Nutrition
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January 31, 2025

Allulose: Health Benefits, Safety, and Uses

Written By
Erin Coleman RD
Medically Reviewed by
Updated On
February 5, 2025

Imagine enjoying sweetness with fewer calories and a reduced impact on blood sugar. Some sugar substitutes, like allulose, provide an option for those looking to modify their sugar intake.

Allulose is a low-calorie sweetener that has been studied for its potential effects on metabolism and blood sugar regulation.

This article explores the perks, safety, and many uses of allulose.

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What is Allulose?

Allulose is a sugar substitute classified by the FDA as generally recognized as safe (GRAS). It can be used in various recipes instead of added sugars to reduce calorie content.

It's a naturally occurring sugar in raisins, figs, kiwi fruit, jackfruit, corn, molasses, maple syrup, and wheat. 

Allulose is commercially made by heating fructose (sugar molecule) and altering its chemical form, resulting in a liquid or granulated sweetener. 

Allulose is a low-calorie sweetener that is not fully metabolized by the body, resulting in a reduced impact on blood sugar compared to regular sugar. Researchers found that allulose is nearly calorie-free, containing about 1/10th of the calories of regular sugar.

The discovery of allulose is somewhat recent; industrial production and its introduction to store shelves began around 2010. Researchers initially discovered allulose from wheat, and the FDA classifies it as a carbohydrate.

Allulose vs. Sugar – Nutritional Comparison

Allulose has unique nutritional properties.

Caloric Content

Allulose has significantly fewer calories than table sugar, as it is absorbed but minimally metabolized by the body. 

Research suggests that allulose is about 70% as sweet as sucrose and provides approximately 0.4 calories per gram (versus 4 calories per gram in sugar), or less than 10% of the calories of sugar.

Many pure allulose products list zero calories on the food label. Why? The body doesn't fully metabolize the calories (all from carbohydrates). They're absorbed by the small intestine and excreted.

The nutritional content of 1 teaspoon (about 4 grams) of allulose listed on food labels vs. similar sugar substitutes and table sugar is as follows:

[2, 36, 37, 39, 44, 50]

However, the FDA describes allulose as containing 0.4 calories per gram, equating to 1.6 calories in a scoop (4-gram portion).

Allulose doesn't offer many micronutrients, which are not listed on its nutrition facts label. Allulose sweetens similarly to table sugar in about a 1:1 ratio

Metabolic Effects

Allulose has a zero glycemic index (GI), meaning it doesn't raise blood sugar levels. 

Consequently, allulose does not produce the same effect on blood sugar as sucrose. Some studies suggest that allulose may influence blood sugar levels, particularly in those with type 2 diabetes, though individual responses can vary.

Due to its very low calorie content (but consistent sweet taste), preliminary studies have examined the relationship between allulose intake and metabolic markers such as BMI and body fat, though more research is needed.

Health Benefits of Allulose

Research has explored the potential effects of allulose on metabolic processes, including:

Managing Diabetes

Research suggests that allulose, with a zero glycemic index (GI), may be a suitable sugar substitute for individuals managing blood sugar levels. 

Some studies suggest that allulose may influence post-meal glucose levels and insulin sensitivity, but more research is needed.

In some research studies, the amount of allulose consumed to reduce post-meal blood sugar is 5-10 grams.

Artificial sweeteners like sucralose, aspartame, saccharin, advantame, neotame, and acesulfame potassium may indirectly increase blood sugar levels by altering the gut microbiome.

Weight Loss and Metabolism

Allulose is lower in calories than regular sugar and can be included in certain dietary approaches, such as low-carb or reduced-calorie meal plans.

The FDA notes that based on available information regarding allulose, its caloric contribution is insignificant and may substantially lessen total calories and calories from added sugar when used instead of added sugars

Studies confirm that consuming high amounts of allulose (7 grams two times daily) led to significant decreases in body fat, body mass percentage, body mass index (BMI), subcutaneous fat, and total abdominal fat.

However, researchers recommend additional studies exploring the long-term implications of allulose to prevent or manage metabolic diseases.

Antioxidant and Anti-Inflammatory Properties

While additional studies are warranted, researchers tout the numerous potential physiological effects of allulose, including:

  • Anti-diabetes
  • Anti-obesity
  • Anti-inflammatory
  • Neuroprotective
  • Antioxidant

Animal studies found that allulose consumption is linked to lower food consumption, better blood sugar regulation, and improved appetite control. 

Is Allulose Safe? Understanding the Science

Allulose is a relatively new sugar substitute that continues to be studied for its metabolic effects and safety.

FDA Approval and GRAS Status

The FDA classifies allulose as generally recognized as safe (GRAS), meaning it is considered safe for its intended uses based on current scientific data. While research is ongoing, current studies suggest that allulose is well-tolerated in moderate amounts. 

Allulose is also approved for use in Mexico, Singapore, South Korea, and Japan. 

Furthermore, the FDA does not require allulose to be listed in the "added sugars" section of the nutrition facts label. Still, the total carbohydrates present in allulose must be listed on the label. 

In some other countries, such as Europe and Canada, allulose has not yet been approved for use because it has not been available long enough for rigorous testing based on government standards.

Potential Side Effects and Concerns

Potential side effects of consuming excessive allulose may include digestive problems, such as:

However, more in-depth research studies involving allulose would be helpful. 

Some studies have examined potential associations between high intake of certain sugar alcohols, such as xylitol and erythritol, and cardiovascular health outcomes. More research is needed to understand these relationships fully.

Some allulose products are combined with erythritol or other sugar alcohols.

There are no official safety guidelines for allulose. Some researchers say consuming 5-10 grams of allulose may aid blood sugar control after meals in healthy and diabetic individuals. 

Other studies suggest a single dose maximum of 0.4 grams of allulose per kilogram of body weight or 24 grams for a 132-pound person. However, research is ongoing.

Incorporating Allulose into Your Life

Consider incorporating allulose into your diet with the following ideas, keeping individual tolerance and dietary needs in mind.

Allulose in Foods

You might consume allulose in the following packaged food products or homemade recipes:

  • Keto dessert recipes
  • Ice creams, sorbets, and other frozen dairy desserts
  • Regular and frozen yogurts
  • Jellies and jams
  • Soft and hard candies
  • Syrups, creams, and sauces
  • Rolls, biscuits, and pastries
  • Fillings, gelatins, and puddings
  • Medical foods
  • Salad dressings
  • Coffee mixes
  • Carbonated and non-carbonated beverages
  • Chewing gums

Check the ingredient list on nutrition facts labels to identify allulose. 

Culinary Applications

You can bake or cook with allulose, often in a 1:1 ratio, or replace 2 teaspoons of sugar with 1 tablespoon of allulose

You can also pair allulose with other sweeteners. Numerous sugar substitute products combine allulose with stevia, erythritol, or a combination of sweeteners. 

However, it's important to remember that some studies have linked high blood levels of erythritol to an increased risk of stroke and heart attack. Read all ingredient lists on food labels to identify erythritol or xylitol (also linked to potential heart concerns).

Product Availability and Labels

You can identify allulose on food packaging labels by looking for its name on ingredient lists. Synonyms (other names) for allulose are d-psicose, psicose, d-allulose, and pseudo-fructose.

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Key Takeaways

  • Allulose is a low-calorie sweetener with a reduced impact on blood sugar compared to regular sugar. It can be used in various dietary approaches, though individual responses may vary.
  • It's vital to make informed choices when considering sugar alternatives. 
  • So what are you waiting for? Try allulose (consult with a healthcare professional first if needed) and leave a review in the comments below!
The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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