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Can Kombucha Improve Bowel Regularity? Exploring the Evidence

Why This Was Updated?

Our specialists regularly review advancements in health and wellness, ensuring our articles are updated with the newest information as it becomes accessible.
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Examining whether kombucha can improve bowel regularity requires a thorough exploration of scientific research and individual experiences. Kombucha, a fermented tea beverage, has surged in popularity as a health tonic, driven by its potential digestive benefits and the growing consumer interest in natural remedies. The global kombucha market was valued at $2.8 billion in 2023 and is expected to nearly double by 2028.

Understanding kombucha's potential effects on digestive health can help individuals make informed decisions about integrating it into their diet.

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What is Kombucha?

Kombucha is a fermented tea beverage that has gained popularity for its potential health benefits. Its origins can be traced back to ancient China, with references to the drink dating back as early as 220 BC. (3

It is made by fermenting sweetened tea with a symbiotic culture of bacteria and yeast (SCOBY). The fermentation process involves combining brewed tea (typically green, black, or oolong tea) with sugar. The SCOBY ferments the tea over 6 to 14 days, depending on environmental conditions like temperature and the desired level of fermentation. (3

During fermentation, the yeast and bacteria in the SCOBY convert the sugars into ethanol, carbon dioxide, and organic acids. This results in a slightly effervescent beverage with a tangy, vinegar-like taste. Additional flavorings, such as fruit juices or herbs, can be added after the primary fermentation to enhance the flavor. (3

Kombucha has a complex nutritional profile, which is influenced by various parameters of tea brewing (e.g., tea type, brewing temperature, and time) and strains of microorganisms in the SCOBY (3).

Probiotics

Probiotics are live microorganisms that confer health benefits to the host when administered in adequate amounts. 

Kombucha contains live species of lactic acid bacteria, acetic acid bacteria, and yeast, which have a probiotic function. The specific composition of SCOBY can vary, but common bacteria and yeast reported in kombucha cultures include Acetobacter, Gluconobacter, Lactobacillus, Saccharomyces, Zygosaccharomyces, and Brettanomyces. (44

Antioxidants

Antioxidants are compounds that protect cells from damage by neutralizing free radicals. Free radicals are unstable molecules that cause damage to cells, proteins, and DNA by reacting with other molecules in the body. 

Kombucha is particularly rich in polyphenols, which are plant-derived compounds with antioxidant and anti-inflammatory properties. Different types of tea contain varying profiles of polyphenols. Green tea has the highest polyphenol content compared to black and oolong teas. Common polyphenols extracted from kombucha include flavonols, flavanols, and phenolic acids. (3, 30

Nutrients

Kombucha contains minerals (potassium, manganese, fluoride), vitamins (A, Bs, C, E, K), and amino acids (theanine). These nutrients are derived from the tea leaves used in the brewing process and are augmented by the metabolic activities of the yeast and bacteria during fermentation. (3, 30

Mechanisms of Kombucha in Digestive Health

The gut microbiome is the complex community of trillions of microorganisms in the intestines that supports digestive health by maintaining the integrity of the gut barrier, assisting nutrient absorption, preventing infection, and modulating the immune system. Dysbiosis, or an imbalance of good and bad microorganisms, is linked to gastrointestinal (GI) dysfunction and disease by predisposing individuals to infection, inflammation, and intestinal hyperpermeability ("leaky gut"). Probiotic foods and supplements can prevent and treat dysbiosis by introducing beneficial microorganisms into the GI tract. 

Organic acids in kombucha, including acetic, lactic, gluconic, and glucuronic acids, are produced during fermentation. These organic acids are antimicrobial and antioxidative, assist the liver in detoxification, and support the growth of beneficial gut bacteria. (3

A healthy digestive system produces enough enzymes to digest food effectively, facilitating nutrient absorption. Insufficient digestive enzymes can cause food intolerances and digestive discomfort. The hydrolytic enzymes found in kombucha can support natural digestive processes by aiding in the breakdown of food, promoting optimal digestion.

Scientific Evidence and Research

Human studies on kombucha's impact on bowel regularity are limited, but some small-scale research supports its benefits. 

A pilot study published in 2023 looked at the effects of pasteurized kombucha with inulin and B vitamins on women with irritable bowel syndrome with constipation (IBS-C). After ten days, patients who drank kombucha (220 mL daily) experienced more frequent bowel movements, improved stool consistency, and reduced feelings of incomplete bowel movements. In comparison, patients who drank water during the study did not experience any improvement in IBS symptoms. (29)

Research involving animal models has provided evidence supporting kombucha's role in digestive health by increasing the diversity of the gut microbiota and reducing intestinal permeability and inflammation. More research is needed to confirm if these effects translate to humans. Nonetheless, these findings are promising, considering the known links between dysbiosis, leaky gut, inflammation, and irregular bowel habits.

By examining research on probiotics and their influence on bowel habits, we can infer kombucha's potential impact on bowel regularity. A 2017 systematic review, for example, concluded that probiotic supplements improved constipation in elderly patients by up to 40% compared to placebo. Another 2019 systematic review found that multi-strain probiotics dosed for at least eight weeks were an effective treatment option for alleviating symptoms of IBS, in which irregular bowel movements are a hallmark feature. 

More research is needed to determine the optimal dosage and specific types of kombucha required to achieve effects similar to those of probiotic supplements.

Practical Considerations for Using Kombucha

The consumption of kombucha should be moderated to avoid potential adverse effects while maximizing its digestive health benefits. The Centers for Disease Control and Prevention (CDC) recommends limiting kombucha intake to approximately 4 ounces (about 120 milliliters) daily. This amount is generally considered safe in healthy individuals to obtain digestive benefits without overloading the body with acidity or sugar.

Drinking kombucha may cause side effects, especially if consumed excessively. Common side effects include:

  • Stomach upset
  • Gas and bloating
  • Diarrhea
  • Heartburn or acid reflux
  • Dental erosion

Kombucha is generally not recommended for the following populations (28, 31): 

  • People with weakened immune systems, such as those undergoing chemotherapy or with autoimmune diseases, should avoid kombucha due to the risk of infection from the live bacteria and yeast.
  • People who are pregnant or breastfeeding
  • Due to its sugar content, individuals with diabetes should closely monitor their blood sugar levels when consuming kombucha and stop if they notice elevated trends.

Tips for Incorporating Kombucha Into Your Diet

1. Start Slow: Begin with small amounts to let your digestive system adjust.

2. Stay Consistent: Regular consumption, rather than sporadic, is more likely to yield digestive benefits.

3. Pair With Food: Drinking kombucha with meals can enhance digestion, improve nutrient absorption, and help prevent rapid spikes in blood sugar.

4. Diversify Diet: Kombucha should complement a balanced diet rich in fiber, fruits, vegetables, and other fermented foods to best support gut health. 

Lab Tests and Biomarkers to Monitor

Using labs can help individuals objectively assess the need for and impact of kombucha on their health and make data-driven decisions to optimize its benefits for digestive and metabolic health.

You should tailor the amount and frequency of kombucha consumption based on symptoms and laboratory findings. For example, if bowel habits and inflammation markers improve, it may be beneficial to maintain current intake. Adjusting the dosage or frequency might be necessary if no significant changes are observed.

Comprehensive Stool Analysis

Comprehensive stool tests analyze the composition and diversity of gut bacteria. A healthy microbiome typically shows a diverse range of beneficial bacteria and an abundance of short-chain fatty acids. By comparing stool tests before and after a period of kombucha consumption, one can assess changes in gut microbiota diversity and the presence of beneficial probiotics introduced by kombucha.

These tests also measure the levels of digestive enzymes and food breakdown products, which can indicate how well the digestive system is breaking down and absorbing food. Improved enzyme and malabsorption markers after consuming kombucha suggest enhanced digestive function due to the hydrolytic enzymes present in the beverage.

Stool tests can measure fecal calprotectin, lactoferrin, and secretory IgA, which are markers of gut inflammation. A reduction in these markers after drinking kombucha indicates decreased intestinal inflammation, suggesting improved gut health.

Metabolic Health Markers

Due to its sugar content, drinking kombucha may contribute to elevated blood sugar levels. Patients with prediabetes and diabetes should regularly monitor their blood glucose, hemoglobin A1c, and insulin to assess how kombucha affects blood sugar control. 

Some research suggests that kombucha can help combat fatty liver disease. A liver function panel includes alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT). These markers are often elevated in liver disease. Reductions in these enzymes indicate that kombucha is reducing liver damage and improving liver function. 

Alternative Approaches to Bowel Regularity

Dietary fiber is essential for maintaining bowel regularity. Soluble fiber dissolves in water to form a gel-like substance, which can help soften stool and improve its passage. Insoluble fiber does not dissolve in water and helps add bulk to the stool, promoting movement through the digestive tract. Adults should aim to eat 25-35 grams of fiber daily. Fiber-rich foods include fruits, vegetables, whole grains, legumes, nuts, and seeds.

Dehydration causes constipation by leading the body to absorb more water from the colon, resulting in hard, dry stools that are difficult to pass. Staying well hydrated helps soften stool and promotes intestinal motility, making it easier to pass stool and prevent constipation. On average, adult males and females need approximately 125 and 91 ounces of fluid daily, respectively, to stay hydrated. Hydration requirements will vary depending on age, weight, and activity levels. 

Physical activity stimulates the muscles in the intestines, helping to move stool through the digestive tract. Regular exercise, such as walking, jogging, or yoga, can reduce constipation.

Disengagement from the mind-body connection during meals can make digestive processes less effective, leading to digestive symptoms like gas, bloating, and irregular movements. Practicing mindful eating by eating slowly, chewing food thoroughly, and listening to hunger and satiety cues "turns on" the parasympathetic nervous system to enhance gastrointestinal function. 

The following supplements are backed by evidence supporting their role in optimizing bowel function:

  • Fiber supplements can be helpful for those unable to meet fiber requirements through diet alone. Flaxseed and psyllium husk are examples of fiber supplements that can relieve constipation.  
  • Digestive enzymes can aid in the breakdown of food, improving digestion and nutrient absorption. They can be particularly beneficial for individuals with irregular bowel habits due to enzyme deficiencies or food intolerances. 
  • Digestive bitters are herbal extracts that stimulate digestive secretions and intestinal motility. They are often recommended for patients struggling with digestive enzyme insufficiencies, bloating, and constipation. 

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Key Takeaways

  • Kombucha's probiotic content and potential impact on digestive health show promise in promoting bowel regularity. Its bioactive compounds, like polyphenols and enzymes, may support overall gut function.
  • Drinking kombucha should complement a healthy diet, adequate hydration, and regular exercise as part of a holistic health plan to support gut health.
  • The clinical evidence available to support the benefits of drinking kombucha for bowel regularity is limited, and it's important to recognize that individual responses may vary. Consulting a healthcare provider ensures personalized guidance on incorporating kombucha and other therapies into one's health routine to optimize bowel function.
The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.
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  1. Al-Mohammadi, A.-R., Ismaiel, A. A., Ibrahim, R. A., et al. (2021). Chemical Constitution and Antimicrobial Activity of Kombucha Fermented Beverage. Molecules, 26(16), 5026. https://doi.org/10.3390/molecules26165026
  2. Anderson, S. (2022, September 14). This is What Happens to Your Body When You are Dehydrated. Rupa Health. https://www.rupahealth.com/post/this-is-what-happens-to-your-body-when-you-are-dehydrated
  3. Antolak, H., Piechota, D., & Kucharska, A. (2021). Kombucha Tea—A Double Power of Bioactive Compounds from Tea and Symbiotic Culture of Bacteria and Yeasts (SCOBY). Antioxidants, 10(10), 1541. https://doi.org/10.3390/antiox10101541
  4. Armstrong, L., & Johnson, E. (2018). Water Intake, Water Balance, and the Elusive Daily Water Requirement. Nutrients, 10(12), 1928. https://doi.org/10.3390/nu10121928
  5. Asano, T., Yuasa, K., Kunugita, K., et al. (1994). Effects of Gluconic Acid on Human Faecal Bacteria. Microbial Ecology in Health and Disease, 7(5), 247–256. https://doi.org/10.3109/08910609409141362
  6. Batista, P., Penas, M. R., Pintado, M., et al. (2022). Kombucha: Perceptions and Future Prospects. Foods, 11(13), 1977. https://doi.org/10.3390/foods11131977
  7. Bertagna, B. (2024, January 9). The Science Behind Mindful Eating: How It Impacts Digestion and Overall Health. Rupa Health. https://www.rupahealth.com/post/the-science-behind-mindful-eating-how-it-impacts-digestion-and-overall-health
  8. Bertagna, B. (2024, March 7). Fermented Foods For Gut Health: What The Science Says. Rupa Health. https://www.rupahealth.com/post/fermented-foods-for-gut-health-what-the-science-says
  9. Christie, J. (2022, December 13). How Many Grams of Fiber Should You Consume Per Day? Www.rupahealth.com. https://www.rupahealth.com/post/95-of-americans-arent-getting-enough-fiber-how-many-grams-of-fiber-should-we-be-consuming-per-day
  10. Cloyd, J. (2022, December 15). Fatigue, Brain Fog, And Headaches Are Signs Of This Gastrointestinal Disorder. Rupa Health. https://www.rupahealth.com/post/ibs-c-diagnosis-and-natural-treatments-options
  11. Cloyd, J. (2023, February 28). A Functional Medicine Protocol for Leaky Gut Syndrome. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-protocol-for-leaky-gut-syndrome
  12. Cloyd, J. (2023, April 20). Top Intestinal Inflammatory Biomarkers Commonly Used In Functional Medicine. Rupa Health. https://www.rupahealth.com/post/top-intestinal-inflammatory-biomarkers-commonly-used-in-functional-medicine
  13. Cloyd, J. (2023, April 28). How to Heal Your Gut Naturally With Functional Nutrition. Rupa Health. https://www.rupahealth.com/post/how-to-heal-your-gut-naturally-with-functional-nutrition
  14. Cloyd, J. (2023, May 24). What are Digestive Enzymes: How to Test Your Patients Levels. Rupa Health. https://www.rupahealth.com/post/what-are-digestive-enzymes-how-to-test-your-patients-levels
  15. Cloyd, J. (2023, July 3). The Importance of Comprehensive Stool Testing in Functional Medicine. Rupa Health. https://www.rupahealth.com/post/the-importance-of-comprehensive-stool-testing-in-functional-medicine
  16. Cloyd, J. (2023, November 8). Flaxseeds 101: The Top 5 Therapeutic Uses of These Powerful Medicinal Seeds. Rupa Health. https://www.rupahealth.com/post/top-5-therapeutic-uses-of-flaxseed
  17. Cloyd, J. (2024, January 8). The Science of Hydration: How Water Intake Affects Overall Health. Rupa Health. https://www.rupahealth.com/post/the-science-of-hydration-how-water-intake-affects-overall-health
  18. Cloyd, K. (2023, October 4). Inflammation and Gut Health: Understanding the Impact on Overall Well-Being. Rupa Health. https://www.rupahealth.com/post/inflammation-and-gut-health-understanding-the-impact-on-overall-well-being
  19. Costa, M. A. de C., Vilela, D. L. de S., Fraiz, G. M., et al. (2021). Effect of kombucha intake on the gut microbiota and obesity-related comorbidities: A systematic review. Critical Reviews in Food Science and Nutrition, 63(19), 1–16. https://doi.org/10.1080/10408398.2021.1995321
  20. Dale, H. F., Rasmussen, S. H., Asiller, Ö. Ö., et al. (2019). Probiotics in Irritable Bowel Syndrome: An Up-to-Date Systematic Review. Nutrients, 11(9). https://doi.org/10.3390/nu11092048
  21. DeCesaris, L. (2022, June 6). What Is Gut Dysbiosis? 7 Signs To Watch For. Rupa Health. https://www.rupahealth.com/post/how-your-gut-bacteria-affects-your-overall-health
  22. Fasting Insulin. Rupa Health. https://www.rupahealth.com/biomarkers/fasting-insulin
  23. Glucose. Rupa Health. https://www.rupahealth.com/biomarkers/glucose
  24. Greenan, S. (2021, November 5). A Functional Medicine Approach To IBS. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-ibs
  25. Greenan, S. (2021, December 8). 5 Probiotic-Rich Foods To Eat Instead Of Taking Supplements. Rupa Health. https://www.rupahealth.com/post/the-different-types-of-probiotics-health-benefits
  26. Hemoglobin A1C. Rupa Health. https://www.rupahealth.com/biomarkers/hba1c
  27. Hepatic Testing. Rupa Health. https://www.rupahealth.com/health-categories/hepatic
  28. Is Kombucha Good for You? (2023, March 6). Cleveland Clinic. https://health.clevelandclinic.org/what-are-kombuchas-health-benefits-and-how-much-can-you-safely-drink
  29. Isakov, V. A., Pilipenko, V. I., Vlasova, A. V., et al. (2023). Evaluation of the Efficacy of Kombucha-Based Drink Enriched with Inulin and Vitamins for the Management of Constipation-Predominant Irritable Bowel Syndrome in Females: A Randomized Pilot Study. Current Developments in Nutrition, 7(12), 102037. https://doi.org/10.1016/j.cdnut.2023.102037
  30. Jakubczyk, K., Kałduńska, J., Kochman, J., et al. (2020). Chemical Profile and Antioxidant Activity of the Kombucha Beverage Derived from White, Green, Black and Red Tea. Antioxidants, 9(5), 447. https://doi.org/10.3390/antiox9050447
  31. Johnson, J. (2021, April 16). The potential side effects of kombucha and how to drink it safely. Medical News Today. https://www.medicalnewstoday.com/articles/kombucha-side-effects#side-effects
  32. Kombucha Tea Global Market Report. (2024, January). The Business Research Company. https://www.thebusinessresearchcompany.com/report/kombucha-tea-global-market-report
  33. Lee, C., Kim, J., Wang, S., et al. (2019). Hepatoprotective Effect of Kombucha Tea in Rodent Model of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis. International Journal of Molecular Sciences, 20(9). https://doi.org/10.3390/ijms20092369
  34. Lind, E., Mähönen, H., Latonen, R.-M., et al. (2023). Erosive potential of ice tea beverages and kombuchas. Acta Odontologica Scandinavica, 81(6), 1–8. https://doi.org/10.1080/00016357.2023.2199848
  35. Maholy, N. (2023, June 29). The Role of Probiotics and Prebiotics in Gut Health: An Integrative Perspective. Rupa Health. https://www.rupahealth.com/post/the-role-of-probiotics-and-prebiotics-in-gut-health-an-integrative-perspective
  36. Martínez-Martínez, M. I., Calabuig-Tolsá, R., & Cauli, O. (2017). The effect of probiotics as a treatment for constipation in elderly people: A systematic review. Archives of Gerontology and Geriatrics, 71, 142–149. https://doi.org/10.1016/j.archger.2017.04.004
  37. Pakravan, N., Kermanian, F., & Mahmoudi, E. (2019). Filtered Kombucha tea ameliorates the leaky gut syndrome in young and old mice model of colitis. Iranian Journal of Basic Medical Sciences, 22(10), 1158–1165. https://doi.org/10.22038/ijbms.2019.36189.8622
  38. Preston, J. (2023, February 23). Functional Medicine Treatment for Malabsorption Syndrome. Rupa Health. https://www.rupahealth.com/post/functional-medicine-treatment-for-malabsorption-syndrome
  39. Psyllium. Mount Sinai Health System. https://www.mountsinai.org/health-library/supplement/psyllium
  40. Sweetnich, J. (2023, June 30). Top 5 Antioxidants That Can Improve Your Health and How To Test Your Patient's Levels. Rupa Health. https://www.rupahealth.com/post/top-5-antioxidants-to-improve-your-health
  41. Unexplained Severe Illness Possibly Associated with Consumption of Kombucha Tea -- Iowa, 1995. (1995, December 8). CDC. https://www.cdc.gov/mmwr/preview/mmwrhtml/00039742.htm
  42. Weinberg, J. L. (2023, December 26). The Power of Polyphenols: Functional Medicine's Antioxidant Superstars. Rupa Health. https://www.rupahealth.com/post/the-power-of-polyphenols-functional-medicines-antioxidant-superstars
  43. Weinberg, J. L. (2024, January 18). Chronic Constipation and Gut Motility: Functional Medicine Interventions and Solutions. Rupa Health. https://www.rupahealth.com/post/chronic-constipation-and-gut-motility-functional-medicine-interventions-and-solutions
  44. Yang, J., Lagishetty, V., Kurnia, P., et al. (2022). Microbial and Chemical Profiles of Commercial Kombucha Products. Nutrients, 14(3), 670. https://doi.org/10.3390/nu14030670
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