loss success, a lower risk of medical complications, and an exceptional quality of life.

Insulin resistance, a condition that affects the body's ability to use the hormone insulin effectively, may contribute to weight management challenges. This condition affects 40% of adults aged 18-44. Fortunately, natural and conventional approaches can support improved hormone balance and weight management.Β 

This article focuses on practical strategies for managing weight when dealing with insulin resistance to support overall health and well-being.Β 

[signup]

What Is Insulin Resistance And How Does It Affect Weight?

Insulin resistance describes impaired insulin sensitivity, a problem that occurs when cells in fat, muscles, and the liver don't respond appropriately to insulin (a hormone produced by the pancreas).

Insulin is responsible for moving sugar (obtained from foods consumed) from the bloodstream into other cells within the body. Insulin resistance causes the pancreas to make more insulin in response to high blood sugar levels, affecting hormone balance. Fortunately, insulin resistance can be managed, and people with this condition can work towards achieving their weight management goals.Β 

The Relationship Between Insulin Resistance and Weight Gain

Research has discovered a link between weight gain and insulin resistance. Studies show that increased body weight often appears with excessive insulin production. However, evidence suggests that this phenomenon might be related to overeating rather than hyperinsulinemia (high insulin levels) itself.

Weight gain eventually slows after tissues become more resistant to insulin and the body can't make enough insulin to meet its needs. Prolonged insulin resistance may lead to prediabetes (affecting 1 in 3 adults in the United States) and eventually diabetes. Unintentional weight loss is a sign of type 2 diabetes.

The Link Between Insulin Resistance and Body Fat

Where an individual carries their body weight may also affect the risk of insulin irregularities, as research suggests that excess abdominal fat and around the organs (visceral fat) is a leading cause of insulin resistance.Β 

A waist circumference of 40 inches or greater in men and 35 inches or more in women is associated with impaired insulin sensitivity. Additionally, abdominal fat alters hormones that promote inflammation, potentially leading to insulin resistance.

Some forms of diabetes, such as prediabetes and gestational diabetes (diabetes that appears during pregnancy), for example, may be managed by adopting healthy lifestyle habits. Studies show that a 7% weight loss in overweight or obese individuals decreases the onset of type 2 diabetes by 58%.Β 

5 Strategies for Supporting Weight Management with Insulin Resistance

The following strategies can help people struggling with insulin resistance manage their body weight and support insulin function:

#1. Dietary Changes

Consider the following dietary changes to support weight management with insulin resistance.

Eat these nutritious foods:

  • Lean proteins: Eggs, organic meats, chicken, fish, seafood, Greek yogurt, and low-fat cottage.
  • High-fiber foods: Beans, peas, other legumes, whole grains, fruits, vegetables, nuts, and seeds.
  • Non-starchy vegetables: Leafy greens, asparagus, mushrooms, broccoli, and cauliflower.
  • Heart-healthy fats: Avocados, nuts, seeds, nut butters, olive oil, and other plant-based oils.
  • Whole grains: Brown rice, quinoa, oatmeal, whole-grain pasta, wild rice, and barley.

Eating a healthy, balanced diet consisting of recommended portions of each food group is crucial.Β 

Focus on plant-based foods, as studies show that plant-based diets may support a healthy metabolism and overall well-being.

Reduce the intake of:

  • Added sugars
  • Highly processed foods, such as pre-packaged snacks and microwavable dinnersΒ 
  • Refined carbohydrates (white bread, sugary cereals, white rice, regular pasta)
  • Alcohol
  • Saturated fats (animal fats)
  • High-fat meats
  • Highly processed meats (hot dogs, salami, sausage)
  • Fried foods
  • Cookies, cakes, pies, and ice cream
  • Sugar-sweetened drinks (sweet tea, soda, lemonade, fruit juice, and other sugar-sweetened beverages)
  • Sugar-sweetened breakfast cereals
  • Sugar-sweetened sauces and condiments
  • Fruits canned in syrup

These foods can negatively affect insulin function by causing the pancreas to produce more insulin.

#2. Physical Activity

Exercise may support insulin sensitivity by moving sugar into the muscles. A single session of moderate-intensity exercise can increase glucose uptake by at least 40%. Researchers suggest that 30-45 minutes of moderate-intensity exercise daily or shorter bouts of high-intensity interval training (HIIT) may be beneficial for supporting insulin function.Β 

Regular exercise aids in weight management by increasing calorie expenditure and metabolism, boosting muscle mass, reducing body fat, and supporting a better night's sleep – an essential component of healthy weight management and improved insulin sensitivity.

#3. Medication and Medical Interventions

If lifestyle interventions have been unsuccessful in facilitating weight management, medications may be a solution. Some medicines aid in weight management by supporting insulin sensitivity or reducing appetite, while others help manage coexisting medical conditions.

Taking dietary supplements (under the direction of a healthcare provider) or undergoing hormone therapy for hormone imbalance can support metabolism, making weight management easier. Weight loss surgery might also be an option for some obese individuals.Β 

#4. Improved Hydration

About 75% of individuals in the United States are chronically dehydrated, which can hinder weight management in those struggling with insulin resistance. Drinking more water may support weight management in people with and without insulin resistance by reducing hunger and the risk of overeating.

Studies show that drinking more water increases satiety, and consuming 2 cups of water before meals may support weight management in overweight or obese people. Increasing water consumption can also support healthy blood sugar levels.

#5. Supplement Use

Taking certain supplements may help support insulin function during weight management. Examples of supplements to consider:

  • Cinnamon: Taking 4 grams of cinnamon daily (about 1 teaspoon) may support healthy blood glucose levels in people with prediabetes and obesity.Β 
  • Fenugreek: Studies show that fenugreek may support healthy blood sugar levels.Β 
  • Ginseng: Research suggests that ginseng may support glycemic control.
  • Biotin: Studies show that taking at least 9 milligrams of biotin daily may support healthy blood sugar levels.
  • Banaba: One study demonstrated supplementing with 500 milligrams of banaba twice daily may support insulin sensitivity.
  • Flavonoids: Studies suggest that flavonoid supplements may support insulin function in overweight and obese study subjects.Β 
  • Fiber supplements: Taking 17 grams of NUTRIOSE fiber supplements twice daily may support insulin function.Β 
  • Alpha-lipoic acid (ALA): Researchers found 400 milligrams of ALA may support insulin function.
  • Omega-3 fatty acids: Studies demonstrate that omega-3 supplementation may support insulin sensitivity among individuals with metabolic concerns.
  • Magnesium and vitamin D: Studies show that combining magnesium with vitamin D may support blood sugar control.
  • Vitamin K: Vitamin K supplementation may support insulin sensitivity and overall health.Β 
  • Probiotics: Probiotic supplements may support insulin function in women with polycystic ovary syndrome (PCOS).
  • Resveratrol: Researchers found that resveratrol supplementation may support healthy blood sugar levels and insulin sensitivity.Β 

Individuals should always consult with a medical provider before taking dietary supplements and to establish appropriate dosing, especially if they take medications or have a chronic disease.

Why Is Managing Weight Harder with Insulin Resistance?

Insulin resistance makes weight management more challenging because the body's impaired ability to use insulin for energy may increase fat storage. However, managing weight with insulin resistance is still entirely possible with the proper lifestyle habits or support plan.

Factors Contributing to Weight Retention

Factors that contribute to weight retention in people with insulin resistance include:

Additional Tips for Weight Management Success

Here are some other tips for success in managing weight with insulin resistance:

Prioritize SleepΒ 

Getting plenty of sleep is vital for supporting insulin sensitivity and managing weight with insulin resistance. Sleeping more than seven hours per night can support insulin function, lower the risk of type 2 diabetes, and enhance weight management in overweight or obese individuals.

Β To achieve a better night's sleep, consider the following recommendations:

  • Set a regular sleep schedule that allows at least seven sleep hours per night.
  • Sleep in a relaxing, quiet, dark, and cool room.
  • Participate in regular exercise, but avoid physical activity right before bed.
  • Avoid screen time (televisions, computers, phones) before bedtime.
  • Avoid smoking, large meals, caffeine, and alcohol before you go to sleep.

Individuals with sleep apnea or other sleep disorders should seek treatment from their provider if they're not able to get a good night's rest using natural methods.

Manage Stress

Studies show that stress may affect insulin function, promote inflammation, and increase the risk of obesity through its effects on behaviors, cognition, and physiology.Β 

Ways to minimize stress to support weight management with insulin resistance include:

These techniques can enhance insulin utilization, balance hormone levels, and support fat management.

Seek Professional Guidance

Individuals should consult a healthcare provider, dietitian, or diabetes educator to create a personalized weight management plan based on their health history, lifestyle, treatment preferences, and goals.

[signup]

Key Takeaways

It's vital to understand the impact of insulin resistance on weight management. To recap, the strategies for managing weight with insulin resistance include:

Patience, consistency, and professional guidance are the keys to weight management success, a lower risk of medical complications, and an exceptional quality of life.

The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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Anderson, S. (2022, September 14). This is what happens to your body when you are dehydrated. Rupa Health. https://www.rupahealth.com/post/this-is-what-happens-to-your-body-when-you-are-dehydrated

Anderson, S. (2022, July 22). 5 conditions that make it harder to lose weight. Rupa Health. https://www.rupahealth.com/post/cant-lose-weight-these-5-medical-problems-may-be-whyΒ 

Badaam, K. M., & Zingade, U. S. (2021). The effect of traditional aerobic exercise and sprint interval training on insulin resistance in men with prediabetes: A randomized controlled trial. Cureus, 13(12). https://doi.org/10.7759/cureus.20789

Barber, T. M., Kabisch, S., Randeva, H. S., Pfeiffer, A. F. H., & Weickert, M. O. (2022). Implications of resveratrol in obesity and insulin resistance: A state-of-the-art review. Nutrients, 14(14), 2870. https://doi.org/10.3390/nu14142870

Bertagna, B. (2023, December 13). Fenugreek for diabetes: A closer look at its mechanisms in improving blood sugar control. Rupa Health. https://www.rupahealth.com/post/fenugreek-for-diabetes-a-closer-look-at-its-mechanisms-in-improving-blood-sugar-control

Bertagna, B. (2024, January 11). The science behind meditation and sleep: How mindfulness practices improve sleep quality. Rupa Health. https://www.rupahealth.com/post/the-science-behind-meditation-and-sleep-how-mindfulness-practices-improve-sleep-quality

Blake, K. (2023, April 28). What is a heart healthy diet and who should follow one? Rupa Health. https://www.rupahealth.com/post/what-is-a-heart-healthy-diet-and-who-should-follow-one

Capece, U., Moffa, S., Improta, I., Di Giuseppe, G., Nista, E. C., Cefalo, C. M. A., Cinti, F., Pontecorvi, A., Gasbarrini, A., Giaccari, A., & Mezza, T. (2022). Alpha-Lipoic acid and glucose metabolism: A comprehensive update on biochemical and therapeutic features. Nutrients, 15(1), 18. https://doi.org/10.3390/nu15010018

CDC. (2019, August 12). The insulin resistance–diabetes connection. Centers for Disease Control and Prevention; CDC. https://www.cdc.gov/diabetes/basics/insulin-resistance.html

CDC. (2022). Getting enough sleep? Centers for Disease Control and Prevention. https://www.cdc.gov/sleep/features/getting-enough-sleep.html

Chaunt, L. A. (2023a, April 3). Mental health benefits of yoga and meditation. Rupa Health. https://www.rupahealth.com/post/mental-health-benefits-of-yoga-and-meditation

Chaunt, L. A. (2023b, April 13). Using functional nutrition to address hormone imbalances. Rupa Health. https://www.rupahealth.com/post/using-functional-nutrition-to-address-hormone-imbalances

Christie, J. (2022, December 13). 95% of Americans aren't getting enough fiber: How many grams should we be consuming per day? Www.rupahealth.com. https://www.rupahealth.com/post/95-of-americans-arent-getting-enough-fiber-how-many-grams-of-fiber-should-we-be-consuming-per-day

Christie, J. (2024, April 1). A root cause medicine protocol for PCOS. Rupa Health. https://www.rupahealth.com/post/a-root-cause-medicine-protocol-for-pcosΒ 

Christie, J. (2023a, January 6). A functional medicine approach to obesity and weight management. Rupa Health. https://www.rupahealth.com/post/an-integrative-approach-to-obesity

Christie, J. (2023b, November 30). Caffeine for diabetes: A comprehensive overview. Rupa Health. https://www.rupahealth.com/post/caffeine-for-diabetes-a-comprehensive-overview

Cleveland Clinic. (2021a, September 21). Polycystic ovary syndrome (PCOS) & treatment. Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/8316-polycystic-ovary-syndrome-pcos

Cleveland Clinic. (2021b, December 16). Insulin resistance: What it is, causes, symptoms & treatment. Cleveland Clinic; Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/22206-insulin-resistance

Cloyd, J. (2023a, April 4). Integrative medicine approach to patients with sleep apnea. Rupa Health. https://www.rupahealth.com/post/integrative-medicine-approach-to-patients-with-sleep-apnea

Cloyd, J. (2024, January 2). A functional medicine approach to prediabetes. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-prediabetesΒ 

Cloyd, J. (2023b, April 28). What is the difference between medical-grade supplements and over-the-counter supplements? Rupa Health. https://www.rupahealth.com/post/what-is-the-difference-between-medical-grade-supplements-and-over-the-counter-supplements

Cloyd, J. (2023c, July 5). Integrative approaches to managing high blood sugar: Specialty testing, lifestyle modifications, and natural remedies. Rupa Health. https://www.rupahealth.com/post/integrative-approaches-to-managing-high-blood-sugar-testing-lifestyle-modifications-and-natural-remedies

Cloyd, J. (2023d, October 2). A functional medicine approach to stress management. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-stress-management

Cloyd, J. (2023e, November 2). The top 4 therapeutic uses of ginseng to boost your health. Rupa Health. https://www.rupahealth.com/post/the-top-4-therapeutic-uses-of-ginseng-to-boost-your-health

Cloyd, J. (2024, January 8). The science of hydration: How water intake affects overall health. Rupa Health. https://www.rupahealth.com/post/the-science-of-hydration-how-water-intake-affects-overall-health

Coleman, E. (2024, April 16). Indoles for cancer prevention: Understanding the protective role of cruciferous vegetables. Rupa Health. https://www.rupahealth.com/post/indoles-for-cancer-prevention-understanding-the-protective-role-of-cruciferous-vegetables

DeCesaris, L. (2023, May 22). Discussing the metabolic health benefits of diet induced thermogenesis with your patients. Rupa Health. https://www.rupahealth.com/post/what-is-diet-induced-thermogenesis

DePorto, T. (2023, January 6). Omega 3's: The superfood nutrient you need to know about. Rupa Health. https://www.rupahealth.com/post/omega-3s-the-superfood-nutrient-you-need-to-know-about

Diorio, B. (2023, January 17). Why most functional medicine practitioners say no to alcohol. Rupa Health. https://www.rupahealth.com/post/why-most-functional-medicine-practitioners-say-no-to-alcohol

Freeman, A. M., & Pennings, N. (2023). Insulin resistance. Nih.gov; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK507839/

Gao, H., Geng, T., Huang, T., & Zhao, Q. (2017). Fish oil supplementation and insulin sensitivity: A systematic review and meta-analysis. Lipids in Health and Disease, 16(1). https://doi.org/10.1186/s12944-017-0528-0Β 

Greenan, S. (2021, October 11). 7 early signs of insulin resistance. Rupa Health. https://www.rupahealth.com/post/what-is-insulin-resistanceΒ 

Handbook of Non Drug Intervention (HANDI) Project Team. (2013). Pre-meal water consumption for weight loss. Australian Family Physician, 42(7), 478. https://pubmed.ncbi.nlm.nih.gov/23826600/

Kalaichandran, A. (2024a, February 22). Cinnamon: A simple spice with profound health benefits. Rupa Health. https://www.rupahealth.com/post/cinnamon-a-simple-spice-with-profound-health-benefits

Kalaichandran, A. (2024b, March 20). The gentle power of tai chi: A promising approach to blood pressure management. Rupa Health. https://www.rupahealth.com/post/the-gentle-power-of-tai-chi-a-promising-approach-to-blood-pressure-management

Kijmanawat, A., Panburana, P., Reutrakul, S., & Tangshewinsirikul, C. (2018). Effects of probiotic supplements on insulin resistance in gestational diabetes mellitus: A double-blind randomized controlled trial. Journal of Diabetes Investigation, 10(1), 163–170. https://doi.org/10.1111/jdi.12863

Kline, C. E., Chasens, E. R., Bizhanova, Z., Sereika, S. M., Buysse, D. J., Imes, C. C., Kariuki, J. K., Mendez, D. D., Cajita, M. I., Rathbun, S. L., & Burke, L. E. (2021). The association between sleep health and weight change during a 12-month behavioral weight loss intervention. International Journal of Obesity, 45(3), 639–649. https://doi.org/10.1038/s41366-020-00728-8

Kouzi, S. A. (2015). Natural supplements for improving insulin sensitivity and glucose uptake in skeletal muscle. Frontiers in Bioscience, 7(1), 107–121. https://doi.org/10.2741/e720

Li, S., Guerin-Deremaux, L., Pochat, M., Wils, D., Reifer, C., & Miller, L. E. (2010). NUTRIOSE dietary fiber supplementation improves insulin resistance and determinants of metabolic syndrome in overweight men: A double-blind, randomized, placebo-controlled study. Applied Physiology, Nutrition, and Metabolism, 35(6), 773–782. https://doi.org/10.1139/h10-074

LΓ³pez-Murillo, L. D., GonzΓ‘lez-Ortiz, M., MartΓ­nez-Abundis, E., Cortez-Navarrete, M., & PΓ©rez-Rubio, K. G. (2021). Effect of banaba (lagerstroemia speciosa) on metabolic syndrome, insulin sensitivity, and insulin secretion. Journal of Medicinal Food, 25. https://doi.org/10.1089/jmf.2021.0039Β 

Maholy, N. (2023, April 14). How to reduce stress through mind-body therapies. Rupa Health. https://www.rupahealth.com/post/how-to-reduce-stress-through-mind-body-therapies

Maholy, N. (2023, March 15). How processed sugar affects our health. Rupa Health. https://www.rupahealth.com/post/how-processed-sugar-affects-our-healthΒ 

Miao, C., Guo, Q., Fang, X., Chen, Y., Zhao, Y., & Zhang, Q. (2021). Effects of probiotic and synbiotic supplementation on insulin resistance in women with polycystic ovary syndrome: A meta-analysis. Journal of International Medical Research, 49(7), 030006052110317. https://doi.org/10.1177/03000605211031758Β 

Manna, P., & Kalita, J. (2016). Beneficial role of vitamin K supplementation on insulin sensitivity, glucose metabolism, and the reduced risk of type 2 diabetes: A review. Nutrition, 32(7-8), 732–739. https://doi.org/10.1016/j.nut.2016.01.011

Mayo Clinic. (2023, September 15). Diabetes - symptoms and causes. Mayo Clinic; Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/diabetes/symptoms-causes/syc-20371444

McMacken, M., & Shah, S. (2017). A plant-based diet for the prevention and treatment of type 2 diabetes. Journal of Geriatric Cardiology: JGC, 14(5), 342–354. https://doi.org/10.11909/j.issn.1671-5411.2017.05.009

Mohd, W., Hani Ajrina Zulkeflee, Rahim, A., & Noor, T. (2023). Association of vitamin D and magnesium with insulin sensitivity and their influence on glycemic control. World Journal of Diabetes, 14(1), 26–34. https://doi.org/10.4239/wjd.v14.i1.26

National Institute of Diabetes and Digestive and Kidney Diseases. (2019, September 15). Diabetes statistics. National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/health-statistics/diabetes-statistics

Preston, J. (2024, February 15). Magnesium 101: RDA, magnesium-rich foods, and supplementation. Rupa Health. https://www.rupahealth.com/post/magnesium-101-rda-magnesium-rich-foods-and-supplementationΒ 

Sedaghat, G., Montazerifar, F., Keykhaie, M. A., Karajibani, M., Shourestani, S., & Dashipour, A. (2021). Effect of pre-meal water intake on the serum levels of copeptin, glycemic control, lipid profile and anthropometric indices in patients with type 2 diabetes mellitus: A randomized, controlled trial. Journal of Diabetes & Metabolic Disorders, 20(1). https://doi.org/10.1007/s40200-020-00724-9

Singh, T., Ahmed, T. H., Mohamed, N., Elhaj, M. S., Mohammed, Z., Paulsingh, C. N., Mohamed, M. B., & Khan, S. (2022). Does insufficient sleep increase the risk of developing insulin resistance: A systematic review. Cureus, 14(3). https://doi.org/10.7759/cureus.23501

Stanford, J. (2024a, March 12). Mastering the Bs: A comprehensive cheat sheet on vitamins B1, 2, 3, 5, 6, 7, 9, 12 for healthcare practitioners. Rupa Health. https://www.rupahealth.com/post/a-comprehensive-cheat-sheet-on-b-vitamins

Stanford, J. (2024b, March 19). Exploring the link between insulin resistance and obesity. Rupa Health. https://www.rupahealth.com/post/insulin-resistance-obesity

Stanford, J. (2024c, March 21). Insulin resistance and inflammation: Understanding the connection. Rupa Health. https://www.rupahealth.com/post/insulin-resistance-and-inflammation-understanding-the-connection

Sweetnich, J. (2023, May 24). Overview of the pancreas: Top conditions, specialty testing, and integrative medicine treatment options. Rupa Health. https://.rupahealth.com/post/pancrease-101-with-testing-top-conditions

Sweetnich, J. (2023, May 4). Getting to know vitamin D: From testing to supplementing and meeting your RDAs. Rupa Health. https://www.rupahealth.com/post/vitamin-d-101-testing-rdas-and-supplementingΒ 

Taylor, K., & Jones, E. B. (2024). Adult dehydration. PubMed; StatPearls Publishing. https://www.google.com/url?q=https://www.ncbi.nlm.nih.gov/books/NBK555956/&sa=D&source=docs&ust=1714158252348225&usg=AOvVaw2imFroacIE76XiH47PjFC7

Tingle, R. (2022, June 6). 10 type 2 diabetes risk factors you may not know about. Rupa Health. https://www.rupahealth.com/post/what-causes-type-2-diabetes

U.S. Department of Agriculture. (2020). MyPlate. MyPlate; U.S. Department of Agriculture. https://www.myplate.gov/

Understanding insulin resistance | ADA. (2024). Diabetes.org. https://diabetes.org/health-wellness/insulin-resistance

Weinberg, J. (2023, February 21). 5 lab tests to run on your hypoglycemia patients. Rupa Health. https://www.rupahealth.com/post/5-lab-test-for-your-hypoglycemia-patients

Weinberg, J. (2024, January 11). Enhancing sleep quality during shorter days: Insights from functional medicine. Rupa Health. https://www.rupahealth.com/post/enhancing-sleep-quality-during-shorter-days-insights-from-functional-medicine

Yao, J., Zhang, Y., Zhao, J., Wang, X.-Z., Lin, Y., Sun, L., Lu, Q.-Y., & Fan, G.-J. (2022). Efficacy of flavonoids-containing supplements on insulin resistance and associated metabolic risk factors in overweight and obese subjects: A systematic review and meta-analysis of 25 randomized controlled trials. Frontiers in Endocrinology, 13. https://doi.org/10.3389/fendo.2022.917692

Yaribeygi, H., Maleki, M., Butler, A. E., Jamialahmadi, T., & Sahebkar, A. (2022). Molecular mechanisms linking stress and insulin resistance. EXCLI Journal, 21, 317–334. https://doi.org/10.17179/excli2021-4382

Yoshimura, H. (2023a, April 10). Integrative medicine approaches to managing anxiety and depression naturally. Rupa Health. https://www.rupahealth.com/post/integrative-medicine-approaches-to-managing-anxiety-and-depression-naturally

Yoshimura, H. (2023b, November 7). The remarkable power of exercise on our health: A comprehensive overview. Rupa Health. https://www.rupahealth.com/post/the-remarkable-power-of-exercise-on-our-health-a-comprehensive-overview

Yoshimura, H. (2023c, November 13). Sweat it out: The powerful connection between exercise and insulin sensitivity. Rupa Health. https://www.rupahealth.com/post/sweat-it-out-the-powerful-connection-between-exercise-and-insulin-sensitivity

Yoshimura, H. (2023a, August 21). A root cause medicine approach to gestational diabetes. Rupa Health. https://www.rupahealth.com/post/a-root-cause-medicine-approach-to-gestational-diabetesΒ 

Yoshimura, H. (2023b, November 22). Nature’s sweet vs. factory’s treat: What’s the difference between natural sugars and added sugars? Rupa Health. https://www.rupahealth.com/post/natures-sweet-vs-factorys-treat-whats-the-difference-between-natural-sugars-and-added-sugarsΒ 

Zhang, Y., Ding, Y., Fan, Y., Xu, Y., Lu, Y., Zhai, L., & Wang, L. (2022, October 31). Influence of biotin intervention on glycemic control and lipid profile in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. Frontiers in Psychology. https://www.frontiersin.org/articles/10.3389/fnut.2022.1046800/fullΒ 

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