Living with a condition that causes severe stomach pain, bloating, and frequent trips to the restroom can be incredibly challenging. For many people with Irritable Bowel Syndrome (IBS), these symptoms are a daily reality, and they can have far-reaching health effects beyond digestive troubles.
But there is hope. Research reveals a connection between IBS and mental health issues like anxiety and depression, which suggests that treating one area may provide benefit for the other.
In 2021, a genome-wide association study (GWAS) was published in Nature Genetics. This Study revealed genetic associations between IBS and certain mental health disorders.
This discovery could lead to new treatments and a better understanding of both IBS and related mental health conditions.
[signup]
The Study At A Glance
This study aimed to explore the genetic links between Irritable Bowel Syndrome (IBS) and mental health disorders such as anxiety and depression. The researchers sought to identify shared genetic factors to better understand the biological connections between these conditions, potentially leading to more effective treatments.
The researchers conducted a genome-wide association study (GWAS), analyzing the DNA of over 50,000 individuals with IBS and comparing it to more than 400,000 individuals without the condition.
They sourced data from the UK Biobank and the Bellygenes initiative, an international project focused on identifying genes linked to digestive disorders. To ensure the reliability of their findings, the results were validated using data from 23andMe.
The study focused on individuals of European descent to ensure consistency and accuracy in the genetic analyses. Both males and females were represented, though IBS is more prevalent among females.
The comprehensive methodology and rigorous validation of this study provide support for the genetic factors linking IBS to mental health disorders, offering new insights into these conditions.
Key Findings
The study identified six genetic variations significantly more common in individuals with Irritable Bowel Syndrome (IBS).
These genetic differences are primarily associated with the brain and nervous system rather than the gut. This suggests that IBS may stem from the brain or nerves communicating with the gut, emphasizing the complex interactions involved in the gut-brain axis.
The gut-brain axis involves a complex interplay between the central and enteric nervous systems; it is influenced by genetic factors, environmental stressors, and gut microbiome alterations, which together contribute to both gastrointestinal and psychiatric symptoms through shared neural pathways and signaling mechanisms.
Additionally, these same genetic variations are linked to an increased risk of mood and anxiety disorders, including anxiety, depression, and insomnia.
This overlap indicates that the genetic factors contributing to IBS may also influence the development of these mental health disorders, explaining why these conditions often occur together.
Specific Genes Associated with IBS and Depression, Anxiety and Neuroticism Identified in this Study
The following six genes were highlighted in the study as increasing genetic susceptibility for IBS:
NCAM1
NCAM1 is associated with neuroticism, anxiety, mood disorders, and anorexia nervosa.
CADM2
CADM2 is associated with neuroticism, anxiety, and cannabis use.
CADM2 is predominantly expressed in the brain but not in the gut, implicating it more strongly in the central nervous system's role in IBS and mental health conditions.
PHF2 / FAM120A
PHF2/FAM120A is associated with neuroticism, depression, and autism. These genes play key roles in brain development.
DOCK9
DOCK9 is expressed in the nervous system, including the gut's enteric nervous system, suggesting a role in the brain-gut axis influencing both IBS and mood disorders.
CKAP2/TPTE2P3
These genes may also have roles in both the central and enteric nervous systems.
BAG6
Although BAG6 is not directly associated with the nervous system, its role in cellular processes may still contribute to the pathophysiology of IBS, particularly through its interaction with the immune system and stress responses.
These genes highlight the complex interplay between genetic factors that influence both IBS and mental health conditions, particularly through mechanisms involving the nervous system and the brain-gut axis.
Significance of the Findings
The study indicates that IBS and mental health disorders like anxiety and depression share common genetic roots, emphasizing the strong connection between the brain and gut.
Also, by demonstrating the genetic underpinnings of IBS and its connection to depression and anxiety, the study challenges the theory that these conditions are purely psychological.
This finding invites a paradigm shift in the understanding of these conditions from being distinct to being closely interconnected through shared biological pathways.
The discovery of shared genetic factors creates possibilities for developing treatments that simultaneously target both gut and mental health symptoms, offering a more complete approach to managing IBS and its associated mental health challenges.
Limitations of the Study
While the study provides valuable insights, it has limitations.
The genetic influence on IBS is modest, meaning genetics only contributes a small part to the overall risk. Factors like diet, stress, and lifestyle likely have a much greater impact.
The relationship between these genetic and environmental factors remains unclear, necessitating further research to better understand their interaction in causing IBS.
Additionally, the study primarily focused on individuals of European ancestry, which limits the generalizability of the findings to other populations.
Genetic differences across ethnic groups suggest these results may not be universally applicable, highlighting the importance of further research involving more diverse populations to ensure the findings are relevant and effective for a broader range of people.
Functional Medicine Labs for Brain-Gut Health
Exploring the brain-gut connection is crucial in understanding conditions like IBS and related mental health disorders. Functional medicine tests provide valuable insights into how gut health impacts overall well-being.
Some key lab tests and panels offered through Rupa Health include:
GI Effects® Comprehensive Profile (3-day) by Genova Diagnostics
This test offers a comprehensive evaluation of digestive function, gut microbiome composition, and inflammation. It assesses key areas such as digestion, absorption, gut flora and inflammation, helping to identify potential issues that may contribute to gastrointestinal and systemic health concerns.
GI-MAP (GI Microbial Assay Plus) by Diagnostic Solutions
This test uses DNA-based stool analysis to identify pathogens, gut dysbiosis, and markers of inflammation, offering insights into potential contributors to IBS symptoms.
Array 2 - Intestinal Antigenic Permeability Screen by Cyrex Laboratories
This test is vital for those with chronic GI or neurological symptoms, food sensitivities, or autoimmune conditions.
It evaluates intestinal permeability and gut barrier dysfunction, providing insights into how these issues may influence systemic inflammation and disrupt the gut-brain connection, potentially impacting overall neurological health.
Natural Support for the Gut-Brain Axis
Consume Probiotics: include fermented foods like yogurt, kefir, sauerkraut, kimchi, and kombucha to promote a healthy gut microbiome.
Manage Stress: practice stress-reducing techniques such as meditation, deep breathing, yoga, or mindfulness to reduce the impact of stress on gut health.
Exercise Regularly: engage in moderate physical activity like walking, swimming, or cycling to promote healthy gut motility and reduce inflammation.
Prioritize Sleep: ensure 7-9 hours of quality sleep per night to regulate the body’s circadian rhythms and promote gut health.
Practice Mindful Eating: eat slowly and mindfully to improve digestion and foster a positive connection between the brain and gut.
[signup]
Key Takeaways
- This study identifies a genetic link between IBS and mental health disorders, highlighting the important connection between the brain and gut, and shifting the understanding of IBS to include its mental health aspects.
- These findings suggest the potential for developing treatments that address both gut and mental health symptoms simultaneously, offering a more holistic approach to managing IBS.
- Further research is needed to explore how genetic and environmental factors like diet and stress interact in IBS, despite the significant progress this study represents.
Living with a condition that causes severe stomach pain, bloating, and frequent trips to the restroom can be incredibly challenging. For many people with Irritable Bowel Syndrome (IBS), these symptoms are a daily reality, and they can have far-reaching effects beyond digestive troubles.
But there is hope. Research reveals a connection between IBS and mental health issues like anxiety and depression, which suggests that addressing one area may provide benefits for the other.
In 2021, a genome-wide association study (GWAS) was published in Nature Genetics. This Study revealed genetic associations between IBS and certain mental health conditions.
This discovery could lead to new insights and a better understanding of both IBS and related mental health conditions.
[signup]
The Study At A Glance
This study aimed to explore the genetic links between Irritable Bowel Syndrome (IBS) and mental health conditions such as anxiety and depression. The researchers sought to identify shared genetic factors to better understand the biological connections between these conditions, potentially leading to more effective approaches.
The researchers conducted a genome-wide association study (GWAS), analyzing the DNA of over 50,000 individuals with IBS and comparing it to more than 400,000 individuals without the condition.
They sourced data from the UK Biobank and the Bellygenes initiative, an international project focused on identifying genes linked to digestive conditions. To ensure the reliability of their findings, the results were validated using data from 23andMe.
The study focused on individuals of European descent to ensure consistency and accuracy in the genetic analyses. Both males and females were represented, though IBS is more prevalent among females.
The comprehensive methodology and rigorous validation of this study provide support for the genetic factors linking IBS to mental health conditions, offering new insights into these conditions.
Key Findings
The study identified six genetic variations significantly more common in individuals with Irritable Bowel Syndrome (IBS).
These genetic differences are primarily associated with the brain and nervous system rather than the gut. This suggests that IBS may involve the brain or nerves communicating with the gut, emphasizing the complex interactions involved in the gut-brain axis.
The gut-brain axis involves a complex interplay between the central and enteric nervous systems; it is influenced by genetic factors, environmental stressors, and gut microbiome alterations, which together contribute to both gastrointestinal and psychiatric symptoms through shared neural pathways and signaling mechanisms.
Additionally, these same genetic variations are linked to an increased risk of mood and anxiety conditions, including anxiety, depression, and insomnia.
This overlap indicates that the genetic factors contributing to IBS may also influence the development of these mental health conditions, explaining why these conditions often occur together.
Specific Genes Associated with IBS and Depression, Anxiety and Neuroticism Identified in this Study
The following six genes were highlighted in the study as increasing genetic susceptibility for IBS:
NCAM1
NCAM1 is associated with neuroticism, anxiety, mood conditions, and anorexia nervosa.
CADM2
CADM2 is associated with neuroticism, anxiety, and cannabis use.
CADM2 is predominantly expressed in the brain but not in the gut, implicating it more strongly in the central nervous system's role in IBS and mental health conditions.
PHF2 / FAM120A
PHF2/FAM120A is associated with neuroticism, depression, and autism. These genes play key roles in brain development.
DOCK9
DOCK9 is expressed in the nervous system, including the gut's enteric nervous system, suggesting a role in the brain-gut axis influencing both IBS and mood conditions.
CKAP2/TPTE2P3
These genes may also have roles in both the central and enteric nervous systems.
BAG6
Although BAG6 is not directly associated with the nervous system, its role in cellular processes may still contribute to the pathophysiology of IBS, particularly through its interaction with the immune system and stress responses.
These genes highlight the complex interplay between genetic factors that influence both IBS and mental health conditions, particularly through mechanisms involving the nervous system and the brain-gut axis.
Significance of the Findings
The study indicates that IBS and mental health conditions like anxiety and depression share common genetic roots, emphasizing the strong connection between the brain and gut.
Also, by demonstrating the genetic underpinnings of IBS and its connection to depression and anxiety, the study challenges the theory that these conditions are purely psychological.
This finding invites a paradigm shift in the understanding of these conditions from being distinct to being closely interconnected through shared biological pathways.
The discovery of shared genetic factors creates possibilities for developing approaches that simultaneously address both gut and mental health symptoms, offering a more complete approach to managing IBS and its associated mental health challenges.
Limitations of the Study
While the study provides valuable insights, it has limitations.
The genetic influence on IBS is modest, meaning genetics only contributes a small part to the overall risk. Factors like diet, stress, and lifestyle likely have a much greater impact.
The relationship between these genetic and environmental factors remains unclear, necessitating further research to better understand their interaction in contributing to IBS.
Additionally, the study primarily focused on individuals of European ancestry, which limits the generalizability of the findings to other populations.
Genetic differences across ethnic groups suggest these results may not be universally applicable, highlighting the importance of further research involving more diverse populations to ensure the findings are relevant and effective for a broader range of people.
Functional Medicine Labs for Brain-Gut Health
Exploring the brain-gut connection is crucial in understanding conditions like IBS and related mental health conditions. Functional medicine tests provide valuable insights into how gut health impacts overall well-being.
Some key lab tests and panels offered through Rupa Health include:
GI Effects® Comprehensive Profile (3-day) by Genova Diagnostics
This test offers a comprehensive evaluation of digestive function, gut microbiome composition, and inflammation. It assesses key areas such as digestion, absorption, gut flora and inflammation, helping to identify potential issues that may contribute to gastrointestinal and systemic health concerns.
GI-MAP (GI Microbial Assay Plus) by Diagnostic Solutions
This test uses DNA-based stool analysis to identify pathogens, gut dysbiosis, and markers of inflammation, offering insights into potential contributors to IBS symptoms.
Array 2 - Intestinal Antigenic Permeability Screen by Cyrex Laboratories
This test is vital for those with chronic GI or neurological symptoms, food sensitivities, or autoimmune conditions.
It evaluates intestinal permeability and gut barrier function, providing insights into how these issues may influence systemic inflammation and disrupt the gut-brain connection, potentially impacting overall neurological health.
Natural Support for the Gut-Brain Axis
Consume Probiotics: consider including fermented foods like yogurt, kefir, sauerkraut, kimchi, and kombucha to support a healthy gut microbiome.
Manage Stress: practice stress-reducing techniques such as meditation, deep breathing, yoga, or mindfulness to help manage the impact of stress on gut health.
Exercise Regularly: engage in moderate physical activity like walking, swimming, or cycling to support healthy gut motility and help manage inflammation.
Prioritize Sleep: aim for 7-9 hours of quality sleep per night to help regulate the body’s circadian rhythms and support gut health.
Practice Mindful Eating: eat slowly and mindfully to help improve digestion and foster a positive connection between the brain and gut.
[signup]
Key Takeaways
- This study identifies a genetic link between IBS and mental health conditions, highlighting the important connection between the brain and gut, and shifting the understanding of IBS to include its mental health aspects.
- These findings suggest the potential for developing approaches that address both gut and mental health symptoms simultaneously, offering a more holistic approach to managing IBS.
- Further research is needed to explore how genetic and environmental factors like diet and stress interact in IBS, despite the significant progress this study represents.
[1.] Almario CV, Sharabi E, Chey WD, Lauzon M, Higgins CS, Spiegel BM. Prevalence and Burden of Illness of Rome IV Irritable Bowel Syndrome in the United States: Results from a Nationwide Cross-Sectional Study. Gastroenterology. 2023;165(6):1475-1487. doi:https://doi.org/10.1053/j.gastro.2023.08.010
[2.] Array 2 by cyrex laboratories. (n.d.). Rupa Health. https://www.rupahealth.com/lab-tests/cyrex-array-2
[3.] Cherpak CE. Mindful Eating: A Review Of How The Stress-Digestion-Mindfulness Triad May Modulate And Improve Gastrointestinal And Digestive Function. Integr Med (Encinitas). 2019 Aug;18(4):48-53. PMID: 32549835; PMCID: PMC7219460.
[4.] Cloyd, J. (2023a, March 29). Top 5 differential diagnosis for abdominal pain and how to treat with functional medicine. Rupa Health. https://www.rupahealth.com/post/top-5-differential-diagnoses-for-abdominal-pain-and-how-to-treat-with-functional-medicine
[5.] Cloyd, J. (2023b, June 8). A functional medicine IBS-D protocol: Testing, differential diagnosis, and treatment. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-ibs-d-protocol-testing-nutrition-and-supplements
[6.] Cloyd, J. (2024, February 28). Dietary strategies for bloating: Understanding and alleviating digestive discomfort. Rupa Health. https://www.rupahealth.com/post/dietary-strategies-for-bloating-understanding-and-alleviating-digestive-discomfort
[7.] Creedon, K. (2022, August 4). 6 speciality labs that get to the root cause of insomnia. Www.rupahealth.com. https://www.rupahealth.com/post/6-speciality-labs-that-get-to-the-root-cause-of-insomnia
[8.] Eijsbouts, C., Zheng, T., Kennedy, N. A., Bonfiglio, F., Anderson, C. A., Moutsianas, L., Holliday, J., Shi, J., Shringarpure, S., Voda, A.-I., Farrugia, G., Franke, A., Hübenthal, M., Abecasis, G., Zawistowski, M., Skogholt, A. H., Ness-Jensen, E., Hveem, K., Esko, T., & Teder-Laving, M. (2021). Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders. Nature Genetics, 53(11), 1543–1552. https://doi.org/10.1038/s41588-021-00950-8
[9.] Garnås E. Fermented Vegetables as a Potential Treatment for Irritable Bowel Syndrome. Curr Dev Nutr. 2023 Feb 18;7(3):100039. doi: 10.1016/j.cdnut.2023.100039. PMID: 37181929; PMCID: PMC10111609.
[10.] GI effects® comprehensive profile - 3 day by genova diagnostics. (n.d.). Rupa Health. https://www.rupahealth.com/lab-tests/genova-gi-effects-comprehensive-profile-3-day
GI-MAP by diagnostic solutions. (2020). Rupa Health. https://www.rupahealth.com/lab-tests/diagnostic-solutions-gi-map?utm_source=google&utm_medium=cpc&utm_campaign=20893116874&utm_content=&utm_term=&gad_source=1&gclid=Cj0KCQjwxeyxBhC7ARIsAC7dS3-PVAAlFJUlCH89_lMt9R2TQRaFtXSKUE1a3zITUxdmlOaJrq8FFrYaArHqEALw_wcB
[11.] Johannesson E, Ringström G, Abrahamsson H, Sadik R. Intervention to increase physical activity in irritable bowel syndrome shows long-term positive effects. World J Gastroenterol. 2015 Jan 14;21(2):600-8. doi: 10.3748/wjg.v21.i2.600. PMID: 25593485; PMCID: PMC4294172.
[12.] Kresge, K. (2023, February 21). An integrative medicine approach to depression. Rupa Health. https://www.rupahealth.com/post/an-integrative-medicine-approach-to-depression
[13.] Maholy, N. (2023, February 17). A functional medicine approach to anxiety: Testing, nutrition, & supplements. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-anxiety
[14.] Mayer, E.A., Ryu, H.J. & Bhatt, R.R. The neurobiology of irritable bowel syndrome. Mol Psychiatry 28, 1451–1465 (2023). https://doi.org/10.1038/s41380-023-01972-w
[15.] Qin HY, Cheng CW, Tang XD, Bian ZX. Impact of psychological stress on irritable bowel syndrome. World J Gastroenterol. 2014 Oct 21;20(39):14126-31. doi: 10.3748/wjg.v20.i39.14126. PMID: 25339801; PMCID: PMC4202343.
%201.svg){kind=logo}
Ready to become a world class gut health expert? Join Jeannie Gorman, MS, CCN, for a 
