Research Studies
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August 28, 2024

Genetic Study Links IBS to Mood and Anxiety Disorders

Written By
Medically Reviewed by
Updated On
January 14, 2025

Living with a condition that causes severe stomach pain, bloating, and frequent trips to the restroom can be incredibly challenging. For many people with Irritable Bowel Syndrome (IBS), these symptoms are a daily reality, and they can have far-reaching effects beyond digestive troubles. 

But there is hope. Research reveals a connection between IBS and mental health issues like anxiety and depression, which suggests that addressing one area may provide benefits for the other.

In 2021, a genome-wide association study (GWAS) was published in Nature Genetics. This Study revealed genetic associations between IBS and certain mental health conditions. 

This discovery could lead to new insights and a better understanding of both IBS and related mental health conditions.

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The Study At A Glance

This study aimed to explore the genetic links between Irritable Bowel Syndrome (IBS) and mental health conditions such as anxiety and depression. The researchers sought to identify shared genetic factors to better understand the biological connections between these conditions, potentially leading to more effective approaches.

The researchers conducted a genome-wide association study (GWAS), analyzing the DNA of over 50,000 individuals with IBS and comparing it to more than 400,000 individuals without the condition. 

They sourced data from the UK Biobank and the Bellygenes initiative, an international project focused on identifying genes linked to digestive conditions. To ensure the reliability of their findings, the results were validated using data from 23andMe.

The study focused on individuals of European descent to ensure consistency and accuracy in the genetic analyses. Both males and females were represented, though IBS is more prevalent among females

The comprehensive methodology and rigorous validation of this study provide support for the genetic factors linking IBS to mental health conditions, offering new insights into these conditions.

Key Findings

The study identified six genetic variations significantly more common in individuals with Irritable Bowel Syndrome (IBS). 

These genetic differences are primarily associated with the brain and nervous system rather than the gut. This suggests that IBS may involve the brain or nerves communicating with the gut, emphasizing the complex interactions involved in the gut-brain axis.

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The gut-brain axis involves a complex interplay between the central and enteric nervous systems; it is influenced by genetic factors, environmental stressors, and gut microbiome alterations, which together contribute to both gastrointestinal and psychiatric symptoms through shared neural pathways and signaling mechanisms.

Additionally, these same genetic variations are linked to an increased risk of mood and anxiety conditions, including anxiety, depression, and insomnia

This overlap indicates that the genetic factors contributing to IBS may also influence the development of these mental health conditions, explaining why these conditions often occur together.

Specific Genes Associated with IBS and Depression, Anxiety and Neuroticism Identified in this Study

The following six genes were highlighted in the study as increasing genetic susceptibility for IBS:

NCAM1

NCAM1 is associated with neuroticism, anxiety, mood conditions, and anorexia nervosa.

CADM2

CADM2 is associated with neuroticism, anxiety, and cannabis use.

CADM2 is predominantly expressed in the brain but not in the gut, implicating it more strongly in the central nervous system's role in IBS and mental health conditions.

PHF2 / FAM120A

PHF2/FAM120A is associated with neuroticism, depression, and autism. These genes play key roles in brain development.

DOCK9

DOCK9 is expressed in the nervous system, including the gut's enteric nervous system, suggesting a role in the brain-gut axis influencing both IBS and mood conditions.

CKAP2/TPTE2P3

These genes may also have roles in both the central and enteric nervous systems.

BAG6

Although BAG6 is not directly associated with the nervous system, its role in cellular processes may still contribute to the pathophysiology of IBS, particularly through its interaction with the immune system and stress responses.

These genes highlight the complex interplay between genetic factors that influence both IBS and mental health conditions, particularly through mechanisms involving the nervous system and the brain-gut axis.

Significance of the Findings

The study indicates that IBS and mental health conditions like anxiety and depression share common genetic roots, emphasizing the strong connection between the brain and gut.

Also, by demonstrating the genetic underpinnings of IBS and its connection to depression and anxiety, the study challenges the theory that these conditions are purely psychological.

This finding invites a paradigm shift in the understanding of these conditions from being distinct to being closely interconnected through shared biological pathways.

The discovery of shared genetic factors creates possibilities for developing approaches that simultaneously address both gut and mental health symptoms, offering a more complete approach to managing IBS and its associated mental health challenges.

Limitations of the Study

While the study provides valuable insights, it has limitations. 

The genetic influence on IBS is modest, meaning genetics only contributes a small part to the overall risk. Factors like diet, stress, and lifestyle likely have a much greater impact. 

The relationship between these genetic and environmental factors remains unclear, necessitating further research to better understand their interaction in contributing to IBS.

Additionally, the study primarily focused on individuals of European ancestry, which limits the generalizability of the findings to other populations. 

Genetic differences across ethnic groups suggest these results may not be universally applicable, highlighting the importance of further research involving more diverse populations to ensure the findings are relevant and effective for a broader range of people.

Functional Medicine Labs for Brain-Gut Health

Exploring the brain-gut connection is crucial in understanding conditions like IBS and related mental health conditions. Functional medicine tests provide valuable insights into how gut health impacts overall well-being. 

Some key lab tests and panels offered through Rupa Health include:

GI Effects® Comprehensive Profile (3-day) by Genova Diagnostics

This test offers a comprehensive evaluation of digestive function, gut microbiome composition, and inflammation. It assesses key areas such as digestion, absorption, gut flora and inflammation, helping to identify potential issues that may contribute to gastrointestinal and systemic health concerns.

GI-MAP (GI Microbial Assay Plus) by Diagnostic Solutions

This test uses DNA-based stool analysis to identify pathogens, gut dysbiosis, and markers of inflammation, offering insights into potential contributors to IBS symptoms.

Array 2 - Intestinal Antigenic Permeability Screen by Cyrex Laboratories

This test is vital for those with chronic GI or neurological symptoms, food sensitivities, or autoimmune conditions. 

It evaluates intestinal permeability and gut barrier function, providing insights into how these issues may influence systemic inflammation and disrupt the gut-brain connection, potentially impacting overall neurological health.

Natural Support for the Gut-Brain Axis

It provides tips for maintaining a healthy gut-brain connection, including consuming probiotics, practicing mindful eating, managing stress, prioritizing sleep, and exercising regularly.

Consume Probiotics: consider including fermented foods like yogurt, kefir, sauerkraut, kimchi, and kombucha to support a healthy gut microbiome.

Manage Stress: practice stress-reducing techniques such as meditation, deep breathing, yoga, or mindfulness to help manage the impact of stress on gut health.

Exercise Regularly: engage in moderate physical activity like walking, swimming, or cycling to support healthy gut motility and help manage inflammation.

Prioritize Sleep: aim for 7-9 hours of quality sleep per night to help regulate the body’s circadian rhythms and support gut health.

Practice Mindful Eating: eat slowly and mindfully to help improve digestion and foster a positive connection between the brain and gut.

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Key Takeaways

  • This study identifies a genetic link between IBS and mental health conditions, highlighting the important connection between the brain and gut, and shifting the understanding of IBS to include its mental health aspects.
  • These findings suggest the potential for developing approaches that address both gut and mental health symptoms simultaneously, offering a more holistic approach to managing IBS.
  • Further research is needed to explore how genetic and environmental factors like diet and stress interact in IBS, despite the significant progress this study represents.
The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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