A Root Cause Medicine Approach
|
November 7, 2024

How Functional Medicine Practitioners View Inflammation

Medically Reviewed by
Updated On
November 13, 2024

Inflammation is the body's response to an irritant, be that a germ, a virus, or a foreign body. A finger swells around a splinter, a joint swells after an injury, or the liver swells with an infection. In other words, inflammation is a tool the immune system uses to protect the body from something bad.

Chronic inflammation, which lasts months or even years, can be associated with various health conditions, including heart disease, diabetes, autoimmune disorders, and certain types of cancer

In functional medicine, managing chronic inflammation often involves a comprehensive strategy that may include specialized tests, dietary adjustments, and natural remedies alongside conventional treatments.

[signup]

Understanding Inflammation: Acute vs. Chronic

Inflammation can be broken down into two categories: acute or immediate and chronic or ongoing.

Acute Inflammation

Acute inflammation is the body's immediate response to an injury or infection. This response results in local vasodilation, increased vascular permeability, and the release of mediators that bring other inflammatory cells to the affected area.  

There are five classical clinical features of acute inflammation:

  • Redness
  • Heat
  • Swelling
  • Pain
  • Loss of function

While there can be many causes of acute inflammation, they can be broken down into two categories:

  • Injuries such as cuts, scrapes, bruises, or sprains cause a localized inflammatory response to protect the injured area.
  • Infections such as strep throat or the flu will result in inflammation so the body can try to contain the infection.

Chronic Inflammation

Chronic inflammation is associated with various health conditions, including: 

Chronic inflammation may contribute to tissue damage, organ dysfunction, joint deterioration, and DNA damage, highlighting the importance of addressing its underlying causes.

The Functional Medicine Approach to Inflammation

Functional medicine, which adopts a holistic perspective, aims to address the underlying factors contributing to chronic inflammation. This approach often involves personalized treatment plans that consider individual factors including: 

Genetics: Some disorders, such as celiac disease and scleroderma, are known to have genetic factors that make someone more or less likely to develop the disorder.

Individual lifestyles: This can affect a patient's chances of developing a chronic inflammatory disease. For example, foods high in saturated fats have been associated with increased systemic inflammation.

Environmental factors: These factors affect many chronic inflammatory diseases, including myasthenia gravis and lupus.

These personalized plans facilitate a system-based approach that examines the entire body, including gut health, immune function, and hormonal balance. Additionally, functional medicine emphasizes prevention through early detection and lifestyle modifications, complementing traditional medical treatments.

Key Causes of Chronic Inflammation in Functional Medicine

Functional medicine recognizes that inflammation can be influenced by a variety of non-viral factors. Practitioners address these contributing elements alongside any existing health conditions. Key causes of chronic inflammation include:

Diet and Nutrition

There is substantial evidence indicating a correlation between diet and inflammation. Certain foods may promote inflammation, while others can help reduce it. For instance, a Mediterranean diet has been associated with improved gut health and reduced systemic inflammation. 

Gut Health

A healthy gut plays a crucial role in managing inflammation. Conditions such as increased intestinal permeability (often referred to as "leaky gut"), dysbiosis, and Crohn's disease are linked to systemic inflammation.

Toxins and Environmental Factors

Exposure to toxins, such as benzene, halocarbons, ketones, and nitrosamines, can lead to systemic inflammation.

Heavy metals, pesticides, and dust mites can also lead to chronic inflammation.

Chronic Stress

Stress induces the production of cortisol, commonly known as the "stress hormone." Chronically elevated cortisol levels can promote inflammation and directly affect pain perception and other bodily systems, resulting in a "psychoneuroendocrine" response.

Sleep Deprivation

Adequate sleep is vital for controlling inflammation and maintaining overall physical health. A study by Harvard Medical School found that insufficient sleep not only causes chronic inflammation but also contributes to other factors that promote inflammation, highlighting the importance of sleep in inflammation management 

Sedentary Lifestyle

Finally, movement is vital in controlling chronic inflammation and overall health.

Regular physical activity is essential for controlling chronic inflammation and maintaining overall health.

Inactivity has been linked to increased inflammation, whereas regular exercise can reduce multiple causes of inflammation and offer a protective effect against the body becoming inflamed.

An article in the prestigious journal Nature suggested that regular exercise may reduce chronic inflammation and have a protective effect on the body, keeping it from becoming inflamed in the first place.

Functional Medicine Treatment Strategies for Inflammation

Functional medicine uses a variety of strategies to manage inflammation, including:

  • Dietary modifications: Focus on anti-inflammatory, antioxidant, and fiber-rich foods. Eliminate any foods to which the patient is sensitive, along with high-fat and saturated-fat foods. Additionally, ensure the patient is adequately hydrated.
  • Nutritional supplements: Curcumin, omega-3, and vitamin D are common supplements functional medicine practitioners use to support appropriate inflammatory responses.
  • Stress management techniques: Examples include mindfulness, yoga, and biofeedback. Counseling and therapy may also be implemented if needed.
  • Exercise and movement: Regular physical activity is vital in maintaining overall health and reducing inflammation.
  • Sleep optimization: Ensure good sleep hygiene practices and sleep tracking.

Please consult with a healthcare professional before implementing any of these treatment strategies.

Potential Risks and Considerations in Functional Medicine's Approach

As with any treatment approach, it is essential for patients to avoid unsupported claims and rely on evidence-based practices. Patients should consult peer-reviewed materials and discuss their treatment plans with qualified healthcare professionals.

If a patient is consulting with multiple physicians, it is important to communicate the treatment strategies employed by each to ensure safe and coordinated care. Additionally, when taking supplements, patients should inform their medical team, as many over-the-counter supplements can interact with prescription medications or cause side effects.

[signup]

Key Takeaways

  • Functional medicine can be a valuable and effective approach to managing chronic inflammation, particularly when integrated with traditional medical practices. 
  • It emphasizes a holistic, whole-person strategy that targets prevention through dietary and lifestyle modifications, as well as supplements. 
  • Functional medicine prioritizes multi-system, whole-body strategies over symptom-specific treatments.
  • It is important to recognize that functional medicine tailors its approach to each individual patient rather than applying generalized treatments. 
  • Patients and their healthcare providers are encouraged to explore functional medicine as a complementary strategy for treating chronic inflammation, ensuring that all treatment decisions are well-informed and coordinated.
The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

Learn more

No items found.

Lab Tests in This Article

No lab tests!

Abstract 10712: Mrna COVID vaccines dramatically increase endothelial inflammatory markers and ACS risk as measured by the puls cardiac test: A warning | circulation. (n.d.). https://www.ahajournals.org/doi/10.1161/circ.144.suppl_1.10712

Acute inflammation. Acute inflammation - an overview | ScienceDirect Topics. (n.d.). https://www.sciencedirect.com/topics/immunology-and-microbiology/acute-inflammation

Agarwal, S. K. (2010, August). The genetics of systemic sclerosis. Discovery medicine. https://pmc.ncbi.nlm.nih.gov/articles/PMC3803145/

Airton    C.  Martins, Alessanda    A.D.    Santos, Ana    C.B.A.  Lopes, Anatoly    V.    Skalny, Michael      Aschner, Alexey    A.    Tinkov, & Monica    M.B.  Paoliello. (n.d.). Endothelial dysfunction induced by cadmium and Mercury and its relationship to hypertension. http://www.eurekaselect.com. https://www.eurekaselect.com/article/113514

AL;, P. D. (n.d.). Chemical-induced inflammation and inflammatory diseases. International journal of occupational medicine and environmental health. https://pubmed.ncbi.nlm.nih.gov/8972163/

Allison, M. A., Jensky, N. E., Marshall, S. J., Bertoni, A. G., & Cushman, M. (2012, January). Sedentary behavior and adiposity-associated inflammation: The multi-ethnic study of Atherosclerosis. American journal of preventive medicine. https://pmc.ncbi.nlm.nih.gov/articles/PMC3244676/

Blake, K. (2024, September 17). Anti-inflammatory diet 101: What to eat and avoid, plus specialty labs to monitor results. Rupa Health. https://www.rupahealth.com/post/anti-inflammatory-diet

Bryant, Ayeesha. (2024, September 17). How to have a good night's sleep: Top proven strategies for better rest. Rupa Health. https://www.rupahealth.com/post/how-to-have-a-good-night-sleep-top-proven-strategies-for-better-rest

Bryant, Ayesha. (2024, September 30). Rheumatoid arthritis vs. osteoarthritis: Key differences explained. Rupa Health. https://www.rupahealth.com/post/rheumatoid-arthritis-vs-osteoarthritis-key-differences-explained

Cloyd, J. (2024a, September 17). A functional medicine protocol for Crohn’s disease. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-protocol-for-crohns-disease

Cloyd, J. (2024b, September 17). Drug interactions with common herbs and supplements. Rupa Health. https://www.rupahealth.com/post/drug-interactions-with-common-herbs-and-supplements

Cloyd, J. (2024c, September 17). Revolutionizing Integrative Medicine Multiple Sclerosis Treatment Options: Evidence-based nutrition approaches plus essential specialty labs for Optimal Patient Care. Rupa Health. https://www.rupahealth.com/post/integrative-nutrition-approach-to-multiple-sclerosis-ms-including-5-specialty-labs-to-run-on-your-ms-patients

Cloyd, J. (2024d, September 18). How a leaky gut could be contributing to your inflammation. Rupa Health. https://www.rupahealth.com/post/how-a-leaky-gut-could-be-contributing-to-your-inflammation

Cloyd, J. (2024e, September 18). The anti-inflammatory lifestyle: From diet to mindfulness. Rupa Health. https://www.rupahealth.com/post/the-anti-inflammatory-lifestyle-from-diet-to-mindfulness

Cloyd, J. (2024a, September 17). Sleep requirements by Age Group & Why It's important. Rupa Health. https://www.rupahealth.com/post/sleep-requirements-by-age-group-why-its-important

Cloyd, J. (2024b, October 4). The Science of Hydration: How Water Intake Affects Overall Health. Rupa Health. https://www.rupahealth.com/post/the-science-of-hydration-how-water-intake-affects-overall-health

DeCesaris, L. (2024, September 17). What is gut dysbiosis? 7 signs to watch for. Rupa Health. https://www.rupahealth.com/post/how-your-gut-bacteria-affects-your-overall-health

Defending against disease with an anti-inflammation lifestyle. Anti-Inflammation Lifestyle - Brigham and Women's Hospital. (n.d.). https://www.brighamandwomens.org/patients-and-families/meals-and-nutrition/bwh-nutrition-and-wellness-hub/special-topics/anti-inflammatory-lifestyle

DePorto, T. (2024, October 3). Omega 3s: The Superfood nutrient you need to know about. Rupa Health. https://www.rupahealth.com/post/omega-3s-the-superfood-nutrient-you-need-to-know-about

Filippis, F. D., Pellegrini, N., Vannini, L., Jeffery, I. B., Storia, A. L., Laghi, L., Serrazanetti, D. I., Cagno, R. D., Ferrocino, I., Lazzi, C., Turroni, S., Cocolin, L., Brigidi, P., Neviani, E., Gobbetti, M., O’Toole, P. W., & Ercolini, D. (2016, November 1). High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome. Gut. https://gut.bmj.com/content/65/11/1812.long

Garrison, K. (2024, September 17). Cortisol and stress: Exploring the connection for Better Health. Rupa Health. https://www.rupahealth.com/post/cortisol-and-stress-exploring-the-connection-for-better-health

Gerow, S. (2024, September 18). Smartwatches: The gateway to advanced health tracking for functional medicine practitioners. Rupa Health. https://www.rupahealth.com/post/smart-watches-the-gateway-to-advanced-health-tracking-for-functional-medicine-practitioners

Gleeson, M., Bishop, N. C., Stensel, D. J., Lindley, M. R., Mastana, S. S., & Nimmo, M. A. (2011, August 5). The anti-inflammatory effects of exercise: Mechanisms and implications for the prevention and treatment of disease. Nature News. https://www.nature.com/articles/nri3041

Greenan, S. (2024, September 17). What is functional medicine? how do I find a functional medicine practitioner?. Rupa Health. https://www.rupahealth.com/post/what-is-functional-medicine

Hannibal, K. E., & Bishop, M. D. (2014, December). Chronic stress, cortisol dysfunction, and pain: A psychoneuroendocrine rationale for stress management in pain rehabilitation. Physical therapy. https://pmc.ncbi.nlm.nih.gov/articles/PMC4263906/

How sleep deprivation can cause inflammation. Harvard Health. (2024, April 29). https://www.health.harvard.edu/healthbeat/how-sleep-deprivation-can-cause-inflammation

Inflammatory cell. Inflammatory Cell - an overview | ScienceDirect Topics. (n.d.). https://www.sciencedirect.com/topics/immunology-and-microbiology/inflammatory-cell

Inflammatory mediator. Inflammatory Mediator - an overview | ScienceDirect Topics. (n.d.). https://www.sciencedirect.com/topics/medicine-and-dentistry/inflammatory-mediator

Kamen, D. L. (2014, August). Environmental influences on systemic lupus erythematosus expression. Rheumatic diseases clinics of North America. https://pmc.ncbi.nlm.nih.gov/articles/PMC4198387/

Khakham, C. (2024a, September 17). How to start using biofeedback in your wellness clinic. Rupa Health. https://www.rupahealth.com/post/how-to-start-using-biofeedback-in-your-wellness-clinic

Khakham, C. (2024b, September 17). Top medical evidence supporting curcumin's health benefits. Rupa Health. https://www.rupahealth.com/post/top-medical-evidence-supporting-curcumins-health-benefits

Khakham, C. (2024c, September 17). Understanding your risk of cardiovascular disease with Functional Medicine Labs. Rupa Health. https://www.rupahealth.com/post/understanding-your-risk-of-cardiovascular-disease-with-functional-medicine-labs

Khakham, C. (2024d, October 2). Integrative approaches to the treatment of lupus: A comprehensive review. Rupa Health. https://www.rupahealth.com/post/integrative-approaches-to-the-treatment-of-lupus-a-comprehensive-review

Pahwa, R. (2023, August 7). Chronic inflammation. StatPearls [Internet]. https://www.ncbi.nlm.nih.gov/books/NBK493173/

Pan, Z., Gong, T., & Liang, P. (2024). Heavy Metal Exposure and Cardiovascular Disease. Circulation research, 134(9), 1160–1178. https://doi.org/10.1161/CIRCRESAHA.123.323617

Preston, J. (2024, September 27). How to build natural immunity during a bad flu season. Rupa Health. https://www.rupahealth.com/post/building-immunity-during-flu-season

professional, C. C. medical. (2024, July 26). Inflammation: What you need to know. Cleveland Clinic. https://my.clevelandclinic.org/health/symptoms/21660-inflammation

Ramanlal, R. (2023, January 23). Physiology, vasodilation. StatPearls [Internet]. https://www.ncbi.nlm.nih.gov/books/NBK557562/#:~:text=Vasodilation%20is%20the%20widening%20of,blood%20flow%2C%20reducing%20blood%20pressure.

Sweetnich, Jerrica. (2024, September 17). Top 5 antioxidants that can improve your health and how to test your patient's levels. Rupa Health. https://www.rupahealth.com/post/top-5-antioxidants-to-improve-your-health

Sweetnich, Jessica. (2024, September 17). Vitamin D 101. Rupa Health. https://www.rupahealth.com/post/vitamin-d-101-testing-rdas-and-supplementing

Taylor, A. K. (2019, January 31). Celiac disease. GeneReviews® [Internet]. https://www.ncbi.nlm.nih.gov/books/NBK1727/

Teeter, L. A. (2024, September 25). Mental health benefits of yoga and meditation. Rupa Health. https://www.rupahealth.com/post/mental-health-benefits-of-yoga-and-meditation

Tingle, R. (2024, September 17). 8 signs and symptoms of an autoimmune disease. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-autoimmune-disease

U.S. Department of Health and Human Services. (2024, September 6). Scleroderma. National Institute of Arthritis and Musculoskeletal and Skin Diseases. https://www.niams.nih.gov/health-topics/scleroderma

U.S. National Library of Medicine. (2021, May 18). What is inflammation? InformedHealth.org [Internet]. https://www.ncbi.nlm.nih.gov/books/NBK279298/

U.S. National Library of Medicine. (n.d.). Myasthenia gravis: Medlineplus genetics. MedlinePlus. https://medlineplus.gov/genetics/condition/myasthenia-gravis/

Wautier, J.-L., & Wautier, M.-P. (2022, March 26). Vascular permeability in diseases. International journal of molecular sciences. https://pmc.ncbi.nlm.nih.gov/articles/PMC8998843/

Weinberg, J. (2024a, September 17). An integrative medicine approach to celiac disease. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-celiac-disease

Weinberg, J. (2024b, September 17). Drooping of the eye and double vision are the first symptoms in more than half of people who develop this autoimmune disease. Rupa Health. https://www.rupahealth.com/post/myasthenia-gravis

Weinberg, J. L. (2024, September 17). A comprehensive review of integrative approaches for the treatment of osteoarthritis: Diagnosis, differential diagnosis, and therapy options. Rupa Health. https://www.rupahealth.com/post/integrative-approaches-to-the-treatment-of-osteoarthritis-a-comprehensive-review

Weinberg, J. (2024, September 17). 4 science backed health benefits of the Mediterranean diet. Rupa Health. https://www.rupahealth.com/post/4-science-backed-health-benefits-of-the-mediterranean-diet

Yoshimura, H. (2024, September 17). A root cause medicine approach to chronic inflammation. Rupa Health. https://www.rupahealth.com/post/a-root-cause-medicine-approach-to-chronic-inflammation

Yoshimura, H. (2024, September 18). The remarkable power of exercise on our health: A comprehensive overview. Rupa Health. https://www.rupahealth.com/post/the-remarkable-power-of-exercise-on-our-health-a-comprehensive-overview

Order from 30+ labs in 20 seconds (DUTCH, Mosaic, Genova & More!)
We make ordering quick and painless — and best of all, it's free for practitioners.

Latest Articles

View more on A Root Cause Medicine Approach
Subscribe to the magazine for expert-written articles straight to your inbox
Join the thousands of savvy readers who get root cause medicine articles written by doctors in their inbox every week!
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Are you a healthcare practitioner?
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Subscribe to the Magazine for free to keep reading!
Subscribe for free to keep reading, If you are already subscribed, enter your email address to log back in.
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Are you a healthcare practitioner?
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Trusted Source
Rupa Health
Medical Education Platform
Visit Source
Visit Source
American Cancer Society
Foundation for Cancer Research
Visit Source
Visit Source
National Library of Medicine
Government Authority
Visit Source
Visit Source
Journal of The American College of Radiology
Peer Reviewed Journal
Visit Source
Visit Source
National Cancer Institute
Government Authority
Visit Source
Visit Source
World Health Organization (WHO)
Government Authority
Visit Source
Visit Source
The Journal of Pediatrics
Peer Reviewed Journal
Visit Source
Visit Source
CDC
Government Authority
Visit Source
Visit Source
Office of Dietary Supplements
Government Authority
Visit Source
Visit Source
National Heart Lung and Blood Institute
Government Authority
Visit Source
Visit Source
National Institutes of Health
Government Authority
Visit Source
Visit Source
Clinical Infectious Diseases
Peer Reviewed Journal
Visit Source
Visit Source
Brain
Peer Reviewed Journal
Visit Source
Visit Source
The Journal of Rheumatology
Peer Reviewed Journal
Visit Source
Visit Source
Journal of the National Cancer Institute (JNCI)
Peer Reviewed Journal
Visit Source
Visit Source
Journal of Cardiovascular Magnetic Resonance
Peer Reviewed Journal
Visit Source
Visit Source
Hepatology
Peer Reviewed Journal
Visit Source
Visit Source
The American Journal of Clinical Nutrition
Peer Reviewed Journal
Visit Source
Visit Source
The Journal of Bone and Joint Surgery
Peer Reviewed Journal
Visit Source
Visit Source
Kidney International
Peer Reviewed Journal
Visit Source
Visit Source
The Journal of Allergy and Clinical Immunology
Peer Reviewed Journal
Visit Source
Visit Source
Annals of Surgery
Peer Reviewed Journal
Visit Source
Visit Source
Chest
Peer Reviewed Journal
Visit Source
Visit Source
The Journal of Neurology, Neurosurgery & Psychiatry
Peer Reviewed Journal
Visit Source
Visit Source
Blood
Peer Reviewed Journal
Visit Source
Visit Source
Gastroenterology
Peer Reviewed Journal
Visit Source
Visit Source
The American Journal of Respiratory and Critical Care Medicine
Peer Reviewed Journal
Visit Source
Visit Source
The American Journal of Psychiatry
Peer Reviewed Journal
Visit Source
Visit Source
Diabetes Care
Peer Reviewed Journal
Visit Source
Visit Source
The Journal of the American College of Cardiology (JACC)
Peer Reviewed Journal
Visit Source
Visit Source
The Journal of Clinical Oncology (JCO)
Peer Reviewed Journal
Visit Source
Visit Source
Journal of Clinical Investigation (JCI)
Peer Reviewed Journal
Visit Source
Visit Source
Circulation
Peer Reviewed Journal
Visit Source
Visit Source
JAMA Internal Medicine
Peer Reviewed Journal
Visit Source
Visit Source
PLOS Medicine
Peer Reviewed Journal
Visit Source
Visit Source
Annals of Internal Medicine
Peer Reviewed Journal
Visit Source
Visit Source
Nature Medicine
Peer Reviewed Journal
Visit Source
Visit Source
The BMJ (British Medical Journal)
Peer Reviewed Journal
Visit Source
Visit Source
The Lancet
Peer Reviewed Journal
Visit Source
Visit Source
Journal of the American Medical Association (JAMA)
Peer Reviewed Journal
Visit Source
Visit Source
Pubmed
Comprehensive biomedical database
Visit Source
Visit Source
Harvard
Educational/Medical Institution
Visit Source
Visit Source
Cleveland Clinic
Educational/Medical Institution
Visit Source
Visit Source
Mayo Clinic
Educational/Medical Institution
Visit Source
Visit Source
The New England Journal of Medicine (NEJM)
Peer Reviewed Journal
Visit Source
Visit Source
Johns Hopkins
Educational/Medical Institution
Visit Source
Visit Source

Hey practitioners! 👋 Join Dr. Chris Magryta and Dr. Erik Lundquist for a comprehensive 6-week course on evaluating functional medicine labs from two perspectives: adult and pediatric. In this course, you’ll explore the convergence of lab results across different diseases and age groups, understanding how human lab values vary on a continuum influenced by age, genetics, and time. Register Here! Register Here.

Hey practitioners! 👋 Join Dr. Terry Wahls for a 3-week bootcamp on integrating functional medicine into conventional practice, focusing on complex cases like Multiple Sclerosis. Learn to analyze labs through a functional lens, perform nutrition-focused physical exams, and develop personalized care strategies. Register Here.