Boric Acid Suppositories: Uses, Benefits, and Safety

Vaginal infections are among the most common gynecological issues faced by women of reproductive age. Bacterial vaginosis affects approximately 30% of women at some point in their lives, and estimates suggest that approximately 70% will experience at least one yeast infection. Despite traditional treatments being effective for many women, a considerable percentage experience persistent or recurrent infections (17). 

Factors contributing to treatment failures include antibiotic resistance, biofilm formation, disruptions in the natural vaginal flora, and incomplete eradication of the underlying causes. This persistent challenge has spurred interest in alternative therapies, with boric acid suppositories emerging as a promising option for those seeking effective and reliable relief.

[signup]

What Are Boric Acid Suppositories?

Chemically, boric acid is hydrogen borate (H₃BO₃). It is a weak acid with antifungal and antibacterial properties. ​​Boric acid suppositories are intravaginal treatments that are available over the counter and are composed of boric acid. When inserted vaginally, the suppositories dissolve to release boric acid, which helps restore the natural pH balance and combats harmful microorganisms that cause infections.

The use of boric acid in medicine dates back to the early 19th century. Initially employed as an antiseptic and preservative, its applications expanded over time. Boric acid gained prominence in the late 20th century as an effective treatment for persistent and recurrent vaginal infections, particularly when other therapies failed. (3) 

Boric acid exhibits broad-spectrum antimicrobial activity, which is primarily attributed to the following actions:

• Disruption of Microbial Cell Function: Boric acid exerts its antimicrobial effects by penetrating the cells of harmful microorganisms and disrupting their normal functions. Specifically, boric acid interferes with cellular processes such as enzyme activity and energy production. At lower concentrations, boric acid inhibits the growth and reproduction of pathogenic bacteria and yeast. Boric acid can kill pathogenic bacteria and yeast when used in higher concentrations. (14, 20) 
• Inhibition of Biofilm Formation: Biofilms are protective layers that microorganisms create to shield themselves from external threats, including antibiotics and the host's immune system. Boric acid can inhibit the formation of biofilms and disrupt those that are present and matured in the vagina (26).   
• Regulation of Vaginal pH: The vagina is naturally acidic, with a pH typically ranging from 3.8 to 4.5. Many pathogens responsible for vaginal infections thrive in neutral or slightly alkaline conditions. Boric acid creates an inhospitable environment for these microorganisms by maintaining an acidic pH.

Common Uses of Boric Acid Suppositories

Boric acid suppositories are commonly used for treating bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC), particularly in cases of recurrent infections and resistance to first-line treatments.

Bacterial Vaginosis (BV)

BV is one of the most common types of vaginal infections in women of reproductive age. It occurs when there's an imbalance in the vaginal flora, specifically a reduction of beneficial Lactobacillus spp. that allows for an overgrowth of harmful bacteria like Gardnerella vaginalis. 

Common signs and symptoms of BV include: 

• Thin white or gray vaginal discharge
• Pain, itching, or burning of the vagina and surrounding tissues
• Strong fish-like vaginal odor
• Burning with urination

Yeast Infections

VVC, commonly called a vaginal yeast infection, is an infection affecting the vaginal and vulvar tissues caused primarily by the yeast species Candida albicans, although other Candida species can also be responsible.

Factors that can promote yeast overgrowth include:

• Antibiotic use
• Hormonal changes
• Diabetes
• Immune suppression
• Lifestyle factors, such as tight-fitting clothing, high-sugar diets, and poor hygiene

Common symptoms of VVC include:

• Intense itching and general discomfort in the vaginal and vulvar areas
• Inflammation (redness and swelling) of the vaginal tissues
• Thick, white, odorless discharge resembling cottage cheese
• Burning with urination or during sexual intercourse

How to Use Boric Acid Suppositories Safely

This medicine is indicated for intravaginal use only. Boric acid is toxic when ingested orally. Read the packaging instructions carefully before use and follow the instructions on the label or provided by your doctor. 

Suppository Administration

• Wash your hands before and after handling the suppository.
• Lie down in a comfortable position, such as on your back with knees bent. Gently insert the suppository into the vagina as far as it will comfortably go using your fingers or a specialized applicator.
• Wear a panty liner to absorb any discharge. Nighttime administration is often recommended to prevent activity-associated leakage during the day.
• Keep suppositories in a cool, dry place away from direct sunlight.

Dosage

Per standard-of-care medical guidelines, boric acid is not recommended as a first-line agent for treating uncomplicated BV or VVC. If used as an alternative to first-line agents, your doctor may recommend a dose of 600 mg inserted vaginally nightly for 7 to 14 days. 

For recurrent BV, boric acid is often used as part of a combination therapy. The United States Centers for Disease Control and Prevention (CDC) guidelines recommend initial treatment with an oral nitroimidazole (metronidazole or tinidazole) followed by intravaginal boric acid 600 mg daily for 21 days, and then suppressive metronidazole gel twice weekly for 4-6 months.

For recurrent or azole-resistant VVC, particularly infections caused by non-albicans Candida species, the Infectious Diseases Society of America (IDSA) recommends boric acid 600 mg administered intravaginally once daily for 14 days. If symptoms recur, the same regimen can be repeated.

Potential Side Effects

When used as prescribed, boric acid is safe and generally well tolerated. Mild side effects may occur, including (5): 

• Mild burning, redness, and irritation
• Watery vaginal discharge

Stop using this medicine and get medical help immediately if you experience any of the following signs of an allergic reaction (5): 

• Hives
• Rash
• Difficulty breathing
• Swelling of the face, lips, tongue, or throat
• Fever

Contact your doctor if you experience new or worsening symptoms when using boric acid suppositories (5).

Contraindications

The following people should not use boric acid suppositories:

• People who are pregnant
• People with open vaginal sores
• People with pelvic inflammatory disease or an active sexually transmitted infection
• Children

Who Should Consider Using Boric Acid Suppositories?

Boric acid suppositories are beneficial to the following groups of people:

• Patients with recurrent VVC, especially those caused by non-albicans Candida species or azole-resistant strains
• Patients with recurrent BV, particularly those who have experienced multiple recurrences and have not responded to conventional antibiotic treatments
• Patients with mixed infections involving yeast and bacteria, where conventional treatments have been ineffective
• Patients requiring maintenance therapy to prevent recurrence of vaginal infections after initial successful treatment
• Patients seeking an alternative to conventional antifungal and antibiotic treatments

Scientific Evidence on Boric Acid Suppositories

Numerous clinical studies have evaluated the efficacy of boric acid suppositories in treating vaginal infections. These studies highlight boric acid's ability to restore vaginal flora balance and reduce infection symptoms effectively.

A 2011 medical review analyzed 14 studies, including randomized clinical trials and case series, and found that boric acid achieved fungal cure rates ranging from 40% to 100% in patients with recurrent VVC. The researchers concluded that boric acid was a safe and cost-effective alternative to other treatments, particularly for infections caused by non-albicans Candida species or azole-resistant fungal strains.

A 2007 study compared boric acid vaginal suppositories (600 mg daily for 14 days) to fluconazole (a single oral dose of 150 mg) in diabetic patients with VVC. The study found that boric acid had a significantly higher mycological cure rate for Candida glabrata infections compared to fluconazole (63.6% vs. 28.6%).

Researchers conducting a 2009 study reported that the addition of intravaginal boric acid to a pharmacologic treatment and maintenance protocol effectively reduced the symptomatic recurrence of BV.

Potential Risks and Precautions

Risk of Overuse: While boric acid is effective, overusing it may lead to excessive vaginal irritation and disrupt the natural microbiota balance. However, there is currently no evidence to suggest that boric acid causes microbial resistance. Nonetheless, it's important to adhere to recommended dosages and consult a healthcare provider for prolonged use.

Sustainability of Boric Acid: Boric acid is considered to have a relatively low environmental impact compared to many pharmaceutical products. It is a naturally occurring mineral, and its production does not involve extensive chemical processing. However, like all substances, responsible use and disposal are essential to minimize any potential environmental effects. (6) 

Frequently Asked Questions (FAQs)

Can I Use Boric Acid Suppositories During My Period?

Yes, boric acid suppositories can be used during menstruation. However, some women may find it uncomfortable to insert a suppository while menstruating. It's advisable to follow personal comfort levels and consult with a healthcare provider if unsure.

Can I Use Boric Acid With Other Treatments?

Boric acid can be used alongside other treatments, such as antibiotics, antifungals, and probiotics. Patients are always advised to consult with a healthcare provider before combining therapies. This ensures that there are no interactions and that each treatment is appropriately timed for maximum effectiveness.

Are Boric Acid Suppositories Safe for Long-Term Use?

When used as directed, boric acid suppositories are generally safe for long-term use, especially for maintenance therapy to prevent recurrent infections. However, prolonged use should be monitored by a healthcare provider to ensure ongoing safety and effectiveness.

[signup]

Key Takeaways

• Boric acid suppositories offer a safe, economical, and effective alternative for managing chronic and recurrent vaginal infections like bacterial vaginosis and yeast infections. 
• Numerous clinical studies prove boric acid's efficacy in treating vaginal infections that recur after or are resistant to standard antibiotic and antifungal therapies. 
• Before incorporating boric acid suppositories into your healthcare routine, consult with a healthcare provider. They can provide personalized advice, ensure the suitability of boric acid for your specific condition, and monitor your progress to ensure safe and effective use.