October 24, 2022

These 4 Things Can Put You At a Higher Risk for Candida Overgrowth

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Medically Reviewed by

Updated On

September 17, 2024

Candida Albicans is the most common cause of candida overgrowth in the gut. In a healthy person, the gut microbiota encompasses about 66 genera of fungi, primarily candida species, and Saccharomyces. Along with being present in the gut, it is also on your skin, mouth, oral cavity, and vagina. It is typically kept in check by having a symbiotic relationship with other microbes in the gut, such as bacteria, viruses, and fungi. A disruption to our internal ecosystem by poor nutrition, medications, or disease processes can affect the healthy balance of our gut organisms and lead to candida overgrowth.

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What is Candida Overgrowth?

Candida is a normal fungus present on your skin, oral cavity, vaginal tract, and gastrointestinal tract. This fungus becomes intrusive when it overpopulates beyond what is considered commensal, meaning a healthy part of our gut flora. Overgrowth is caused by an imbalance in the gut flora and disruption to the immune system.

Candida Overgrowth Signs & Symptom

It's important to note that overgrowth of candida in the gut can eventually lead to candida overgrowth throughout the body if left untreated. Awareness of symptoms early on is vital to patients' overall health and well-being. Symptoms of Candida in the gi tract may include:

Abdominal pain
Diarrhea
Bloody stool (rare)
Bloating
Mucus present in stool
Fever
Fatigue

4 Things That Can Cause Candida Overgrowth in the Gut

Many factors can lead to dysbiosis in the gut, which causes insult to the integrity of the intestinal tract and lead to things like candida overgrowth. Here are some of the most common causes of intrusive candida in the gut:

Lifestyle

Eating a diet high in processed foods, refined sugar, and excessive alcohol consumption can cause dysbiosis allowing candida to overgrow in the GI tract.

Continuous higher stress levels can also weaken the immune system and disrupt the gut microbiome, causing an imbalance between the microbes in the GI tract, creating the perfect environment for the overgrowth of opportunistic bacteria and fungi.

Medications

Steroids, antibiotics, proton pump inhibitors (PPIs), and immunosuppressive medications can negatively impact your gut's integrity.

Steroids: While steroid-class drugs are meant to decrease inflammation, the side effects can also be damaging. The chronic use of steroids can weaken your immune system, putting a patient at higher risk for fungal infections.

Antibiotics: inhibit the growth of various pathogenic bacteria but also target commensal bacteria. Tetracyclines, and macrolides, specifically, can create "collateral damage" by wiping out good bacteria alongside harmful bacteria in the gi tract. This creates an imbalance allowing microbes like candida to become opportunistic.

PPI's: The increase in gastric pH brought on by the overuse of proton pump inhibitors can cause damage to the gastrointestinal tract by weakening the barrier, which increases your risk of gastrointestinal infections. PPIs are a risk factor for Small Intestinal Fungal Overgrowth (SIFO) in patients using them for unexplained gastrointestinal symptoms.

Immunosuppressive Drugs: intentionally weaken your immune system to treat conditions such as organ transplants, HIV, cancer, and autoimmune conditions. While they may be necessary, a potential side effect is candida overgrowth.

Inflammatory bowel disease (IBD)

Inflammatory bowel disease (IBD), the umbrella term for Ulcerative Colitis and Chron's disease, can contribute to candida overgrowth. One study showed that chronic inflammation and treatments used for IBD, such as anti-TNFa agents, lead to gastrointestinal injury. The injury allows pathogens to penetrate the intestinal lining causing microbial imbalance like candida overgrowth.

Diabetes

Increased colonization of candida spp. has been detected in both Type 1 and Type 2 diabetes. This is due to a dysregulated immune system from poor glycemic control and elevated blood glucose levels. A lower immune system creates an environment in the gut that allows candida to go from commensal to pathogenic. Controlling blood sugar by working with a practitioner could help reduce your risk of diabetic-induced candida infection.

Functional Medicine Labs to Test for Candida Overgrowth

‍GI-MAP stool test is a great way to assess gut microbial flora. It tests both candida spp. and Candida Albicans, which can give you insight into gut inflammation, fungal overgrowth, and other organism imbalances.
The GI-Effects pathogen profile is an option that gives both an assessment and viable treatment options. This test can help determine which prescriptive, and natural therapeutics are most effective in addressing your unique gut flora.
A blood test alongside a stool test can provide a comprehensive picture. Looking at IgA, IgG, and IgM reactivity to candida can help determine if this fungus is causing an immune reaction.
If you are at risk for diabetes or have symptoms, running a diabetes panel testing these six biomarkers as a screening or management tool can be beneficial.

Conventional Treatment for Candida Overgrowth

Oral antifungals that fall under 'azoles' are the most commonly used drugs to treat candida infections. Fluconazole is one of the drugs used to treat this condition. It works by inhibiting the Cytochrome p450 enzyme, leading to the arrest of fungal growth. It also creates holes in the cell membrane of the fungus, causing the cells to become permeable and die off.

Other drugs used to treat candida overgrowth include Caspofungin, Terbinafine, and AMP B. There is also evidence that combining antifungals, such as an -azole drug, with one of the prescriptions mentioned above results in better efficacy.

Functional Medicine Treatment for Candida Overgrowth

Treatment for candida overgrowth in the gut is very similar to treatment for candida infection in other areas of the body. Addressing underlying root causes is always a great starting place. Optimizing nutrition, utilizing natural therapies, and modifying your lifestyle can help treat and prevent candida overgrowth.

Nutrition

Candida overgrowth has been correlated to blood sugar dysregulation, typically from high carbohydrate diets that impact conditions such as diabetes. A Candida Diet emphasizes low-sugar, anti-inflammatory foods to promote a healthy microbiome, reduce inflammation, and enhance the immune system.

Herbs & Supplements

Caprylic Acid: has been shown to damage the cellular membrane of C. Albicans species. This research has shown that it is more effective if used as a combination treatment with carvacrol and thymol. In the trifecta approach, caprylic acid breaks down the cell membrane, allowing the natural antifungals- carvacrol and thymol to do the work in killing the fungus.

Oregano (Origanum vulgare): helps address candida overgrowth by breaking down the biofilm that develops over the mucosal and epithelial surface of the intestinal tract. These biofilms are a protective mechanism that organisms use to hide away while they continue to multiply.

Berberine: a constituent in herbs such as Goldenseal, has antifungal properties. Studies of berberine reveal its effectiveness in treating fluconazole-resistant pathogenic candida by altering cellular components and causing DNA damage to the fungal species.

Saccharomyces boulardii: is a yeast-based probiotic that is an effective treatment for breaking down biofilm. It has also been shown to reduce inflammation created by opportunistic infection.

Lifestyle changes

One way to prevent candida overgrowth is to implement mindful choices. Reducing stress, taking probiotics, avoiding the overuse of antibiotics, maintaining a well-balanced diet, and avoiding tobacco and alcohol are all ways to reduce your risk of candida overgrowth.

Mental Health Support

Maintaining healthy mind-body practices can also help restore your gut microbiome. Your gut health has a bi-directional relationship with your brain through the gut-brain axis. This pathway can influence microbial balance and should always be supported when doing a gut healing protocol. Behavioral medicine interventions such as relaxation therapy, Cognitive Behavioral Therapy, Gut-Directed Relaxation Training, and Biofeedback are all therapeutics that have the potential to assist you through gut restoration.

Exercise

Implementing an exercise routine can help with many aspects of candida overgrowth, including support to detoxification pathways, boosting the immune system, reducing stress, and balancing blood sugar. Studies have revealed that exercise enhances beneficial microbial species in the gut, improving the diversity of the gut flora and commensal bacteria.

Sleep

Studies show that inadequate sleep can lead to immune dysfunction and increased inflammatory markers. Establishing a sleep routine can help you best combat candida overgrowth.

Summary

Your gut flora's health depends on a symbiotic relationship between candida and other microbes such as bacteria, viruses, and fungi. When disruption occurs due to medication, disease processes, or inflammation, this lends way to imbalances such as candida overgrowth. Understanding how this can happen is the first step in prevention. If you suffer from chronic unexplained gut issues or you suspect you have candida overgrowth, it is best to work with a healthcare provider that can run the proper tests and implement a holistic treatment plan.

Candida Albicans is a common component of the gut microbiota, which includes about 66 genera of fungi, primarily candida species, and Saccharomyces. Along with being present in the gut, it is also on your skin, mouth, oral cavity, and vagina. It is typically kept in check by having a symbiotic relationship with other microbes in the gut, such as bacteria, viruses, and fungi. A disruption to our internal ecosystem by poor nutrition, medications, or disease processes can affect the healthy balance of our gut organisms and may lead to candida overgrowth.

[signup]

What is Candida Overgrowth?

Candida is a normal fungus present on your skin, oral cavity, vaginal tract, and gastrointestinal tract. This fungus can become more prominent when it grows beyond what is considered commensal, meaning a healthy part of our gut flora. Overgrowth may be associated with an imbalance in the gut flora and disruption to the immune system.

Candida Overgrowth Signs & Symptoms

It's important to note that overgrowth of candida in the gut can potentially spread throughout the body if not addressed. Awareness of symptoms early on is vital to overall health and well-being. Symptoms of Candida in the GI tract may include:

Abdominal discomfort
Diarrhea
Bloody stool (rare)
Bloating
Mucus present in stool
Fever
Fatigue

4 Factors That May Contribute to Candida Overgrowth in the Gut

Many factors can lead to dysbiosis in the gut, which may affect the integrity of the intestinal tract and contribute to conditions like candida overgrowth. Here are some of the most common factors that may influence candida in the gut:

Lifestyle

Eating a diet high in processed foods, refined sugar, and excessive alcohol consumption can contribute to dysbiosis, potentially allowing candida to grow more in the GI tract.

Continuous higher stress levels can also affect the immune system and disrupt the gut microbiome, potentially creating an imbalance between the microbes in the GI tract, which may support the growth of opportunistic bacteria and fungi.

Medications

Steroids, antibiotics, proton pump inhibitors (PPIs), and immunosuppressive medications can impact your gut's integrity.

Steroids: While steroid-class drugs are meant to decrease inflammation, the side effects can also be significant. The chronic use of steroids can affect your immune system, potentially increasing the risk for fungal imbalances.

Antibiotics: These medications inhibit the growth of various pathogenic bacteria but can also affect commensal bacteria. Tetracyclines and macrolides, specifically, can create "collateral damage" by reducing beneficial bacteria alongside harmful bacteria in the GI tract. This may create an imbalance allowing microbes like candida to become more prominent.

PPI's: The increase in gastric pH brought on by the overuse of proton pump inhibitors can affect the gastrointestinal tract by weakening the barrier, which may increase your risk of gastrointestinal imbalances. PPIs are a potential risk factor for Small Intestinal Fungal Overgrowth (SIFO) in patients using them for unexplained gastrointestinal symptoms.

Immunosuppressive Drugs: These drugs intentionally affect your immune system to manage conditions such as organ transplants, HIV, cancer, and autoimmune conditions. While they may be necessary, a potential side effect is candida overgrowth.

Inflammatory bowel disease (IBD)

Inflammatory bowel disease (IBD), the umbrella term for Ulcerative Colitis and Chron's disease, can contribute to candida overgrowth. One study showed that chronic inflammation and treatments used for IBD, such as anti-TNFa agents, may lead to gastrointestinal changes. These changes may allow pathogens to penetrate the intestinal lining, potentially causing microbial imbalances like candida overgrowth.

Diabetes

Increased presence of candida spp. has been detected in both Type 1 and Type 2 diabetes. This may be due to a dysregulated immune system from poor glycemic control and elevated blood glucose levels. A lower immune system may create an environment in the gut that allows candida to grow more. Managing blood sugar by working with a practitioner could help support a balanced gut environment.

Functional Medicine Labs to Test for Candida Overgrowth

‍GI-MAP stool test is a way to assess gut microbial flora. It tests both candida spp. and Candida Albicans, which can provide insight into gut inflammation, fungal presence, and other organism balances.
The GI-Effects pathogen profile is an option that provides both an assessment and potential management options. This test can help determine which prescriptive and natural therapeutics may be effective in supporting your unique gut flora.
A blood test alongside a stool test can provide a comprehensive picture. Looking at IgA, IgG, and IgM reactivity to candida can help determine if this fungus is associated with an immune response.
If you are at risk for diabetes or have symptoms, running a diabetes panel testing these six biomarkers as a screening or management tool can be beneficial.

Conventional Approaches for Candida Overgrowth

Oral antifungals that fall under 'azoles' are commonly used drugs to manage candida imbalances. Fluconazole is one of the drugs used to address this condition. It works by inhibiting the Cytochrome p450 enzyme, which may affect fungal growth. It also creates changes in the cell membrane of the fungus, affecting the cells' permeability.

Other drugs used to manage candida overgrowth include Caspofungin, Terbinafine, and AMP B. There is also evidence that combining antifungals, such as an -azole drug, with one of the prescriptions mentioned above may result in better outcomes.

Functional Medicine Approaches for Candida Overgrowth

Approaches for candida overgrowth in the gut are similar to those for candida presence in other areas of the body. Addressing underlying factors is always a great starting place. Optimizing nutrition, utilizing natural therapies, and modifying your lifestyle may help support a balanced gut environment.

Nutrition

Candida overgrowth has been associated with blood sugar dysregulation, typically from high carbohydrate diets that impact conditions such as diabetes. A Candida Diet emphasizes low-sugar, anti-inflammatory foods to promote a healthy microbiome, support balanced inflammation, and enhance the immune system.

Herbs & Supplements

Caprylic Acid: has been shown to affect the cellular membrane of C. Albicans species. This research suggests it may be more effective if used as a combination approach with carvacrol and thymol. In this approach, caprylic acid may alter the cell membrane, allowing natural compounds like carvacrol and thymol to support the body's defense against the fungus.

Oregano (Origanum vulgare): may help address candida overgrowth by affecting the biofilm that develops over the mucosal and epithelial surface of the intestinal tract. These biofilms are a protective mechanism that organisms use to hide while they continue to multiply.

Berberine: a constituent in herbs such as Goldenseal, has properties that may support the body's defense against fungi. Studies of berberine suggest its potential effectiveness in addressing fluconazole-resistant pathogenic candida by altering cellular components.

Saccharomyces boulardii: is a yeast-based probiotic that may be effective in affecting biofilm. It has also been shown to support a balanced inflammatory response created by opportunistic presence.

Lifestyle changes

One way to support a balanced gut environment is to implement mindful choices. Reducing stress, taking probiotics, avoiding the overuse of antibiotics, maintaining a well-balanced diet, and avoiding tobacco and alcohol are all ways to support a healthy gut environment.

Mental Health Support

Maintaining healthy mind-body practices can also help support your gut microbiome. Your gut health has a bi-directional relationship with your brain through the gut-brain axis. This pathway can influence microbial balance and should always be supported when doing a gut health protocol. Behavioral medicine interventions such as relaxation therapy, Cognitive Behavioral Therapy, Gut-Directed Relaxation Training, and Biofeedback are all tools that have the potential to assist you through gut restoration.

Exercise

Implementing an exercise routine can help with many aspects of gut health, including support to detoxification pathways, boosting the immune system, reducing stress, and balancing blood sugar. Studies have revealed that exercise enhances beneficial microbial species in the gut, improving the diversity of the gut flora and commensal bacteria.

Sleep

Studies show that inadequate sleep can lead to immune changes and increased inflammatory markers. Establishing a sleep routine can help you best support a balanced gut environment.

Summary

Your gut flora's health depends on a symbiotic relationship between candida and other microbes such as bacteria, viruses, and fungi. When disruption occurs due to medication, disease processes, or inflammation, this may lead to imbalances such as candida overgrowth. Understanding how this can happen is the first step in supporting a balanced gut environment. If you experience chronic unexplained gut issues or suspect you have candida overgrowth, it is best to work with a healthcare provider who can run the appropriate tests and help develop a holistic plan.

The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.

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Lab Tests in This Article

GI-MAP by Diagnostic Solutions

Stool

The GI-MAP is a comprehensive stool test that utilizes qPCR technology to detect parasites, bacteria, fungi, and more, allowing practitioners to create personalized treatment protocols to address gut dysfunction.

GI Effects® Fundamentals - 1 day by Genova Diagnostics

Stool

The GI Effects® Fundamentals profile provides a cursory evaluation of the overall health of the GI tract, including insights into digestion/absorption, inflammation/immune response, gut microbial metabolites, and potential dysbiotic or pathological organisms. This is the 1-day version of the test; it is also available as a 3-day test.

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