A Whole Person Care Approach
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July 22, 2022

5 Conditions That Make It Harder To Lose Weight

Written By
Sarah Anderson NP, IFM
Medically Reviewed by
Updated On
January 13, 2025

One of the common challenges people face is unexplained weight gain and difficulty losing weight. Obesity affects 20% of kids, and over 40% of the adult US population is obese, with these numbers increasing yearly. Obesity-related conditions, such as diabetes, high blood pressure, cardiovascular disease, stroke, and some cancers, cost the US healthcare system nearly $173 billion annually and are significant health concerns. Therefore, it's important to explore the factors contributing to this issue to help individuals pursue a healthier lifestyle.

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5 Medical Reasons You Might Be Having Trouble Losing Weight

Many people know that weight gain often results from consuming more calories than are burned. However, frustration arises when someone is doing "all the right things" by staying active and eating healthy, yet continues to gain weight or struggles to lose it. This is when it's helpful to explore potential underlying factors contributing to weight gain.

1. Hypothyroidism

Unintentional weight gain, along with cold intolerance, can be some of the symptoms associated with hypothyroidism. The thyroid plays a role in regulating the body's metabolism. When the thyroid is underactive, as in hypothyroidism, metabolism can slow down, which may contribute to weight gain and difficulty losing weight.

2. Chronic Stress

People experiencing excess stress or mood disorders may have higher levels of the stress hormone called cortisol. Cortisol is involved in metabolism regulation. During periods of constant stress, it may lead to increased cravings for certain foods and changes in body composition.

3. Insulin Resistance

Insulin is a hormone that helps move glucose (sugar) from the bloodstream into cells for energy. When insulin levels are high over time, the body's cells may become resistant to insulin, preventing glucose from entering the cells. This can lead to higher blood glucose levels, which may be stored as fat in the body.

4. Poor Gut Health

Research is increasingly highlighting the importance of a healthy gut microbiome. The gut microbiome may play a role in the body's metabolism, immune system, and hormone function. Some studies suggest that the type of gut flora present may influence weight. In one study, gut flora from different individuals were transplanted into mice, showing varying effects on weight. This is an area of ongoing research.

5. Peri-Menopause & Menopause

Many women believe weight gain during menopause is unavoidable. However, while changes in hormone levels can affect metabolism and body composition, there are ways to address these changes. By understanding and managing these hormonal shifts, it may be possible to support a healthy weight.

Specialty Labs to Explore Factors Affecting Metabolism

Hypothyroidism

In conventional medicine, a TSH (thyroid stimulating hormone) level is often measured. However, a full thyroid panel can provide a more comprehensive view of thyroid health and function.

A full Thyroid Panel includes various markers to assess thyroid function.

Thyroid Levels Chart. It lists various thyroid tests and their standard and optimal reference ranges.

Chronic Stress

Cortisol testing can be done through urine, blood, or saliva, with saliva and urine being common methods.  

Cortisol awakening response (CAR) levels can provide insights into HPA axis function.

Diurnal Cortisol Curve - a test that shows the pattern of cortisol throughout the day.

Insulin Resistance

Several lab tests can provide information about insulin and glucose function.

Hemoglobin A1C (HgbA1C) - a test that gives a 3-month average of blood glucose levels.

Fasting Insulin - a test that provides information about insulin levels in the body.

Poor Gut Health

Comprehensive gut microbiome testing can help assess the health of the microbiome. These tests provide information on gut flora composition and can identify imbalances.    

Menopause

DUTCH Hormone Test is a comprehensive hormone test that can be done at home. It measures levels of major sex hormones and provides insights into hormone metabolism.  

Functional Medicine Approaches to Support Metabolism

Functional Medicine aims to explore underlying factors contributing to weight gain. By using the labs mentioned above, along with a detailed history and examination, a personalized plan can be developed. Other areas of focus include:

Nutrition

While a caloric deficit is important for weight loss, the body also needs to be in a healthy state to achieve this.

Inflammation is often a factor in chronic conditions. The Mediterranean diet is based on whole foods and may help support weight management and reduce inflammation. Research suggests it can be beneficial for weight management and overall health.

Lifestyle Modification

Lifestyle changes are important for supporting a healthy metabolism. Incorporating stress management techniques can help manage cortisol levels. Options include yoga, journaling, meditation, tai chi, and mindfulness.  

Exercise and daily movement are key components of a healthy lifestyle. Exercise can support weight management and offers numerous health benefits. It's beneficial to incorporate movement throughout the day.

Summary

Functional medicine focuses on exploring underlying factors that may contribute to health concerns. A functional medicine approach to weight management involves a thorough history, targeted testing, and addressing potential contributing factors.

The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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