Dentistry
|
May 6, 2024

A Root Cause Medicine Approach to Gum Disease

Written By
Dr. Rachel Magerman ND
Medically Reviewed by
Updated On
September 17, 2024

Gum disease, also known as periodontal disease, is a prevalent yet preventable condition that affects a significant portion of the global population. Gum disease is characterized by inflammation of the gums and supporting structures of the teeth.Β 

Gum disease can lead to serious health complications if left untreated, including tooth loss and systemic health issues. In this article, we will discuss the root cause of gum disease and natural prevention and treatment options.

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What is Gum Disease?

Gum disease, also known as periodontal disease, is a common condition that affects the soft tissue around the teeth. Gingivitis is the earliest stage of gum disease and can be found in up to 90% of the population.Β 

Gingivitis is characterized by inflammation of the gums and can present with swelling, redness, and bleeding during brushing or flossing. Gingivitis is reversible with proper treatment and attention to oral hygiene.Β 

If gingivitis is left untreated, it can progress to periodontitis. Periodontitis occurs when pathogenic bacteria penetrate deeper into the periodontium, resulting in bad breath, receding gums, and pus formation between the teeth and gums.Β 

Recognizing early signs of gingivitis and implementing intervention can help prevent the progression of gum disease and preserve oral health (22).

What is Root Cause Medicine?

Root cause medicine is a holistic approach to healthcare that looks beyond symptom management and focuses on identifying and addressing the underlying factors leading to disease. It focuses on each patient as an individual and examines physical, mental, emotional, and spiritual imbalances in the body.Β 

While conventional medicine only examines labs and symptoms, root cause medicine includes nutrition, lifestyle, genetic abnormalities, and underlying infections and toxicity in the body.Β 

By applying the principles of root cause medicine to oral health and gum disease, practitioners can offer more comprehensive and personalized treatment approaches that address underlying factors contributing to disease (57).

Identifying the 4 Most Common Root Causes of Gum Disease

There might be a genetic factor influencing someone’s predisposition to getting gum disease. However, the following root causes tend to have an even larger impact on oral health:

Identifying the 4 Most Common Root Causes of Gum Disease

1. Nutrient Deplete Diet:Β 

Nutrition plays an important role in maintaining oral health, influencing the risk of developing cavities, gum disease, and even oral cancer. A high-sugar, high-saturated fat, and low-fiber diet has been shown to increase the risk of periodontal disease.Β 

In addition, alcohol abuse is correlated with an increase in gum disease.Β 

On the contrary, a diet high in omega-3 fatty acids, low sugar, and high fiber diet reduces the risk of periodontal disease. Specifically, following a Mediterranean diet, vegetarian diet, or DASH diet is correlated with a decrease in gum disease (32).

2. Poor Gut Health:Β 

Gut dysbiosis is correlated with various diseases throughout the human body. There is microbial transmission between the oral cavity and gut microbiome, emphasizing the presence of an oral gut microbiome axis.Β 

The link between oral health and gut dysbiosis is bi-directional. For example, in patients with Irritable Bowel Disease (IBD), studies show a direct change in the oral microbiome leading to early stages of gum disease.Β 

It is also predicted that inflammation within the gut from Crohn's, Celiac, IBS, etc, triggers an immune response resulting in proinflammatory cytokines entering systemic circulation and affecting the oral microbiome.Β 

Furthermore, oral pathogens such as P. gingivalis, a bacteria implicated in gingivitis, produce damage to the gut lining which can lead to gastrointestinal disease (2, 7, 33).Β 

3. High Stress:Β 

When under stress, the body releases cortisol, adrenaline, and noradrenaline which have all been associated with changes in the oral microbiome. Increased cortisol levels produce shifts in the oral cavity closely linked to those with periodontal disease.Β 

Additionally, the secretion of noradrenaline and adrenaline promoted the growth of Actinomyces, Eikenella, and Campylobacter within the oral cavity. These findings suggest hormonal changes when under stress are correlated with a rise in pathogenic bacteria promoting the development of gum disease (34).

To learn more about the connection between stress and oral health, read this article:

4. Exposure to Environmental Toxins:Β 

Smoking tobacco increases your risk of developing periodontal disease by 5-20-fold. Individuals who regularly smoke cigarettes are at greater risk for developing bone loss, deep periodontal pockets of inflammation, and tooth loss. It has also been shown that smoking is correlated with a decrease in the effectiveness of treatments.Β 

In addition to smoking, the presence of elevated heavy metals such as lead, cadmium, and mercury is associated with an increased risk of developing periodontitis (21, 22).

How to Prevent and Treat Gum Disease

After understanding the root causes, the pathway to treatment becomes much clearer.Β 

First, Increase Nutrients in the Diet:Β 

Nutrients provide the building blocks for gum health, which is why increasing nutrients is the best way to start a treatment plan.

  • Micronutrients such as vitamins C, A, E, folic acid, and calcium are necessary for maintaining periodontal health and preventing gum disease.Β 
  • Increasing the intake of carotenoids through consuming carrots, sweet potatoes, and green leafy vegetables aids in supporting vitamin A levels.Β 
  • Increasing citrus fruits such as oranges, lemons, and grapefruit supports healthy vitamin C levels.Β 
  • For more specific guidance on following this type of diet, you can read more about the Mediterranean diet (32).

Nutrient-dense foods that also have anti-inflammatory properties are another important group to add to the diet.Β 

  • Shifting total fat intake to include more omega-3 fatty acids supports healthy inflammation levels and has been shown to decrease the risk of gum disease.Β 
  • Foods high in omega-3 fatty acids include olive oil, salmon, flaxseed, walnuts, and soybeans (32).

The intake of dietary fiber in the diet is inversely correlated with periodontal disease. Examples of foods high in fiber are fruits, oats, vegetables, and beans.Β 

In addition to incorporating healthy food choices, supplementing with xylitol and CoQ10 has shown a significant reduction in gingival inflammation and pathogenic bacteria (31, 32).

Second, Improve Gut Health:

In addition to a healthy diet, implementing probiotics and fermented foods can beneficially impact our gut microbiome. A healthier gut microbiome is linked to improved oral health.

Fermented foods such as sauerkraut, kefir, kimchi, and yogurt contain beneficial probiotics aiding in a healthy gut. It has also been shown that a diet high in fermented foods decreases signs of inflammation in the gut.Β 

Incorporating probiotic and prebiotic supplements also aids in improving gut health by regulating the colonization of healthy strains of bacteria and decreasing pathogenic strains (30, 47).

If poor gut health is significant, providers should target this more directly. Here are helpful articles to learn more about improving gut health:

Third, Reduce Stress With Stress Management TechniquesΒ 

Because stress hormones are closely correlated with an increase in periodontal disease, stress management is a critical part of a well-rounded oral health treatment plan.Β 

Implementing stress reduction techniques such as meditation, yoga, and regular exercise are effective methods in calming stress hormones.Β 

One study showed that practicing yoga accelerates treatment outcomes by decreasing stress in periodontal disease. Further research has shown practicing pranayama, a type of yoga, results in a decrease in salivary cortisol and, thus, a decrease in the level of plaque and gingival inflammation (1, 38).Β 

Finally, Decrease Toxic Load and Support Gentle Detoxification

Periodontal disease is associated with increased exposure to heavy metals and smoking tobacco. These metals can be found either within the cigarettes themselves, in unclean water, or in contaminated foods.Β 

To decrease exposure to environmental toxins, it is recommended to eat primarily organic-grown food, avoid processed foods, eliminate plastics, and avoid aluminum-based cooking equipment.Β 

According to the Environmental Protection Agency, one-quarter of Americans are exposed to toxicants within the water supply. To decrease this exposure, it is recommended to install a carbon-based filter into the main water line of your home (35).

It also may be beneficial to implement the following practices that support the body’s detoxification pathways:

  • Eat or supplement additional specific nutrients such as B vitamins, sulfur-rich foods, and antioxidants like vitamins C and E because they all support the liver and protect against oxidative stress.Β 
  • Supplement with milk thistle, NAC, and curcumin, which can also enhance kidney and liver detoxification (54).
  • Dosages need to be discussed with a healthcare practitioner who can make a recommendation based on total medical history.

How to Integrate Root Cause Medicine with Conventional Dental Care

Holistic dentistry approaches gum disease with a focus on oral health and its relation to other organ systems. Conventional dentistry focuses on treating symptoms rather than looking at the underlying cause.Β 

It is important to treat periodontal disease with a holistic approach to identify the root causes of disease and make the necessary lifestyle adjustments needed to correct underlying pathology.Β 

Functional medicine practitioners and dentists must collaborate to optimize patient outcomes. By working together, medical professionals and dentists can address both the dental aspects of gum disease and its systemic implications (52).

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Key Takeaways

  • The adoption of root-cause medicine in treating periodontal disease offers significant promise in both the prevention and treatment of gum disease.Β 
  • Patients need to integrate holistic health strategies such as proper nutrition and stress management techniques when treating periodontal disease.Β 
  • Readers should be encouraged to seek out healthcare practitioners who embrace a comprehensive approach to dental care.

Gum disease, also known as periodontal disease, is a prevalent condition that affects a significant portion of the global population. It is characterized by inflammation of the gums and supporting structures of the teeth.Β 

Gum disease can lead to serious health complications if left unaddressed, including tooth loss and potential systemic health issues. In this article, we will discuss factors contributing to gum disease and natural options that may help support oral health.

[signup]

What is Gum Disease?

Gum disease, also known as periodontal disease, is a common condition that affects the soft tissue around the teeth. Gingivitis is the earliest stage of gum disease and can be found in up to 90% of the population.Β 

Gingivitis is characterized by inflammation of the gums and can present with swelling, redness, and bleeding during brushing or flossing. Gingivitis is reversible with proper attention to oral hygiene.Β 

If gingivitis is left unaddressed, it can progress to periodontitis. Periodontitis occurs when bacteria penetrate deeper into the periodontium, resulting in bad breath, receding gums, and pus formation between the teeth and gums.Β 

Recognizing early signs of gingivitis and implementing intervention can help support oral health and prevent the progression of gum disease (22).

What is Root Cause Medicine?

Root cause medicine is a holistic approach to healthcare that looks beyond symptom management and focuses on identifying and addressing factors contributing to disease. It focuses on each patient as an individual and examines physical, mental, emotional, and spiritual aspects of health.Β 

While conventional medicine often examines labs and symptoms, root cause medicine includes nutrition, lifestyle, genetic factors, and underlying infections and toxicity in the body.Β 

By applying the principles of root cause medicine to oral health and gum disease, practitioners can offer more comprehensive and personalized approaches that address factors contributing to disease (57).

Identifying the 4 Most Common Factors Contributing to Gum Disease

There might be a genetic factor influencing someone’s predisposition to gum disease. However, the following factors tend to have a larger impact on oral health:

Identifying the 4 Most Common Factors Contributing to Gum Disease

1. Nutrient Deplete Diet:Β 

Nutrition plays an important role in maintaining oral health, influencing the risk of developing cavities, gum disease, and even oral cancer. A high-sugar, high-saturated fat, and low-fiber diet has been associated with an increased risk of periodontal disease.Β 

In addition, alcohol consumption is associated with an increase in gum disease.Β 

On the contrary, a diet high in omega-3 fatty acids, low sugar, and high fiber diet may help support oral health. Specifically, following a Mediterranean diet, vegetarian diet, or DASH diet is associated with a decrease in gum disease (32).

2. Poor Gut Health:Β 

Gut dysbiosis is associated with various conditions throughout the human body. There is microbial transmission between the oral cavity and gut microbiome, emphasizing the presence of an oral-gut microbiome axis.Β 

The link between oral health and gut dysbiosis is bi-directional. For example, in patients with Irritable Bowel Disease (IBD), studies show a direct change in the oral microbiome leading to early stages of gum disease.Β 

It is also suggested that inflammation within the gut from Crohn's, Celiac, IBS, etc., may trigger an immune response resulting in proinflammatory cytokines entering systemic circulation and affecting the oral microbiome.Β 

Furthermore, oral pathogens such as P. gingivalis, a bacteria implicated in gingivitis, may impact the gut lining which can contribute to gastrointestinal issues (2, 7, 33).Β 

3. High Stress:Β 

When under stress, the body releases cortisol, adrenaline, and noradrenaline which have all been associated with changes in the oral microbiome. Increased cortisol levels are linked to shifts in the oral cavity associated with periodontal disease.Β 

Additionally, the secretion of noradrenaline and adrenaline may promote the growth of Actinomyces, Eikenella, and Campylobacter within the oral cavity. These findings suggest hormonal changes when under stress are associated with a rise in bacteria that may contribute to gum disease (34).

To learn more about the connection between stress and oral health, read this article:

4. Exposure to Environmental Toxins:Β 

Smoking tobacco is associated with an increased risk of developing periodontal disease. Individuals who regularly smoke cigarettes may experience greater risk for developing bone loss, deep periodontal pockets of inflammation, and tooth loss. It has also been shown that smoking is associated with a decrease in the effectiveness of treatments.Β 

In addition to smoking, the presence of elevated heavy metals such as lead, cadmium, and mercury is associated with an increased risk of developing periodontitis (21, 22).

How to Support Oral Health

After understanding the contributing factors, the pathway to supporting oral health becomes clearer.Β 

First, Increase Nutrients in the Diet:Β 

Nutrients provide the building blocks for gum health, which is why increasing nutrients is a helpful way to start a plan to support oral health.

  • Micronutrients such as vitamins C, A, E, folic acid, and calcium are important for maintaining periodontal health.Β 
  • Increasing the intake of carotenoids through consuming carrots, sweet potatoes, and green leafy vegetables may help support vitamin A levels.Β 
  • Increasing citrus fruits such as oranges, lemons, and grapefruit may help support healthy vitamin C levels.Β 
  • For more specific guidance on following this type of diet, you can read more about the Mediterranean diet (32).

Nutrient-dense foods that also have anti-inflammatory properties are another important group to add to the diet.Β 

  • Shifting total fat intake to include more omega-3 fatty acids may help support healthy inflammation levels and is associated with a decreased risk of gum disease.Β 
  • Foods high in omega-3 fatty acids include olive oil, salmon, flaxseed, walnuts, and soybeans (32).

The intake of dietary fiber in the diet is inversely associated with periodontal disease. Examples of foods high in fiber are fruits, oats, vegetables, and beans.Β 

In addition to incorporating healthy food choices, supplementing with xylitol and CoQ10 has shown a significant reduction in gingival inflammation and bacteria (31, 32).

Second, Support Gut Health:

In addition to a healthy diet, implementing probiotics and fermented foods can beneficially impact our gut microbiome. A healthier gut microbiome is linked to improved oral health.

Fermented foods such as sauerkraut, kefir, kimchi, and yogurt contain beneficial probiotics that may aid in a healthy gut. It has also been shown that a diet high in fermented foods is associated with decreased signs of inflammation in the gut.Β 

Incorporating probiotic and prebiotic supplements may also aid in improving gut health by supporting the colonization of healthy strains of bacteria and decreasing pathogenic strains (30, 47).

If poor gut health is significant, providers should target this more directly. Here are helpful articles to learn more about supporting gut health:

Third, Manage Stress With Stress Management TechniquesΒ 

Because stress hormones are associated with an increase in periodontal disease, stress management is a critical part of a well-rounded oral health plan.Β 

Implementing stress reduction techniques such as meditation, yoga, and regular exercise are effective methods in calming stress hormones.Β 

One study showed that practicing yoga may support treatment outcomes by decreasing stress in periodontal disease. Further research has shown practicing pranayama, a type of yoga, is associated with a decrease in salivary cortisol and, thus, a decrease in the level of plaque and gingival inflammation (1, 38).Β 

Finally, Reduce Exposure to Toxins and Support Gentle Detoxification

Periodontal disease is associated with increased exposure to heavy metals and smoking tobacco. These metals can be found either within the cigarettes themselves, in unclean water, or in contaminated foods.Β 

To decrease exposure to environmental toxins, consider eating primarily organic-grown food, avoiding processed foods, eliminating plastics, and avoiding aluminum-based cooking equipment.Β 

According to the Environmental Protection Agency, one-quarter of Americans are exposed to toxicants within the water supply. To decrease this exposure, consider installing a carbon-based filter into the main water line of your home (35).

It also may be beneficial to explore the following practices that support the body’s detoxification pathways:

  • Consider eating or supplementing additional specific nutrients such as B vitamins, sulfur-rich foods, and antioxidants like vitamins C and E because they all support the liver and protect against oxidative stress.Β 
  • Consider supplementing with milk thistle, NAC, and curcumin, which may also support kidney and liver detoxification (54).
  • Dosages should be discussed with a healthcare practitioner who can make a recommendation based on total medical history.

How to Integrate Root Cause Medicine with Conventional Dental Care

Holistic dentistry approaches gum disease with a focus on oral health and its relation to other organ systems. Conventional dentistry often focuses on treating symptoms rather than looking at contributing factors.Β 

It is important to address periodontal disease with a holistic approach to identify the factors contributing to disease and make the necessary lifestyle adjustments needed to support overall health.Β 

Functional medicine practitioners and dentists can collaborate to optimize patient outcomes. By working together, medical professionals and dentists can address both the dental aspects of gum disease and its systemic implications (52).

[signup]

Key Takeaways

  • The adoption of root-cause medicine in addressing periodontal disease offers significant promise in both the support and management of gum health.Β 
  • Patients may benefit from integrating holistic health strategies such as proper nutrition and stress management techniques when addressing periodontal health.Β 
  • Readers are encouraged to seek out healthcare practitioners who embrace a comprehensive approach to dental care.
The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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1. Ananthalakshmi, R., Mahendra, J., Jayamathi, P., Mahendra, L., Kareem, N., & Subramaniam, S. (2018). Effect of Sudarshan Kriya Pranayama on periodontal status and human salivary beta-defensin-2: An interventional study. Dental Research Journal, 15(5), 327–333. https://pubmed.ncbi.nlm.nih.gov/30233652/

2. Arimatsu, K., Yamada, H., Miyazawa, H., Minagawa, T., Nakajima, M., Ryder, M. I., Gotoh, K., Motooka, D., Nakamura, S., Iida, T., & Yamazaki, K. (2014). Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota. Scientific Reports, 4(1). https://doi.org/10.1038/srep04828

3. Bertagna, B. (2024, February 13). The Link Between Oral Health and Overall Well-Being. Rupa Health. https://www.rupahealth.com/post/the-link-between-oral-health-and-overall-well-being

4. Bertanga, B. (2024a, January 4). Understanding the Potential Benefits of Milk Thistle for Fatty Liver. Rupa Health. https://www.rupahealth.com/post/understanding-the-potential-benefits-of-milk-thistle-for-fatty-liver

5. Bertanga, B. (2024b, March 14). Oral Microbiome 101: Understanding the Basics of Your Mouth’s Microbial World. Rupa Health. https://www.rupahealth.com/post/oral-microbiome-101-understanding-the-basics-of-your-mouths-microbial-world

6. Blake, K. (2023, May 22). Anti Inflammatory Diet 101: What to Eat and Avoid Plus Specialty Labs To Monitor Results. Rupa Health. https://www.rupahealth.com/post/anti-inflammatory-diet

7. Byrd, K. M., & Gulati, A. S. (2021). The β€œGum–Gut” Axis in Inflammatory Bowel Diseases: A Hypothesis-Driven Review of Associations and Advances. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.620124

8. Christie, J. (2022, December 13). 95% of American’s Aren’t Getting Enough Fiber: How Many Grams Should We Be Consuming Per Day? Www.rupahealth.com. https://www.rupahealth.com/post/95-of-americans-arent-getting-enough-fiber-how-many-grams-of-fiber-should-we-be-consuming-per-day

9. Christie, J. (2023, January 25). The Health Risk of Plastics. Rupa Health. https://www.rupahealth.com/post/the-health-risk-of-plastics

10. Cloyd, J. (2022, December 8). 3 Natural Treatments For Inflammatory Bowel Disease. Rupa Health. https://www.rupahealth.com/post/inflammatory-bowel-disease-ibd-treatments-for-flares-and-remission

11.Β Cloyd, J. (2023a, February 28). A Functional Medicine Protocol for Leaky Gut Syndrome. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-protocol-for-leaky-gut-syndrome

12.Β Cloyd, J. (2023b, June 5). A Functional Medicine Celiac Disease Protocol: Specialty Testing, Nutrition, and Supplements. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-celiac-disease-protocol-diagnosis-nutrition-and-supplements

13.Β Cloyd, J. (2023c, October 2). A Functional Medicine Approach to Stress Management. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-stress-management

14.Β Cloyd, J. (2023d, October 18). The 6 Most Important Uses of Omega-3s For Your Health. Rupa Health. https://www.rupahealth.com/post/the-6-most-important-uses-of-omega-3s-for-your-health

15.Β Cloyd, J. (2023e, November 13). The Anti-Inflammatory Lifestyle: From Diet to Mindfulness. Rupa Health. https://www.rupahealth.com/post/the-anti-inflammatory-lifestyle-from-diet-to-mindfulness

16.Β Cloyd, J. (2024, January 26). Vitamin E: Enhancing Reproductive Health and Hormonal Balance. Rupa Health. https://www.rupahealth.com/post/vitamin-e-enhancing-reproductive-health-and-hormonal-balance

17.Β Cloyd, K. (2023a, October 4). Inflammation and Gut Health: Understanding the Impact on Overall Well-Being. Rupa Health. https://www.rupahealth.com/post/inflammation-and-gut-health-understanding-the-impact-on-overall-well-being

18.Β Cloyd, K. (2023b, December 20). Interpreting Oxidative Stress Markers. Rupa Health. https://www.rupahealth.com/post/interpreting-oxidative-stress-markers

19.Β DePorto, T. (2023, January 10). Timeline: What Happens Inside Your Body When You Quit Smoking? Rupa Health. https://www.rupahealth.com/post/what-happens-to-our-bodies-when-we-quit-smoking-a-timeline

20.Β Diorio, B. (2022, October 25). How to Balance Adrenaline Levels Naturally. Rupa Health. https://www.rupahealth.com/post/adrenaline

21.Β  Emecen-Huja, P., Li, H-F., Ebersole, J. L., Lambert, J., & Bush, H. (2019). Epidemiologic evaluation of Nhanes for environmental Factors and periodontal disease. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-019-44445-3

22.Β Gasner, N. S., & Schure, R. S. (2023, April 10). Periodontal Disease. PubMed; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK554590/

23.Β Greenan, S. (2021, November 5). A Functional Medicine Approach To IBS. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-ibs

24.Β Kalaichandran, A. (2024, February 23). Extinguishing the Habit, Igniting Life: The Transformative Impact of Quitting Smoking. Rupa Health. https://www.rupahealth.com/post/extinguishing-the-habit-igniting-life-the-transformative-impact-of-quitting-smoking

25.Β Khakham, C. (2023a, March 28). An integrative medicine approach to kidney disease. Rupa Health. https://www.rupahealth.com/post/an-integrative-medicine-approach-to-kidney-disease

26.Β Khakham, C. (2023b, July 10). Understanding Environmental Toxins and Their Impact on Health. Rupa Health. https://www.rupahealth.com/post/understanding-environmental-toxins-and-their-impact-on-health

27.Β Kresge, K. (2023, January 31). An Integrative Approach to Mental Health. Rupa Health. https://www.rupahealth.com/post/an-integrative-approach-to-mental-health

28.Β Maholy, N. (2023a, April 14). How to reduce stress through mind-body therapies. Rupa Health. https://www.rupahealth.com/post/how-to-reduce-stress-through-mind-body-therapies

29.Β Maholy, N. (2023b, May 10). A Functional Medicine Immune Support Protocol. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-immune-support-protocol

30.Β Maholy, N. (2023c, June 29). The Role of Probiotics and Prebiotics in Gut Health: An Integrative Perspective. Rupa Health. https://www.rupahealth.com/post/the-role-of-probiotics-and-prebiotics-in-gut-health-an-integrative-perspective

31.Β Manthena, S. (2015). Effectiveness of CoQ10 Oral Supplements as an Adjunct to Scaling and Root Planing in Improving Periodontal Health. JOURNAL of CLINICAL and DIAGNOSTIC RESEARCH. https://doi.org/10.7860/jcdr/2015/13486.6291

32.Β Martinon, P., Fraticelli, L., Giboreau, A., Dussart, C., Bourgeois, D., & Carrouel, F. (2021). Nutrition as a Key Modifiable Factor for Periodontitis and Main Chronic Diseases. Journal of Clinical Medicine, 10(2), E197. https://doi.org/10.3390/jcm10020197

33.Β Nakajima, M., Arimatsu, K., Kato, T., Matsuda, Y., Minagawa, T., Takahashi, N., Ohno, H., & Yamazaki, K. (2015). Oral Administration of P. gingivalis Induces Dysbiosis of Gut Microbiota and Impaired Barrier Function Leading to Dissemination of Enterobacteria to the Liver. PLOS ONE, 10(7), e0134234. https://doi.org/10.1371/journal.pone.0134234

34.Β Paudel, D., Uehara, O., Giri, S., Yoshida, K., Morikawa, T., Kitagawa, T., Matsuoka, H., Miura, H., Toyofuku, A., Kuramitsu, Y., Ohta, T., Kobayashi, M., & Abiko, Y. (2022). Effect of psychological stress on the oral-gut microbiota and the potential oral-gut-brain axis. The Japanese Dental Science Review, 58, 365–375. https://doi.org/10.1016/j.jdsr.2022.11.003

35.Β Pizzorno, J. (2017). Toxin Exposure Reduction. Integrative Medicine (Encinitas, Calif.), 16(6), 8–10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438086/

36.Β Stanford, J. (2024a, February 15). Pro-Inflammatory Foods: What to Avoid and Why. Rupa Health. https://www.rupahealth.com/post/pro-inflammatory-foods-what-to-avoid-and-why

37.Β Stanford, J. (2024b, March 12). Mastering the Bs: A Comprehensive Cheat Sheet on Vitamins B1, 2, 3, 5, 6, 7, 9, 12 for Healthcare Practitioners. Rupa Health. https://www.rupahealth.com/post/a-comprehensive-cheat-sheet-on-b-vitamins

38.Β Sudhanshu, A., Sharma, U., Vadiraja, H., Rana, R., & Singhal, R. (2017). Impact of yoga on periodontal disease and stress management. International Journal of Yoga, 10(3), 121. https://doi.org/10.4103/0973-6131.213468

39. Sweetnich, J. (2023a, February 17). 6 Health Benefits of Prebiotics. Rupa Health. https://www.rupahealth.com/post/6-health-benefits-of-prebiotics

40. Sweetnich, J. (2023b, February 28). How to Balance Cortisol Levels Naturally. Rupa Health. https://www.rupahealth.com/post/how-to-balance-cortisol-levels-naturally

41. Sweetnich, J. (2023c, March 24). Vitamin A 101: Health Benefits, Testing, & Top Foods. Rupa Health. https://www.rupahealth.com/post/vitamin-a-101-health-benefits-testing-top-foods

42.Β Sweetnich, J. (2023d, March 28). Calcium 101: Testing, top foods, & supplements. Rupa Health. https://www.rupahealth.com/post/calcium-101-testing-top-foods-supplements

43. Sweetnich, J. (2023e, April 13). What is NAC’s Role in The Body? Rupa Health. https://www.rupahealth.com/post/what-is-nacs-role-in-the-body

44. Sweetnich, J. (2023f, May 8). The Antioxidant Powerhouse: Exploring Testing, Health Benefits, and Sources of Vitamin E. Rupa Health. https://www.rupahealth.com/post/vitamin-e-101

45. Sweetnich, J. (2023g, May 8). Understanding the Importance of Folate Testing and Proper Supplementation for Optimal Health. Rupa Health. https://www.rupahealth.com/post/understanding-the-importance-of-folate-testing-and-proper-supplementation-for-optimal-health

46. Sweetnich, J. (2023h, May 19). Overview of The Liver 101: Top Conditions, Specialty Testing, and Integrative Medicine Treatment Options. Rupa Health. https://www.rupahealth.com/post/overview-liver-101-top-conditions-and-testing

47. Weaver, B. J. (2021, July 12). A fermented-food diet increases microbiome diversity and lowers inflammation, Stanford study finds. News Center. https://med.stanford.edu/news/all-news/2021/07/fermented-food-diet-increases-microbiome-diversity-lowers-inflammation

48. Weinberg, J. (2022, November 16). 4 Science Backed Health Benefits of The Mediterranean Diet. Rupa Health. https://www.rupahealth.com/post/4-science-backed-health-benefits-of-the-mediterranean-diet

49. Weinburg, J. (2022, April 14). 4 Lifestyle Changes That Help Manage Crohn’s Disease. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-crohns-disease

50. Weinburg, J. (2024a, January 2). Impact of Plant-Based Diets on Chronic Inflammation Reduction. Rupa Health. https://www.rupahealth.com/post/impact-of-plant-based-diets-on-chronic-inflammation-reduction

51. Weinburg, J. (2024b, February 29). The Neurobiology of Stress: Cortisol and Beyond. Rupa Health. https://www.rupahealth.com/post/the-neurobiology-of-stress-cortisol-and-beyond

52. Whitman, S. (2023, February 24). What is Functional Dentistry. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-dentistry

53. Yoshimura, H. (2023a, June 21). The Use Of Nutrition And Dietary Changes In Managing Chronic Illnesses. Rupa Health. https://www.rupahealth.com/post/the-use-of-nutrition-and-dietary-changes-in-managing-chronic-illnesses

54. Yoshimura, H. (2023b, August 1). A Comprehensive Guide to Nutrition and Supplements for Supporting Detoxification Pathways. Rupa Health. https://www.rupahealth.com/post/a-comprehensive-guide-to-nutrition-and-supplements-for-supporting-detoxification-pathways

55. Yoshimura, H. (2023c, August 9). Heavy Metals Test 101: Why Testing Heavy Metals is Important For A Root Cause Medicine Approach. Rupa Health. https://www.rupahealth.com/post/heavy-metals-test-101-why-testing-heavy-metals-is-important-for-a-root-cause-medicine-approach

56. Yoshimura, H. (2023d, September 6). A Root Cause Approach To Mercury Toxicity: A Comprehensive Guide. Rupa Health. https://www.rupahealth.com/post/a-root-cause-approach-to-mercury-toxicity-a-comprehensive-guide

57. Yoshimura, H. (2023e, October 3). Digging Deeper: How Root Cause Medicine Addresses Chronic Health Issues. Rupa Health. https://www.rupahealth.com/post/digging-deeper-how-root-cause-medicine-addresses-chronic-health-issues

58. Yoshimura, H. (2023f, November 7). The remarkable power of exercise on our health: A comprehensive overview. Rupa Health. https://www.rupahealth.com/post/the-remarkable-power-of-exercise-on-our-health-a-comprehensive-overview

59. Yoshimura, H. (2023g, November 29). Tooth Tales: The Not-So-Sweet Impact of Sugar on Dental Decay. Rupa Health. https://www.rupahealth.com/post/tooth-tales-the-not-so-sweet-impact-of-sugar-on-dental-decay

60. Yoshimura, H. (2024, March 14). The Relationship Between Oral Health and Systemic Disease. Rupa Health. https://www.rupahealth.com/post/the-relationship-between-oral-health-and-systemic-diseaseΒ 

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